KEGG   PATHWAY: ngi04150
Entry
ngi04150                    Pathway                                
Name
mTOR signaling pathway - Nannospalax galili (Upper Galilee mountains blind mole rat)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
ngi04150  mTOR signaling pathway
ngi04150

Organism
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
Gene
103724452  Tnf; tumor necrosis factor [KO:K03156]
103724454  Atp6v1g2; ATPase H+ transporting V1 subunit G2 [KO:K02152]
103724772  Wnt3; Wnt family member 3 [KO:K00312]
103724773  Wnt9b; Wnt family member 9B [KO:K01064]
103724913  Sgk1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
103725249  Fzd1; frizzled class receptor 1 [KO:K02432]
103725267  Rps6ka6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
103725586  Rps6kb2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
103725673  Wdr59; WD repeat domain 59 [KO:K20409]
103725755  Atp6v1e2; ATPase H+ transporting V1 subunit E2 [KO:K02150]
103726107  Braf; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
103726390  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103726621  Ikbkb; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103726879  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103726958  Atp6v1b1; ATPase H+ transporting V1 subunit B1 [KO:K02147]
103727049  Mapkap1; mitogen-activated protein kinase associated protein 1 [KO:K20410]
103727173  Cab39l; calcium binding protein 39 like [KO:K08272]
103727512  Ulk2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
103727530  Tnfrsf1a; TNF receptor superfamily member 1A [KO:K03158]
103727729  Wnt6; Wnt family member 6 [KO:K00445]
103727730  Wnt10a; Wnt family member 10A [KO:K01357]
103727788  Irs1; insulin receptor substrate 1 [KO:K16172]
103728043  Lamtor3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
103728056  Eif4e; eukaryotic translation initiation factor 4E [KO:K03259]
103729666  Prkcg; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
103729990  Fzd3; frizzled class receptor 3 [KO:K02329]
103730305  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103730373  Wnt7a; Wnt family member 7A [KO:K00572]
103730533  Rptor; regulatory associated protein of MTOR complex 1 [KO:K07204]
103730604  Wnt16; Wnt family member 16 [KO:K01558]
103730943  Rragb; Ras related GTP binding B [KO:K16185]
103731514  Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
103731799  Atp6v1g3; ATPase H+ transporting V1 subunit G3 [KO:K02152]
103732646  Dvl3; dishevelled segment polarity protein 3 [KO:K02353]
103732729  Grb2; growth factor receptor bound protein 2 [KO:K04364]
103732884  Tbc1d7; TBC1 domain family member 7 [KO:K20396]
103732897  Mtor; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
103733068  Rragd; Ras related GTP binding D [KO:K16186]
103733121  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103733534  Lamtor4; late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 [KO:K20399]
103733723  Igf1; insulin like growth factor 1 [KO:K05459]
103733926  [KO:K13302] [EC:2.7.11.1]
103734094  Prkaa2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
103734513  Atp6v1g1; ATPase H+ transporting V1 subunit G1 [KO:K02152]
103734912  Wnt2b; Wnt family member 2B [KO:K00182]
103734938  Nras; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103735176  Wnt8a; Wnt family member 8A [KO:K00714]
103735399  Lpin2; lipin 2 [KO:K15728] [EC:3.1.3.4]
103735725  Rps6ka2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
103736031  Fzd7; frizzled class receptor 7 [KO:K02432]
103736232  Rps6ka3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
103736717  Kras; KRAS proto-oncogene, GTPase [KO:K07827]
103736801  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103736961  Ddit4; DNA damage inducible transcript 4 [KO:K08270]
103737117  Rps6ka1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
103737276  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103737337  Stk11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
103737375  Wnt2; Wnt family member 2 [KO:K00182]
103737658  Slc3a2; solute carrier family 3 member 2 [KO:K06519]
103737771  Lrp6; LDL receptor related protein 6 [KO:K03068]
103738044  Pten; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103738147  Deptor; DEP domain containing MTOR interacting protein [KO:K20402]
103738202  Cab39; calcium binding protein 39 [KO:K08272]
103738226  Eif4e2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
103738297  Fzd2; frizzled class receptor 2 [KO:K02235]
103738387  Eif4b; eukaryotic translation initiation factor 4B [KO:K03258]
103738596  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103738670  Stradb; STE20-related kinase adaptor beta [KO:K17532]
103738715  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103738986  Ins; insulin [KO:K04526]
103739037  Wnt3a; Wnt family member 3A [KO:K00312]
103739053  Clip1; CAP-Gly domain containing linker protein 1 [KO:K10421]
103739374  Wnt5b; Wnt family member 5B [KO:K00444]
103739915  Slc38a9; solute carrier family 38 member 9 [KO:K14995]
103740035  Slc7a5; solute carrier family 7 member 5 [KO:K13780]
103740093  Rnf152; ring finger protein 152 [KO:K15705] [EC:2.3.2.27]
103740409  Wnt9a; Wnt family member 9A [KO:K01064]
