KEGG   PATHWAY: btax04820
Entry
btax04820                   Pathway                                
Name
Cytoskeleton in muscle cells - Budorcas taxicolor (takin)
Class
Cellular Processes; Cell motility
Pathway map
btax04820  Cytoskeleton in muscle cells
btax04820

Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128065257  COL1A1; collagen alpha-1(I) chain [KO:K06236]
128046458  COL1A2; collagen alpha-2(I) chain [KO:K06236]
128043774  COL3A1; collagen alpha-1(III) chain [KO:K19720]
128056076  COL5A1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
128043772  COL5A2; collagen alpha-2(V) chain [KO:K19721]
128051523  COL5A3; collagen alpha-3(V) chain isoform X1 [KO:K19721]
128045570  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
128045800  COL11A1; collagen alpha-1(XI) chain [KO:K19721]
128052443  COL27A1; collagen alpha-1(XXVII) chain [KO:K19721]
128055522  COL11A2; collagen alpha-2(XI) chain [KO:K19721]
128044990  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
128058571  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
128059283  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
128047380  DCN; decorin [KO:K04660]
128050493  VCAN; versican core protein isoform X1 [KO:K06793]
128065962  ELN; elastin isoform X1 [KO:K14211]
128050602  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
128057689  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
128045507  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
128060926  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
128048315  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
128054540  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
128050621  COMP; cartilage oligomeric matrix protein [KO:K04659]
128045667  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
128053041  THBS2; thrombospondin-2 [KO:K04659]
128054588  THBS4; thrombospondin-4 [KO:K04659]
128054422  FBN1; fibrillin-1 [KO:K06825]
128051764  FBN3; fibrillin-3 [KO:K23342]
128051790  FBN2; fibrillin-2 [KO:K23342]
128069713  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
128070154  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
128070152  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
128057793  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
128057845  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
128071532  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
128047079  FBLN2; fibulin-2 isoform X1 [KO:K17307]
128047583  FBLN1; fibulin-1 isoform X1 [KO:K17307]
128043424  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
128047329  NID1; nidogen-1 [KO:K06826]
128054061  NID2; nidogen-2 [KO:K06826]
128071425  fibronectin-like [KO:K05717]
128068063  FN1; fibronectin isoform X1 [KO:K05717]
128056498  SDC1; syndecan-1 [KO:K06257]
128059550  SDC2; syndecan-2 isoform X1 [KO:K16336]
128061359  SDC3; syndecan-3 [KO:K16337]
128058528  SDC4; syndecan-4 [KO:K16338]
128061392  AGRN; agrin [KO:K06254]
128069790  BGN; biglycan [KO:K08118]
128067421  DSC2; desmocollin-2 [KO:K07601]
128067361  DSG2; desmoglein-2 [KO:K07597]
128047981  PKP2; plakophilin-2 [KO:K12642]
128064548  JUP; junction plakoglobin [KO:K10056]
128056268  DSP; desmoplakin [KO:K10381]
128058884  VIM; vimentin [KO:K07606]
128064785  DES; desmin [KO:K07610]
128053075  LAMA2; laminin subunit alpha-2 [KO:K05637]
128067370  LAMA1; laminin subunit alpha-1 [KO:K05637]
128065939  ITGA1; integrin alpha-1 [KO:K06480]
128066170  ITGA2; integrin alpha-2 [KO:K06481]
128065265  ITGA2B; integrin alpha-IIb [KO:K06476]
128065072  ITGA3; integrin alpha-3 [KO:K06482]
128043513  ITGA4; integrin alpha-4 [KO:K06483]
128048841  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
128063440  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
128048509  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
128058543  ITGA8; integrin alpha-8 [KO:K06584]
128046826  ITGA9; integrin alpha-9 [KO:K06585]
128044498  ITGA10; integrin alpha-10 [KO:K06586]
128054246  ITGA11; integrin alpha-11 [KO:K06587]
128061467  ITGAV; integrin alpha-V [KO:K06487]
128058839  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
128064875  ITGB3; integrin beta-3 [KO:K06493]
128064497  ITGB4; integrin beta-4 [KO:K06525]
128061565  ITGB5; integrin beta-5 [KO:K06588]
128068538  ITGB6; integrin beta-6 [KO:K06589]
128048309  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
128046829  ITGB8; integrin beta-8 [KO:K06591]
128052212  TLN1; talin-1 [KO:K06271]
128054345  TLN2; talin-2 isoform X1 [KO:K06271]
128047281  VCL; vinculin isoform X1 [KO:K05700]
128047259  ACTN2; alpha-actinin-2 [KO:K21073]
