KEGG   PATHWAY: ngi04010
Entry
ngi04010                    Pathway                                
Name
MAPK signaling pathway - Nannospalax galili (Upper Galilee mountains blind mole rat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ngi04010  MAPK signaling pathway
ngi04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
Gene
103724426  Hspa1l; heat shock protein family A (Hsp70) member 1 like [KO:K03283]
103724452  Tnf; tumor necrosis factor [KO:K03156]
103724495  Nlk; nemo like kinase [KO:K04468] [EC:2.7.11.24]
103724510  Nf1; neurofibromin 1 [KO:K08052]
103724612  Rps6ka5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
103724766  Mapt; microtubule associated protein tau [KO:K04380]
103724776  [KO:K04460] [EC:3.1.3.16]
103724822  Map2k3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103724902  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103724991  Map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
103724994  Rela; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103725267  Rps6ka6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
103725320  Epha2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
103725766  Ppm1b; protein phosphatase, Mg2+/Mn2+ dependent 1B [KO:K04461] [EC:3.1.3.16]
103725874  Map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
103725901  Tgfa; transforming growth factor alpha [KO:K08774]
103725934  Mapkapk2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
103725949  Elk4; ELK4, ETS transcription factor [KO:K04376]
103726015  Rasgrf1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
103726107  Braf; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
103726280  Dusp10; dual specificity phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
103726376  Taok2; TAO kinase 2 [KO:K04429] [EC:2.7.11.1]
103726390  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103726469  Dusp6; dual specificity phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
103726473  Kitlg; KIT ligand [KO:K05461]
103726484  Rac1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103726514  Cacnb2; calcium voltage-gated channel auxiliary subunit beta 2 [KO:K04863]
103726522  Map2k7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103726600  [KO:K04437]
103726621  Ikbkb; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103726649  Pla2g4a; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
103726795  Taok3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
103726874  Jund; JunD proto-oncogene, AP-1 transcription factor subunit [KO:K04449]
103727190  Fgf9; fibroblast growth factor 9 [KO:K04358]
103727233  Flt1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
103727235  Flt3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
103727451  Rasgrp1; RAS guanyl releasing protein 1 [KO:K04350]
103727530  Tnfrsf1a; TNF receptor superfamily member 1A [KO:K03158]
103727536  Ntf3; neurotrophin 3 [KO:K04356]
103727544  Fgf6; fibroblast growth factor 6 [KO:K04358]
103727545  Fgf23; fibroblast growth factor 23 [KO:K22428]
103727922  Hspa8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
103728037  Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
103728043  Lamtor3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
103728077  Nfkb1; nuclear factor kappa B subunit 1 [KO:K02580]
103728095  Prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103728439  Mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
103728592  Irak4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103728817  Tgfb2; transforming growth factor beta 2 [KO:K13376]
103729272  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
103729666  Prkcg; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
103729667  Cacng7; calcium voltage-gated channel auxiliary subunit gamma 7 [KO:K04872]
103729669  Cacng6; calcium voltage-gated channel auxiliary subunit gamma 6 [KO:K04871]
103729702  Cacng8; calcium voltage-gated channel auxiliary subunit gamma 8 [KO:K04873]
103730317  Mknk1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
103730477  Taok1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
103730505  Crk; CRK proto-oncogene, adaptor protein [KO:K04438]
103730679  Tek; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
103730723  Hgf; hepatocyte growth factor [KO:K05460]
103730725  Cacna2d1; calcium voltage-gated channel auxiliary subunit alpha2delta 1 [KO:K04858]
103730772  Vegfa; vascular endothelial growth factor A [KO:K05448]
103730795  Srf; serum response factor [KO:K04378]
103731190  Dusp9; dual specificity phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
103731212  Irak1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103731216  Flna; filamin A [KO:K04437]
103731232  Ikbkg; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
103731375  Cacna1e; calcium voltage-gated channel subunit alpha1 E [KO:K04852]
103731514  Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
103731664  Ptprr; protein tyrosine phosphatase, receptor type R [KO:K04458] [EC:3.1.3.48]
