KEGG   PATHWAY: mlf04150
Entry
mlf04150                    Pathway                                
Name
mTOR signaling pathway - Myotis lucifugus (little brown bat)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
mlf04150  mTOR signaling pathway
mlf04150

Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102432867  SLC7A5; LOW QUALITY PROTEIN: large neutral amino acids transporter small subunit 1 [KO:K13780]
102442663  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
102441588  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X3 [KO:K14995]
102427446  ATP6V1A; V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
102425415  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
102439179  ATP6V1B2; V-type proton ATPase subunit B, brain isoform isoform X1 [KO:K02147]
102442571  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
102428837  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X2 [KO:K02148]
102427644  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
102438262  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
102420621  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
102425122  V-type proton ATPase subunit E 1-like isoform X1 [KO:K02150]
102427002  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
102430094  V-type proton ATPase subunit G 3 [KO:K02152]
102422711  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
102424885  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
102442475  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
102421501  ragulator complex protein LAMTOR2 [KO:K20398]
102442904  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
102426209  LAMTOR3; ragulator complex protein LAMTOR3 isoform X4 [KO:K04370]
102426954  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
102420346  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
102438279  FLCN; folliculin isoform X1 [KO:K09594]
102436707  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
102438148  FNIP2; folliculin-interacting protein 2 isoform X2 [KO:K20401]
102438834  RRAGA; ras-related GTP-binding protein A [KO:K16185]
102423406  RRAGB; ras-related GTP-binding protein B isoform X3 [KO:K16185]
102442083  RRAGC; ras-related GTP-binding protein C [KO:K16186]
102425558  RRAGD; ras-related GTP-binding protein D isoform X1 [KO:K16186]
102426630  SESN2; sestrin-2 isoform X2 [KO:K20394]
102421534  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X2 [KO:K23080]
102422670  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
102421633  MIOS; GATOR complex protein MIOS isoform X1 [KO:K20407]
102432721  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
102441164  WDR24; GATOR complex protein WDR24 [KO:K20408]
102426819  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
102440448  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
102433006  GATOR complex protein DEPDC5 [KO:K20404]
102440999  NPRL2; GATOR complex protein NPRL2 [KO:K20405]
102420426  NPRL3; GATOR complex protein NPRL3 [KO:K20406]
102429293  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
102429568  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
102430610  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
102424796  AKT1S1; LOW QUALITY PROTEIN: proline-rich AKT1 substrate 1 [KO:K16184]
102434974  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102419155  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
102424858  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
102439163  TELO2; telomere length regulation protein TEL2 homolog isoform X2 [KO:K11137]
102421932  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
102431115  CLIP1; LOW QUALITY PROTEIN: CAP-Gly domain-containing linker protein 1 [KO:K10421]
102440478  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
102426579  LPIN1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
102421838  LPIN3; LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
102441928  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
102440434  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
102418433  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102437938  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
102433516  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
102416807  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
102431191  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
102429245  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X2 [KO:K04688] [EC:2.7.11.1]
102433676  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102439562  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
102437206  RPS6; 40S ribosomal protein S6 [KO:K02991]
102441009  STRADA; STE20-related kinase adapter protein alpha isoform X4 [KO:K08271]
102440546  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
102421316  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
102427480  CAB39; calcium-binding protein 39 isoform X1 [KO:K08272]
102438468  CAB39L; calcium-binding protein 39-like [KO:K08272]
102440094  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
102438720  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
102440346  TSC1; hamartin [KO:K07206]
102422720  TSC2; tuberin isoform X1 [KO:K07207]
102435314  TMEM202; LOW QUALITY PROTEIN: transmembrane protein 202 [KO:K20396]
102442563  TBC1 domain family member 7 isoform X1 [KO:K20396]
102422024  LOW QUALITY PROTEIN: GTP-binding protein Rheb-like [KO:K07208]
102441557  RHEB; GTP-binding protein Rheb [KO:K07208]
102428383  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
102433775  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102417121  WNT2; protein Wnt-2 [KO:K00182]
102440610  WNT2B; LOW QUALITY PROTEIN: protein Wnt-2b [KO:K00182]
102429304  WNT3; proto-oncogene Wnt-3 [KO:K00312]
102422483  WNT5A; protein Wnt-5a [KO:K00444]
102436468  WNT5B; protein Wnt-5b [KO:K00444]
102420490  WNT6; protein Wnt-6 [KO:K00445]
102440256  WNT7A; protein Wnt-7a [KO:K00572]
102417803  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
102427177  WNT8B; protein Wnt-8b [KO:K00714]
102427165  WNT9A; protein Wnt-9a [KO:K01064]
102417616  WNT9B; protein Wnt-9b [KO:K01064]
102425605  WNT10A; protein Wnt-10a isoform X1 [KO:K01357]
102436360  WNT10B; protein Wnt-10b [KO:K01357]
102429600  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
102440107  WNT16; LOW QUALITY PROTEIN: protein Wnt-16 [KO:K01558]
102438581  FZD1; frizzled-1 [KO:K02432]
102433622  FZD7; frizzled-7 [KO:K02432]
102437539  FZD3; frizzled-3 isoform X1 [KO:K02329]
102432960  FZD4; frizzled-4 isoform X1 [KO:K02354]
102429852  FZD5; LOW QUALITY PROTEIN: frizzled-5 [KO:K02375]
102420951  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
102442257  FZD6; frizzled-6 [KO:K02376]
102435819  FZD9; LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
102427391  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
102423336  LRP5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
102424701  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
102419260  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
102428794  GSK3B; glycogen synthase kinase-3 beta isoform X13 [KO:K03083] [EC:2.7.11.26]
102437558  TNF; tumor necrosis factor isoform X1 [KO:K03156]
102419664  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102417312  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4 [KO:K07209] [EC:2.7.11.10]
102430737  INS; insulin [KO:K04526]
102424041  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102437355  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
102430595  IGF1R; LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102421027  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102442926  SOS1; son of sevenless homolog 1 [KO:K03099]
102437531  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102431999  KRAS; GTPase KRas isoform X1 [KO:K07827]
102430744  NRAS; GTPase NRas [KO:K07828]
102435241  BRAF; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102434453  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102417411  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
102423748  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102417755  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102422236  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102438050  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
102441142  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
102432403  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102442509  IRS1; insulin receptor substrate 1 [KO:K16172]
102427890  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102441522  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
102429230  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102426106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102419324  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
102422649  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102441064  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102433534  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102428304  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102431196  PDPK1; LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102443221  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102439923  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102425603  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102430032  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
102433880  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
102436489  PRR5L; proline-rich protein 5-like [KO:K20411]
102422264  RHOA; transforming protein RhoA [KO:K04513]
102430746  transforming protein RhoA-like isoform X1 [KO:K04513]
102438932  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102428240  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102419083  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
102421134  SGK1; serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
mlf00561  Glycerolipid metabolism
mlf04010  MAPK signaling pathway
mlf04140  Autophagy - animal
mlf04151  PI3K-Akt signaling pathway
mlf04152  AMPK signaling pathway
mlf04810  Regulation of actin cytoskeleton
mlf04910  Insulin signaling pathway
KO pathway
ko04150   
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