128069040  ACTN3; alpha-actinin-3 isoform X1 [KO:K21073]
128043956  ACTB; actin, cytoplasmic 1 [KO:K05692]
128064385  ACTG1; actin, cytoplasmic 2 [KO:K05692]
128055357  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
128053542  DAG1; dystroglycan 1 [KO:K06265]
128064822  SGCA; alpha-sarcoglycan [KO:K12565]
128046536  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
128049488  SGCB; beta-sarcoglycan [KO:K12566]
128051743  SGCD; delta-sarcoglycan [KO:K12563]
128057669  SGCG; gamma-sarcoglycan [KO:K12564]
128068313  SGCZ; zeta-sarcoglycan [KO:K27062]
128047480  SSPN; sarcospan [KO:K22194]
128070127  DMD; dystrophin [KO:K10366]
128058424  SNTA1; alpha-1-syntrophin isoform X1 [KO:K24063]
128063337  SNTB2; beta-2-syntrophin [KO:K24064]
128071122  beta-2-syntrophin [KO:K24064]
128059313  SNTB1; beta-1-syntrophin [KO:K24064]
128067423  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
128046608  FLNC; filamin-C [KO:K27393]
128044333  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
128044334  sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
128063966  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
128044903  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
128069887  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
128065125  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
128047663  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
128061193  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
128048871  ANK3; ankyrin-3 [KO:K09259]
128055954  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
128063264  SPTBN4; spectrin beta chain, non-erythrocytic 4 [KO:K06115]
128054794  SPTBN5; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 5 [KO:K06115]
128055267  SPTBN1; spectrin beta chain, non-erythrocytic 1 [KO:K06115]
128068676  SPTBN2; spectrin beta chain, non-erythrocytic 2 [KO:K23932]
128061328  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
128048306  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
128068616  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
128064378  myosin-1 [KO:K24220]
128064379  myosin-2 [KO:K24220]
128064380  MYH8; myosin-8 [KO:K24220]
128064381  myosin-4 [KO:K24220]
128052379  MYH15; myosin-15 [KO:K24220]
128058904  MYH7B; myosin-7B isoform X1 [KO:K24220]
128065208  myosin-3 [KO:K24220]
128065423  MYH13; myosin-13 [KO:K24220]
128054194  myosin-7 [KO:K17751]
128054195  myosin-6 [KO:K17751]
128043499  MYH11; myosin-11 isoform X1 [KO:K10352]
128063353  MYH14; myosin-14 [KO:K10352]
128065145  MYH10; myosin-10 isoform X1 [KO:K10352]
128047692  MYH9; myosin-9 isoform X1 [KO:K10352]
128061834  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
128044416  MYL3; myosin light chain 3 [KO:K12749]
128065119  MYL4; myosin light chain 4 [KO:K12750]
128062159  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
128046447  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
128058295  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
128063455  MYL11; myosin regulatory light chain 11 [KO:K12758]
128047452  MYBPC1; myosin-binding protein C, slow-type isoform X1 [KO:K12557]
128063354  MYBPC2; myosin-binding protein C, fast-type [KO:K12558]
128060158  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
128045541  MYBPHL; myosin-binding protein H-like [KO:K24494]
128061446  MYBPH; myosin-binding protein H [KO:K24494]
128047971  ACTA1; actin, alpha skeletal muscle [KO:K10354]
128054423  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
128047350  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
128061322  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
128063309  TNNT1; troponin T, slow skeletal muscle [KO:K10372]
128058135  TNNC2; troponin C, skeletal muscle [KO:K12042]
128068541  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
128068507  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
128063310  TNNI3; troponin I, cardiac muscle [KO:K12044]
128061238  TNNT2; troponin T, cardiac muscle [KO:K12045]
128054209  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
128052479  TPM2; tropomyosin beta chain [KO:K10374]
128050312  LOW QUALITY PROTEIN: tropomyosin alpha-3 chain-like [KO:K09290]
128044429  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
128048068  LOW QUALITY PROTEIN: tropomyosin alpha-3 chain-like [KO:K09290]
128051408  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
128058184  tropomyosin alpha-4 chain-like [KO:K10375]
128043950  TTN; titin isoform X1 [KO:K12567] [EC:2.7.11.1]
128051661  MYOT; myotilin isoform X1 [KO:K19875]
