KEGG   PATHWAY: ccaj04141
Entry
ccaj04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Cajanus cajan (pigeon pea)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ccaj04141  Protein processing in endoplasmic reticulum
ccaj04141

Other DBs
GO: 0030433 0034976
Organism
Cajanus cajan (pigeon pea) [GN:ccaj]
Gene
109788478  protein transport protein Sec61 subunit alpha [KO:K10956]
109788866  preprotein translocase subunit SECY, chloroplastic isoform X1 [KO:K10956]
109811935  protein transport protein Sec61 subunit alpha [KO:K10956]
109790799  protein transport protein Sec61 subunit beta [KO:K09481]
109819049  protein transport protein Sec61 subunit beta [KO:K09481]
109807272  protein transport protein Sec61 subunit gamma [KO:K07342]
109804224  protein transport protein Sec61 subunit gamma [KO:K07342]
109800415  uncharacterized protein LOC109800415 isoform X1 [KO:K12275]
109788780  dnaJ protein ERDJ2A [KO:K09540]
109802361  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1A [KO:K12666]
109810605  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1B [KO:K12666]
109790098  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
109792854  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
109799894  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
109801456  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
109788666  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
109796183  LOW QUALITY PROTEIN: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
109788424  probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3B [KO:K19478]
109798250  oligosaccharyltransferase complex subunit ostc [KO:K26501]
109809217  transmembrane protein 258 [KO:K26502]
109810719  mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
109810676  mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
109796174  LOW QUALITY PROTEIN: heat shock 70 kDa protein 17 [KO:K09486]
109818463  luminal-binding protein 4 [KO:K09490] [EC:3.6.4.10]
109818465  luminal-binding protein [KO:K09490] [EC:3.6.4.10]
109814761  dnaJ protein ERDJ3B [KO:K09517]
109798154  dnaJ protein P58IPK homolog [KO:K09523]
109814326  heat shock protein 90-6, mitochondrial [KO:K09487]
109816537  heat shock protein 90-5, chloroplastic [KO:K09487]
109789169  endoplasmin homolog isoform X1 [KO:K09487]
109814841  probable glucan 1,3-alpha-glucosidase [KO:K05546] [EC:3.2.1.207]
109817495  glucosidase 2 subunit beta [KO:K08288]
109806040  calnexin homolog [KO:K08054]
109806041  calnexin homolog [KO:K08054]
109813683  calnexin homolog [KO:K08054]
109802523  calreticulin-3 [KO:K08057]
109819226  calreticulin [KO:K08057]
109800214  calreticulin-3 [KO:K08057]
109816992  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS1 [KO:K01230] [EC:3.2.1.113]
109807339  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS2 [KO:K01230] [EC:3.2.1.113]
109789197  mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS3 [KO:K23741] [EC:3.2.1.209]
109805342  SEC12-like protein 1 isoform X1 [KO:K14003]
109787703  SEC12-like protein 2 isoform X1 [KO:K14003]
109819207  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
109819228  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
109814973  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
109814975  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
109807725  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
109807726  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
109797481  GTP-binding protein SAR1A [KO:K07953] [EC:3.6.5.-]
109793045  GTP-binding protein SAR1B [KO:K07953] [EC:3.6.5.-]
109811265  protein transport protein SEC13 homolog B [KO:K14004]
109816823  protein transport protein SEC13 homolog B [KO:K14004]
109798372  protein transport protein SEC31 homolog B isoform X1 [KO:K14005]
109809267  protein transport protein SEC23 isoform X2 [KO:K14006]
109808318  protein transport protein SEC23 [KO:K14006]
109797105  protein transport protein SEC23 [KO:K14006]
109789500  protein transport protein SEC23 [KO:K14006]
109795781  protein transport protein Sec24-like At3g07100 [KO:K14007]
109796070  protein transport protein Sec24-like At4g32640 [KO:K14007]
109803127  UDP-glucose:glycoprotein glucosyltransferase [KO:K11718] [EC:2.4.1.-]
109793983  alpha-mannosidase I MNS5 isoform X1 [KO:K10084]
109807330  alpha-mannosidase I MNS4 [KO:K10085]
109816077  protein disulfide-isomerase isoform X1 [KO:K09580] [EC:5.3.4.1]
109799119  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
109808969  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
109808189  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
109812193  protein disulfide-isomerase 5-2 [KO:K09580] [EC:5.3.4.1]
109788111  protein disulfide isomerase-like 1-4 [KO:K09580] [EC:5.3.4.1]
109792711  protein disulfide isomerase-like 1-6 [KO:K09580] [EC:5.3.4.1]
