KEGG   PATHWAY: ko04060
Entry
ko04060                     Pathway                                
Name
Cytokine-cytokine receptor interaction
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ko04060  Cytokine-cytokine receptor interaction
ko04060

Orthology
K02582  NGFB; nerve growth factor, beta
K02583  NGFR, TNFRSF16, CD271; tumor necrosis factor receptor superfamily member 16
K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
K03157  LTB, TNFC; lymphotoxin beta (TNF superfamily, member 3)
K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
K03159  TNFRSF3, LTBR; lymphotoxin beta receptor TNFR superfamily member 3
K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
K03161  TNFSF5, CD40L, CD154; tumor necrosis factor ligand superfamily member 5
K04175  CXCR1, IL8RA, CD181; C-X-C chemokine receptor type 1
K04176  CCR1, CD191; C-C chemokine receptor type 1
K04177  CCR2, CD192; C-C chemokine receptor type 2
K04178  CCR3, CD193; C-C chemokine receptor type 3
K04179  CCR4, CD194; C-C chemokine receptor type 4
K04180  CCR5, CD195; C-C chemokine receptor type 5
K04181  CCR6, CD196; C-C chemokine receptor type 6
K04182  CCR7, CD197; C-C chemokine receptor type 7
K04183  CCR8, CDw198; C-C chemokine receptor type 8
K04184  CCR9, CDw199; C-C chemokine receptor type 9
K04185  CCR10; C-C chemokine receptor type 10
K04186  ACKR4, CCRL1, CCR11; atypical chemokine receptor 4
K04188  CXCR3, GPR9, CD183; C-X-C chemokine receptor type 3
K04189  CXCR4, CD184; C-X-C chemokine receptor type 4
K04190  CXCR5, BLR1, CD185; C-X-C chemokine receptor type 5
K04191  CXCR6, CD186; C-X-C chemokine receptor type 6
K04192  CX3CR1; CX3C chemokine receptor 1
K04193  XCR1; XC chemokine receptor 1
K04304  CXCR7, ACKR3, RDC1; C-X-C chemokine receptor type 7 (atypical chemokine receptor 3)
K04383  IL1A; interleukin 1 alpha
K04386  IL1R1, CD121a; interleukin 1 receptor type I
K04387  IL1R2, CD121b; interleukin 1 receptor type II
K04388  TGFBR2; TGF-beta receptor type-2 [EC:2.7.11.30]
K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
K04519  IL1B; interleukin 1 beta
K04662  BMP4; bone morphogenetic protein 4
K04663  BMP5; bone morphogenetic protein 5
K04664  GDF5; growth differentiation factor 5
K04665  AMH; anti-mullerian hormone
K04666  NODAL; nodal
K04667  INHBA; inhibin beta A chain
K04670  ACVR2A; activin receptor type-2A [EC:2.7.11.30]
K04671  BMPR2; bone morphogenetic protein receptor type-2 [EC:2.7.11.30]
K04672  AMHR2; anti-mullerian hormone receptor type-2 [EC:2.7.11.30]
K04673  BMPR1A, ALK3, CD292; bone morphogenetic protein receptor type-1A [EC:2.7.11.30]
K04674  TGFBR1, ALK5; TGF-beta receptor type-1 [EC:2.7.11.30]
K04675  ACVR1, ALK2; activin receptor type-1 [EC:2.7.11.30]
K04687  IFNG; interferon gamma
K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
K04723  IL1RAP; interleukin 1 receptor accessory protein
K04736  IL3; interleukin 3
K04737  IL3RA, CD123; interleukin 3 receptor alpha
K04738  CSF2RB, IL3RB, CD131; cytokine receptor common subunit beta
K05050  CXCR2, IL8RB, CD182; C-X-C chemokine receptor type 2
K05055  IL6R, CD126; interleukin 6 receptor
K05056  IL11RA; interleukin 11 receptor alpha
K05057  OSMR; oncostatin M receptor
K05058  LIFR, CD118; leukemia inhibitory factor receptor
K05059  CNTFR; ciliary neurotrophic factor receptor
K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
K05061  CSF3R, CD114; granulocyte colony-stimulating factor receptor
K05062  LEPR, CD295; leptin receptor
K05063  IL12RB1, CD212; interleukin 12 receptor beta-1
