KEGG   PATHWAY: eee04144
Entry
eee04144                    Pathway                                
Name
Endocytosis - Electrophorus electricus (electric eel)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
eee04144  Endocytosis
eee04144

Other DBs
GO: 0006897
Organism
Electrophorus electricus (electric eel) [GN:eee]
Gene
113571372  ADP-ribosylation factor 6 [KO:K07941]
113569719  ADP-ribosylation factor 6 [KO:K07941]
113580068  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
113575273  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
113578361  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
113574477  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
113575555  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like isoform X1 [KO:K00889] [EC:2.7.1.68]
113585976  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like [KO:K00889] [EC:2.7.1.68]
113577592  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
113576479  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
113576136  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
113586823  phospholipase D2-like [KO:K01115] [EC:3.1.4.4]
113572116  phospholipase D1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
113573035  dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
113592214  dynamin-3-like isoform X1 [KO:K01528] [EC:3.6.5.5]
113591583  LOW QUALITY PROTEIN: dynamin-1-like [KO:K01528] [EC:3.6.5.5]
113582844  dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
113587305  dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
113568450  clta; clathrin light chain A isoform X1 [KO:K04644]
113580085  cltb; clathrin light chain B isoform X1 [KO:K04645]
113584373  clathrin heavy chain 1 isoform X1 [KO:K04646]
113584900  clathrin heavy chain 1-like [KO:K04646]
113584925  clathrin heavy chain 1-like isoform X1 [KO:K04646]
113580265  ap2a1; AP-2 complex subunit alpha-1 [KO:K11824]
113586066  AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
113573713  ap2b1; LOW QUALITY PROTEIN: AP-2 complex subunit beta [KO:K11825]
113576954  AP-2 complex subunit mu-B isoform X1 [KO:K11826]
113570083  AP-2 complex subunit mu-A-like isoform X1 [KO:K11826]
113578630  ap2s1; AP-2 complex subunit sigma [KO:K11827]
113585907  ehd2; EH domain-containing protein 2 isoform X1 [KO:K12469]
113573697  EH domain-containing protein 2-like [KO:K12469]
113590741  tgfbr1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
113583131  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
113591515  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
113591517  uncharacterized protein LOC113591517 isoform X1 [KO:K04388] [EC:2.7.11.30]
113590604  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
113575425  zinc finger FYVE domain-containing protein 9-like isoform X1 [KO:K04679]
113583658  zfyve16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
113590404  zinc finger FYVE domain-containing protein 9-like isoform X1 [KO:K04679]
113590822  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
113585069  mothers against decapentaplegic homolog 3-like [KO:K23605]
113574086  mothers against decapentaplegic homolog 3 [KO:K23605]
113590665  tfrc; transferrin receptor protein 1 [KO:K06503]
113576148  transferrin receptor protein 1-like isoform X1 [KO:K06503]
113590114  transferrin receptor protein 1-like [KO:K06503]
113587946  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
113590490  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
113586382  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
113588015  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
113589671  fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
113571264  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
113573593  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
113586501  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
113579444  cbl; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
113571604  cblb; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
113580511  E3 ubiquitin-protein ligase CBL-like [KO:K22518] [EC:2.3.2.27]
113576138  sh3kbp1; SH3 domain-containing kinase-binding protein 1 [KO:K12470]
113579752  endophilin-A3-like isoform X1 [KO:K11247]
113583489  endophilin-A3-like isoform X1 [KO:K11247]
113586711  endophilin-A2-like [KO:K11247]
113587551  sh3gl1; endophilin-A2 isoform X1 [KO:K11247]
113568723  endophilin-A1-like [KO:K11247]
113585338  sh3gl2; endophilin-A1 isoform X1 [KO:K11247]
113575635  endophilin-B1-like [KO:K11248]
113591231  endophilin-B1-like isoform X1 [KO:K11248]
113590666  endophilin-B2-like isoform X1 [KO:K21269]
113577559  endophilin-B2-like isoform X1 [KO:K21269]
113589825  amph; amphiphysin isoform X1 [KO:K12562]
113584305  myc box-dependent-interacting protein 1-like isoform X1 [KO:K12562]
