KEGG   PATHWAY: ifu04141
Entry
ifu04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Ictalurus furcatus (blue catfish)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ifu04141  Protein processing in endoplasmic reticulum
ifu04141

Other DBs
GO: 0030433 0034976
Organism
Ictalurus furcatus (blue catfish) [GN:ifu]
Gene
128598910  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
128599007  vcp; transitional endoplasmic reticulum ATPase [KO:K13525]
128599137  xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
128599461  bcl2a; apoptosis regulator Bcl-2a [KO:K02161]
128599470  cul1b; cullin-1b [KO:K03347]
128599559  [KO:K01230] [EC:3.2.1.113]
128599579  txndc5; thioredoxin domain-containing protein 5 [KO:K13984] [EC:5.3.4.1]
128599622  sec61g; protein transport protein Sec61 subunit gamma [KO:K07342]
128599728  tram1; translocating chain-associated membrane protein 1 [KO:K14010]
128599787  sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
128599824  dnajc5b; dnaJ homolog subfamily C member 5 isoform X1 [KO:K09525]
128599872  pdia4; protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
128599886  mbtps2; membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
128599919  ubqln4; ubiquilin-4 [KO:K04523]
128600304  dnajb1a; dnaJ homolog subfamily B member 1a [KO:K09507]
128600366  prkcsh; glucosidase 2 subunit beta isoform X1 [KO:K08288]
128600863  pdia6; protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
128600950  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
128600953  atf6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
128600968  man1a1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
128600973  [KO:K14026]
128601060  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
128601142  ubxn2a; UBX domain-containing protein 2A isoform X1 [KO:K24349]
128601290  sel1l; protein sel-1 homolog 1 [KO:K14026]
128601306  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
128601307  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
128601752  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
128601896  dnajb1b; dnaJ homolog subfamily B member 1b [KO:K09507]
128601964  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
128601988  cryaa; alpha-crystallin A chain [KO:K09541]
128602025  [KO:K03283]
128602031  [KO:K03283]
128602036  [KO:K03283]
128602137  [KO:K02159]
128602505  [KO:K02159]
128602514  [KO:K02159]
128602566  [KO:K01367] [EC:3.4.22.52]
128602567  [KO:K03853] [EC:3.4.22.53]
128602684  rrbp1b; ribosome-binding protein 1b isoform X1 [KO:K14000]
128602703  dnaja2a; dnaJ homolog subfamily A member 2a [KO:K09503]
128602877  [KO:K03853] [EC:3.4.22.53]
128602878  [KO:K03853] [EC:3.4.22.53]
128603337  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
128603357  [KO:K05546] [EC:3.2.1.207]
128603367  hspa5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
128603383  rnf185; E3 ubiquitin-protein ligase RNF185 isoform X1 [KO:K10666] [EC:2.3.2.27]
128603603  cryabb; crystallin, alpha B, b [KO:K09542]
128603696  ube2g1a; ubiquitin-conjugating enzyme E2 G1a [KO:K10575] [EC:2.3.2.23]
128603712  derl2; derlin-2 [KO:K13989]
128604150  erlec1; endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
128604281  dnaja1; dnaJ homolog subfamily A member 1 [KO:K09502]
128604372  wfs1a; wolframin isoform X1 [KO:K14020]
128604430  [KO:K01228] [EC:3.2.1.106]
128604432  tusc3; tumor suppressor candidate 3 [KO:K19478]
128604453  [KO:K01228] [EC:3.2.1.106]
128605290  bag2; BAG family molecular chaperone regulator 2 [KO:K09556]
128605392  prkn; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
128605451  ube2d3; ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
128605489  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
128605628  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128605655  sar1ab; secretion associated, Ras related GTPase 1Ab [KO:K07953] [EC:3.6.5.-]
128605657  dnajb12a; dnaJ homolog subfamily B member 12a [KO:K09518]
128606081  derl1; derlin-1 [KO:K11519]
128606372  dnaja2b; dnaJ homolog subfamily A member 2b [KO:K09503]
128606670  herpud1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
128606764  mbtps1; membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
128607002  krtcap2; keratinocyte-associated protein 2 isoform X1 [KO:K28202]
128607074  ssr3; translocon-associated protein subunit gamma [KO:K13251]
128607353  ube2d4; ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
