Entry
Name
PI3K-Akt signaling pathway - Myotis lucifugus (little brown bat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Myotis lucifugus (little brown bat) [GN:
mlf ]
Gene
102429928 FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358 ]
102432233 FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428 ]
102426780 PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
102426433 VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448 ]
102438597 VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858 ]
102431995 GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452 ]
102420805 NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
102421027 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
102435667 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
102433573 OSMR; LOW QUALITY PROTEIN: oncostatin-M-specific receptor subunit beta [KO:K05057 ]
102420320 IL2RB; LOW QUALITY PROTEIN: interleukin-2 receptor subunit beta [KO:K05069 ]
102438125 IL6R; LOW QUALITY PROTEIN: interleukin-6 receptor subunit alpha [KO:K05055 ]
102436222 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
102419381 IFNAR2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131 ]
102427246 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
102428769 COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237 ]
102428453 COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237 ]
102420284 COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237 ]
102437344 COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238 ]
102423308 COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131 ]
102422649 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
102441064 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
102433534 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
102427890 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
102441522 LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649 ]
102429230 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
102426106 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
102419324 LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649 ]
102418229 LPAR1; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 1 [KO:K04289 ]
102420431 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
102420482 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
102428334 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
102431535 GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538 ]
102420203 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
102441805 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
102442437 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
102428001 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
102422498 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
106697041 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
102432910 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
102432599 GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347 ]
102428066 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
102431853 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
102432692 guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548 ]
102420164 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
102439715 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
102425527 PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290 ]
102429282 PIK3R6; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290 ]
102424858 MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266 ]
102418433 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
102437938 eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259 ]
102433516 EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259 ]
102416807 EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259 ]
102431191 EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259 ]
102439562 EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258 ]
102422076 MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631 ]
102432188 PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
102430803 PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382 ] [EC:3.1.3.16 ]
102421388 PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456 ]
102442817 PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
102431175 PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354 ]
102423271 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354 ]
102440385 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform-like [KO:K04354 ]
102437363 PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354 ]
102422214 PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354 ]
102433629 PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583 ]
102428034 PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583 ]
102433480 PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584 ]
102417642 PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584 ]
102432946 PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584 ]
102430062 PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5 [KO:K11584 ]
102442935 PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584 ]
102417307 CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333 ]
102439094 CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625 ]
102439228 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
102428529 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
102418405 ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450 ]
102429560 ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
102431250 CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
102416978 CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048 ]
102443216 CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048 ]
102427186 CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048 ]
102421849 CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048 ]
102439961 CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047 ]
102428756 ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049 ]
102441536 MCL1; LOW QUALITY PROTEIN: induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539 ]
102435748 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
Compound
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Engelman JA, Luo J, Cantley LC
Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
Journal
Reference
Authors
Song G, Ouyang G, Bao S
Title
The activation of Akt/PKB signaling pathway and cell survival.
Journal
Reference
Authors
Hers I, Vincent EE, Tavare JM
Title
Akt signalling in health and disease.
Journal
Reference
Authors
Duronio V
Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
Journal
Reference
Authors
Kim D, Chung J.
Title
Akt: versatile mediator of cell survival and beyond.
Journal
Reference
Authors
Koyasu S
Title
The role of PI3K in immune cells.
Journal
Reference
Authors
Okkenhaug K, Vanhaesebroeck B.
Title
PI3K in lymphocyte development, differentiation and activation.
Journal
Reference
Authors
Richardson CJ, Schalm SS, Blenis J
Title
PI3-kinase and TOR: PIKTORing cell growth.
Journal
Reference
Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
Title
Akt, FoxO and regulation of apoptosis.
Journal
Reference
Authors
Georgescu MM
Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
Journal
Reference
Authors
West KA, Castillo SS, Dennis PA
Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
Journal
Reference
Authors
Wymann MP, Pirola L
Title
Structure and function of phosphoinositide 3-kinases.
Journal
Reference
Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
Title
Regulation of Raf-Akt Cross-talk.
Journal
Reference
Authors
Kikani CK, Dong LQ, Liu F
Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
Journal
Reference
Authors
Blume-Jensen P, Hunter T
Title
Oncogenic kinase signalling.
Journal
Reference
Authors
Osaki M, Oshimura M, Ito H
Title
PI3K-Akt pathway: its functions and alterations in human cancer.
Journal
Reference
Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Related pathway
mlf04620 Toll-like receptor signaling pathway
mlf04662 B cell receptor signaling pathway
KO pathway
LinkDB
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