KEGG   PATHWAY: cpoc04145
Entry
cpoc04145                   Pathway                                
Name
Phagosome - Cavia porcellus (domestic guinea pig)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
cpoc04145  Phagosome
cpoc04145

Other DBs
GO: 0045335
Organism
Cavia porcellus (domestic guinea pig) [GN:cpoc]
Gene
100731471  Vamp3; vesicle-associated membrane protein 3 [KO:K13505]
100726106  Stx7; syntaxin-7 [KO:K08488]
100731713  Actg1; actin, cytoplasmic 2 [KO:K05692]
100135470  Actb; actin, cytoplasmic 1 [KO:K05692]
100725425  Coro1a; coronin-1A [KO:K13882]
100726913  Stx18; syntaxin-18 isoform X1 [KO:K08492]
100727822  Sec22b; vesicle-trafficking protein SEC22b [KO:K08517]
100724396  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X2 [KO:K06751]
100723126  patr class I histocompatibility antigen, alpha chain E-like isoform X2 [KO:K06751]
100733898  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
100733617  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-18 alpha chain-like [KO:K06751]
100723401  HLA class I histocompatibility antigen, B-46 alpha chain-like isoform X2 [KO:K06751]
100723960  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
100712777  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
100713317  HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X2 [KO:K06751]
100718695  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
100720632  HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
100717851  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
100718133  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
100713671  HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
100714501  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
100714780  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
100715615  HLA class II histocompatibility antigen, DP alpha 1 chain-like isoform X1 [KO:K06752]
100716183  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
100716469  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
100719246  HLA class II histocompatibility antigen, DRB1-16 beta chain [KO:K06752]
100735392  HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752]
100735670  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
100735949  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
100720894  HLA class II histocompatibility antigen, DRB1-1 beta chain-like [KO:K06752]
100715902  uncharacterized protein LOC100715902 [KO:K06752]
100719800  HLA class II histocompatibility antigen, DRB1-1 beta chain-like [KO:K06752]
100723790  Rab5a; ras-related protein Rab-5A [KO:K07887]
100714048  Rab5b; ras-related protein Rab-5B [KO:K07888]
100716247  Rab5c; ras-related protein Rab-5C [KO:K07889]
100727802  Eea1; early endosome antigen 1 [KO:K12478]
100729829  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
100715633  Tfrc; transferrin receptor protein 1 [KO:K06503]
100732540  Hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
100733879  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100726524  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100724011  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
100716597  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X4 [KO:K02148]
100725980  Atp6v1c1; V-type proton ATPase subunit C 1 isoform X2 [KO:K02148]
100716088  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
100725691  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
100722091  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
100730842  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
100712974  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
100723558  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
100712761  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
100713097  Atp6v0e2; V-type proton ATPase subunit e 2 [KO:K02153]
100726215  Atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
101787762  Atp6v0a2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100717816  Atp6v0a1; V-type proton ATPase 116 kDa subunit a isoform X5 [KO:K02154]
100735854  Atp6v0a4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100712820  Tcirg1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
100733139  Atp6v0d1; V-type proton ATPase subunit d 1 isoform X2 [KO:K02146]
100717063  Atp6v0d2; V-type proton ATPase subunit d 2 isoform X3 [KO:K02146]
100716527  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
100735418  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
100720289  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
100724336  Atp6ap1; V-type proton ATPase subunit S1 [KO:K03662]
100721839  Rab7a; ras-related protein Rab-7a [KO:K07897]
100717487  Rab7b; ras-related protein Rab-7b [KO:K07898]
100713008  Rilp; rab-interacting lysosomal protein isoform X2 [KO:K13883]
100733085  Dync1h1; LOW QUALITY PROTEIN: cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
100729376  Dync2h1; LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
100721199  Dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X3 [KO:K10415]
100722097  Dync1i1; cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
100715806  Dync1li2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
100716888  Dync1li1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
100728750  Tuba8; tubulin alpha-8 chain isoform X2 [KO:K07374]
100731885  tubulin alpha-3 chain [KO:K07374]
100732987  tubulin alpha-3 chain [KO:K07374]
100726492  tubulin alpha-1A chain-like [KO:K07374]
100734500  Tuba4a; tubulin alpha-4A chain [KO:K07374]
100728634  tubulin alpha-8 chain-like isoform X2 [KO:K07374]
100729187  tubulin alpha-8 chain-like [KO:K07374]
100726777  tubulin alpha-1A chain [KO:K07374]
