KEGG   PATHWAY: ehs04060
Entry
ehs04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Eurypyga helias (sunbittern)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ehs04060  Cytokine-cytokine receptor interaction
ehs04060

Organism
Eurypyga helias (sunbittern) [GN:ehs]
Gene
104504889  CCL19; C-C motif chemokine 19 [KO:K05512]
104507007  CCL21; C-C motif chemokine 21 [KO:K16062]
104506242  C-C motif chemokine 4 homolog [KO:K12964]
104506243  C-C motif chemokine 4-like [KO:K12964]
104517090  C-C motif chemokine 5-like [KO:K21083]
104506244  CCL5; C-C motif chemokine 5 [KO:K12499]
104506474  CCL20; C-C motif chemokine 20 [KO:K14625]
104510207  interleukin-8 [KO:K10030]
104510208  interleukin-8-like [KO:K10030]
104510209  interleukin-8-like [KO:K10030]
104510464  growth-regulated alpha protein-like [KO:K10030]
104505339  CXCL12; stromal cell-derived factor 1 [KO:K10031]
104512487  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
104504916  lymphotactin-like [KO:K05507]
104508922  flocculation protein FLO11-like [KO:K05508]
104516051  IL15; interleukin-15 [KO:K05433]
104505967  IL21; interleukin-21 [KO:K05434]
104505991  interleukin-5-like [KO:K05428]
104506887  PRL; prolactin [KO:K05439]
104503734  THPO; thrombopoietin [KO:K06854]
104517166  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
104505612  IL12A; interleukin-12 subunit alpha [KO:K05406]
104509798  IL12B; interleukin-12 subunit beta [KO:K05425]
104516148  IL10; interleukin-10 [KO:K05443]
104508757  interleukin-20-like [KO:K22667]
104502753  IL22; interleukin-22 [KO:K05445]
104517087  interferon kappa-like [KO:K05414]
104511443  LOW QUALITY PROTEIN: interferon-like [KO:K05415]
104515339  IFNG; interferon gamma [KO:K04687]
104509934  interleukin-1 beta-like [KO:K04519]
104504622  IL18; interleukin-18 [KO:K05482]
104503511  interleukin-17A-like [KO:K05489]
104505416  LOW QUALITY PROTEIN: interleukin-17F-like [KO:K05494]
104502831  IL17B; interleukin-17B [KO:K05490]
104509900  IL17D; interleukin-17D [KO:K05492]
104511714  IL16; LOW QUALITY PROTEIN: pro-interleukin-16 [KO:K22628]
104510532  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
104511975  LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
104517380  tumor necrosis factor ligand superfamily member 15-like [KO:K05478]
104514136  LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
104510644  EDA; ectodysplasin-A [KO:K05480]
104506932  NGF; beta-nerve growth factor [KO:K02582]
104516909  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
104508411  CD40LG; CD40 ligand [KO:K03161]
104512608  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
104513881  TGFB2; transforming growth factor beta-2 [KO:K13376]
104504203  TGFB3; transforming growth factor beta-3 [KO:K13377]
104506813  GDF2; growth/differentiation factor 2 [KO:K05503]
104514614  BMP10; bone morphogenetic protein 10 [KO:K22670]
104504710  BMP3; bone morphogenetic protein 3 [KO:K05496]
104506815  GDF10; bone morphogenetic protein 3B [KO:K22674]
104510128  MSTN; growth/differentiation factor 8 isoform X1 [KO:K05497]
104506879  INHBA; inhibin beta A chain [KO:K04667]
104507518  INHBB; inhibin beta B chain [KO:K22687]
104503569  GDF3; growth/differentiation factor 3 [KO:K05495]
104516528  NODAL; nodal homolog [KO:K04666]
104515392  GDF9; growth/differentiation factor 9 [KO:K22673]
104511555  INHBC; inhibin beta C chain [KO:K22688]
104510164  LOW QUALITY PROTEIN: inhibin beta E chain-like [KO:K22689]
104504901  bone morphogenetic protein 7-like [KO:K21283]
104514575  bone morphogenetic protein 2-like [KO:K21283]
104507578  bone morphogenetic protein 2-like [KO:K21283]
104509313  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
104502925  GDF5; growth/differentiation factor 5 [KO:K04664]
104517323  BMP5; bone morphogenetic protein 5 [KO:K04663]
104510771  BMP6; bone morphogenetic protein 6 [KO:K16620]
104504453  BMP7; bone morphogenetic protein 7 [KO:K16621]
104512541  LOW QUALITY PROTEIN: C-C chemokine receptor type 8-like [KO:K04183]
104512971  CCR8; C-C chemokine receptor type 8 [KO:K04183]
104509187  LOW QUALITY PROTEIN: C-C chemokine receptor type 9-like [KO:K04184]
104513950  LOW QUALITY PROTEIN: C-C chemokine receptor type 7-like [KO:K04182]
104504326  CCR4; C-C chemokine receptor type 4 [KO:K04179]
104504643  C-C chemokine receptor type 5-like [KO:K04180]
104503139  C-C chemokine receptor type 5-like [KO:K04180]
104511633  CCR6; C-C chemokine receptor type 6 [KO:K04181]
104512119  C-X-C chemokine receptor type 2-like [KO:K05050]
104513828  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
104510132  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104512663  ACKR3; atypical chemokine receptor 3 [KO:K04304]
104509973  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
104509574  XCR1; chemokine XC receptor 1 [KO:K04193]
