KEGG   PATHWAY: cgib04115
Entry
cgib04115                   Pathway                                
Name
p53 signaling pathway - Carassius gibelio (silver crucian carp)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
cgib04115  p53 signaling pathway
cgib04115

Organism
Carassius gibelio (silver crucian carp) [GN:cgib]
Gene
127972527  serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
127957325  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
128014228  serine/threonine-protein kinase Chk2-like isoform X1 [KO:K06641] [EC:2.7.11.1]
128027031  serine/threonine-protein kinase ATR-like [KO:K06640] [EC:2.7.11.1]
127941762  serine/threonine-protein kinase Chk1-like [KO:K02216] [EC:2.7.11.1]
127985384  serine/threonine-protein kinase Chk1-like isoform X1 [KO:K02216] [EC:2.7.11.1]
127938030  RAB6-interacting golgin-like [KO:K19748]
127984571  RAB6-interacting golgin-like [KO:K19748]
127956464  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
127972941  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
127967885  protein Mdm4-like isoform X1 [KO:K10127]
128022365  protein Mdm4 isoform X1 [KO:K10127]
127972656  cellular tumor antigen p53-like isoform X1 [KO:K04451]
127957502  cellular tumor antigen p53 isoform X1 [KO:K04451]
128017696  cellular tumor antigen p53-like [KO:K04451]
128011372  cellular tumor antigen p53-like isoform X1 [KO:K04451]
127934024  relA-associated inhibitor-like isoform X1 [KO:K27356]
127977675  relA-associated inhibitor-like isoform X1 [KO:K27356]
127943101  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
127987607  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
127956439  cyclin-dependent kinase inhibitor 1D [KO:K06625]
127962195  G1/S-specific cyclin-D1 [KO:K04503]
128016536  G1/S-specific cyclin-D1-like [KO:K04503]
127956853  G1/S-specific cyclin-D2b [KO:K10151]
127947336  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
127978113  G1/S-specific cyclin-D2-like [KO:K10151]
128014237  G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
127987601  G1/S-specific cyclin-D3 [KO:K10152]
127968260  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
128022703  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
127951658  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
127979376  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
127953547  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
127935432  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
128015620  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
127961935  G1/S-specific cyclin-E1 [KO:K06626]
127979210  G1/S-specific cyclin-E2-like [KO:K06626]
127974335  G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
127935806  G1/S-specific cyclin-E2-like [KO:K06626]
128016682  G1/S-specific cyclin-E1-like [KO:K06626]
128030026  G1/S-specific cyclin-E2-like isoform X1 [KO:K06626]
127967894  cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
127964638  protein reprimo A [KO:K10128]
127945150  reprimo-like protein [KO:K10128]
128011885  reprimo, TP53 dependent G2 arrest mediator homolog 3 [KO:K10128]
128020220  protein reprimo A-like [KO:K10128]
127958878  G2/mitotic-specific cyclin-B1-like [KO:K05868]
127977012  G2/mitotic-specific cyclin-B1-like isoform X1 [KO:K05868]
127993383  G2/mitotic-specific cyclin-B1 [KO:K05868]
127961597  G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
128016970  G2/mitotic-specific cyclin-B2-like [KO:K21770]
127975793  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
128031669  cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
127941463  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
127951292  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
127962959  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
127967754  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
127959768  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
127950341  growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
128031482  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
128022541  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
128015515  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
127986689  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
128026543  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
128018513  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
127947372  G2 and S phase-expressed protein 1-like [KO:K10129]
128014482  G2 and S phase-expressed protein 1 [KO:K10129]
128011912  zinc finger protein 385A isoform X1 [KO:K26543]
127944671  zinc finger protein 385A-like isoform X1 [KO:K26543]
127933391  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
127976223  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
127947238  p53-induced death domain-containing protein 1-like [KO:K10130]
128014037  LOW QUALITY PROTEIN: p53-induced death domain-containing protein 1 [KO:K10130]
127958284  hematopoietic death receptor isoform X1 [KO:K04722]
127965397  caspase-8 [KO:K04398] [EC:3.4.22.61]
127957571  caspase-22 isoform X1 [KO:K04398] [EC:3.4.22.61]
127959451  caspase-8 [KO:K04398] [EC:3.4.22.61]
127959455  caspase 8, apoptosis-related cysteine peptidase, like 1 isoform X1 [KO:K04398] [EC:3.4.22.61]
128015385  caspase-8-like [KO:K04398] [EC:3.4.22.61]
