KEGG   PATHWAY: npd03040
Entry
npd03040                    Pathway                                
Name
Spliceosome - Nothoprocta perdicaria (Chilean tinamou)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
npd03040  Spliceosome
npd03040

Other DBs
GO: 0005681
Organism
Nothoprocta perdicaria (Chilean tinamou) [GN:npd]
Gene
112942320  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
112942391  PRPF18; pre-mRNA-splicing factor 18 isoform X1 [KO:K12817]
112942410  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
112942713  [KO:K14280]
112942815  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
112942855  [KO:K14280]
112942930  SRSF7; serine/arginine-rich splicing factor 7 [KO:K12896]
112942948  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
112943193  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
112943234  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
112943633  SNRPD1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
112943660  TXNL4A; thioredoxin-like protein 4A [KO:K12859]
112943678  [KO:K14276]
112943791  MAGOH; protein mago nashi homolog [KO:K12877]
112943842  [KO:K14279]
112943873  LSM7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
112943893  [KO:K14279]
112943897  CHERP; calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
112943898  [KO:K14279]
112943904  [KO:K14279]
112943907  [KO:K14279]
112943955  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
112944011  [KO:K14279]
112944038  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
112944314  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
112944487  THOC2; THO complex subunit 2 [KO:K12879]
112944552  RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885]
112944575  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
112944618  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
112944673  U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
112944828  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
112945081  [KO:K14276]
112945093  SNRPB2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
112945141  [KO:K14280]
112945272  ALYREF; THO complex subunit 4 [KO:K12881]
112945667  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
112945846  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 isoform X1 [KO:K12820] [EC:5.6.2.6]
112946047  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
112946293  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
112946357  PRPF40A; pre-mRNA-processing factor 40 homolog A [KO:K12821]
112946378  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
112946398  [KO:K12893]
112946454  PHF5A; PHD finger-like domain-containing protein 5A [KO:K12834]
112946467  SNU13; NHP2-like protein 1 [KO:K12845]
112946697  RBM25; RNA-binding protein 25 isoform X1 [KO:K12822]
112946875  LSM4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
112946925  [KO:K14280]
112946926  [KO:K14280]
112947203  CRNKL1; crooked neck-like protein 1 [KO:K12869]
112947467  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
112947515  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
112947560  CCDC12; coiled-coil domain-containing protein 12 [KO:K12871]
112947827  CDC5L; cell division cycle 5-like protein [KO:K12860]
112947857  U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
112947978  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
112948350  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
112948440  [KO:K14276]
112948544  [KO:K14277]
112948677  [KO:K12883]
112948919  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
112948974  HNRNPU; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
112949256  PLRG1; pleiotropic regulator 1 [KO:K12862]
112949618  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
112949695  CTNNBL1; beta-catenin-like protein 1 [KO:K12864]
112949752  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
112950184  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
112950244  USP39; U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
112950332  DDX23; probable ATP-dependent RNA helicase DDX23 isoform X1 [KO:K12858] [EC:5.6.2.7]
112950497  SNRPG; small nuclear ribonucleoprotein G [KO:K11099]
112950592  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
112950614  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
112950701  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
112950718  SF3A3; splicing factor 3A subunit 3 isoform X1 [KO:K12827]
112950746  PPIE; peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
112950761  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
112950774  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
112950838  [KO:K03283]
112950936  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
112951056  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
112951220  PRPF38B; pre-mRNA-splicing factor 38B [KO:K12850]
112951309  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
112951507  BCAS2; pre-mRNA-splicing factor SPF27 [KO:K12861]
112951969  SNRPD2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
112951974  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
112952100  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
112952577  TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824]
112952627  DDX46; probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
112952688  SF3A2; splicing factor 3A subunit 2 isoform X1 [KO:K12826]
112952727  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
112953081  ISY1; pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
112953586  RBM8A; RNA-binding protein 8A [KO:K12876]
112953644  DDX5; probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
112953979  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
112954178  [KO:K14280]
112954360  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
112954410  THOC3; THO complex subunit 3 [KO:K12880]
112954427  SLU7; pre-mRNA-splicing factor SLU7 [KO:K12819]
112954547  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
112954732  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
112955013  SNW1; SNW domain-containing protein 1 [KO:K06063]
112955036  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086]
112955777  [KO:K14276]
112955947  SF3B1; splicing factor 3B subunit 1 [KO:K12828]
112956124  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
112956392  [KO:K12741]
112956750  [KO:K14280]
112956989  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
112957150  SMNDC1; survival of motor neuron-related-splicing factor 30 [KO:K12839]
112957299  [KO:K14277]
112957500  PPIH; peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
112957691  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
112957718  [KO:K14280]
112957719  [KO:K14280]
112957828  PQBP1; LOW QUALITY PROTEIN: polyglutamine-binding protein 1 [KO:K12865]
112957977  AQR; RNA helicase aquarius [KO:K12874]
112958248  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
112958472  LSM5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
112958498  RP9; retinitis pigmentosa 9 protein [KO:K19604]
112958563  RBM17; splicing factor 45 isoform X1 [KO:K12840]
112958794  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
112958869  U2AF2; splicing factor U2AF 65 kDa subunit [KO:K12837]
112959002  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
112959217  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
112959263  SNRPE; small nuclear ribonucleoprotein E [KO:K11097]
112959454  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
112959465  WBP11; WW domain-binding protein 11 [KO:K12866]
112959857  BUD31; protein BUD31 homolog [KO:K12873]
112960257  DHX8; ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
112960274  DDX42; ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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