KEGG   PATHWAY: aamp04714
Entry
aamp04714                   Pathway                                
Name
Thermogenesis - Arvicola amphibius (Eurasian water vole)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
aamp04714  Thermogenesis
aamp04714

Other DBs
GO: 1990845
Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119813409  Adrb3; beta-3 adrenergic receptor [KO:K04143]
119814107  Gnas; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
119814944  neuroendocrine secretory protein 55 isoform X1 [KO:K04632]
119800365  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
119809754  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
119807554  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
119800380  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
119824190  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
119822579  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
119801694  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
119823121  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
119811771  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
119827754  Adcy10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
119800975  Prkacb; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
119802004  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
119820446  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
119814789  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
119821362  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
119801303  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
119826298  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
119806715  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
119807891  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
119817157  Prdm16; histone-lysine N-methyltransferase PRDM16 [KO:K22410] [EC:2.1.1.367]
119814332  Znf516; zinc finger protein 516 [KO:K22411]
119816860  Kdm1a; lysine-specific histone demethylase 1A isoform X1 [KO:K11450] [EC:1.14.99.66]
119802249  Ucp1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
119815767  Kdm3b; LOW QUALITY PROTEIN: lysine-specific demethylase 3B [KO:K15601] [EC:1.14.11.65]
119806765  Kdm3a; lysine-specific demethylase 3A isoform X1 [KO:K15601] [EC:1.14.11.65]
119808863  Smarca4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
119820148  Smarca2; LOW QUALITY PROTEIN: probable global transcription activator SNF2L2 [KO:K11647] [EC:5.6.2.-]
119823183  Smarcb1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
119810037  Smarcc1; SWI/SNF complex subunit SMARCC1 isoform X1 [KO:K11649]
119803332  Smarcc2; SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
119823459  Smarcd1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650]
119811763  Smarcd2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
119807023  Smarcd3; LOW QUALITY PROTEIN: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 [KO:K11650]
119812204  Smarce1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651]
119811081  Actg1; actin, cytoplasmic 2 [KO:K05692]
119825660  Actb; actin, cytoplasmic 1 [KO:K05692]
119825938  Actl6a; actin-like protein 6A isoform X1 [KO:K11340]
119825214  Actl6b; actin-like protein 6B [KO:K11652]
119816402  Arid1a; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
119820440  Arid1b; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
119820976  Dpf1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
119818696  Dpf3; zinc finger protein DPF3 isoform X1 [KO:K22198]
119807937  Pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
119820587  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
119813155  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
119822988  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
119823276  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
119823839  Mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
119823840  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
119809862  Ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
119819075  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
119818913  Sirt6; NAD-dependent protein deacetylase sirtuin-6 isoform X1 [KO:K11416] [EC:2.3.1.286]
119802871  Fgf21; fibroblast growth factor 21 [KO:K22429]
119803062  Plin1; perilipin-1 [KO:K08768]
119820308  Lipe; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
119816161  Pnpla2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
119808158  Mgll; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
119816370  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
119810200  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
119801352  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
119825157  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
119820999  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
119822790  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
119806497  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
119819991  Gcg; pro-glucagon [KO:K05259]
119817308  bone morphogenetic protein 8A-like isoform X1 [KO:K16622]
119817859  Bmp8a; bone morphogenetic protein 8A [KO:K16622]
119826798  Cnr1; cannabinoid receptor 1 isoform X2 [KO:K04277]
119817163  Nppa; natriuretic peptides A [KO:K12334]
119817164  Nppb; natriuretic peptides B [KO:K12335]
119801342  Npr1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
119811553  Prkg1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
119817224  Prkg2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
119801033  Klb; beta-klotho isoform X1 [KO:K22404]
119811944  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
119803586  Frs2; LOW QUALITY PROTEIN: fibroblast growth factor receptor substrate 2 [KO:K12461]
119813014  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
119818434  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
119806329  Sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
119800249  Hras; GTPase HRas isoform X1 [KO:K02833]
119804230  GTPase KRas-like [KO:K07827]
119806318  Kras; GTPase KRas isoform X1 [KO:K07827]
119801497  Nras; GTPase NRas [KO:K07828]
119816400  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
119804739  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
119804854  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
119820494  Rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
119818627  Tsc1; hamartin isoform X1 [KO:K07206]
119811857  Tsc2; tuberin isoform X1 [KO:K07207]
119807890  Rheb; GTP-binding protein Rheb [KO:K07208]
119813137  Rptor; LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
119816408  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
119812888  Mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