113580418  myc box-dependent-interacting protein 1-like [KO:K12562]
113587870  epn3; epsin-3 isoform X1 [KO:K12471]
113572588  epsin-1-like [KO:K12471]
113584939  epn2; epsin-2 isoform X1 [KO:K12471]
113570618  epsin-1-like isoform X1 [KO:K12471]
113574481  eps15l1; epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
113581089  eps15; epidermal growth factor receptor substrate 15 [KO:K12472]
113585971  LOW QUALITY PROTEIN: epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
113589220  uncharacterized protein LOC113589220 [KO:K12472]
113572212  spart; spartin [KO:K19366]
113582272  spartin-like isoform X1 [KO:K19366]
113584271  nedd4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
113584578  nedd4l; E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
113569662  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
113579696  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
113587252  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
113582353  E3 ubiquitin-protein ligase Itchy-like isoform X1 [KO:K05632] [EC:2.3.2.26]
113571667  E3 ubiquitin-protein ligase Itchy-like isoform X1 [KO:K05632] [EC:2.3.2.26]
113570666  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
113583267  smurf2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
113575189  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
113579398  wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
113573232  low-density lipoprotein receptor-like [KO:K12473]
113579405  low-density lipoprotein receptor-like [KO:K12473]
113589511  ldlrap1; low density lipoprotein receptor adapter protein 1 [KO:K12474]
113569924  low density lipoprotein receptor adapter protein 1-like [KO:K12474]
113573716  protein FAM43B-like isoform X1 [KO:K12474]
113583581  low density lipoprotein receptor adapter protein 1-B-like [KO:K12474]
113583638  disabled homolog 2-like isoform X1 [KO:K12475]
113586241  disabled homolog 2-like [KO:K12475]
113586574  C-C chemokine receptor type 5-like isoform X1 [KO:K04180]
113569352  C-C chemokine receptor type 5-like [KO:K04180]
113583700  C-X-C chemokine receptor type 1-like [KO:K05050]
113585078  C-X-C chemokine receptor type 2-like [KO:K05050]
113585130  C-X-C chemokine receptor type 1-like [KO:K05050]
113582600  C-X-C chemokine receptor type 4-like [KO:K04189]
113585300  C-X-C chemokine receptor type 4-like [KO:K04189]
113577359  grk1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
113591131  grk7; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
113568347  beta-adrenergic receptor kinase 2-like [KO:K00910] [EC:2.7.11.15]
113583216  beta-adrenergic receptor kinase 2-like [KO:K00910] [EC:2.7.11.15]
113591386  G protein-coupled receptor kinase 5-like isoform X1 [KO:K08291] [EC:2.7.11.16]
113584115  G protein-coupled receptor kinase 5-like [KO:K08291] [EC:2.7.11.16]
113571255  grk6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
113584174  arrestin red cell-like isoform X1 [KO:K04439]
113574672  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
113580797  arrestin red cell [KO:K04439]
113582930  neural Wiskott-Aldrich syndrome protein-like isoform X1 [KO:K23612]
113575817  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
113579657  actr2; actin-related protein 2 [KO:K17260]
113585161  actin-related protein 2-A-like [KO:K17260]
113572712  actin-related protein 2-A isoform X1 [KO:K17260]
113578559  actr3; actin-related protein 3 [KO:K18584]
113580267  actin-related protein 2/3 complex subunit 1A-A-like [KO:K05757]
113582006  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
113569982  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
113583705  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
113585138  actin-related protein 2/3 complex subunit 2-A-like [KO:K05758]
113573735  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
113576019  actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
113589954  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
113583609  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
113588486  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
113567915  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
113588345  actin-related protein 2/3 complex subunit 5-A-like [KO:K05754]
113580402  wipf3; WAS/WASL-interacting protein family member 3 [KO:K19475]
113582525  WAS/WASL-interacting protein family member 2-like [KO:K19475]
113582764  WAS/WASL-interacting protein family member 1-like [KO:K19475]
113581153  LOW QUALITY PROTEIN: WAS/WASL-interacting protein family member 2-like [KO:K19475]
113589380  WAS/WASL-interacting protein family member 1-like [KO:K19475]
113578453  heat shock cognate 71 kDa protein [KO:K03283]
113580846  heat shock 70 kDa protein [KO:K03283]
113568294  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