103731702  Pdgfd; platelet derived growth factor D [KO:K05450]
103731713  Mecom; MDS1 and EVI1 complex locus protein EVI1 [KO:K04462] [EC:2.1.1.367]
103731814  Cacna1s; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
103731832  Ptpn7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
103731917  Tab2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
103732132  Map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
103732354  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
103732429  Pla2g4c; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
103732608  Cacna1b; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
103732670  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
103732729  Grb2; growth factor receptor bound protein 2 [KO:K04364]
103732823  Stk3; serine/threonine kinase 3 [KO:K04412]
103732971  Ptpn5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
103733041  Fgf7; fibroblast growth factor 7 [KO:K04358]
103733473  Hspb1; heat shock protein family B (small) member 1 [KO:K04455]
103733713  Dusp4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103733723  Igf1; insulin like growth factor 1 [KO:K05459]
103733801  Ret; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
103734036  Fgf10; fibroblast growth factor 10 [KO:K04358]
103734390  Kdr; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
103734391  Kit; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
103734393  Pdgfra; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103734582  Ecsit; ECSIT signalling integrator [KO:K04405]
103734750  Ppp3r1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
103734905  Rap1a; RAP1A, member of RAS oncogene family [KO:K04353]
103734938  Nras; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103734944  Ngf; nerve growth factor [KO:K02582]
103734978  Nfatc3; nuclear factor of activated T-cells 3 [KO:K17333]
103735023  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103735057  Mapk8ip1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
103735233  Angpt4; angiopoietin 4 [KO:K05467]
103735473  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103735474  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103735493  Mapk8ip2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
103735725  Rps6ka2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
103736047  Cd14; CD14 molecule [KO:K04391]
103736084  Fgf1; fibroblast growth factor 1 [KO:K18496]
103736232  Rps6ka3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
103736717  Kras; KRAS proto-oncogene, GTPase [KO:K07827]
103736801  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103736811  Map2k5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
103736944  Ppp3cb; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
103737023  Map3k4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
103737078  Map3k6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
103737097  Stmn1; stathmin 1 [KO:K04381]
103737117  Rps6ka1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
103737138  Jun; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
103737191  Pspn; persephin [KO:K25416]
103737198  Nrtn; neurturin [KO:K25414]
103737276  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103737285  Gadd45b; growth arrest and DNA damage inducible beta [KO:K04402]
103737305  Mknk2; MAP kinase interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
103737334  Efna2; ephrin A2 [KO:K05462]
103737403  Fgf22; fibroblast growth factor 22 [KO:K04358]
103737431  Met; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
103737601  Mras; muscle RAS oncogene homolog [KO:K07831]
103737701  Dusp16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103737833  Fgf16; fibroblast growth factor 16 [KO:K04358]
103738053  Fas; Fas cell surface death receptor [KO:K04390]
103738122  Cacnb4; calcium voltage-gated channel auxiliary subunit beta 4 [KO:K04865]
103738178  Efna5; ephrin A5 [KO:K05462]
103738271  Dusp3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
103738278  Dusp2; dual specificity phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103738320  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103738367  Ngfr; nerve growth factor receptor [KO:K02583]
103738394  Cacna1g; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
103738502  Pak2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
103738660  Map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
103738778  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
103738782  Rasgrp2; RAS guanyl releasing protein 2 [KO:K12361]
103738787  Rps6ka4; ribosomal protein S6 kinase A4 [KO:K16510] [EC:2.7.11.1]
103738800  Vegfb; vascular endothelial growth factor B [KO:K16858]
103738912  Tradd; TNFRSF1A associated via death domain [KO:K03171]
103738986  Ins; insulin [KO:K04526]
103738988  Igf2; insulin like growth factor 2 [KO:K13769]
103739115  Rasa1; RAS p21 protein activator 1 [KO:K04352]
103739124  Mef2c; myocyte enhancer factor 2C [KO:K04454]
103739185  Ppm1a; protein phosphatase, Mg2+/Mn2+ dependent 1A [KO:K04457] [EC:3.1.3.16]