119802583  Akt1s1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
119814876  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
119813254  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
119821193  40S ribosomal protein S6-like [KO:K02991]
119818034  Rps6; 40S ribosomal protein S6 [KO:K02991]
119807118  40S ribosomal protein S6-like [KO:K02991]
119800250  40S ribosomal protein S6-like [KO:K02991]
119823120  Acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
119804592  Acsl4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
119812038  Acsl1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
119812079  Acsl6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
119820762  Acsl3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
119804932  LOW QUALITY PROTEIN: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial-like [KO:K03934] [EC:7.1.1.2]
119820696  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
119827486  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
119814166  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
119810090  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
119809107  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119803219  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119810541  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119816982  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
119818379  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119825922  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
119810417  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
119821308  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
119814511  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
119815378  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
119821089  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
119823492  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
119804764  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
119814379  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
119808469  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
119821547  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
119822367  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119816292  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119817139  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
119800371  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
119808111  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
119803343  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
119813558  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
119807886  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
119810302  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
119822816  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
119815606  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7-like [KO:K03951]
119825491  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
119819937  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
119807526  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
119821505  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
119810151  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial-like [KO:K03954]
119827973  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
119808788  acyl carrier protein, mitochondrial-like [KO:K03955]
119812443  acyl carrier protein, mitochondrial-like [KO:K03955]
119807454  acyl carrier protein, mitochondrial [KO:K03955]
119810775  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
119811058  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
119803407  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
119813692  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
119818574  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
119800598  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958]
119806913  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
119804078  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
119825606  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
119825940  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
119825963  Ndufb6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
119801780  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
119811753  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
119823332  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
119812927  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
119804641  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
119826441  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
119802653  NADH dehydrogenase [ubiquinone] 1 subunit C2-like [KO:K03968]
119814706  Ndufaf1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
119809653  Ndufaf2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160]
119810102  Ndufaf3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [KO:K09008]
119826844  Ndufaf4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
119814722  Ndufaf5; arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162] [EC:2.1.1.-]
119826749  Ndufaf6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163]
119806904  Ndufaf7; protein arginine methyltransferase NDUFAF7, mitochondrial [KO:K18164]
119811196  Ndufaf8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 [KO:K24726]
119809157  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
119816786  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
119827624  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
119809004  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
119816634  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
119822897  cytochrome c1, heme protein, mitochondrial [KO:K00413]
119810716  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
119818376  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
119817782  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
119823100  cytochrome b-c1 complex subunit 7 [KO:K00417]
119826150  cytochrome b-c1 complex subunit 7 [KO:K00417]
119812643  cytochrome b-c1 complex subunit 8 [KO:K00418]
119822943  cytochrome b-c1 complex subunit 10 [KO:K00420]
119824516  cytochrome b-c1 complex subunit 10-like [KO:K00420]
119801810  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
119815669  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
119808969  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
119820956  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
119800700  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
119823348  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
119824540  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
