KEGG   PATHWAY: ccrc03040
Entry
ccrc03040                   Pathway                                
Name
Spliceosome - Colias croceus (clouded yellow)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
ccrc03040  Spliceosome
ccrc03040

Other DBs
GO: 0005681
Organism
Colias croceus (clouded yellow) [GN:ccrc]
Gene
123692188  U1 spliceosomal RNA [KO:K14276]
123701109  U1 spliceosomal RNA [KO:K14276]
123697624  U2 spliceosomal RNA [KO:K14277]
123701563  U2 spliceosomal RNA [KO:K14277]
123701114  U4 spliceosomal RNA [KO:K14278]
123704486  U4 spliceosomal RNA [KO:K14278]
123705755  U4 spliceosomal RNA [KO:K14278]
123702048  U5 spliceosomal RNA [KO:K14279]
123695240  U5 spliceosomal RNA [KO:K14279]
123699416  U5 spliceosomal RNA [KO:K14279]
123704232  U5 spliceosomal RNA [KO:K14279]
123697627  U5 spliceosomal RNA [KO:K14279]
123698290  U6 spliceosomal RNA [KO:K14280]
123698094  probable ATP-dependent RNA helicase DDX46 [KO:K12811] [EC:5.6.2.7]
123700337  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
123705844  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
123694126  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
123693026  pre-mRNA-processing factor 17 [KO:K12816]
123694784  pre-mRNA-splicing factor 18 [KO:K12817]
123691356  ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
123696889  pre-mRNA-splicing factor Slu7 [KO:K12819]
123702267  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [KO:K12820] [EC:5.6.2.6]
123706106  small nuclear ribonucleoprotein-associated protein B [KO:K11086]
123702335  probable small nuclear ribonucleoprotein Sm D1 [KO:K11087]
123702909  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
123700450  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
123694617  probable small nuclear ribonucleoprotein E [KO:K11097]
123694403  small nuclear ribonucleoprotein F [KO:K11098]
123703445  probable small nuclear ribonucleoprotein G [KO:K11099]
123704636  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
123693393  U1 small nuclear ribonucleoprotein C [KO:K11095]
123693518  pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
123694141  DEAD-box ATP-dependent RNA helicase 20-like [KO:K12823] [EC:5.6.2.7]
123694248  ATP-dependent RNA helicase p62 [KO:K12823] [EC:5.6.2.7]
123694345  ATP-dependent RNA helicase dbp2-like isoform X1 [KO:K12823] [EC:5.6.2.7]
123694499  DEAD-box ATP-dependent RNA helicase 20-like [KO:K12823] [EC:5.6.2.7]
123692401  U2 small nuclear ribonucleoprotein A' [KO:K11092]
123694335  U1 small nuclear ribonucleoprotein A [KO:K11094]
123694916  splicing factor 3A subunit 1 [KO:K12825]
123691692  splicing factor 3A subunit 2 [KO:K12826]
123694894  splicing factor 3A subunit 3 [KO:K12827]
123691185  splicing factor 3B subunit 1 [KO:K12828]
123699692  splicing factor 3B subunit 2 [KO:K12829]
123694190  splicing factor 3B subunit 3 isoform X1 [KO:K12830]
123696154  splicing factor 3B subunit 4 [KO:K12831]
123701936  splicing factor 3B subunit 5 [KO:K12832]
123692587  splicing factor 3B subunit 6 [KO:K12833]
123696531  PHD finger-like domain-containing protein 5A [KO:K12834]
123696308  ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
123693893  splicing factor U2af 38 kDa subunit [KO:K12836]
123695260  splicing factor U2AF 50 kDa subunit [KO:K12837]
123698775  poly(U)-binding-splicing factor half pint isoform X1 [KO:K12838]
123690748  survival of motor neuron-related-splicing factor 30 [KO:K12839]
123693803  splicing factor 45 isoform X1 [KO:K12840]
123692383  calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
123694982  U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
123704380  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
123698133  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
123704739  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
123695389  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
123698027  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
123694858  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
123702422  U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
123702471  U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662]
123691072  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
123690983  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
123694478  NHP2-like protein 1 [KO:K12845]
123702552  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
123702410  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
123693924  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
123692459  zinc finger matrin-type protein 2 isoform X1 [KO:K12848]
123703167  pre-mRNA-splicing factor 38-like [KO:K12849]
123702978  pre-mRNA-splicing factor 38B isoform X1 [KO:K12850]
123701309  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
123702355  putative U5 small nuclear ribonucleoprotein 200 kDa helicase isoform X1 [KO:K12854] [EC:5.6.2.6]
123698097  pre-mRNA-processing factor 6 [KO:K12855]
123696483  pre-mRNA-processing-splicing factor 8 [KO:K12856]
123697887  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
123701183  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
123701517  thioredoxin-like protein 4A [KO:K12859]
123691378  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
123693277  cell division cycle 5-like protein [KO:K12860]
123693647  pre-mRNA-splicing factor SPF27 [KO:K12861]
123696930  pleiotropic regulator 1 [KO:K12862]
123706382  protein CWC15 homolog [KO:K12863]
123705729  beta-catenin-like protein 1 [KO:K12864]
123700564  heat shock protein 68-like [KO:K03283]
123703557  heat shock protein 68-like [KO:K03283]
123704021  heat shock protein 68-like [KO:K03283]
123692423  heat shock protein 68-like [KO:K03283]
123692968  heat shock 70 kDa protein cognate 4 [KO:K03283]
123694883  heat shock protein 68-like [KO:K03283]
123699962  polyglutamine-binding protein 1 [KO:K12865]
123703902  puff-specific protein Bx42 [KO:K06063]
123706230  pre-mRNA-splicing factor syf1 homolog [KO:K12867]
123697858  pre-mRNA-splicing factor Syf2 [KO:K12868]
123697272  protein crooked neck [KO:K12869]
123692907  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
123705157  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
123702440  peptidyl-prolyl cis-trans isomerase [KO:K09564] [EC:5.2.1.8]
123693163  coiled-coil domain-containing protein 12 [KO:K12871]
123698769  pre-mRNA-splicing factor RBM22 [KO:K12872]
123695518  protein BUD31 homolog [KO:K12873]
123699462  RNA helicase aquarius [KO:K12874]
123699443  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
123704184  RNA-binding protein 8A [KO:K12876]
123704457  protein mago nashi [KO:K12877]
123694475  THO complex subunit 1 [KO:K12878]
123691830  THO complex subunit 2 [KO:K12879]
123702890  THO complex subunit 3 [KO:K12880]
123695956  THO complex subunit 4 isoform X1 [KO:K12881]
123698512  nuclear cap-binding protein subunit 1 [KO:K12882]
123702242  nuclear cap-binding protein subunit 2 [KO:K12883]
123695081  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
123694896  heterogeneous nuclear ribonucleoprotein 87F-like isoform X1 [KO:K12741]
123699139  heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
123700101  serine/arginine-rich splicing factor 1B [KO:K12890]
123695407  serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891]
123700668  serine-arginine protein 55 isoform X1 [KO:K12893]
123693913  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
123705233  RNA-binding protein 1-like isoform X1 [KO:K12896]
123696528  transformer-2 protein homolog alpha isoform X1 [KO:K12897]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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