K05064  IL12RB2; interleukin 12 receptor beta-2
K05065  IL23R; interleukin 23 receptor
K05066  CSF2RA, GMCSFR, CD116; granulocyte-macrophage colony-stimulating factor receptor alpha
K05067  IL5RA, CD125; interleukin 5 receptor alpha
K05068  IL2RA, CD25; interleukin 2 receptor alpha
K05069  IL2RB, CD122; interleukin 2 receptor beta
K05070  IL2RG, CD132; interleukin 2 receptor gamma
K05071  IL4R, CD124; interleukin 4 receptor
K05072  IL7R, CD127; interleukin 7 receptor
K05073  IL9R, CD129; interleukin 9 receptor
K05074  IL15RA, CD215; interleukin 15 receptor alpha
K05075  IL21R, CD360; interleukin 21 receptor
K05076  IL13RA1, CD213A1; interleukin 13 receptor alpha-1
K05077  IL13RA2, CD213A2; interleukin 13 receptor alpha-2
K05078  TSLPR; thymic stromal-derived lymphopoietin receptor
K05079  EPOR; erythropoietin receptor
K05080  GHR; growth hormone receptor
K05081  PRLR; prolactin receptor
K05082  TPOR, MPL, CD110; thrombopoietin receptor
K05090  CSF1R, FMS, CD115; macrophage colony-stimulating factor 1 receptor [EC:2.7.10.1]
K05130  IFNAR1; interferon receptor 1
K05131  IFNAR2; interferon receptor 2
K05132  IFNGR1, CD119; interferon gamma receptor 1
K05133  IFNGR2; interferon gamma receptor 2
K05134  IL10RA, CD210A; interleukin 10 receptor alpha
K05135  IL10RB, CD210B; interleukin 10 receptor beta
K05136  IL20RA; interleukin 20 receptor alpha
K05137  IL20RB; interleukin 20 receptor beta
K05138  IL22RA1; interleukin 22 receptor alpha 1
K05140  IFNLR1, IL28RA; interferon lambda receptor 1
K05141  TNFRSF1B, TNFR2, CD120b; tumor necrosis factor receptor superfamily member 1B
K05142  TNFRSF4, OX40, CD134; tumor necrosis factor receptor superfamily member 4
K05143  TNFRSF6B, DCR3; tumor necrosis factor receptor superfamily member 6B
K05144  TNFRSF7, CD27; tumor necrosis factor receptor superfamily member 7
K05145  TNFRSF8, CD30; tumor necrosis factor receptor superfamily member 8
K05146  TNFRSF9, CD137; tumor necrosis factor receptor superfamily member 9
K05147  TNFRSF11A, RANK, CD265; tumor necrosis factor receptor superfamily member 11A
K05148  TNFRSF11B, OPG; tumor necrosis factor receptor superfamily member 11B
K05149  TNFRSF12A, FN14, TWEAKR, CD266; tumor necrosis factor receptor superfamily member 12A
K05150  TNFRSF13B, TACI, CD267; tumor necrosis factor receptor superfamily member 13B
K05151  TNFRSF13C, BAFFR, CD268; tumor necrosis factor receptor superfamily member 13C
K05152  TNFRSF14, HVEM, CD270; tumor necrosis factor receptor superfamily member 14
K05153  TNFRSF17, BCMA, CD269; tumor necrosis factor receptor superfamily member 17
K05154  TNFRSF18, GITR, CD357; tumor necrosis factor receptor superfamily member 18
K05155  TNFRSF19, TROY; tumor necrosis factor receptor superfamily member 19
K05156  RELT, TNFRSF19L; tumor necrosis factor receptor superfamily member 19-like
K05157  TNFRSF21, DR6, CD358; tumor necrosis factor receptor superfamily member 21
K05160  TNFRSF25; tumor necrosis factor receptor superfamily member 25
K05162  EDAR; tumor necrosis factor receptor superfamily member EDAR
K05163  EDA2R, TNFRSF27, XEDAR; tumor necrosis factor receptor superfamily member 27
K05164  IL17RA, CD217; interleukin 17 receptor A
K05165  IL17RB, IL17RH1; interleukin 17 receptor B
K05166  IL17RC, IL17RL; interleukin 17 receptor C
K05168  IL17RE; interleukin 17 receptor E
K05171  IL1RL1, ST2; interleukin 1 receptor-like 1
K05172  IL1RL2, IL1RRP2; interleukin 1 receptor-like 2
K05173  IL18R1, IL1RRP, CD218a; interleukin 18 receptor 1
K05174  IL18RAP, ACPL, CD218b; interleukin 18 receptor accessory protein