100716197  tubulin alpha-1B chain-like [KO:K07374]
100716481  tubulin alpha-1B chain [KO:K07374]
100720651  Tubb4a; LOW QUALITY PROTEIN: tubulin beta-4A chain [KO:K07375]
100713236  Tubb1; tubulin beta-1 chain [KO:K07375]
100728260  Tubb4b; tubulin beta-4B chain [KO:K07375]
100732882  tubulin beta-3 chain [KO:K07375]
100733481  Tubb6; LOW QUALITY PROTEIN: tubulin beta-6 chain [KO:K07375]
100718713  Tubb; tubulin beta chain [KO:K07375]
100731652  Tubb2a; tubulin beta-2A chain [KO:K07375]
100712735  tubulin beta-2B chain [KO:K07375]
100726596  Lamp1; lysosome-associated membrane glycoprotein 1 isoform X2 [KO:K06528]
100717075  Lamp2; lysosome-associated membrane glycoprotein 2 isoform X3 [KO:K06528]
100721082  1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
100726206  M6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
100729682  Nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
100725291  Mpo; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
100714385  Ctsv; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
100722492  Ctss; cathepsin S [KO:K01368] [EC:3.4.22.27]
100723492  Sec61a1; protein transport protein Sec61 subunit alpha [KO:K10956]
100725024  Sec61a2; protein transport protein Sec61 subunit alpha [KO:K10956]
100717560  Sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
101787015  protein transport protein Sec61 subunit gamma-like [KO:K07342]
100725897  Sec61g; protein transport protein Sec61 subunit gamma [KO:K07342]
100716745  Tap1; antigen peptide transporter 1 isoform X1 [KO:K05653] [EC:7.4.2.14]
100717574  Tap2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
100728485  calreticulin-like [KO:K08057]
100713922  Calr; calreticulin [KO:K08057]
100726237  Canx; calnexin [KO:K08054]
101787486  natural cytotoxicity triggering receptor 1-like [KO:K06513]
100721479  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
100722313  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
100722862  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
100723692  putative high affinity immunoglobulin gamma Fc receptor IC [KO:K06498]
101787193  Fcgr2a; low affinity immunoglobulin gamma Fc region receptor II-a isoform X2 [KO:K06472]
100192391  Fcgr2b; low affinity immunoglobulin gamma Fc region receptor II precursor [KO:K12560]
101788791  low affinity immunoglobulin gamma Fc region receptor IV isoform X1 [KO:K06463]
100733374  C1r; LOW QUALITY PROTEIN: complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
100135561  Itgam; LOW QUALITY PROTEIN: integrin alpha-M [KO:K06461]
100727919  integrin beta-2 [KO:K06464]
100727643  LOW QUALITY PROTEIN: integrin beta-2-like [KO:K06464]
100135462  C3; complement C3 preproprotein [KO:K03990]
100730989  Colec11; collectin-11 [KO:K10066]
100722741  Colec12; collectin-12 [KO:K10062]
100732862  Mbl2; mannose-binding protein C [KO:K03991]
100727376  mannose-binding protein A-like [KO:K03991]
100135615  Sftpa1; pulmonary surfactant-associated protein A precursor [KO:K10067]
100728956  Sftpd; pulmonary surfactant-associated protein D [KO:K10068]
100728575  Itgav; integrin alpha-V [KO:K06487]
100729266  Itga2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
100725679  Itga5; integrin alpha-5 [KO:K06484]
100719502  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
100731365  Itgb3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
100713066  Itgb5; integrin beta-5 [KO:K06588]
100727882  Thbs1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
100720036  Thbs4; thrombospondin-4 [KO:K04659]
100720040  Comp; LOW QUALITY PROTEIN: cartilage oligomeric matrix protein [KO:K04659]
100735538  Thbs2; thrombospondin-2 [KO:K04659]
100714970  Thbs3; thrombospondin-3 isoform X1 [KO:K04659]
100717682  Tlr2; toll-like receptor 2 [KO:K10159]
100733137  Tlr6; toll-like receptor 6 [KO:K10169]
100724803  Tlr4; toll-like receptor 4 [KO:K10160]
100735312  Cd14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391]
100733022  Mrc2; C-type mannose receptor 2 isoform X1 [KO:K06560]
100722768  Pla2r1; secretory phospholipase A2 receptor [KO:K06560]
100720301  Mrc1; macrophage mannose receptor 1 [KO:K06560]
100728135  CD209 antigen-like protein C [KO:K06563]
100728416  CD209 antigen-like protein E [KO:K06563]
100715309  Cd209; CD209 antigen [KO:K06563]
100715591  CD209 antigen-like protein E [KO:K06563]
100716447  CD209 antigen-like protein C [KO:K06563]
100717455  LOW QUALITY PROTEIN: CD209 antigen-like protein E [KO:K06563]
100715879  CD209 antigen-like protein E [KO:K06563]
100716160  CD209 antigen-like protein E [KO:K06563]
100725843  Clec7a; C-type lectin domain family 7 member A isoform X2 [KO:K10074]
100731555  Msr1; macrophage scavenger receptor types I and II isoform X1 [KO:K06558]
100716503  Marco; macrophage receptor MARCO [KO:K13884]
100725301  Olr1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
100322870  Scarb1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
100730182  Cd36; platelet glycoprotein 4 [KO:K06259]
100732048  cytochrome b-245 light chain isoform X1 [KO:K08009]
100735552  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100727219  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
100726055  Ncf1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
100733153  Ncf2; neutrophil cytosol factor 2 [KO:K08010]
100729267  Ncf4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
cpoc04142  Lysosome
cpoc04144  Endocytosis
cpoc04610  Complement and coagulation cascades
cpoc04612  Antigen processing and presentation
cpoc04620  Toll-like receptor signaling pathway
cpoc04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
LinkDB

DBGET integrated database retrieval system