KEGG   PATHWAY: lroh04912
Entry
lroh04912                   Pathway                                
Name
GnRH signaling pathway - Labeo rohita (rohu)
Description
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
Class
Organismal Systems; Endocrine system
Pathway map
lroh04912  GnRH signaling pathway
lroh04912

Organism
Labeo rohita (rohu) [GN:lroh]
Gene
127179946  gnrh3; gonadotropin-releasing hormone 3 [KO:K05252]
127152204  gnrh2; progonadoliberin-2 [KO:K05252]
127178189  gnrhr3; gonadotropin releasing hormone receptor 3 isoform X1 [KO:K04280]
127167660  gnrhr2; gonadotropin releasing hormone receptor 2 isoform X1 [KO:K04280]
127180370  gnrhr4; gonadotropin releasing hormone receptor 4 [KO:K04280]
127181436  gnrhr1; gonadotropin releasing hormone receptor 1 [KO:K04280]
127166815  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
127173117  adcy1b; adenylate cyclase type 1b isoform X1 [KO:K08041] [EC:4.6.1.1]
127183422  adcy1a; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
127179109  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
127181325  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
127178345  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
127182895  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
127170903  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
127154638  adcy6a; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
127154831  adcy6b; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
127167860  adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
127175788  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
127182519  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
127179900  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
127153464  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
127161786  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
127172869  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
127159391  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
127168154  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
127180703  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
127166992  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
127163197  atf4b; activating transcription factor 4b [KO:K04374]
127165849  gnaq; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
127153994  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
127176505  gna11b; guanine nucleotide-binding protein subunit alpha-11b [KO:K04635]
127179467  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
127179468  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
127168134  plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
127179936  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
127182802  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
127182984  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
127172757  itpr1b; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
127166842  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
127180437  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
127169168  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
127177273  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
127157137  calml4b; calmodulin-like protein 4 [KO:K02183]
127173904  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
127179643  calm1a; calmodulin-1a [KO:K02183]
127152231  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
127168935  calml4a; calmodulin-like protein 4a [KO:K02183]
127175157  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
127182897  calm1b; calmodulin-1b [KO:K02183]
127169829  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
127171585  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
127165937  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
127167888  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
127174003  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
127174722  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
127152422  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
127166764  prkcaa; LOW QUALITY PROTEIN: protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
127163386  prkcab; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
127160219  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
127163312  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
127167169  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
127173261  prkcdb; protein kinase C, delta b [KO:K06068] [EC:2.7.11.13]
127164112  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
127170043  cacna1db; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
127172762  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
127169880  cacna1fb; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
127169482  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
127162533  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a isoform X1 [KO:K04857]
127169628  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
127171924  map3k1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
127166627  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
127155446  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
127156602  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
127174736  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
127174013  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
127154860  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
127173065  mapk14b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
127160702  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
127160703  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
127180572  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
127169462  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
127169667  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
127173906  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
127165244  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
127165245  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127165246  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127157537  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
127158235  cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
127158265  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127158631  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
127158929  cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
127158936  cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
127158970  cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
127158974  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127179630  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
127179819  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
127160695  cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
127161098  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127182996  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
127170502  si:ch211-168k14.2; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
127165554  pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
127155946  pld1b; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
127179532  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
127154786  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
127154286  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
127178154  cdc42l; cell division cycle 42, like [KO:K04393]
127173196  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
127173925  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
127162692  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
127164041  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
127173973  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127152220  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
127174909  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127152675  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127165315  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
127183046  jun; transcription factor AP-1 [KO:K04448]
127175582  lhb; lutropin subunit beta [KO:K08521]
127180244  cga; LOW QUALITY PROTEIN: glycoprotein hormones alpha chain [KO:K08522]
127179473  ptk2ba; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
127183199  ptk2bb; protein tyrosine kinase 2 beta, b [KO:K05871] [EC:2.7.10.2]
127168284  mmp2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
127182330  mmp14b; matrix metalloproteinase-14b [KO:K07763] [EC:3.4.24.80]
127168695  mmp14a; matrix metalloproteinase-14a [KO:K07763] [EC:3.4.24.80]
127176614  hbegfa; heparin-binding EGF-like growth factor a [KO:K08523]
127152002  hbegfb; heparin-binding EGF-like growth factor b [KO:K08523]
127176285  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
127156110  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
127167204  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
127160635  grb2b; growth factor receptor-bound protein 2b isoform X1 [KO:K04364]
127172877  sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
127174997  sos2; son of sevenless homolog 2 [KO:K03099]
127156808  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
127168650  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
127156990  kras; GTPase KRas isoform X1 [KO:K07827]
127160738  zgc:55558; GTPase KRas [KO:K07827]
127169998  nras; GTPase NRas [KO:K07828]
127154571  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
127172884  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
127180735  map2k1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127153291  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
127153476  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
127164820  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
127162808  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
127169677  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
127175937  egr1; early growth response protein 1 [KO:K09203]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:15350605
  Authors
Ruf F, Sealfon SC.