128607754  ufd1l; ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
128607859  dnajc5aa; dnaJ (Hsp40) homolog, subfamily C, member 5aa [KO:K09525]
128607970  calr; calreticulin [KO:K08057]
128608156  bcap31; B-cell receptor-associated protein 31 [KO:K14009]
128608297  edem3; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
128608613  ubxn4; UBX domain-containing protein 4 [KO:K24348]
128608641  uggt2; UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1 [KO:K11718] [EC:2.4.1.-]
128608642  dnajc3a; dnaJ homolog subfamily C member 3a [KO:K09523]
128608898  nfe2l2a; nuclear factor erythroid 2-related factor 2a [KO:K05638]
128608991  dnajb2; dnaJ homolog subfamily B member 2 isoform X1 [KO:K09508]
128609146  man1a2; mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [KO:K01230] [EC:3.2.1.113]
128609154  dnajc10; dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
128609216  dnajb11; dnaJ homolog subfamily B member 11 [KO:K09517]
128609598  bag1; BAG family molecular chaperone regulator 1 [KO:K09555]
128609602  [KO:K07342]
128609608  marchf6; E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
128609665  uggt1; UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [KO:K11718] [EC:2.4.1.-]
128609779  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
128609838  sec62; translocation protein SEC62 [KO:K12275]
128609849  pdia7; protein disulfide isomerase family A, member 7 isoform X1 [KO:K08056] [EC:5.3.4.1]
128609976  ostc; oligosaccharyltransferase complex subunit ostc [KO:K26501]
128610000  sec24d; protein transport protein Sec24D [KO:K14007]
128610096  dnajc3b; dnaJ homolog subfamily C member 3b [KO:K09523]
128610126  plaa; phospholipase A-2-activating protein [KO:K14018]
128610341  capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
128611044  canx; calnexin [KO:K08054]
128611403  si:ch211-274f20.2; calnexin [KO:K08054]
128611450  syvn1; E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
128611454  lman2; vesicular integral-membrane protein VIP36 isoform X1 [KO:K10082]
128611512  ganabb; neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
128611516  ubxn1; UBX domain-containing protein 1 [KO:K24348]
128611531  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
128611533  magt1; magnesium transporter protein 1 [KO:K19478]
128611658  wfs1b; wolframin [KO:K14020]
128611787  sil1; nucleotide exchange factor SIL1 isoform X1 [KO:K14001]
128612171  hspa4l; heat shock 70 kDa protein 4L [KO:K09485]
128612271  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
128612326  [KO:K01367] [EC:3.4.22.52]
128612370  atxn3; ataxin-3 [KO:K11863] [EC:3.4.22.-]
128612377  ero1a; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
128612425  dnajc5gb; dnaJ (Hsp40) homolog, subfamily C, member 5 gamma b [KO:K09525]
128612736  sec23a; protein transport protein Sec23A [KO:K14006]
128612763  preb; prolactin regulatory element-binding protein [KO:K14003]
128612862  stt3b; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
128612947  ube2d1a; ubiquitin-conjugating enzyme E2 D1a [KO:K06689] [EC:2.3.2.23]
128613529  rad23ab; RAD23 homolog A, nucleotide excision repair protein b isoform X1 [KO:K10839]
128613606  calr3a; calreticulin 3a [KO:K08057]
128613644  ubxn6; UBX domain-containing protein 6 [KO:K14011]
128613664  ero1b; ERO1-like protein beta isoform X1 [KO:K10976] [EC:1.8.4.-]
128613701  ssr1; translocon-associated protein subunit alpha isoform X1 [KO:K13249]
128614239  selenos; selenoprotein S [KO:K14025]
128614261  zgc:153993; apoptosis regulator BAX [KO:K02159]
128614438  sec61a1l; protein transport protein Sec61 subunit alpha-like 2 [KO:K10956]
128614637  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
128614777  os9; protein OS-9 isoform X1 [KO:K10088]
128614893  edem1; ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
128614918  sec61a1; protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
128615369  stub1; E3 ubiquitin-protein ligase CHIP isoform X1 [KO:K09561] [EC:2.3.2.27]
128615445  p4hb; protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
128615596  hspbp1; hsp70-binding protein 1 [KO:K09562]
128615623  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
128615651  ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
128615837  ngly1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
128615983  ssr2; translocon-associated protein subunit beta [KO:K13250]
