KEGG   PATHWAY: leri00230
Entry
leri00230                   Pathway                                
Name
Purine metabolism - Leucoraja erinacea (little skate)
Class
Metabolism; Nucleotide metabolism
Pathway map
leri00230  Purine metabolism
leri00230

Module
leri_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:leri00230]
leri_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:leri00230]
leri_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:leri00230]
leri_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:leri00230]
leri_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:leri00230]
leri_M00546  Purine degradation, xanthine => urea [PATH:leri00230]
leri_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:leri00230]
leri_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:leri00230]
Other DBs
GO: 0006163 0042278
Organism
Leucoraja erinacea (little skate) [GN:leri]
Gene
129709107  LOW QUALITY PROTEIN: ADP-ribose pyrophosphatase, mitochondrial-like [KO:K13988] [EC:3.6.1.13]
129706827  ADP-ribose pyrophosphatase, mitochondrial-like isoform X1 [KO:K13988] [EC:3.6.1.13]
129708126  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
129707959  nudt5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
129701102  pgm1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
129698604  pgm2; phosphoglucomutase-2 isoform X1 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
129702116  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
129702601  ribose-phosphate pyrophosphokinase 2-like isoform X1 [KO:K00948] [EC:2.7.6.1]
129697292  ppat; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
129702967  gart; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
129706810  pfas; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
129697301  paics; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
129713762  adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
129698894  atic; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
129705433  aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
129713156  cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]
129705745  cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
129696883  trifunctional nucleotide phosphoesterase protein YfkN-like [KO:K01081] [EC:3.1.3.5]
129697153  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
129697154  cytosolic 5'-nucleotidase 1A-like isoform X1 [KO:K01081] [EC:3.1.3.5]
129706993  5'(3')-deoxyribonucleotidase, mitochondrial-like [KO:K01081] [EC:3.1.3.5]
129704199  nt5c2a; 5'-nucleotidase, cytosolic IIa isoform X1 [KO:K01081] [EC:3.1.3.5]
129699563  nt5e; LOW QUALITY PROTEIN: 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
129705247  pnp6; purine nucleoside phosphorylase 6 [KO:K03783] [EC:2.4.2.1]
129707586  pnp4a; purine nucleoside phosphorylase 4a [KO:K03783] [EC:2.4.2.1]
129702806  lacc1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
129705320  hprt1l; hypoxanthine phosphoribosyltransferase 1, like isoform X1 [KO:K00760] [EC:2.4.2.8]
129702341  hprt1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
129707868  impdh1b; inosine-5'-monophosphate dehydrogenase 1b isoform X1 [KO:K00088] [EC:1.1.1.205]
129704636  LOW QUALITY PROTEIN: inosine-5'-monophosphate dehydrogenase 2-like [KO:K00088] [EC:1.1.1.205]
129699372  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
129702730  nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
129706888  nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
129707050  nucleoside diphosphate kinase A-like isoform X1 [KO:K00940] [EC:2.7.4.6]
129708474  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
129696879  ak9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
129696636  entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
129704206  entpd1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
129708247  soluble calcium-activated nucleotidase 1-like [KO:K12304] [EC:3.6.1.6]
129713221  entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
129699818  entpd6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
129700015  entpd5a; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
129694063  zgc:103759; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
129701185  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
129695930  uncharacterized protein LOC129695930 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129697556  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129697635  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129695604  nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
129703656  gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
129694551  LOW QUALITY PROTEIN: GMP reductase 2-like [KO:K00364] [EC:1.7.1.7]
129708438  GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
129695500  gda; guanine deaminase [KO:K01487] [EC:3.5.4.3]
129714194  guanylate kinase-like isoform X1 [KO:K00942] [EC:2.7.4.8]
129698341  rrm1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
129709752  rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
129697083  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
129697286  hddc2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
129713328  LOW QUALITY PROTEIN: deoxycytidine kinase 2-like [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
129701732  zgc:110540; deoxynucleoside kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
129713508  hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
129694530  prune; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
129710284  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
129705029  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08042] [EC:4.6.1.1]
129711549  LOW QUALITY PROTEIN: adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
