Entry Name AMPK signaling pathway - Myotis lucifugus (little brown bat)
Description AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Myotis lucifugus (little brown bat) [GN:
mlf ]
Gene 102416978 CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048 ]
102417307 CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333 ]
102417642 PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584 ]
102417838 PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha [KO:K07202 ]
102418401 IRS4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446 ]
102418433 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
102419367 SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 isoform X1 [KO:K07191 ]
102421388 PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456 ]
102421849 CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048 ]
102422214 PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354 ]
102422649 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
102424796 AKT1S1; LOW QUALITY PROTEIN: proline-rich AKT1 substrate 1 [KO:K16184 ]
102424912 TBC1D1; LOW QUALITY PROTEIN: TBC1 domain family member 1 [KO:K18341 ]
102425288 PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200 ]
102426106 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
102427186 CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048 ]
102427890 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
102428034 PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583 ]
102428212 PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200 ]
102428529 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
102429074 IRS2; LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187 ]
102429230 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
102430062 PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5 [KO:K11584 ]
102430132 PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199 ]
102430803 PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382 ] [EC:3.1.3.16 ]
102430862 PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199 ]
102431175 PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354 ]
102431250 CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
102432188 PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
102432946 PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584 ]
102433480 PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584 ]
102433534 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
102433629 PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583 ]
102435787 PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530 ]
102436674 PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200 ]
102437363 PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354 ]
102439961 CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047 ]
102440546 STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532 ]
102441009 STRADA; STE20-related kinase adapter protein alpha isoform X4 [KO:K08271 ]
102441064 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
102442817 PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
102442935 PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584 ]
102443216 CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048 ]
Compound C00354 D-Fructose 1,6-bisphosphate
C00665 beta-D-Fructose 2,6-bisphosphate
C00668 alpha-D-Glucose 6-phosphate
C01172 beta-D-Glucose 6-phosphate
C04677 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C09731 Epigallocatechin gallate
Reference Authors Steinberg GR, Kemp BE
Title AMPK in Health and Disease.
Journal Reference Authors Hardie DG.
Title The AMP-activated protein kinase pathway--new players upstream and downstream.
Journal Reference Authors Russo GL, Russo M, Ungaro P
Title AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
Journal Reference Authors Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
Title AMPK in the brain: its roles in energy balance and neuroprotection.
Journal Reference Authors Li J, McCullough LD
Title Effects of AMP-activated protein kinase in cerebral ischemia.
Journal Reference Authors Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
Title The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
Journal Reference Authors Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
Title Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
Journal Reference Authors Shackelford DB, Shaw RJ
Title The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
Journal Reference Authors Chung JH, Manganiello V, Dyck JR
Title Resveratrol as a calorie restriction mimetic: therapeutic implications.
Journal Reference Authors Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
Title Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
Journal Reference Authors Towler MC, Hardie DG
Title AMP-activated protein kinase in metabolic control and insulin signaling.
Journal Reference Authors Richter EA, Hargreaves M
Title Exercise, GLUT4, and skeletal muscle glucose uptake.
Journal Reference Authors Kahn BB, Alquier T, Carling D, Hardie DG
Title AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
Journal Reference Authors Minokoshi Y, Toda C, Okamoto S
Title Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
Journal Reference Authors Guggino WB, Stanton BA
Title New insights into cystic fibrosis: molecular switches that regulate CFTR.
Journal Reference Authors Cheng A, Saltiel AR
Title More TORC for the gluconeogenic engine.
Journal Reference Authors Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
Title TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
Journal Reference Authors Morris DL, Rui L
Title Recent advances in understanding leptin signaling and leptin resistance.
Journal Reference Authors Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
Title Role of hypothalamic AMP-kinase in food intake regulation.
Journal Reference Authors Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
Title Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
Journal Related mlf01040 Biosynthesis of unsaturated fatty acids
mlf04920 Adipocytokine signaling pathway
KO pathway
