Entry
Name
Protein processing in endoplasmic reticulum - Ictalurus furcatus (blue catfish)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
ifu04141 Protein processing in endoplasmic reticulum
Ortholog table
Other DBs
Organism
Ictalurus furcatus (blue catfish) [GN:
ifu ]
Gene
128614438 sec61a1l; protein transport protein Sec61 subunit alpha-like 2 [KO:K10956 ]
128614918 sec61a1; protein transport protein Sec61 subunit alpha-like 1 [KO:K10956 ]
128599622 sec61g; protein transport protein Sec61 subunit gamma [KO:K07342 ]
128625251 rpn1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666 ]
128625066 rpn2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667 ]
128619686 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668 ]
128624447 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad1-like [KO:K12668 ]
128619696 ddost; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670 ]
128612862 stt3b; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151 ] [EC:2.4.99.18 ]
128620172 stt3a; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151 ] [EC:2.4.99.18 ]
128609154 dnajc10; dnaJ homolog subfamily C member 10 [KO:K09530 ] [EC:1.8.4.-]
128611454 lman2; vesicular integral-membrane protein VIP36 isoform X1 [KO:K10082 ]
128605655 sar1ab; secretion associated, Ras related GTPase 1Ab [KO:K07953 ] [EC:3.6.5.-]
128625539 si:dkey-13n15.2; protein transport protein Sec24C isoform X1 [KO:K14007 ]
128608641 uggt2; UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1 [KO:K11718 ] [EC:2.4.1.-]
128609665 uggt1; UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [KO:K11718 ] [EC:2.4.1.-]
128614893 edem1; ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084 ]
128619370 edem2; ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085 ]
128622114 si:ch211-282j22.3; ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086 ]
128608297 edem3; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086 ]
128613664 ero1b; ERO1-like protein beta isoform X1 [KO:K10976 ] [EC:1.8.4.-]
128613701 ssr1; translocon-associated protein subunit alpha isoform X1 [KO:K13249 ]
128619558 zgc:113278; translocating chain-associated membrane protein 1-like 1-like [KO:K14010 ]
128599728 tram1; translocating chain-associated membrane protein 1 [KO:K14010 ]
128617069 nploc4; nuclear protein localization protein 4 homolog isoform X1 [KO:K14015 ]
128607754 ufd1l; ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016 ]
128621106 hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283 ]
128607859 dnajc5aa; dnaJ (Hsp40) homolog, subfamily C, member 5aa [KO:K09525 ]
128612425 dnajc5gb; dnaJ (Hsp40) homolog, subfamily C, member 5 gamma b [KO:K09525 ]
128599824 dnajc5b; dnaJ homolog subfamily C member 5 isoform X1 [KO:K09525 ]
128601306 hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079 ]
128624972 yod1; ubiquitin thioesterase OTU1 isoform X1 [KO:K13719 ] [EC:3.1.2.-]
128613529 rad23ab; RAD23 homolog A, nucleotide excision repair protein b isoform X1 [KO:K10839 ]
128600950 eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237 ]
128608898 nfe2l2a; nuclear factor erythroid 2-related factor 2a [KO:K05638 ]
128616133 atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
128600953 atf6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054 ]
128618455 atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049 ]
128606670 herpud1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027 ]
Compound
Reference
Authors
Naidoo N
Title
ER and aging-Protein folding and the ER stress response.
Journal
Reference
Authors
Malhotra JD, Kaufman RJ
Title
The endoplasmic reticulum and the unfolded protein response.
Journal
Reference
Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
Title
Protein quality control in the ER: the recognition of misfolded proteins.
Journal
Reference
Authors
Stolz A, Wolf DH
Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
Journal
Reference
Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
Journal
Related pathway
KO pathway
LinkDB
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