Entry Name p53 signaling pathway - Ochotona princeps (American pika)
Description p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class Cellular Processes; Cell growth and deathBRITE hierarchy
Pathway map Organism Ochotona princeps (American pika) [GN:
opi ]
Gene 101516244 ADGRB1; LOW QUALITY PROTEIN: adhesion G protein-coupled receptor B1 [KO:K04596 ]
101516300 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
101517311 APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084 ]
101519285 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402 ]
101521693 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
101527810 SERPINE1; plasminogen activator inhibitor 1 isoform X3 [KO:K03982 ]
101528305 TP53I3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133 ] [EC:1.-.-.-]
101528938 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
101530204 BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726 ]
105942711 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131 ]
Reference Authors Levine AJ, Hu W, Feng Z.
Title The P53 pathway: what questions remain to be explored?
Journal Reference Authors Harris SL, Levine AJ.
Title The p53 pathway: positive and negative feedback loops.
Journal Reference Authors Balint E E, Vousden KH.
Title Activation and activities of the p53 tumour suppressor protein.
Journal Reference Authors Taylor WR, Stark GR.
Title Regulation of the G2/M transition by p53.
Journal Reference Authors Hofseth LJ, Hussain SP, Harris CC.
Title p53: 25 years after its discovery.
Journal Reference Authors Pietenpol JA, Stewart ZA.
Title Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
Journal Reference Authors Tokino T, Nakamura Y.
Title The role of p53-target genes in human cancer.
Journal Reference Authors Hermeking H, Benzinger A.
Title 14-3-3 proteins in cell cycle regulation.
Journal Reference Authors Sherr CJ.
Title Divorcing ARF and p53: an unsettled case.
Journal Reference Authors Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
Title The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Journal Reference Authors Resnick-Silverman L, Manfredi JJ
Title Two Faces of SIVA.
Journal Reference Authors Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
Title Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
Journal Reference Authors Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
Title The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
Journal Reference Authors Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
Title A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
Journal Reference Authors Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
Title Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
Journal Related KO pathway