113588047  dnajc6; LOW QUALITY PROTEIN: putative tyrosine-protein phosphatase auxilin [KO:K09526]
113582563  washc4; WASH complex subunit 4 isoform X1 [KO:K18465]
113577064  washc5; WASH complex subunit 5 [KO:K18464]
113585831  LOW QUALITY PROTEIN: WASH complex subunit 2-like [KO:K18462]
113570886  washc1; WASH complex subunit 1 isoform X1 [KO:K18461]
113588010  washc3; WASH complex subunit 3 [KO:K18463]
113583079  F-actin-capping protein subunit alpha-1-like [KO:K10364]
113572074  F-actin-capping protein subunit alpha-1-like [KO:K10364]
113582813  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
113573686  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
113571540  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
113585108  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
113571625  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
113588904  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
113574133  snx12; sorting nexin-12 isoform X1 [KO:K17918]
113580768  snx3; sorting nexin-3 [KO:K17918]
113585348  usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
113586211  stambp; STAM-binding protein isoform X1 [KO:K11866] [EC:3.4.19.12]
113576002  rab7a; ras-related protein Rab-7a [KO:K07897]
113589948  ras-related protein rab7 [KO:K07897]
113572358  ras-related protein rab7-like [KO:K07897]
113578160  ras-related protein rab7-like [KO:K07897]
113587851  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
113567482  stam2; signal transducing adapter molecule 2 [KO:K04705]
113580195  stam; signal transducing adapter molecule 1 [KO:K04705]
113579681  tumor susceptibility gene 101 protein-like isoform X1 [KO:K12183]
113581309  tsg101; tumor susceptibility gene 101 protein [KO:K12183]
113588093  mvb12a; multivesicular body subunit 12A [KO:K12186]
113590368  mvb12b; multivesicular body subunit 12B isoform X1 [KO:K12186]
113586989  vps28; vacuolar protein sorting-associated protein 28 homolog isoform X1 [KO:K12184]
113589572  vps37b; vacuolar protein sorting-associated protein 37B [KO:K12185]
113571510  vacuolar protein sorting-associated protein 37C-like [KO:K12185]
113584070  vacuolar protein sorting-associated protein 37B-like [KO:K12185]
113581001  vacuolar protein sorting-associated protein 37D-like [KO:K12185]
113582864  vps37a; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
113574826  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
113581193  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
113574304  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
113577876  charged multivesicular body protein 6-like [KO:K12195]
113579375  charged multivesicular body protein 6 [KO:K12195]
113577868  charged multivesicular body protein 4b [KO:K12194]
113573839  charged multivesicular body protein 4c-like [KO:K24782]
113578745  charged multivesicular body protein 4c [KO:K24782]
113583334  chmp3; charged multivesicular body protein 3 [KO:K12193]
113574819  chmp2a; charged multivesicular body protein 2a [KO:K12191]
113576632  charged multivesicular body protein 2b [KO:K12192]
113577085  charged multivesicular body protein 2b isoform X1 [KO:K12192]
113581007  charged multivesicular body protein 7-like [KO:K15053]
113570126  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
113590894  vacuolar protein sorting-associated protein 4A [KO:K12196]
113574490  vacuolar protein sorting-associated protein 4B-like isoform X1 [KO:K12196]
113583173  vta1; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
113589541  chmp1b; charged multivesicular body protein 1b [KO:K12197]
113568557  chmp1a; charged multivesicular body protein 1a [KO:K12197]
113574186  charged multivesicular body protein 1b-like isoform X1 [KO:K12197]
113579312  charged multivesicular body protein 5 [KO:K12198]
113568002  charged multivesicular body protein 5-like [KO:K12198]
113578750  ist1; IST1 homolog isoform X1 [KO:K19476]
113571014  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
113573916  spg21; maspardin [KO:K19367]
113570044  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
113577692  sorting nexin-1-like isoform X1 [KO:K17917]
113571040  snx2; sorting nexin-2 isoform X1 [KO:K17917]
113571813  sorting nexin-1-like [KO:K17917]
113576017  sorting nexin-6-like [KO:K17920]
113579341  snx6; sorting nexin-6 isoform X1 [KO:K17920]
113581875  snx5; sorting nexin-5 [KO:K17920]
113576303  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
113572439  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
113579694  GTPase HRas [KO:K02833]
113581312  hras; GTPase HRas [KO:K02833]
113591411  interleukin-2 receptor subunit beta-like isoform X1 [KO:K05069]
113579429  uncharacterized protein LOC113579429 isoform X1 [KO:K05069]
113575423  cytokine receptor common subunit gamma-like isoform X1 [KO:K05070]
113579244  cytokine receptor common subunit gamma-like [KO:K05070]
