PATHWAY: aamp04714 Help
Entry
Name
Thermogenesis - Arvicola amphibius (Eurasian water vole)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Arvicola amphibius (Eurasian water vole) [GN:
aamp ]
Gene
119814107 Gnas; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632 ]
119820446 Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
119814789 Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048 ]
119821362 Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048 ]
119801303 Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048 ]
119826298 Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048 ]
119806715 Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048 ]
119807891 Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047 ]
119808863 Smarca4; transcription activator BRG1 isoform X1 [KO:K11647 ] [EC:5.6.2.-]
119820148 Smarca2; LOW QUALITY PROTEIN: probable global transcription activator SNF2L2 [KO:K11647 ] [EC:5.6.2.-]
119823183 Smarcb1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648 ]
119823459 Smarcd1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650 ]
119811763 Smarcd2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650 ]
119807023 Smarcd3; LOW QUALITY PROTEIN: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 [KO:K11650 ]
119812204 Smarce1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651 ]
119816402 Arid1a; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653 ]
119820440 Arid1b; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653 ]
119807937 Pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530 ]
119809862 Ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202 ]
119819075 Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450 ]
119801352 Prkab2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199 ]
119825157 Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199 ]
119820999 Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200 ]
119822790 Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200 ]
119806497 Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200 ]
119803586 Frs2; LOW QUALITY PROTEIN: fibroblast growth factor receptor substrate 2 [KO:K12461 ]
119806329 Sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099 ]
119813137 Rptor; LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204 ]
119804932 LOW QUALITY PROTEIN: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial-like [KO:K03934 ] [EC:7.1.1.2 ]
119827486 Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935 ] [EC:7.1.1.2 ]
119814166 Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936 ] [EC:7.1.1.2 ]
119810090 Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937 ]
119809107 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938 ]
119803219 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938 ]
119810541 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938 ]
119816982 Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938 ]
119818379 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938 ]
119825922 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938 ]
119810417 Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939 ]
119821308 Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940 ] [EC:7.1.1.2 ]
119814511 Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941 ] [EC:7.1.1.2 ]
119823492 Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944 ]
119804764 Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945 ]
119814379 Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946 ]
119808469 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946 ]
119821547 Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947 ]
119822367 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947 ]
119816292 LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947 ]
119817139 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947 ]
119803343 Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948 ]
119807886 Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949 ]
119810302 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949 ]
119822816 Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950 ]
119815606 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like [KO:K03951 ]
119825491 Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951 ]
119819937 Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952 ]
119807526 Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953 ]
119821505 Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954 ]
119810151 LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial-like [KO:K03954 ]
119810775 Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956 ]
119811058 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956 ]
119803407 Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352 ]
119813692 Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353 ]
119818574 Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957 ]
119800598 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958 ]
119806913 Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958 ]
119804078 Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959 ]
119825606 Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960 ]
119825940 Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961 ]
119825963 Ndufb6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962 ]
119801780 Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963 ]
119811753 Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964 ]
119823332 Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965 ]
119812927 Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966 ]
119804641 Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351 ]
119826441 Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967 ]
119814706 Ndufaf1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159 ]
119809653 Ndufaf2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160 ]
119810102 Ndufaf3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [KO:K09008 ]
119826844 Ndufaf4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161 ]
119814722 Ndufaf5; arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162 ] [EC:2.1.1.-]
119826749 Ndufaf6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163 ]