103740418  Depdc5; DEP domain containing 5 [KO:K20404]
103740453  Gatsl3; GATS protein like 3 [KO:K23080]
103741317  Skp2; S-phase kinase associated protein 2 [KO:K03875]
103741331  Rictor; RPTOR independent companion of MTOR complex 2 [KO:K08267]
103741338  Prkaa1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
103741442  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103741760  Rps6kb1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
103741925  Atp6v1a; ATPase H+ transporting V1 subunit A [KO:K02145] [EC:7.1.2.2]
103741948  Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
103742202  Prkca; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
103742835  Tsc1; tuberous sclerosis 1 [KO:K07206]
103742946  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103742963  Fzd4; frizzled class receptor 4 [KO:K02354]
103743015  Wnt11; Wnt family member 11 [KO:K01384]
103743198  Atp6v1h; ATPase H+ transporting V1 subunit H [KO:K02144]
103743312  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
103743359  [KO:K04513]
103743385  Flcn; folliculin [KO:K09594]
103743417  Wnt7b; Wnt family member 7B [KO:K00572]
103743427  Prr5; proline rich 5 [KO:K20411]
103743684  Akt1s1; AKT1 substrate 1 [KO:K16184]
103743727  Mlst8; MTOR associated protein, LST8 homolog [KO:K08266]
103743944  Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
103743959  Pdpk1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103743962  Rps6; ribosomal protein S6 [KO:K02991]
103743966  Rraga; Ras related GTP binding A [KO:K16185]
103743976  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103743982  Wnt8b; Wnt family member 8B [KO:K00714]
103744444  Fzd5; frizzled class receptor 5 [KO:K02375]
103744519  Lrp5; LDL receptor related protein 5 [KO:K03068]
103744556  Atp6v1f; ATPase H+ transporting V1 subunit F [KO:K02151]
103744754  Strada; STE20-related kinase adaptor alpha [KO:K08271]
103745322  Rheb; Ras homolog enriched in brain [KO:K07208]
103745422  Eif4e1b; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
103745895  Atp6v1e1; ATPase H+ transporting V1 subunit E1 [KO:K02150]
103745923  Sesn2; sestrin 2 [KO:K20394]
103746251  Fzd9; frizzled class receptor 9 [KO:K02842]
103746395  Wnt4; Wnt family member 4 [KO:K00408]
103746884  Akt3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103746928  Prkcb; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
103746990  Grb10; growth factor receptor bound protein 10 [KO:K20064]
103747020  Fnip1; folliculin interacting protein 1 [KO:K20400]
103747602  Lpin1; lipin 1 [KO:K15728] [EC:3.1.3.4]
103747611  Atp6v1c2; ATPase H+ transporting V1 subunit C2 [KO:K02148]
103747668  Atp6v1b2; ATPase H+ transporting V1 subunit B2 [KO:K02147]
103747707  Rragc; Ras related GTP binding C [KO:K16186]
103747814  Lamtor5; late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 [KO:K16344]
103748031  Fzd8; frizzled class receptor 8 [KO:K02375]
103748212  Nprl3; NPR3 like, GATOR1 complex subunit [KO:K20406]
103748283  Tti1; TELO2 interacting protein 1 [KO:K20403]
103748393  Lpin3; lipin 3 [KO:K15728] [EC:3.1.3.4]
103748479  Gatsl2; GATS protein like 2 [KO:K23081]
103748769  Fzd6; frizzled class receptor 6 [KO:K02376]
103748771  Atp6v1c1; ATPase H+ transporting V1 subunit C1 [KO:K02148]
103749032  Wnt5a; Wnt family member 5A [KO:K00444]
103749286  Atp6v1d; ATPase H+ transporting V1 subunit D [KO:K02149]
103749467  Igf1r; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103749510  Prr5l; proline rich 5 like [KO:K20411]
103749746  Dvl1; dishevelled segment polarity protein 1 [KO:K02353]
103750151  Nprl2; NPR2-like, GATOR1 complex subunit [KO:K20405]
103750189  Rhoa; ras homolog family member A [KO:K04513]
103750565  Wnt10b; Wnt family member 10B [KO:K01357]
103750567  Wnt1; Wnt family member 1 [KO:K03209]
103750609  Ulk1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
103750619  Fzd10; frizzled class receptor 10 [KO:K02842]
103750646  Lamtor2; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [KO:K20398]
103750757  Akt2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103750809  Lamtor1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 [KO:K20397]
103751015  Fnip2; folliculin interacting protein 2 [KO:K20401]
103751075  Hras; HRas proto-oncogene, GTPase [KO:K02833]
103751437  Sec13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
103751450  Raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103751703  Mios; meiosis regulator for oocyte development [KO:K20407]
103752158  Dvl2; dishevelled segment polarity protein 2 [KO:K02353]
103752394  Wdr24; WD repeat domain 24 [KO:K20408]
103752426  Telo2; telomere maintenance 2 [KO:K11137]
103752451  Tsc2; tuberous sclerosis 2 [KO:K07207]
103752536  Akt1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
108491304  Seh1l; SEH1 like nucleoporin [KO:K14299]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
ngi00561  Glycerolipid metabolism
ngi04010  MAPK signaling pathway
ngi04140  Autophagy - animal
ngi04151  PI3K-Akt signaling pathway
ngi04152  AMPK signaling pathway
ngi04810  Regulation of actin cytoskeleton
ngi04910  Insulin signaling pathway
KO pathway
ko04150   

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