113575836  rho-related GTP-binding protein RhoA-B [KO:K04513]
113582797  transforming protein RhoA-like [KO:K04513]
113587089  rho-related GTP-binding protein RhoA-C isoform X1 [KO:K04513]
113587285  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
113583072  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
113572085  rho-related GTP-binding protein RhoA-D [KO:K04513]
113568801  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
113588762  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113568887  BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
113568897  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
113568924  HLA class I histocompatibility antigen, B-41 alpha chain-like [KO:K06751]
113569031  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113569108  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
113583839  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
113592081  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113569159  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
113567983  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113569316  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113569330  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
113569334  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113569366  RT1 class I histocompatibility antigen, AA alpha chain-like [KO:K06751]
113568289  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
113568574  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113568606  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
113583829  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
113583838  zinc-alpha-2-glycoprotein-like isoform X1 [KO:K06751]
113568290  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
113581593  folate receptor gamma-like [KO:K13649]
113568288  riboflavin-binding protein-like [KO:K13649]
113584982  caveolin-1 [KO:K06278]
113578900  caveolin-2-like [KO:K12958]
113569401  caveolin-2-like [KO:K12958]
113587969  caveolin-2-like [KO:K12958]
113584983  caveolin-2-like [KO:K12958]
113569652  cav3; caveolin-3 [KO:K12959]
113585373  EH domain-containing protein 3 [KO:K12476]
113571437  EH domain-containing protein 4-like [KO:K12477]
113590570  eea1; early endosome antigen 1 [KO:K12478]
113588725  ras-related protein Rab-5A [KO:K07887]
113578813  ras-related protein Rab-5A-like [KO:K07887]
113567539  ras-related protein Rab-5B-like [KO:K07888]
113581775  ras-related protein Rab-5C-like [KO:K07889]
113591521  ras-related protein Rab-5C-like [KO:K07889]
113581004  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
113584328  rbsn; rabenosyn-5 [KO:K12481]
113582055  ras-related protein Rab-4A [KO:K07879]
113581509  rufy1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
113571466  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
113585310  EH domain-containing protein 1-like [KO:K12483]
113575945  EH domain-containing protein 1-like [KO:K12483]
113587471  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
113590605  snx4; sorting nexin-4 [KO:K17919]
113577856  rab22a; ras-related protein Rab-22A [KO:K07891]
113583380  rab31; ras-related protein Rab-31 [KO:K07891]
113591043  rab10; ras-related protein Rab-10 isoform X1 [KO:K07903]
113588217  ras-related protein Rab-10-like [KO:K07903]
113582881  rab8a; ras-related protein Rab-8A [KO:K07901]
113592118  ras-related protein Rab-35-like [KO:K07876]
113577580  ras-related protein Rab-35 [KO:K07876]
113580870  ras-related protein Rab-35-like [KO:K07876]
113588587  rab11a; ras-related protein Rab-11A [KO:K07904]
113580014  ras-related protein Rab-11A-like [KO:K07904]
113574478  ras-related protein Rab-11B-like [KO:K07905]
113585980  ras-related protein Rab-11B [KO:K07905]
113579263  uncharacterized protein LOC113579263 isoform X1 [KO:K12484]
113586693  rab11 family-interacting protein 1-like [KO:K12484]
113582465  rab11 family-interacting protein 1-like isoform X1 [KO:K12484]
113585294  uncharacterized protein LOC113585294 isoform X1 [KO:K12484]
113585941  rab11fip2; rab11 family-interacting protein 2 [KO:K12484]
113591202  zfyve27; protrudin isoform X1 [KO:K19368]
113577421  kinesin heavy chain-like isoform X1 [KO:K10396]
113576454  kif5b; kinesin-1 heavy chain isoform X1 [KO:K10396]
113584083  kinesin heavy chain-like [KO:K10396]
113568233  kinesin-1 heavy chain-like isoform X1 [KO:K10396]
113571651  kinesin heavy chain-like [KO:K10396]
113577280  kinesin heavy chain-like [KO:K10396]
113578851  rab11fip4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
113586565  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
113567814  rab11 family-interacting protein 4A-like [KO:K12485]
113591642  partitioning defective 3 homolog isoform X1 [KO:K04237]
113579404  partitioning defective 3 homolog [KO:K04237]