109815243  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
109816507  protein disulfide isomerase-like 2-3 [KO:K09584] [EC:5.3.4.1]
109796944  probable protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
109813585  endoplasmic reticulum oxidoreductin-1 [KO:K10950] [EC:1.8.4.-]
109789890  protein OS-9 homolog [KO:K10088]
109788546  translocon-associated protein subunit alpha [KO:K13249]
109801763  translocon-associated protein subunit beta [KO:K13250]
109816388  uncharacterized protein LOC109816388 [KO:K14009]
109817401  B-cell receptor-associated protein 31 [KO:K14009]
109814226  B-cell receptor-associated protein 31 [KO:K14009]
109795444  uncharacterized protein LOC109795444 [KO:K14009]
109795471  derlin-2.2 [KO:K13989]
109799722  derlin-1 [KO:K13989]
109819078  derlin-1.1 [KO:K13989]
109791269  UBX domain-containing protein 1 [KO:K24348]
109804226  plant UBX domain-containing protein 2 [KO:K14011]
109808371  plant UBX domain-containing protein 4 [KO:K14012]
109796917  plant UBX domain-containing protein 4 [KO:K14012]
109804201  plant UBX domain-containing protein 4 [KO:K14012]
109796588  cell division cycle protein 48 homolog [KO:K13525]
109808141  cell division cycle protein 48 homolog [KO:K13525]
109811596  cell division cycle protein 48 homolog [KO:K13525]
109798889  cell division cycle protein 48 homolog [KO:K13525]
109813568  cell division cycle protein 48 homolog [KO:K13525]
109797161  NPL4-like protein 2 [KO:K14015]
109799199  ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
109802405  ubiquitin fusion degradation protein 1 homolog isoform X1 [KO:K14016]
109805977  ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
109803995  ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
109796198  heat shock cognate 70 kDa protein 2 [KO:K03283]
109788565  heat shock 70 kDa protein [KO:K03283]
109787854  heat shock 70 kDa protein [KO:K03283]
109787856  heat shock 70 kDa protein [KO:K03283]
109802797  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
109802799  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
109802426  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
109802427  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
109802428  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
109812386  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
109803624  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
109816171  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
109812397  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
109812398  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
109812404  probable mediator of RNA polymerase II transcription subunit 37c isoform X1 [KO:K03283]
109812433  heat shock cognate 70 kDa protein 2 [KO:K03283]
109812396  heat shock cognate 70 kDa protein 2 [KO:K03283]
109811856  heat shock 70 kDa protein [KO:K03283]
109798418  heat shock cognate 70 kDa protein 2 [KO:K03283]
109806299  heat shock cognate 70 kDa protein 2 [KO:K03283]
109807362  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
109807442  probable mediator of RNA polymerase II transcription subunit 37c [KO:K03283]
109815896  dnaJ protein homolog 1 [KO:K09503]
109788513  dnaJ protein homolog [KO:K09503]
109788973  dnaJ protein homolog [KO:K09503]
109803403  chaperone protein dnaJ 49 [KO:K09518]
109791872  chaperone protein dnaJ 49 [KO:K09518]
109803438  heat shock protein 83 [KO:K04079]
109800130  F-box/kelch-repeat protein At3g06240 [KO:K04079]
109813107  heat shock cognate protein 80 [KO:K04079]
109814325  heat shock cognate protein 80 [KO:K04079]
109791681  F-box/kelch-repeat protein At3g06240 [KO:K04079]
109791684  F-box/kelch-repeat protein At3g06240 isoform X1 [KO:K04079]
109789073  heat shock protein 83 isoform X1 [KO:K04079]
109789122  uncharacterized protein LOC109789122 [KO:K04079]
109806472  putative F-box protein At3g16210 isoform X1 [KO:K04079]
109793017  hsp70 nucleotide exchange factor FES1 [KO:K09562]
109793582  nucleotide exchange factor SIL1 isoform X1 [KO:K09562]
109791344  17.5 kDa class I heat shock protein [KO:K13993]
109809228  22.0 kDa class IV heat shock protein [KO:K13993]
109803476  17.3 kDa class I heat shock protein [KO:K13993]
109811278  small heat shock protein, chloroplastic [KO:K13993]
109818690  18.1 kDa class I heat shock protein-like [KO:K13993]
109818696  17.5 kDa class I heat shock protein [KO:K13993]
109818697  17.5 kDa class I heat shock protein [KO:K13993]
109818699  17.3 kDa class I heat shock protein [KO:K13993]
109818553  15.7 kDa heat shock protein, peroxisomal [KO:K13993]
109803573  17.5 kDa class I heat shock protein [KO:K13993]
109804327  17.3 kDa class I heat shock protein-like [KO:K13993]
109790030  17.1 kDa class II heat shock protein [KO:K13993]
109795287  15.4 kDa class V heat shock protein [KO:K13993]