103739339  Il1rap; interleukin 1 receptor accessory protein [KO:K04723]
103739378  Cacna1c; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
103739384  Cacna2d4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
103739547  Map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
103739583  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
103739659  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103739660  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103739701  Daxx; death domain associated protein [KO:K02308]
103739777  Tgfb3; transforming growth factor beta 3 [KO:K13377]
103739898  Il1a; interleukin 1 alpha [KO:K04383]
103739899  Il1b; interleukin 1 beta [KO:K04519]
103739909  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
103740292  Vegfd; vascular endothelial growth factor D [KO:K05449]
103740694  Faslg; Fas ligand [KO:K04389]
103741080  Dusp5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103741127  Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103741188  Traf2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
103741326  Gdnf; glial cell derived neurotrophic factor [KO:K05452]
103741442  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103741458  Crkl; CRK like proto-oncogene, adaptor protein [KO:K04438]
103741627  Araf; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
103741629  Elk1; ELK1, ETS transcription factor [KO:K04375]
103741673  Cacna1f; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
103742198  Cacng1; calcium voltage-gated channel auxiliary subunit gamma 1 [KO:K04866]
103742200  Cacng4; calcium voltage-gated channel auxiliary subunit gamma 4 [KO:K04869]
103742201  Cacng5; calcium voltage-gated channel auxiliary subunit gamma 5 [KO:K04870]
103742202  Prkca; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
103742218  Map2k6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103742434  Areg; amphiregulin [KO:K09782]
103742473  Ereg; epiregulin [KO:K09784]
103742625  Fgf5; fibroblast growth factor 5 [KO:K04358]
103742642  Egf; epidermal growth factor [KO:K04357]
103742913  Ddit3; DNA damage inducible transcript 3 [KO:K04452]
103743005  Pak1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
103743027  Arrb1; arrestin beta 1 [KO:K04439]
103743120  Cdc25b; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
103743128  Map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
103743281  Fgf20; fibroblast growth factor 20 [KO:K04358]
103743312  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
103743354  Gadd45a; growth arrest and DNA damage inducible alpha [KO:K04402]
103743355  Gng12; G protein subunit gamma 12 [KO:K04347]
103743629  Fgf21; fibroblast growth factor 21 [KO:K22429]
103743645  Ntf4; neurotrophin 4 [KO:K12457]
103743663  Flt3lg; fms related tyrosine kinase 3 ligand [KO:K05454]
103743672  Rras; related RAS viral (r-ras) oncogene homolog [KO:K07829]
103743810  Cacnb1; calcium voltage-gated channel auxiliary subunit beta 1 [KO:K04862]
103743825  Erbb2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
103743861  Artn; artemin [KO:K25415]
103743920  Myc; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
103743942  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
103743944  Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
103743976  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103744005  Fgf8; fibroblast growth factor 8 [KO:K04358]
103744019  Nfkb2; nuclear factor kappa B subunit 2 [KO:K04469]
103744177  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
103744180  Il1r1; interleukin 1 receptor type 1 [KO:K04386]
103744489  Erbb4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
103744639  Tgfbr2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
103744662  Myd88; myeloid differentiation primary response 88 [KO:K04729]
103744668  [KO:K02187] [EC:3.4.22.56]
103744757  Map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
103744902  Tgfbr1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
103744942  Pla2g4b; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
103744945  Pla2g4e; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
103744946  Pla2g4d; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
103744947  Pla2g4f; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
103745076  Rap1b; RAP1B, member of RAS oncogene family [KO:K07836]
103745233  Vegfc; vascular endothelial growth factor C [KO:K05449]
103745287  Angpt2; angiopoietin 2 [KO:K05466]
103745570  Mapkapk5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
103745770  Fgfr1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
103745996  [KO:K03283]
103746394  Cdc42; cell division cycle 42 [KO:K04393]
103746501  Erbb3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
103746759  Rasgrp3; RAS guanyl releasing protein 3 [KO:K12362]
103746770  Hspa6; heat shock protein family A (Hsp70) member 6 [KO:K03283]
103746884  Akt3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103746927  Cacng3; calcium voltage-gated channel auxiliary subunit gamma 3 [KO:K04868]