113585692  partitioning defective 6 homolog gamma-like [KO:K06093]
113575673  partitioning defective 6 homolog gamma-like [KO:K06093]
113587976  partitioning defective 6 homolog beta-like isoform X1 [KO:K06093]
113573637  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
113586870  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
113584149  prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
113575458  cell division control protein 42 homolog [KO:K04393]
113586656  cell division control protein 42 homolog isoform X1 [KO:K04393]
113572585  cell division control protein 42 homolog [KO:K04393]
113577474  smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
113585460  smap1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
113574731  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
113588131  ARF GTPase-activating protein GIT2-like [KO:K12487]
113573310  ARF GTPase-activating protein GIT2-like isoform X1 [KO:K12487]
113570514  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like [KO:K12488]
113590307  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like [KO:K12488]
113589354  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12488]
113579143  asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
113573817  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12488]
113571970  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12488]
113585739  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12489]
113590999  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
113570319  acap3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
113574704  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like [KO:K12489]
113587172  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12489]
113585533  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
113581579  arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18439]
113567858  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like [KO:K18439]
113587440  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like [KO:K18439]
113573503  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
113573380  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12490]
113583773  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3-like [KO:K12491]
113574006  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
113570320  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K17848]
113572430  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
113579062  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
113573572  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
113588091  PH and SEC7 domain-containing protein 4-like isoform X1 [KO:K12494]
113573409  PH and SEC7 domain-containing protein 2-like isoform X1 [KO:K12494]
113576746  PH and SEC7 domain-containing protein 1-like isoform X1 [KO:K12494]
113571484  PH and SEC7 domain-containing protein 1-like [KO:K12494]
113583997  iqsec3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
113589353  LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 1-like [KO:K12495]
113578776  IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
113589830  LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
113570804  IQ motif and SEC7 domain-containing protein 3-like isoform X1 [KO:K12495]
113572285  IQ motif and SEC7 domain-containing protein 1-like isoform X1 [KO:K12495]
113579504  cyth3; cytohesin-3 [KO:K18441]
113577647  cytohesin-1 isoform X1 [KO:K18441]
113580096  cytohesin-4-like [KO:K18441]
113573023  cytohesin-2-like [KO:K18441]
113571409  cytohesin-1-like isoform X1 [KO:K18441]
113575325  cytohesin-3 isoform X1 [KO:K18441]
113572881  cytohesin-2-like [KO:K18441]
113590691  brefeldin A-inhibited guanine nucleotide-exchange protein 1-like [KO:K18442]
113587973  brefeldin A-inhibited guanine nucleotide-exchange protein 2-like isoform X1 [KO:K18442]
113578244  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
113580260  ADP-ribosylation factor 1-like [KO:K07937]
113583772  ADP-ribosylation factor 1 [KO:K07937]
113587159  arf1; ADP-ribosylation factor 1 [KO:K07937]
113584454  ADP-ribosylation factor 3-like isoform X1 [KO:K07938]
113581541  ADP-ribosylation factor 3 [KO:K07938]
113572485  ADP-ribosylation factor 4-like isoform X1 [KO:K07939]
113580534  ADP-ribosylation factor 4 isoform X1 [KO:K07939]
113579986  ADP-ribosylation factor 4-like [KO:K07939]
113572370  arf4; ADP-ribosylation factor 4 [KO:K07939]
113580532  ADP-ribosylation factor 4-like [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
eee04060  Cytokine-cytokine receptor interaction
eee04070  Phosphatidylinositol signaling system
eee04130  SNARE interactions in vesicular transport
eee04142  Lysosome
eee04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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