119806904 Ndufaf7; protein arginine methyltransferase NDUFAF7, mitochondrial [KO:K18164 ]
119811196 Ndufaf8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 [KO:K24726 ]
119809157 Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234 ] [EC:1.3.5.1 ]
119816786 Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235 ] [EC:1.3.5.1 ]
119827624 Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236 ]
119809004 Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237 ]
119801810 cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263 ]
119815669 cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263 ]
119800700 LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265 ]
119808129 cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270 ]
119811757 cytochrome c oxidase assembly protein COX11, mitochondrial [KO:K02258 ]
119823977 LOW QUALITY PROTEIN: cytochrome c oxidase assembly protein COX14-like [KO:K18181 ]
119818496 cytochrome c oxidase assembly protein COX16 homolog, mitochondrial [KO:K18182 ]
119827249 cytochrome c oxidase assembly protein COX18, mitochondrial isoform X1 [KO:K17797 ]
119827018 cytochrome c oxidase assembly protein COX20, mitochondrial [KO:K18184 ]
119813213 cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175 ]
119802760 cytochrome c oxidase assembly factor 4 homolog, mitochondrial [KO:K18177 ]
119816174 Atp5f1c; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136 ]
119800757 Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127 ]
119807929 ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128 ]
119827952 ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128 ]
119822775 Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128 ]
119818833 Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128 ]
119812397 Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128 ]
119826216 ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128 ]
119817869 ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138 ]
119812417 Atp5pd; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138 ]
119824693 Atp5pf; ATP synthase-coupling factor 6, mitochondrial [KO:K02131 ]
119809837 Slc25a20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109 ]
119819243 Slc25a29; mitochondrial basic amino acids transporter [KO:K15109 ]
Compound
Reference
Authors
Inagaki T, Sakai J, Kajimura S
Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
Journal
Reference
Authors
Harms M, Seale P
Title
Brown and beige fat: development, function and therapeutic potential.
Journal
Reference
Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
Journal
Reference
Authors
Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
Title
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
Journal
Reference
Authors
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
Title
Regulation of brown fat by AMP-activated protein kinase.
Journal
Reference
Authors
Kooijman S, van den Heuvel JK, Rensen PC
Title
Neuronal Control of Brown Fat Activity.
Journal
Reference
Authors
Contreras C, Nogueiras R, Dieguez C, Rahmouni K, Lopez M
Title
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
Journal
Reference
Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
Title
Regulation of adipocyte lipolysis.
Journal
Reference
Authors
Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
Title
The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
Journal
Reference
Authors
Collins S, Yehuda-Shnaidman E, Wang H
Title
Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
Journal
Reference
Authors
Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
Title
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
Journal
Reference
Authors
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
Title
ASK1 signalling regulates brown and beige adipocyte function.
Journal
Reference
Authors
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Journal
Reference
Authors
Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS
Title
Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.
Journal
Reference
Authors
Sambeat A, Gulyaeva O, Dempersmier J, Tharp KM, Stahl A, Paul SM, Sul HS
Title
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
Journal
Reference
Authors
Villarroya F, Peyrou M, Giralt M
Title
Transcriptional regulation of the uncoupling protein-1 gene.
Journal
Reference
Authors
Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S
Title
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
Journal
Reference
Authors
Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F
Title
Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
Journal
Reference
Authors
Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, Liu G, Jin W, Chang Y
Title
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
Journal
Reference
Authors
Klingenberg M
Title
UCP1 - A sophisticated energy valve.
Journal
Reference
Authors
Bertholet AM, Kirichok Y
Title
UCP1: A transporter for H(+) and fatty acid anions.
Journal
Reference
Authors
Betz MJ, Enerback S
Title
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.
Journal
Reference
Authors
Tseng YH, Cypess AM, Kahn CR
Title
Cellular bioenergetics as a target for obesity therapy.
Journal
Reference
Authors
Fenzl A, Kiefer FW
Title
Brown adipose tissue and thermogenesis.
Journal
Reference
Authors
Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stockli J, James DE
Title
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.
Journal
Reference
Authors
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM
Title
FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.
Journal
Reference
Authors
Zois NE, Bartels ED, Hunter I, Kousholt BS, Olsen LH, Goetze JP
Title
Natriuretic peptides in cardiometabolic regulation and disease.
Journal
Reference
Authors
Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, Console L, Palmieri F
Title
The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
Journal
Reference
Authors
McCoin CS, Knotts TA, Adams SH
Title
Acylcarnitines--old actors auditioning for new roles in metabolic physiology.
Journal
Reference
Authors
Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J
Title
Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
Journal
Related pathway
aamp04923 Regulation of lipolysis in adipocytes
KO pathway
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