KEGG   PATHWAY: dcc00230
Entry
dcc00230                    Pathway                                
Name
Purine metabolism - Dermochelys coriacea (leatherback sea turtle)
Class
Metabolism; Nucleotide metabolism
Pathway map
dcc00230  Purine metabolism
dcc00230

Module
dcc_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:dcc00230]
dcc_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:dcc00230]
dcc_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:dcc00230]
dcc_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:dcc00230]
dcc_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:dcc00230]
dcc_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:dcc00230]
dcc_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:dcc00230]
Other DBs
GO: 0006163 0042278
Organism
Dermochelys coriacea (leatherback sea turtle) [GN:dcc]
Gene
119854713  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X2 [KO:K13988] [EC:3.6.1.13]
119842704  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
119850155  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
119859790  phosphoglucomutase-1 isoform X2 [KO:K01835] [EC:5.4.2.2]
119854641  PGM2; phosphoglucomutase-2 isoform X1 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
119861569  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
119856389  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
119854540  PPAT; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
119851722  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
119849367  PFAS; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
119854539  PAICS; multifunctional protein ADE2 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
119852181  ADSL; adenylosuccinate lyase isoform X2 [KO:K01756] [EC:4.3.2.2]
119863694  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
119841131  APRT; adenine phosphoribosyltransferase isoform X1 [KO:K00759] [EC:2.4.2.7]
119842864  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
119858043  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
119845444  NT5C1A; cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
119858541  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
119852645  LOW QUALITY PROTEIN: cytosolic 5'-nucleotidase 1B-like [KO:K01081] [EC:3.1.3.5]
119855733  LOW QUALITY PROTEIN: trifunctional nucleotide phosphoesterase protein YfkN-like [KO:K01081] [EC:3.1.3.5]
119853556  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
119841921  purine nucleoside phosphorylase isoform X2 [KO:K03783] [EC:2.4.2.1]
119850174  LACC1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
119861400  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
119859349  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X9 [KO:K00088] [EC:1.1.1.205]
119859523  IMPDH2; LOW QUALITY PROTEIN: inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
119847396  NME7; nucleoside diphosphate kinase 7 isoform X5 [KO:K00940] [EC:2.7.4.6]
119862510  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
119842713  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
119842715  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
119862970  NME3; nucleoside diphosphate kinase 3 isoform X2 [KO:K00940] [EC:2.7.4.6]
119860252  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
119852635  AK9; adenylate kinase 9 isoform X2 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
119844042  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
119844043  ectonucleoside triphosphate diphosphohydrolase 8-like isoform X1 [KO:K01510] [EC:3.6.1.5]
119844047  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
119852037  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
119858201  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
119843242  CANT1; soluble calcium-activated nucleotidase 1 isoform X1 [KO:K12304] [EC:3.6.1.6]
119848824  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
119857460  ENTPD5; LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
119847056  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
119856545  ITPA; inosine triphosphate pyrophosphatase isoform X2 [KO:K01519] [EC:3.6.1.66]
119853095  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
119856150  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X2 [KO:K01518] [EC:3.6.1.17]
119861003  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X2 [KO:K01951] [EC:6.3.5.2]
119851162  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
119841672  GMPR2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
119855695  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
119850796  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
119844641  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
119851114  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X4 [KO:K10808] [EC:1.17.4.1]
119853897  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
119852865  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
119848726  DGUOK; deoxyguanosine kinase, mitochondrial isoform X4 [KO:K00904] [EC:2.7.1.113]
119855251  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
119847903  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
119851996  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
119851129  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
119852477  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
119841869  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
119863244  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
119845889  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
119841199  ADCY7; adenylate cyclase type 7 isoform X3 [KO:K08047] [EC:4.6.1.1]
119851950  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
119862420  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
119860501  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
119855071  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
119863817  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
119855223  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
119861416  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
119863238  LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
119861906  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
119849360  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
119858842  guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
119847826  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
119856143  NPR2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
119856320  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
119863724  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
119851872  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X11 [KO:K13755] [EC:3.1.4.17]
119846071  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
119845595  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
119846798  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
119857154  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
119854341  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
119855586  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
119858419  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
119861768  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
122455382  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
119843216  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
119849692  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
119853767  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
119863578  PDE11A; LOW QUALITY PROTEIN: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
119856823  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
119852864  ADSS2; LOW QUALITY PROTEIN: adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
119859361  adenylosuccinate synthetase isozyme 2-like isoform X1 [KO:K01939] [EC:6.3.4.4]
119857102  AMPD3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
119846217  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
119846460  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
119858348  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
119841571  ADA; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
119850077  ADA2; adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
119860617  AK4; adenylate kinase 4, mitochondrial isoform X2 [KO:K00939] [EC:2.7.4.3]
119856646  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
119844308  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
119844406  AK1; adenylate kinase isoenzyme 1 isoform X2 [KO:K00939] [EC:2.7.4.3]
119846017  adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
119845467  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
119859382  adenylate kinase 8-like [KO:K00939] [EC:2.7.4.3]
119859651  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
119855431  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
119855509  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
119844275  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
119854021  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
119852814  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
119852908  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
119860416  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
119848339  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X2 [KO:K13293] [EC:3.1.4.53]
119855465  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2 [KO:K13293] [EC:3.1.4.53]
119846160  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
119850939  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
119853426  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X2 [KO:K18436] [EC:3.1.4.53]
119855642  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
119862002  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
119859433  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
119852674  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
119854623  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
119859278  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
119860449  uricase-like [KO:K00365] [EC:1.7.3.3]
119860117  uricase-like [KO:K00365] [EC:1.7.3.3]
119860910  LOW QUALITY PROTEIN: allantoinase, mitochondrial-like [KO:K01466] [EC:3.5.2.5]
119852654  ALLC; LOW QUALITY PROTEIN: probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
dcc00030  Pentose phosphate pathway
dcc00220  Arginine biosynthesis
dcc00250  Alanine, aspartate and glutamate metabolism
dcc00260  Glycine, serine and threonine metabolism
dcc00340  Histidine metabolism
dcc00630  Glyoxylate and dicarboxylate metabolism
dcc00730  Thiamine metabolism
dcc00740  Riboflavin metabolism
dcc00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

DBGET integrated database retrieval system