128064541  TCAP; telethonin [KO:K19879]
128049486  SYNPO2; synaptopodin-2 [KO:K24066]
128043720  NEB; nebulin isoform X1 [KO:K18267]
128058569  NEBL; nebulette [KO:K25865]
128050718  MYOZ3; myozenin-3 [KO:K26050]
128047471  MYOZ1; myozenin-1 [KO:K26050]
128049600  MYOZ2; myozenin-2 isoform X1 [KO:K26050]
128051354  PDLIM4; PDZ and LIM domain protein 4 [KO:K23353]
128052553  PDLIM2; PDZ and LIM domain protein 2 isoform X1 [KO:K23353]
128067738  PDLIM1; PDZ and LIM domain protein 1 [KO:K23353]
128068186  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
128058506  F-actin-capping protein subunit alpha-1 [KO:K10364]
128045535  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
128046254  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
128054300  LOW QUALITY PROTEIN: F-actin-capping protein subunit alpha-2-like [KO:K10364]
128048799  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
128067951  CAPZB; F-actin-capping protein subunit beta [KO:K10365]
128064056  XIRP1; xin actin-binding repeat-containing protein 1 isoform X1 [KO:K27381]
128064452  XIRP2; xin actin-binding repeat-containing protein 2 isoform X1 [KO:K27381]
128067712  NRAP; nebulin-related-anchoring protein isoform X1 [KO:K24421]
128047752  MYPN; myopalladin isoform X1 [KO:K22028]
128050352  PDLIM7; PDZ and LIM domain protein 7 isoform X1 [KO:K19867]
128048679  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
128049396  PDLIM5; PDZ and LIM domain protein 5 [KO:K19867]
128044680  TMOD4; tropomodulin-4 isoform X1 [KO:K10370]
128052580  TMOD1; tropomodulin-1 isoform X1 [KO:K10370]
128054219  TMOD2; tropomodulin-2 [KO:K10370]
128054326  TMOD3; tropomodulin-3 [KO:K10370]
128046505  ZYX; zyxin [KO:K06273]
128070354  FHL1; four and a half LIM domains protein 1 [KO:K14365]
128055812  FHL2; four and a half LIM domains protein 2 [KO:K14380]
128045703  FHL3; four and a half LIM domains protein 3 [KO:K24414]
128058049  LMOD3; leiomodin-3 [KO:K22030]
128046963  LMOD2; leiomodin-2 [KO:K22030]
128061559  LMOD1; leiomodin-1 [KO:K22030]
128067726  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
128067693  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
128056670  ANKRD23; ankyrin repeat domain-containing protein 23 [KO:K21438]
128064675  FMNL1; formin-like protein 1 [KO:K23957]
128047297  FMNL3; formin-like protein 3 [KO:K23957]
128067101  FMNL2; formin-like protein 2 [KO:K23957]
128066541  INF2; inverted formin-2 [KO:K23958]
128053834  DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512]
128055884  DAAM2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
128051121  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
128070104  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
128057559  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
128047365  FMN2; formin-2 [KO:K02184]
128067511  MYOM1; myomesin-1 [KO:K24495]
128068301  MYOM2; myomesin-2 [KO:K24495]
128068880  MYOM3; myomesin-3 [KO:K24495]
128064399  ENO3; beta-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
128047879  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
128061881  ENO1; alpha-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
128049449  ANK2; ankyrin-2 [KO:K09255]
128063791  CKM; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
128056083  TRIM54; tripartite motif-containing protein 54 isoform X1 [KO:K10653]
128059318  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
128061637  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
128044442  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
128045802  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
128060150  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
128050907  OBSCN; obscurin isoform X1 [KO:K17531] [EC:2.7.11.1]
128053913  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
128059566  PLEC; plectin isoform X1 [KO:K10388]
128066779  SYNE3; nesprin-3 [KO:K21761]
128053170  SYNE1; nesprin-1 [KO:K19326]
128054581  SYNE2; nesprin-2 [KO:K19346]
128070598  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
128047295  SUN2; SUN domain-containing protein 2 isoform X1 [KO:K19347]
128045608  TMEM43; transmembrane protein 43 isoform X1 [KO:K27488]
128070022  EMD; emerin [KO:K12569]
128061458  LBR; delta(14)-sterol reductase LBR [KO:K19532] [EC:1.3.1.70]
128044385  LMNA; lamin [KO:K12641]
128050441  LMNB1; lamin-B1 [KO:K07611]
128050585  LMNB2; lamin-B2 [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
btax04512  ECM-receptor interaction
btax04814  Motor proteins
KO pathway
ko04820   
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