109813891  18.2 kDa class I heat shock protein [KO:K13993]
109790764  18.1 kDa class I heat shock protein [KO:K13993]
109790916  17.3 kDa class I heat shock protein [KO:K13993]
109790917  18.5 kDa class I heat shock protein [KO:K13993]
109798887  heat shock 22 kDa protein, mitochondrial isoform X1 [KO:K13993]
109792106  16.9 kDa class I heat shock protein 2 [KO:K13993]
109807856  17.4 kDa class III heat shock protein [KO:K13993]
109791820  17.9 kDa class II heat shock protein [KO:K13993]
109793844  22.0 kDa class IV heat shock protein [KO:K13993]
109799673  small heat shock protein, chloroplastic isoform X2 [KO:K13993]
109794504  class I heat shock protein [KO:K13993]
109803917  17.3 kDa class I heat shock protein [KO:K13993]
109806468  16.9 kDa class I heat shock protein 3 [KO:K13993]
109809564  26.5 kDa heat shock protein, mitochondrial [KO:K13993]
109809580  small heat shock protein, chloroplastic [KO:K13993]
109793263  18.1 kDa class I heat shock protein-like [KO:K13993]
109815433  class I heat shock protein-like [KO:K13993]
109788692  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
109800103  phospholipase A-2-activating protein [KO:K14018]
109808312  ubiquitin receptor RAD23b [KO:K10839]
109801548  ubiquitin receptor RAD23c [KO:K10839]
109805951  ubiquitin receptor RAD23d [KO:K10839]
109818572  ubiquitin receptor RAD23c [KO:K10839]
109798466  ubiquitin domain-containing protein DSK2a isoform X1 [KO:K04523]
109799981  ubiquitin domain-containing protein DSK2b isoform X1 [KO:K04523]
109795837  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
109788593  ataxin-3 homolog [KO:K11863] [EC:3.4.22.-]
109788132  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
109808178  eukaryotic translation initiation factor 2 subunit alpha homolog [KO:K03237]
109800131  subtilisin-like protease SBT6.1 isoform X1 [KO:K08653] [EC:3.4.21.112]
109807982  membrane-bound transcription factor site-2 protease homolog isoform X1 [KO:K07765] [EC:3.4.24.85]
109800128  serine/threonine-protein kinase/endoribonuclease IRE1a [KO:K08852] [EC:2.7.11.1 3.1.26.-]
109811494  serine/threonine-protein kinase/endoribonuclease IRE1a isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
109816138  probable E3 ubiquitin ligase SUD1 isoform X1 [KO:K10661] [EC:2.3.2.27]
109807577  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
109807378  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
109790588  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
109817521  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
109805733  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
109798649  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
109810890  ERAD-associated E3 ubiquitin-protein ligase HRD1B isoform X2 [KO:K10601] [EC:2.3.2.27]
109797827  uncharacterized protein LOC109797827 [KO:K10666] [EC:2.3.2.27]
109802817  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
109803139  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
109790702  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
109810417  E3 ubiquitin-protein ligase RMA1H1 [KO:K10666] [EC:2.3.2.27]
109813784  E3 ubiquitin-protein ligase RMA3 [KO:K10666] [EC:2.3.2.27]
109788379  E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
109800820  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF185 [KO:K10666] [EC:2.3.2.27]
109799676  ERAD-associated E3 ubiquitin-protein ligase component HRD3A [KO:K14026]
109805843  E3 ubiquitin protein ligase RIN2 [KO:K10636] [EC:2.3.2.36]
109791272  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
109805858  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
109808270  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
109807093  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
109808095  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
109789573  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
109796155  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
109798810  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
109800111  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
109806089  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
109790424  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
109812899  cullin-1 [KO:K03347]
109807764  cullin-1 isoform X1 [KO:K03347]
109794994  SKP1-like protein 1A [KO:K03094]
109787902  SKP1-like protein 14 [KO:K03094]
109787903  SKP1-like protein 14 [KO:K03094]
109795669  SKP1-like protein 1A [KO:K03094]
109795796  SKP1-like protein 1B [KO:K03094]
109800888  SKP1-like protein 1A [KO:K03094]
109787896  uncharacterized protein LOC109787896 [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
ccaj00510  N-Glycan biosynthesis
ccaj03050  Proteasome
ccaj03060  Protein export
KO pathway
ko04141   
LinkDB

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