KEGG   PATHWAY: mpah04350
Entry
mpah04350                   Pathway                                
Name
TGF-beta signaling pathway - Mus pahari (shrew mouse)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
mpah04350  TGF-beta signaling pathway
mpah04350

Other DBs
GO: 0007179
Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110313492  Igsf1; immunoglobulin superfamily member 1 isoform X1 [KO:K26168]
110315992  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
110316251  Cul1; cullin-1 [KO:K03347]
110317764  Acvr1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
110318109  Bmp7; bone morphogenetic protein 7 isoform X1 [KO:K16621]
110318164  Acvr2a; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
110318208  Rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
110318240  Tgif2; homeobox protein TGIF2 isoform X1 [KO:K19553]
110318284  Bmp2; bone morphogenetic protein 2 [KO:K21283]
110318359  Acvr1c; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
110318384  Rgma; repulsive guidance molecule A [KO:K23096]
110318400  Fbn1; fibrillin-1 [KO:K06825]
110318839  Gdf5; growth/differentiation factor 5 [KO:K04664]
110318968  Id1; DNA-binding protein inhibitor ID-1 [KO:K04680]
110319000  Grem1; gremlin-1 isoform X1 [KO:K23318]
110319023  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
110319737  Bmpr1b; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
110319818  Pitx2; pituitary homeobox 2 isoform X1 [KO:K04686]
110319926  Skil; ski-like protein isoform X1 [KO:K18499]
110320020  Mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
110320211  E2f5; transcription factor E2F5 [KO:K04682]
110320439  Smad9; mothers against decapentaplegic homolog 9 [KO:K16791]
110320529  Hfe2; hemojuvelin [KO:K23100]
110321649  Tgfb2; transforming growth factor beta-2 isoform X1 [KO:K13376]
110321721  Fmod; fibromodulin [KO:K08121]
110321925  Bmpr2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
110322117  Inhbb; inhibin beta B chain [KO:K22687]
110322419  [KO:K04668]
110322501  Grem2; gremlin-2 [KO:K23318]
110322579  [KO:K04668]
110322784  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
110322864  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
110323104  [KO:K19558]
110323113  Ski; ski oncogene isoform X1 [KO:K26503]
110323305  Zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
110323354  Id3; DNA-binding protein inhibitor ID-3 [KO:K17694]
110323468  Bmp8a; bone morphogenetic protein 8A isoform X1 [KO:K16622]
110323546  Tmem53; transmembrane protein 53 isoform X1 [KO:K28359]
110323643  [KO:K04685]
110324496  Id2; DNA-binding protein inhibitor ID-2 [KO:K17693]
110324521  Tgfb3; transforming growth factor beta-3 [KO:K13377]
110324858  Gdf7; growth/differentiation factor 7 isoform X1 [KO:K20013]
110325344  Bmpr1a; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
110325391  Bmp4; bone morphogenetic protein 4 [KO:K04662]
110326229  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
110326378  [KO:K04513]
110326392  Lemd3; inner nuclear membrane protein Man1 isoform X1 [KO:K19410]
110326543  Dcn; decorin [KO:K04660]
110326932  Ifng; interferon gamma [KO:K04687]
110327017  Nodal; nodal homolog [KO:K04666]
110327044  Inhbc; inhibin beta C chain [KO:K22688]
110327048  Amh; muellerian-inhibiting factor [KO:K04665]
110327113  Inhbe; inhibin beta E chain [KO:K22689]
110327239  Acvr2b; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
110327432  Bmp5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
110327555  Thsd4; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
110327573  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
110327577  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
110327694  Smad6; mothers against decapentaplegic homolog 6 [KO:K04677]
110327907  Rhoa; transforming protein RhoA isoform X1 [KO:K04513]
110327934  [KO:K14736]
110328212  Neo1; neogenin isoform X1 [KO:K06766]
110328279  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
110328604  [KO:K14736]
110328718  Sin3a; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
110328968  Fst; follistatin isoform X1 [KO:K04661]
110329047  Zfyve16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
110329343  Mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110329347  Emp3; epithelial membrane protein 3 [KO:K26257]
110329554  Chrd; chordin isoform X1 [KO:K04657]
110329678  Tfrc; transferrin receptor protein 1 [KO:K06503]
110329736  Nrros; negative regulator of reactive oxygen species isoform X1 [KO:K26317]
110330048  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
110330216  Lrrc32; leucine-rich repeat-containing protein 32 [KO:K26316]
110331264  Smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
110331333  Ncor1; nuclear receptor corepressor 1 [KO:K04650]
110331422  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
110331448  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110331774  Skp1; S-phase kinase-associated protein 1 [KO:K03094]
110331992  Nog; noggin [KO:K04658]
110332834  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
110333104  Smad7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
110333204  Smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
110333249  Bambi; BMP and activin membrane-bound inhibitor homolog isoform X1 [KO:K10162]
110333549  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
110333632  Smad5; mothers against decapentaplegic homolog 5 isoform X1 [KO:K16790]
110333720  Bmp6; bone morphogenetic protein 6 isoform X1 [KO:K16620]
110333724  Id4; DNA-binding protein inhibitor ID-4 [KO:K17695]
110333849  Inhba; inhibin beta A chain [KO:K04667]
110333928  Hfe; hereditary hemochromatosis protein isoform X1 [KO:K26535]
110334488  Sp1; transcription factor Sp1 isoform X1 [KO:K04684]
110334526  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
110334656  Myc; myc proto-oncogene protein [KO:K04377]
110334711  Acvr1b; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
110334961  Rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
110335229  Amhr2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
110335362  Hamp; hepcidin [KO:K23106]
110335596  Tgif1; homeobox protein TGIF1 isoform X1 [KO:K19383]
110335791  Tnf; tumor necrosis factor isoform X1 [KO:K03156]
110335890  Ltbp1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
110336304  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
110336543  Tgfb1; transforming growth factor beta-1 isoform X1 [KO:K13375]
110336946  Tfdp1; transcription factor Dp-1 [KO:K04683]
110337251  Smad1; mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676]
110337449  E2f4; transcription factor E2F4 [KO:K04682]
110337932  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
110338009  Rgmb; RGM domain family member B [KO:K06847]
110338911  Gdf6; growth/differentiation factor 6 [KO:K20012]
110339179  Smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
mpah04010  MAPK signaling pathway
mpah04110  Cell cycle
mpah04120  Ubiquitin mediated proteolysis
mpah04210  Apoptosis
KO pathway
ko04350   

DBGET integrated database retrieval system