KEGG   PATHWAY: ccw00230
Entry
ccw00230                    Pathway                                
Name
Purine metabolism - Corvus cornix (hooded crow)
Class
Metabolism; Nucleotide metabolism
Pathway map
ccw00230  Purine metabolism
ccw00230

Module
ccw_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ccw00230]
ccw_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ccw00230]
ccw_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ccw00230]
ccw_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ccw00230]
ccw_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ccw00230]
ccw_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ccw00230]
Other DBs
GO: 0006163 0042278
Organism
Corvus cornix (hooded crow) [GN:ccw]
Gene
104697261  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
104695677  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
104694502  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
104695138  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
104690683  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
104691734  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
104686148  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
104690862  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
104698091  trifunctional purine biosynthetic protein adenosine-3-like isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
104698062  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
104690617  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
104690618  trihelix transcription factor GT-2 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
104696338  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
104694586  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
104691851  APRT; adenine phosphoribosyltransferase isoform X1 [KO:K00759] [EC:2.4.2.7]
104684779  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
104685500  cytosolic 5'-nucleotidase 1B-like [KO:K01081] [EC:3.1.3.5]
104688024  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
104695491  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
104694375  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
104683158  NT5DC4; 5'-nucleotidase domain-containing protein 4 isoform X1 [KO:K01081] [EC:3.1.3.5]
104694277  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
104687522  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
104693158  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
104687537  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
104691332  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
120410623  LOW QUALITY PROTEIN: hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
104683492  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
120411956  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
104684655  nucleoside diphosphate kinase A-like isoform X2 [KO:K00940] [EC:2.7.4.6]
104694278  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
104687203  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
120410789  nucleoside diphosphate kinase, mitochondrial-like isoform X1 [KO:K00940] [EC:2.7.4.6]
120410992  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
120411946  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
104689029  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X4 [KO:K01510] [EC:3.6.1.5]
104688210  LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
104696030  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
104688423  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
104688209  ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
104698209  CANT1; soluble calcium-activated nucleotidase 1 isoform X1 [KO:K12304] [EC:3.6.1.6]
104694876  ENTPD4; LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
104685058  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
104696652  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
120412188  U8 snoRNA-decapping enzyme-like isoform X1 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
104695609  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
104685575  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
104686550  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1 [KO:K01518] [EC:3.6.1.17]
104688169  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
104691415  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
104685245  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
104686385  GUK1; guanylate kinase isoform X2 [KO:K00942] [EC:2.7.4.8]
104698094  RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
104692711  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
104685508  RRM2; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
104690903  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
104683771  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
104689701  deoxycytidine kinase 2 isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
104696860  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
104689252  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
104685925  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
104694019  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
104687454  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
104692638  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
104684954  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
104690109  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
104697178  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
104693425  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
104697179  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
104696375  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
104690280  GUCY2F; retinal guanylyl cyclase 2 isoform X1 [KO:K12322] [EC:4.6.1.2]
104686575  NPR2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
104690483  LOW QUALITY PROTEIN: atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
104688878  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
104693823  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
104687161  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
104692277  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X2 [KO:K19021] [EC:3.1.4.17]
104687817  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
104693676  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X4 [KO:K13762] [EC:3.1.4.35]
104689751  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
104697918  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
104687959  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X2 [KO:K13758]
120410951  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
104696408  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
104686261  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2 [KO:K13761] [EC:3.1.4.35]
104684346  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
104693836  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X2 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
104684480  ADSS2; adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
104687000  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
104684653  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
104692564  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
104692409  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
104697508  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
104687872  ADA; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
104692247  ADA2; adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
104688320  AK8; adenylate kinase 8 isoform X3 [KO:K00939] [EC:2.7.4.3]
104688261  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
104688749  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
104695501  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
104695282  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
104695823  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
104685170  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X2 [KO:K00944] [EC:2.7.4.10]
104688198  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
104684449  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
104690600  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X4 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
104690606  ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
104686685  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X6 [KO:K13293] [EC:3.1.4.53]
104695130  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4 [KO:K13293] [EC:3.1.4.53]
104697414  PDE4C; LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
120412260  PDE4A; LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
104689304  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X2 [KO:K18436] [EC:3.1.4.53]
104692924  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X5 [KO:K18436] [EC:3.1.4.53]
104683973  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
104698553  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
104683340  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
104685380  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
104697117  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
104695074  PAPSS2; LOW QUALITY PROTEIN: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
104695300  uricase-like [KO:K00365] [EC:1.7.3.3]
104691858  5-hydroxyisourate hydrolase-like isoform X2 [KO:K07127] [EC:3.5.2.17]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ccw00030  Pentose phosphate pathway
ccw00220  Arginine biosynthesis
ccw00250  Alanine, aspartate and glutamate metabolism
ccw00260  Glycine, serine and threonine metabolism
ccw00340  Histidine metabolism
ccw00630  Glyoxylate and dicarboxylate metabolism
ccw00730  Thiamine metabolism
ccw00740  Riboflavin metabolism
ccw00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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