  Title
Genomics view of gonadotrope signaling circuits.
  Journal
Trends Endocrinol Metab 15:331-8 (2004)
DOI:10.1016/j.tem.2004.07.008
Reference
PMID:15613448
  Authors
Harrison GS, Wierman ME, Nett TM, Glode LM.
  Title
Gonadotropin-releasing hormone and its receptor in normal and malignant cells.
  Journal
Endocr Relat Cancer 11:725-48 (2004)
DOI:10.1677/erc.1.00777
Reference
PMID:15982836
  Authors
Pawson AJ, McNeilly AS.
  Title
The pituitary effects of GnRH.
  Journal
Anim Reprod Sci 88:75-94 (2005)
DOI:10.1016/j.anireprosci.2005.05.010
Reference
  Authors
DeGroot LJ, Jameson JL (ed).
  Title
Endocrinology (Fifth edition)
  Journal
Elsevier Saunders (2006)
Reference
PMID:10707049
  Authors
Naor Z, Benard O, Seger R.
  Title
Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor.
  Journal
Trends Endocrinol Metab 11:91-9 (2000)
DOI:10.1016/S1043-2760(99)00232-5
Reference
PMID:14596811
  Authors
Ruf F, Fink MY, Sealfon SC.
  Title
Structure of the GnRH receptor-stimulated signaling network: insights from genomics.
  Journal
Front Neuroendocrinol 24:181-99 (2003)
DOI:10.1016/S0091-3022(03)00027-X
Reference
PMID:12943720
  Authors
Farshori PQ, Shah BH, Arora KK, Martinez-Fuentes A, Catt KJ.
  Title
Activation and nuclear translocation of PKCdelta, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells.
  Journal
J Steroid Biochem Mol Biol 85:337-47 (2003)
DOI:10.1016/S0960-0760(03)00226-7
Reference
PMID:15080147
  Authors
Shah BH, Catt KJ.
  Title
Matrix metalloproteinases in reproductive endocrinology.
  Journal
Trends Endocrinol Metab 15:47-9 (2004)
DOI:10.1016/j.tem.2004.01.004
Reference
PMID:12963732
  Authors
Roelle S, Grosse R, Aigner A, Krell HW, Czubayko F, Gudermann T.
  Title
Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone.
  Journal
J Biol Chem 278:47307-18 (2003)
DOI:10.1074/jbc.M304377200
Reference
PMID:18708085
  Authors
Naor Z
  Title
Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.
  Journal
Front Neuroendocrinol 30:10-29 (2009)
DOI:10.1016/j.yfrne.2008.07.001
Related
pathway
lroh04010  MAPK signaling pathway
lroh04020  Calcium signaling pathway
lroh04060  Cytokine-cytokine receptor interaction
lroh04080  Neuroactive ligand-receptor interaction
KO pathway
ko04912   
LinkDB

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