104506862  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
104508456  interleukin-2 receptor subunit alpha-like [KO:K05068]
104515386  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
104513840  uncharacterized protein LOC104513840 [KO:K05071]
104511163  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
104511923  IL15RA; LOW QUALITY PROTEIN: interleukin-15 receptor subunit alpha [KO:K05074]
104513838  IL21R; interleukin-21 receptor [KO:K05075]
104514536  CRLF2; LOW QUALITY PROTEIN: cytokine receptor-like factor 2 [KO:K05078]
104514005  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
104507202  LOW QUALITY PROTEIN: granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
104510018  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
104504984  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
104514217  IL13RA2; LOW QUALITY PROTEIN: interleukin-13 receptor subunit alpha-2 [KO:K05077]
104503816  GHR; growth hormone receptor [KO:K05080]
104506618  PRLR; prolactin receptor isoform X1 [KO:K05081]
104516548  LEPR; leptin receptor [KO:K05062]
104513183  LOW QUALITY PROTEIN: interleukin-6 receptor subunit beta-like [KO:K05060]
104507382  LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-2-like [KO:K05064]
104513660  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
104508350  LOW QUALITY PROTEIN: ciliary neurotrophic factor receptor subunit alpha-like [KO:K05059]
104516212  LIFR; leukemia inhibitory factor receptor [KO:K05058]
104511032  oncostatin-M-specific receptor subunit beta-like [KO:K05057]
104506257  IL10RA; LOW QUALITY PROTEIN: interleukin-10 receptor subunit alpha [KO:K05134]
104506181  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
104515912  interleukin-20 receptor subunit alpha-like [KO:K05136]
104511295  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
104515124  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
104505230  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
104508703  IFNGR1; interferon gamma receptor 1 [KO:K05132]
104505863  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
104511666  interleukin-1 receptor type 2-like [KO:K04387]
104503868  interleukin-1 receptor-like 2 [KO:K05172]
104507022  IL18R1; interleukin-18 receptor 1 [KO:K05173]
104507033  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
104516850  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
104510648  IL17RA; interleukin-17 receptor A [KO:K05164]
104515668  LOW QUALITY PROTEIN: T-cell surface glycoprotein CD4-like [KO:K06454]
104517260  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104513483  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
104510595  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
104508066  tumor necrosis factor receptor superfamily member 6B-like [KO:K05143]
104515745  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
104515400  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
104514830  tumor necrosis factor receptor superfamily member 21-like [KO:K05157]
104509647  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
104505049  tumor necrosis factor receptor superfamily member 27-like [KO:K05163]
104514916  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
104512975  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
104514309  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
104504033  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
104515060  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
104510682  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
104510684  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
104503682  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
104511609  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
104502648  tumor necrosis factor receptor superfamily member 19-like [KO:K05155]
104513462  RELL2; RELT-like protein 2 [KO:K26541]
104502820  RELL1; RELT-like protein 1 [KO:K26541]
104517385  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
104505392  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104509912  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104514603  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
104505986  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
104505914  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
104506340  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
104514325  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
104509274  LOW QUALITY PROTEIN: activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
104516446  LOW QUALITY PROTEIN: activin receptor type-1C-like [KO:K13568] [EC:2.7.11.30]
104513063  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
104513433  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
104511681  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
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