119813186  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
119826874  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
119821317  cytochrome c oxidase subunit 6B2 [KO:K02267]
119803616  cytochrome c oxidase subunit 6B1-like [KO:K02267]
119812348  cytochrome c oxidase subunit 6B1-like [KO:K02267]
119820632  cytochrome c oxidase subunit 6B1 [KO:K02267]
119823502  cytochrome c oxidase subunit 6C-2 [KO:K02268]
119804134  cytochrome c oxidase subunit 6C-2-like [KO:K02268]
119808129  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
119821387  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
119810497  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
119820589  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
119821824  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
119824561  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
119804752  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
119807117  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
119818750  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
119809813  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
119824069  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
119822805  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
119818361  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
119806473  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
119813325  protoheme IX farnesyltransferase, mitochondrial [KO:K02257] [EC:2.5.1.141]
119811757  cytochrome c oxidase assembly protein COX11, mitochondrial [KO:K02258]
119823361  cytochrome c oxidase assembly protein COX14 [KO:K18181]
119823977  LOW QUALITY PROTEIN: cytochrome c oxidase assembly protein COX14-like [KO:K18181]
119810243  LOW QUALITY PROTEIN: cytochrome c oxidase assembly protein COX15 homolog [KO:K02259] [EC:1.17.99.9]
119823989  cytochrome c oxidase assembly protein COX15 homolog [KO:K02259] [EC:1.17.99.9]
119818496  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial [KO:K18182]
119808269  cytochrome c oxidase copper chaperone-like [KO:K02260]
119825659  cytochrome c oxidase copper chaperone [KO:K02260]
119827249  cytochrome c oxidase assembly protein COX18, mitochondrial isoform X1 [KO:K17797]
119824982  cytochrome c oxidase assembly protein COX19 [KO:K18183]
119827018  cytochrome c oxidase assembly protein COX20, mitochondrial [KO:K18184]
119813213  cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
119802760  cytochrome c oxidase assembly factor 4 homolog, mitochondrial [KO:K18177]
119823949  cytochrome c oxidase assembly factor 5 [KO:K18178]
119802063  cytochrome c oxidase assembly factor 6 homolog [KO:K18179]
119817808  cytochrome c oxidase assembly factor 7 [KO:K18180]
119814908  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
119803617  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
119801085  ATP synthase subunit gamma, mitochondrial [KO:K02136]
119816174  Atp5f1c; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
119821561  Atp5f1d; ATP synthase subunit delta, mitochondrial [KO:K02134]
119814896  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
119824792  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
119825399  ATP synthase subunit O, mitochondrial-like [KO:K02137]
119813406  ATP synthase subunit O, mitochondrial-like [KO:K02137]
119800757  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
119807929  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
119827952  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
119822775  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
119818833  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
119812397  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
119826216  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
119807061  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
119817869  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
119812417  Atp5pd; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
119814658  ATP synthase subunit e, mitochondrial-like [KO:K02129]
119815865  ATP synthase subunit e, mitochondrial-like [KO:K02129]
119821449  ATP synthase subunit e, mitochondrial-like [KO:K02129]
119826897  Atp5me; ATP synthase subunit e, mitochondrial [KO:K02129]
119811739  ATP synthase subunit f, mitochondrial-like [KO:K02130]
119825734  Atp5mf; ATP synthase subunit f, mitochondrial [KO:K02130]
119824693  Atp5pf; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
119810785  Atp5mg; ATP synthase subunit g, mitochondrial [KO:K02140]
119817978  Cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
119809837  Slc25a20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
119819243  Slc25a29; mitochondrial basic amino acids transporter [KO:K15109]
119819005  Cpt1a; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
119822804  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
119802933  Cpt1c; carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
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Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
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Nat Rev Mol Cell Biol 17:480-95 (2016)
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Brown and beige fat: development, function and therapeutic potential.
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Nat Med 19:1252-63 (2013)
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Mol Cell Biol 25:5466-79 (2005)
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ASK1 signalling regulates brown and beige adipocyte function.
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Nat Commun 7:11158 (2016)
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JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
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Nat Commun 6:7052 (2015)
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Mol Cell 57:235-46 (2015)
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Cell Rep 15:2536-49 (2016)
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Nat Rev Endocrinol 11:617-25 (2015)
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Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
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Biochem Biophys Rep 10:32-38 (2017)
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Related
pathway
aamp00020  Citrate cycle (TCA cycle)
aamp00190  Oxidative phosphorylation
aamp04010  MAPK signaling pathway
aamp04022  cGMP-PKG signaling pathway
aamp04024  cAMP signaling pathway
aamp04150  mTOR signaling pathway
aamp04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
LinkDB

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