KEGG   PATHWAY: mmur04150
Entry
mmur04150                   Pathway                                
Name
mTOR signaling pathway - Microcebus murinus (gray mouse lemur)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
mmur04150  mTOR signaling pathway
mmur04150

Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105855026  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105855054  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
105855189  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
105855459  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
105855473  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
105855775  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
105855821  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105855978  CAB39L; calcium-binding protein 39-like [KO:K08272]
105856247  NPRL3; nitrogen permease regulator 3-like protein isoform X1 [KO:K20406]
105856284  WDR24; WD repeat-containing protein 24 [KO:K20408]
105856303  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
105856333  FLCN; folliculin [KO:K09594]
105856565  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
105856581  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
105856794  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
105856829  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
105856944  FZD7; frizzled-7 [KO:K02432]
105856961  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
105857243  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
105857286  KRAS; GTPase KRas isoform X1 [KO:K07827]
105857532  [KO:K09594]
105857652  WNT10A; protein Wnt-10a [KO:K01357]
105857697  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105857713  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
105857723  [KO:K03259]
105858049  [KO:K14004]
105858137  TNF; tumor necrosis factor isoform X1 [KO:K03156]
105858140  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
105858813  FZD9; frizzled-9 [KO:K02842]
105858824  CASTOR2; GATS-like protein 2 [KO:K23081]
105859557  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
105859584  TSC2; tuberin isoform X1 [KO:K07207]
105859640  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
105859676  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
105859822  INS; insulin [KO:K04526]
105859868  TSC1; hamartin isoform X1 [KO:K07206]
105860071  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
105860329  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
105860401  WNT11; protein Wnt-11 [KO:K01384]
105860427  FZD4; frizzled-4 [KO:K02354]
105860784  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
105860963  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
105860967  SEH1L; LOW QUALITY PROTEIN: nucleoporin SEH1 [KO:K14299]
105861093  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105861590  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
105861618  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105861626  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
105861868  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
105862521  WNT8A; protein Wnt-8a isoform X3 [KO:K00714]
105862660  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105862843  CAB39; calcium-binding protein 39 [KO:K08272]
105862871  IRS1; insulin receptor substrate 1 [KO:K16172]
105863198  [KO:K03259]
105863253  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
105863518  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105863566  SESN2; sestrin-2 [KO:K20394]
105863615  RRAGD; ras-related GTP-binding protein D [KO:K16186]
105863673  WNT3; proto-oncogene Wnt-3 [KO:K00312]
105863738  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105864003  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
105864102  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
105864316  FZD5; frizzled-5 [KO:K02375]
105864522  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
105864858  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
105865143  TBC1D7; TBC1 domain family member 7 [KO:K20396]
105865198  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
105865324  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
105865626  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
105865944  TTI1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
105867065  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
105867075  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
105867131  [KO:K04467] [EC:2.7.11.10]
105867280  MIOS; WD repeat-containing protein mio isoform X1 [KO:K20407]
105867344  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
105867353  WNT16; protein Wnt-16 [KO:K01558]
105867396  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
105867461  [KO:K20411]
105867475  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
105867560  [KO:K09594]
105867678  SOS2; son of sevenless homolog 2 [KO:K03099]
105868083  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105868440  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
105868496  WNT10B; protein Wnt-10b [KO:K01357]
105869061  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105869064  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
105869202  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105869373  WNT2; protein Wnt-2 isoform X1 [KO:K00182]
105869687  [KO:K04527] [EC:2.7.10.1]
105869932  FNIP1; LOW QUALITY PROTEIN: folliculin-interacting protein 1 [KO:K20400]
105870168  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105870314  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105870389  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105870577  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
105870697  [KO:K04371] [EC:2.7.11.24]
105870929  CASTOR1; GATS-like protein 3 isoform X1 [KO:K23080]
105870968  DEPDC5; DEP domain-containing protein 5 isoform X1 [KO:K20404]
105871124  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105871266  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
105871982  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
105872762  FZD10; frizzled-10 [KO:K02842]
105873144  LAMTOR2; ragulator complex protein LAMTOR2 isoform X1 [KO:K20398]
105873244  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105873486  [KO:K03259]
105873508  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105873607  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
105873639  WNT8B; protein Wnt-8b isoform X1 [KO:K00714]
105873684  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
105873938  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105874032  HRAS; GTPase HRas [KO:K02833]
105874131  RRAGA; ras-related GTP-binding protein A [KO:K16185]
105874134  RPS6; 40S ribosomal protein S6 [KO:K02991]
105874527  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105874723  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105874961  RHOA; transforming protein RhoA [KO:K04513]
105875004  NPRL2; nitrogen permease regulator 2-like protein isoform X1 [KO:K20405]
105875194  MAPKAP1; LOW QUALITY PROTEIN: target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
105875446  WDR59; WD repeat-containing protein 59 isoform X1 [KO:K20409]
105875567  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105876736  [KO:K15705] [EC:2.3.2.27]
105876737  [KO:K15705] [EC:2.3.2.27]
105876768  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105877164  FZD3; LOW QUALITY PROTEIN: frizzled-3 [KO:K02329]
105877293  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
105877483  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105877644  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
105877796  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105877858  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
105877972  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
105878144  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105878394  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2 [KO:K07198] [EC:2.7.11.31]
105878569  SLC3A2; 4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519]
105878710  NRAS; GTPase NRas [KO:K07828]
105878754  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
105878831  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
105878936  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105879031  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X2 [KO:K02148]
105879391  FZD1; frizzled-1 [KO:K02432]
105879455  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
105879551  RRAGC; ras-related GTP-binding protein C isoform X1 [KO:K16186]
105879718  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105879917  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105880209  LPIN1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
105880241  ATP6V1D; LOW QUALITY PROTEIN: V-type proton ATPase subunit D [KO:K02149]
105880325  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
105880452  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
105880889  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
105881031  [KO:K04513]
105881062  [KO:K01064]
105881219  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105881752  FNIP2; folliculin-interacting protein 2 isoform X3 [KO:K20401]
105882153  FZD6; frizzled-6 isoform X1 [KO:K02376]
105882158  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
105882367  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
105882561  ATP6V1B2; LOW QUALITY PROTEIN: V-type proton ATPase subunit B, brain isoform [KO:K02147]
105882576  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
105882676  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105883192  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
105883515  WNT9B; protein Wnt-9b [KO:K01064]
105883521  FZD2; frizzled-2 [KO:K02235]
105883925  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
105884529  SOS1; son of sevenless homolog 1 [KO:K03099]
105884851  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
105884979  RPTOR; LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
105886039  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
105886063  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105886161  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
109730641  LRP5L; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5-like protein [KO:K03068]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
mmur00561  Glycerolipid metabolism
mmur04010  MAPK signaling pathway
mmur04140  Autophagy - animal
mmur04151  PI3K-Akt signaling pathway
mmur04152  AMPK signaling pathway
mmur04810  Regulation of actin cytoskeleton
mmur04910  Insulin signaling pathway
KO pathway
ko04150   

DBGET integrated database retrieval system