129699833  LOW QUALITY PROTEIN: adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
129699122  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
129696342  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
129699829  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
129706900  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
129698829  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
129698141  gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
129703312  gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
129703706  gucy1b2; guanylate cyclase soluble subunit beta-2 [KO:K12319] [EC:4.6.1.2]
129713710  guanylyl cyclase C-like [KO:K12320] [EC:4.6.1.2]
129702378  retinal guanylyl cyclase 2-like [KO:K12322] [EC:4.6.1.2]
129715004  gucy2f; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
129704372  gucy2g; LOW QUALITY PROTEIN: guanylate cyclase 2G [KO:K22600] [EC:4.6.1.2]
129701297  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
129695485  atrial natriuretic peptide receptor 1 [KO:K12324] [EC:4.6.1.2]
129695828  npr2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
129710029  soluble guanylate cyclase 88E-like [KO:K01769] [EC:4.6.1.2]
129696083  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
129698685  pde1a; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
129707684  pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1 [KO:K19021] [EC:3.1.4.17]
129705951  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [KO:K13296] [EC:3.1.4.17]
129700222  pde5ab; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
129701678  pde6a; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
129701322  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta-like [KO:K13756] [EC:3.1.4.35]
129708277  pde6gb; phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog b [KO:K13759]
129699087  si:dkey-219c10.4; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
129703084  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A-like isoform X1 [KO:K13761] [EC:3.1.4.35]
129693334  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A-like [KO:K13761] [EC:3.1.4.35]
129712418  pde9ab; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
129694635  pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
129698707  pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
129711651  pde11al; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
129699476  adss2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
129700286  adss1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
129708835  AMP deaminase 1-like [KO:K01490] [EC:3.5.4.6]
129708898  AMP deaminase 2-like isoform X1 [KO:K01490] [EC:3.5.4.6]
129705667  AMP deaminase 3-like isoform X1 [KO:K01490] [EC:3.5.4.6]
129712854  adenosine kinase-like isoform X1 [KO:K00856] [EC:2.7.1.20]
129707473  ada; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
129706075  ada2a; adenosine deaminase 2-A isoform X1 [KO:K19572] [EC:3.5.4.4]
129701304  ak5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
129709788  ak2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
129700024  ak7b; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
129711952  ak8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
129711990  adenylate kinase isoenzyme 5-like isoform X1 [KO:K00939] [EC:2.7.4.3]
129701094  ak4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
129714523  adenylate kinase isoenzyme 5-like isoform X1 [KO:K00939] [EC:2.7.4.3]
129694511  ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
129695352  ak3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
129712186  LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 2-like [KO:K01509] [EC:3.6.1.-]
129697006  ntpcr; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
129697252  venom phosphodiesterase 2-like [KO:K01513] [EC:3.1.4.1 3.6.1.9]
129697253  venom phosphodiesterase 2-like [KO:K01513] [EC:3.1.4.1 3.6.1.9]
129697254  ectonucleotide pyrophosphatase/phosphodiesterase family member 3-like [KO:K01513] [EC:3.1.4.1 3.6.1.9]
129696634  pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
129710960  cAMP-specific 3',5'-cyclic phosphodiesterase 4C-like isoform X1 [KO:K13293] [EC:3.1.4.53]
129701089  pde4ba; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
129714560  pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
129696252  pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
129697421  cAMP-specific 3',5'-cyclic phosphodiesterase 7B-like isoform X1 [KO:K18436] [EC:3.1.4.53]
129694746  pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
129712674  pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
129704479  fhit; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
129697226  enpp4; bis(5'-adenosyl)-triphosphatase enpp4 [KO:K18424] [EC:3.6.1.29]
129704250  papss2b; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2b [KO:K13811] [EC:2.7.7.4 2.7.1.25]
129700986  papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
129700699  uox; uricase isoform X1 [KO:K00365] [EC:1.7.3.3]
129705442  uraha; 5-hydroxyisourate hydrolase isoform X1 [KO:K07127] [EC:3.5.2.17]
129698057  LOW QUALITY PROTEIN: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase-like [KO:K13485] [EC:4.1.1.97]
129703526  zgc:103559; allantoinase, mitochondrial isoform X1 [KO:K01466] [EC:3.5.2.5]
129697053  allc; allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
leri00030  Pentose phosphate pathway
leri00220  Arginine biosynthesis
leri00250  Alanine, aspartate and glutamate metabolism
leri00260  Glycine, serine and threonine metabolism
leri00340  Histidine metabolism
leri00630  Glyoxylate and dicarboxylate metabolism
leri00730  Thiamine metabolism
leri00740  Riboflavin metabolism
leri00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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