128616133  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
128616241  pdia8; protein disulfide isomerase family A, member 8 [KO:K08056] [EC:5.3.4.1]
128616551  ube2d1b; ubiquitin-conjugating enzyme E2 D1b isoform X1 [KO:K06689] [EC:2.3.2.23]
128616620  dnajb12b; dnaJ homolog subfamily B member 12b [KO:K09518]
128616632  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128616731  sar1aa; GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
128616928  sec24c; protein transport protein Sec24C isoform X1 [KO:K14007]
128617069  nploc4; nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
128617877  amfra; autocrine motility factor receptor a [KO:K10636] [EC:2.3.2.36]
128617936  ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
128618095  rnf5; E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
128618144  tmem258; transmembrane protein 258 [KO:K26502]
128618252  svip; small VCP/p97-interacting protein isoform X1 [KO:K14014]
128618455  atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
128618953  dnajc5ab; dnaJ homolog subfamily C member 5 [KO:K09525]
128618975  ube2j2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
128619302  ube4b; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
128619370  edem2; ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
128619558  zgc:113278; translocating chain-associated membrane protein 1-like 1-like [KO:K14010]
128619652  nsfl1c; NSFL1 cofactor p47 [KO:K14012]
128619686  [KO:K12668]
128619696  ddost; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
128619727  ube2j1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
128619806  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
128619807  [KO:K04571]
128619857  ssr4; translocon-associated protein subunit delta [KO:K04571]
128620172  stt3a; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
128620233  hyou1; hypoxia up-regulated protein 1 [KO:K09486]
128620237  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
128620264  sec31a; protein transport protein Sec31A isoform X1 [KO:K14005]
128620379  ubxn8; UBX domain-containing protein 8 [KO:K24351]
128621106  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
128621142  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
128621446  sec63; translocation protein SEC63 homolog [KO:K09540]
128621860  [KO:K09542]
128622114  si:ch211-282j22.3; ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
128622154  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
128622163  [KO:K03868] [EC:2.3.2.32]
128622236  ube2g1b; ubiquitin-conjugating enzyme E2G 1b [KO:K10575] [EC:2.3.2.23]
128622257  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
128622302  sar1b; GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
128622317  si:dkeyp-50d11.2; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
128622566  skp1; S-phase kinase-associated protein 1 [KO:K03094]
128622577  lman1; protein ERGIC-53 isoform X1 [KO:K10080]
128622748  rad23b; UV excision repair protein RAD23 homolog B [KO:K10839]
128622767  man1b1a; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741]
128622950  hsp90b1; endoplasmin [KO:K09487]
128623184  sec24b; protein transport protein Sec24B isoform X1 [KO:K14007]
128623404  ckap4; cytoskeleton-associated protein 4 [KO:K13999]
128623933  dnajc1; dnaJ homolog subfamily C member 1 [KO:K09521]
128623942  cul1a; cullin-1a [KO:K03347]
128624094  ube2d2l; ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), like [KO:K06689] [EC:2.3.2.23]
128624210  calr3b; calreticulin 3b [KO:K08057]
128624447  [KO:K12668]
128624972  yod1; ubiquitin thioesterase OTU1 isoform X1 [KO:K13719] [EC:3.1.2.-]
128624990  [KO:K13249]
128625017  fbxo2; F-box only protein 2 [KO:K10099]
128625066  rpn2; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
128625182  sec13; protein SEC13 homolog [KO:K14004]
128625251  rpn1; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
128625304  [KO:K08852] [EC:2.7.11.1 3.1.26.-]
128625388  [KO:K04554] [EC:2.3.2.23]
128625539  si:dkey-13n15.2; protein transport protein Sec24C isoform X1 [KO:K14007]
128625614  man1b1b; mannosidase, alpha, class 1B, member 1b isoform X1 [KO:K23741]
Compound
C00076  Calcium cation
G00009  
G00010  
G00011  
G00012  
G10694  
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
ifu00510  N-Glycan biosynthesis
ifu03050  Proteasome
ifu03060  Protein export
ifu04210  Apoptosis
KO pathway
ko04141   

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