K05405  IL6; interleukin 6
K05406  IL12A; interleukin 12A
K05407  PF4, CXCL4; platelet factor 4
K05408  CCL3; C-C motif chemokine 3
K05414  IFNA; interferon alpha
K05415  IFNB; interferon beta
K05416  CXCL9; C-X-C motif chemokine 9
K05417  IL11; interleukin 11
K05418  OSM; oncostatin M
K05419  LIF; leukemia inhibitory factor
K05420  CNTF; ciliary neurotrophic factor
K05421  CLCF1, BSF3, CLC; cardiotrophin-like cytokine factor 1
K05422  CTF1, CT1; cardiotrophin 1
K05423  CSF3, GCSF; granulocyte colony-stimulating factor
K05424  LEP; leptin
K05425  IL12B; interleukin 12B
K05426  IL23A; interleukin 23 subunit alpha
K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
K05428  IL5; interleukin 5
K05429  IL2; interleukin 2
K05430  IL4; interleukin 4
K05431  IL7; interleukin 7
K05432  IL9; interleukin 9
K05433  IL15; interleukin 15
K05434  IL21; interleukin 21
K05435  IL13; interleukin 13
K05436  TSLP; thymic stromal lymphopoietin
K05437  EPO; erythropoietin
K05438  GH; growth hormone
K05439  PRL; prolactin
K05440  IFNW; interferon omega
K05441  IFNK; interferon kappa
K05442  IFNE; interferon epsilon
K05443  IL10, CSIF; interleukin 10
K05444  IL19; interleukin 19
K05445  IL22, IL-TIF; interleukin 22
K05446  IL26; interleukin 26
K05447  IFNL1, IL29; interferon lambda 1
K05451  NGFA; nerve growth factor, alpha
K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
K05468  LTA, TNFB; lymphotoxin alpha (TNF superfamily, member 1)
K05469  TNFSF4, OX40L, CD252; tumor necrosis factor ligand superfamily member 4
K05470  TNFSF7, CD70; tumor necrosis factor ligand superfamily member 7
K05471  TNFSF8, CD153; tumor necrosis factor ligand superfamily member 8
K05472  TNFSF9, CD137L; tumor necrosis factor ligand superfamily member 9
K05473  TNFSF11, RANKL, CD254; tumor necrosis factor ligand superfamily member 11
K05474  TNFSF12, TWEAK; tumor necrosis factor ligand superfamily member 12
K05475  TNFSF13, APRIL, CD256; tumor necrosis factor ligand superfamily member 13
K05476  TNFSF13B, TNFSF20, CD257; tumor necrosis factor ligand superfamily member 13B
K05477  TNFSF14, LIGHT, CD258; tumor necrosis factor ligand superfamily member 14
K05478  TNFSF15, VEGI; tumor necrosis factor ligand superfamily member 15
K05479  TNFSF18, GITRL; tumor necrosis factor ligand superfamily member 18
K05480  EDA; ectodysplasin-A
K05481  IL1RN, IL1F3; interleukin 1 receptor antagonist
K05482  IL18, IL1F4; interleukin 18
K05483  IL36RN, IL1F5; interleukin 36 receptor antagonist protein
K05484  IL36A, IL1F6; interleukin 36 alpha
K05485  IL37, IL1F7; interleukin 37
K05486  IL36B, IL1F8; interleukin 36 beta
K05487  IL36G, IL1F9; interleukin 36 gamma
K05488  IL1F10, FKSG75; interleukin 1 family member 10
K05489  IL17A, CTLA8; interleukin 17A
K05490  IL17B, CX1; interleukin 17B
K05491  IL17C, CX2; interleukin 17C
K05492  IL17D, IL27; interleukin 17D
K05493  IL17E, IL25; interleukin 17E
K05494  IL17F, ML1; interleukin 17F
K05495  GDF1; growth differentiation factor 1
K05496  BMP3; bone morphogenetic protein 3
K05497  MSTN, GDF8; growth differentiation factor 8
K05498  BMP15, GDF9B; bone morphogenetic protein 15
K05500  INHA; inhibin, alpha
K05503  GDF2, BMP9; growth differentiation factor 2
K05504  GDF15; growth differentiation factor 15
K05505  CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
K05506  CXCL5_6, SCYB5_6; C-X-C motif chemokine 5/6
K05507  XCL, SCM1; C motif chemokine
K05508  CX3CL1, NTT; C-X3-C motif chemokine 1
K05509  CCL7; C-C motif chemokine 7
K05510  CCL6; C-C motif chemokine 6