103746928  Prkcb; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
103746947  Fgf2; fibroblast growth factor 2 [KO:K18497]
103747075  Csf1r; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103747076  Pdgfrb; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103747093  Ntrk2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
103747342  Fos; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
103747350  Pgf; placental growth factor [KO:K16859]
103747440  Dusp7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103747727  Fgf17; fibroblast growth factor 17 [KO:K04358]
103747824  Csf1; colony stimulating factor 1 [KO:K05453]
103747869  Ppp3cc; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
103747991  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
103748128  Nfatc1; nuclear factor of activated T-cells 1 [KO:K04446]
103748184  Fgf18; fibroblast growth factor 18 [KO:K04358]
103748194  Dusp1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
103748289  Rasa2; RAS p21 protein activator 2 [KO:K08053]
103748401  Stk4; serine/threonine kinase 4 [KO:K04411]
103748489  Bdnf; brain derived neurotrophic factor [KO:K04355]
103748561  Cacna1i; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
103748563  Atf4; activating transcription factor 4 [KO:K04374]
103748567  Tab1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
103748570  Pdgfb; platelet derived growth factor subunit B [KO:K17386]
103748617  Rac2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
103748628  Cacng2; calcium voltage-gated channel auxiliary subunit gamma 2 [KO:K04867]
103748670  Gna12; G protein subunit alpha 12 [KO:K04346]
103748699  Pdgfa; platelet derived growth factor subunit A [KO:K04359]
103748755  Angpt1; angiopoietin 1 [KO:K05465]
103748852  [KO:K04361] [EC:2.7.10.1]
103748972  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103749025  Cacna1d; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
103749031  Cacna2d3; calcium voltage-gated channel auxiliary subunit alpha2delta 3 [KO:K04860]
103749104  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
103749175  Relb; RELB proto-oncogene, NF-kB subunit [KO:K09253]
103749276  Max; MYC associated factor X [KO:K04453]
103749361  Flt4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
103749366  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103749467  Igf1r; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103749513  Traf6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
103750143  Mapkapk3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
103750148  Cacna2d2; calcium voltage-gated channel auxiliary subunit alpha2delta 2 [KO:K04859]
103750263  Ntrk1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
103750268  Rasgrf2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
103750424  Rras2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
103750475  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103750559  Cacnb3; calcium voltage-gated channel auxiliary subunit beta 3 [KO:K04864]
103750713  Rasgrp4; RAS guanyl releasing protein 4 [KO:K12363]
103750714  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
103750755  Map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
103750757  Akt2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103751016  Rapgef2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
103751038  Pdgfc; platelet derived growth factor C [KO:K05450]
103751060  Efna1; ephrin A1 [KO:K05462]
103751070  Efna3; ephrin A3 [KO:K05462]
103751075  Hras; HRas proto-oncogene, GTPase [KO:K02833]
103751081  Efna4; ephrin A4 [KO:K05462]
103751102  Dusp8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103751225  Gadd45g; growth arrest and DNA damage inducible gamma [KO:K04402]
103751450  Raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103751500  Fgf4; fibroblast growth factor 4 [KO:K04358]
103751507  Fgf19; fibroblast growth factor 19 [KO:K22603]
103751508  Fgf3; fibroblast growth factor 3 [KO:K04358]
103751514  Tgfb1; transforming growth factor beta 1 [KO:K13375]
103751744  Map3k20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
103751761  Atf2; activating transcription factor 2 [KO:K04450]
103751850  Prkaca; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
103751889  [KO:K04347]
103751913  Cacna1a; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
103752052  Map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
103752115  Tp53; tumor protein p53 [KO:K04451]
103752182  Arrb2; arrestin beta 2 [KO:K04439]
103752279  [KO:K04437]
103752429  Mapk8ip3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
103752455  Cacna1h; calcium voltage-gated channel subunit alpha1 H [KO:K04855]
103752536  Akt1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
ngi04070  Phosphatidylinositol signaling system
ngi04110  Cell cycle
ngi04115  p53 signaling pathway
ngi04210  Apoptosis
ngi04310  Wnt signaling pathway
ngi04668  TNF signaling pathway
KO pathway
ko04010   

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