127977334  BH3 interacting domain death agonist [KO:K04726]
127951570  apoptosis regulator BAX-like [KO:K02159]
127962465  apoptosis regulator BAX-like [KO:K02159]
127952265  apoptosis regulator BAX-like isoform X1 [KO:K02159]
128016539  apoptosis regulator BAX-like [KO:K02159]
127966656  phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
127976566  apoptosis regulatory protein Siva [KO:K22744]
128031374  apoptosis regulatory protein Siva-like [KO:K22744]
127944542  bcl-2-like protein 1 isoform X1 [KO:K04570]
128011589  bcl-2-like protein 1 [KO:K04570]
127946353  apoptosis regulator Bcl-2-like [KO:K02161]
127950859  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
128025189  apoptosis regulator Bcl-2 [KO:K02161]
128013154  apoptosis regulator Bcl-2-like [KO:K02161]
128031805  quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
127966429  etoposide-induced protein 2.4 homolog isoform X1 [KO:K10134]
128020951  etoposide-induced protein 2.4 homolog [KO:K10134]
127942950  protein shisa-5-like isoform X1 [KO:K10135]
127942953  protein shisa-5-like isoform X1 [KO:K10135]
127942956  protein shisa-5 [KO:K10135]
127986864  protein shisa-5-like [KO:K10135]
127987991  protein shisa-5-like isoform X1 [KO:K10135]
127969701  p53 apoptosis effector related to PMP-22 [KO:K10136]
128026563  p53 apoptosis effector related to PMP-22-like [KO:K10136]
127968216  zinc finger matrin-type protein 3-like [KO:K10137]
128022177  zinc finger matrin-type protein 3 [KO:K10137]
127933915  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
127977233  E3 ubiquitin-protein ligase Siah1-like isoform X1 [KO:K04506] [EC:2.3.2.27]
127958982  cytochrome c-like [KO:K08738]
128016199  cytochrome c [KO:K08738]
127956552  apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
127944670  caspase-9-like isoform X1 [KO:K04399] [EC:3.4.22.62]
128011490  caspase-9 [KO:K04399] [EC:3.4.22.62]
127970959  caspase-7-like [KO:K02187] [EC:3.4.22.56]
127966708  caspase-3a [KO:K02187] [EC:3.4.22.56]
127949347  caspase-3-like [KO:K02187] [EC:3.4.22.56]
128027693  caspase-3-like [KO:K02187] [EC:3.4.22.56]
127970700  apoptosis-inducing factor 2 [KO:K22745]
127983874  insulin-like growth factor-binding protein 3 [KO:K10138]
127938457  insulin-like growth factor-binding protein 3 [KO:K10138]
127956905  LOW QUALITY PROTEIN: insulin-like growth factor I, adult form [KO:K05459]
127962721  plasminogen activator inhibitor 1 [KO:K03982]
128017068  plasminogen activator inhibitor 1-like [KO:K03982]
127934928  adhesion G protein-coupled receptor B1-like [KO:K04596]
127975333  adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
128030474  adhesion G protein-coupled receptor B1-like isoform X1 [KO:K04596]
127962591  CD82 molecule a [KO:K06509]
127934392  CD82 antigen-like [KO:K06509]
127977213  CD82 molecule b [KO:K06509]
128017048  CD82 antigen-like [KO:K06509]
127983957  thrombospondin-1-like [KO:K16857]
127933159  thrombospondin-1-like [KO:K16857]
127976786  thrombospondin-1-like [KO:K16857]
127938619  thrombospondin-1-like [KO:K16857]
127977554  DNA damage-binding protein 2 isoform X1 [KO:K10140]
127935085  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
127938948  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
127978554  ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
127984438  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
127971278  sestrin-3-like [KO:K10141]
127983430  sestrin-1 isoform X1 [KO:K10141]
127972736  sestrin-3-like [KO:K10141]
127938328  sestrin-1-like isoform X1 [KO:K10141]
128027271  sestrin-3 [KO:K10141]
128029479  sestrin-3 [KO:K10141]
127979337  sestrin-2-like [KO:K20394]
127934867  sestrin-2-like [KO:K20394]
127933323  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
127976246  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
127969036  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
128025117  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
127957193  tuberin-like isoform X1 [KO:K07207]
127957194  tuberin-like isoform X1 [KO:K07207]
127958752  tuberin-like isoform X1 [KO:K07207]
127949105  LOW QUALITY PROTEIN: tuberin [KO:K07207]
128019916  tuberin-like isoform X1 [KO:K07207]
128019552  metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
127951228  E3 ubiquitin-protein ligase COP1-like [KO:K10143] [EC:2.3.2.27]
128030928  E3 ubiquitin-protein ligase COP1-like [KO:K10143] [EC:2.3.2.27]
127957885  RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
128014565  RING finger and CHY zinc finger domain-containing protein 1-like isoform X1 [KO:K10144] [EC:2.3.2.27]
127971527  cyclin-G1-like [KO:K10145]
128027383  cyclin-G1 [KO:K10145]
127941540  cyclin-G2-like [KO:K10146]
127974549  cyclin-G2-like [KO:K10146]
127985631  cyclin-G2 [KO:K10146]
127972448  protein phosphatase, Mg2+/Mn2+ dependent, 1Da [KO:K10147] [EC:3.1.3.16]
127958667  protein phosphatase 1D-like [KO:K10147] [EC:3.1.3.16]
127994158  protein phosphatase, Mg2+/Mn2+ dependent, 1Db [KO:K10147] [EC:3.1.3.16]
127963627  tumor protein p73 isoform X1 [KO:K10148]
128018260  tumor protein p73-like [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
cgib04110  Cell cycle
cgib04210  Apoptosis
cgib04218  Cellular senescence
KO pathway
ko04115   
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