K05511  CCL15_23; C-C motif chemokine 15/23
K05512  CCL19, ELC; C-C motif chemokine 19
K05513  CCL28; C-C motif chemokine 28
K05514  CCL1; C-C motif chemokine 1
K06454  CD4; T-cell surface glycoprotein CD4
K06854  THPO; thrombopoietin
K10029  PPBP, CXCL7; platelet basic protein
K10030  IL8, CXCL8; interleukin 8
K10031  CXCL12; C-X-C motif chemokine 12
K10032  CXCL13; C-X-C motif chemokine 13
K10033  CXCL14, SCYB14; C-X-C motif chemokine 14
K10034  CXCL15; C-X-C motif chemokine 15
K10035  CXCL16; C-X-C motif chemokine 16
K12499  CCL5; C-C motif chemokine 5
K12671  CXCL10, IP10; C-X-C motif chemokine 10
K12672  CXCL11, I-TAC; C-X-C motif chemokine 11
K12964  CCL4; C-C motif chemokine 4
K12967  IL33; interleukin 33
K13072  CCL25; C-C motif chemokine 25
K13375  TGFB1; transforming growth factor beta-1
K13376  TGFB2; transforming growth factor beta-2
K13377  TGFB3; transforming growth factor beta-3
K13567  ACVR1B, ALK4; activin receptor type-1B [EC:2.7.11.30]
K13568  ACVR1C, ALK7; activin receptor type-1C [EC:2.7.11.30]
K13578  BMPR1B, ALK6, CDw293; bone morphogenetic protein receptor type-1B [EC:2.7.11.30]
K13594  ACVRL1, ALK1; activin receptor-like kinase 1 [EC:2.7.11.30]
K13596  ACVR2B; activin receptor type-2B [EC:2.7.11.30]
K14624  CCL2, MCP1; C-C motif chemokine 2
K14625  CCL20; C-C motif chemokine 20
K16062  CCL21, SLC; C-C motif chemokine 21
K16595  CCL13; C-C motif chemokine 13
K16596  CCL8; C-C motif chemokine 8
K16597  CCL11; C-C motif chemokine 11
K16598  CCL27; C-C motif chemokine 27
K16620  BMP6; bone morphogenetic protein 6
K16621  BMP7; bone morphogenetic protein 7
K16622  BMP8; bone morphogenetic protein 8
K19598  IL27RA; interleukin 27 receptor alpha
K20012  GDF6; growth differentiation factor 6
K20013  GDF7; growth differentiation factor 7
K21083  CCL17; C-C motif chemokine 17
K21092  CCL14; C-C motif chemokine 14
K21093  CCL16; C-C motif chemokine 16
K21094  CCL18; C-C motif chemokine 18
K21095  CCL22; C-C motif chemokine 22
K21096  CCL26; C-C motif chemokine 26
K21097  CCL24; C-C motif chemokine 24
K21283  BMP2; bone morphogenetic protein 2
K22627  CXCL17; C-X-C motif chemokine 17
K22628  IL16; interleukin 16
K22629  IL27, IL27A; interleukin 27 subunit alpha
K22630  IL31RA; interleukin 31 receptor subunit alpha
K22631  IL31; interleukin 31
K22632  IL32; interleukin 32
K22633  IL34; interleukin 34
K22667  IL20; interleukin 20
K22668  IL24; interleukin 24
K22669  IFNL2_3, IL28; interferon lambda 2/3
K22670  BMP10; bone morphogenetic protein 10
K22671  CCL9; C-C motif chemokine 9
K22672  GDF3; growth differentiation factor 3
K22673  GDF9; growth differentiation factor 9
K22674  GDF10, BMP3B; growth differentiation factor 10
K22679  GDF11; growth differentiation factor 11
K22687  INHBB; inhibin beta B chain
K22688  INHBC; inhibin beta C chain
K22689  INHBE; inhibin beta E chain
K22701  TNFRSF10C, TRAILR3, DCR1, CD263; tumor necrosis factor receptor superfamily member 10C
K22702  TNFRSF10D, TRAILR4, DCR2, CD264; tumor necrosis factor receptor superfamily member 10D
K24382  CTF2; cardiotrophin 2
K24476  EBI3, IL27B; interleukin 27 subunit beta
K26541  RELL; RELT-like protein
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
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Reference
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Evolutionary divergence and functions of the human interleukin (IL) gene family.
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Reference
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