KEGG   PATHWAY: lroh04010
Entry
lroh04010                   Pathway                                
Name
MAPK signaling pathway - Labeo rohita (rohu)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
lroh04010  MAPK signaling pathway
lroh04010

Other DBs
GO: 0000165
Organism
Labeo rohita (rohu) [GN:lroh]
Gene
127157773  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
127173546  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
127164861  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
127152709  cacna1bb; probable voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
127164112  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
127170043  cacna1db; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
127172762  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
127173082  cacna1eb; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
127169379  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
127169880  cacna1fb; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
127169482  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
127173926  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
127160751  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
127166296  LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
127163056  cacna1ia; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
127162533  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a isoform X1 [KO:K04857]
127169628  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
127163798  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X1 [KO:K04858]
127180851  voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
127153415  cacna2d2b; voltage-dependent calcium channel subunit alpha-2/delta-2b [KO:K04859]
127166463  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a [KO:K04859]
127170044  cacna2d3a; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
127172721  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
127164114  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
127156764  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
127162534  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
127167968  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
127154640  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
127154868  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04864]
127171005  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
127166856  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
127166317  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
127157976  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
127166986  cacng2b; calcium channel, voltage-dependent, gamma subunit 2b [KO:K04867]
127163175  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
127168517  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
127162928  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
127163549  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
127166436  cacng4a; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
127166437  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870]
127162581  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
127178850  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
127181416  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a isoform X1 [KO:K04871]
127182031  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
127179036  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
127182336  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
127178783  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
127172869  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
127159391  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
127168154  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
127180703  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
127166764  prkcaa; LOW QUALITY PROTEIN: protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
127163386  prkcab; LOW QUALITY PROTEIN: protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
127160219  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
127163312  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
127178761  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
127160470  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
127166739  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
127152626  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
127175900  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127165049  ppp3cca; LOW QUALITY PROTEIN: protein phosphatase 3, catalytic subunit, gamma isozyme, a [KO:K04348] [EC:3.1.3.16]
127171792  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
127152224  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
127168857  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
127152322  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
127175128  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
127180577  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
127164801  rasgrf2b; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
127172002  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
127180619  rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
127168114  RAS guanyl-releasing protein 2 [KO:K12361]
127152742  rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
127179330  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
127163628  rapgef2a; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
127176523  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
127176774  nf1a; neurofibromin isoform X1 [KO:K08052]
127172108  nf1b; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
127165032  rasa1a; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
127172464  rasa1b; ras GTPase-activating protein 1 [KO:K04352]
127180325  rasa2; ras GTPase-activating protein 2 [KO:K08053]
127169813  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
127173149  rap1ab; ras-related protein rap1ab [KO:K04353]
127163881  rap1b; ras-related protein Rap-1b [KO:K07836]
127175864  egf; pro-epidermal growth factor [KO:K04357]
127166375  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
127176456  fgf1a; putative fibroblast growth factor 1 [KO:K18496]
127152732  fgf1b; fibroblast growth factor 1b [KO:K18496]
127176164  fgf2; fibroblast growth factor 2 [KO:K18497]
127175796  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
127175978  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
127153769  fgf22; fibroblast growth factor 22 [KO:K04358]
127176067  fgf20b; fibroblast growth factor 20b [KO:K04358]
127164486  fgf6b; fibroblast growth factor 6b [KO:K04358]
127176482  fgf16; fibroblast growth factor 16 [KO:K04358]
127164903  fgf5; fibroblast growth factor 5 [KO:K04358]
127165580  fgf10b; fibroblast growth factor 10b [KO:K04358]
127171948  fgf8b; fibroblast growth factor 8b isoform X1 [KO:K04358]
127156481  fgf6a; fibroblast growth factor 6a [KO:K04358]
127172475  fgf18b; fibroblast growth factor 18b [KO:K04358]
127157456  fgf7; fibroblast growth factor 7 [KO:K04358]
127168077  fgf20a; fibroblast growth factor 20a [KO:K04358]
127168485  fgf4; fibroblast growth factor 4 [KO:K04358]
127152264  fgf10a; fibroblast growth factor 10a [KO:K04358]
127168576  fgf3; fibroblast growth factor 3 [KO:K04358]
127174689  fgf8a; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
127169363  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
127167790  fgf19; fibroblast growth factor 19 [KO:K22603]
127163180  fgf21; fibroblast growth factor 21 [KO:K22429]
127164405  fgf23; fibroblast growth factor 23 [KO:K22428]
127156480  uncharacterized protein LOC127156480 [KO:K22428]
127154738  ngfa; neurotrophin-7 [KO:K02582]
127167070  ngfb; nerve growth factor isoform X1 [KO:K02582]
127168692  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
127163672  ntf3; neurotrophin-3 [KO:K04356]
127163542  insulin [KO:K04526]
127176089  insb; preproinsulin b [KO:K04526]
127164980  ins; insulin [KO:K04526]
127164105  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
127156959  igf2b; insulin-like growth factor 2b [KO:K13769]
127168478  igf2a; insulin-like growth factor 2a [KO:K13769]
127162991  pdgfbb; uncharacterized protein pdgfbb [KO:K04359]
127153154  pdgfaa; platelet-derived growth factor alpha polypeptide a isoform X1 [KO:K04359]
127163317  pdgfab; platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359]
127153680  si:ch211-79m20.1; uncharacterized protein si:ch211-79m20.1 [KO:K17386]
127176608  pdgfc; platelet-derived growth factor C [KO:K05450]
127177739  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
127173125  csf1a; macrophage colony-stimulating factor 1a [KO:K05453]
127164306  kitlgb; kit ligand b [KO:K05461]
127156943  kitlga; kit ligand a [KO:K05461]
127163886  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
127178380  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
127179376  pgfb; placenta growth factor [KO:K16859]
127183387  pgfa; snake venom vascular endothelial growth factor toxin HF [KO:K16859]
127172427  vegfc; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
127173537  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
127163750  hgfa; hepatocyte growth factor a [KO:K05460]
127180854  hepatocyte growth factor [KO:K05460]
127181901  angpt1; angiopoietin-1 [KO:K05465]
127178517  angiopoietin-1 isoform X1 [KO:K05465]
127182025  angpt2b; angiopoietin-2b isoform X1 [KO:K05466]
127175578  angpt2a; angiopoietin-2a [KO:K05466]
127181807  efna1a; ephrin-A1a [KO:K05462]
127170234  efna5b; ephrin-A5b isoform X1 [KO:K05462]
127155159  efna2a; ephrin-A2 isoform X1 [KO:K05462]
127178076  efna1b; ephrin-A1b [KO:K05462]
127178078  efna3b; ephrin-A3b [KO:K05462]
127173048  ephrin-A2 [KO:K05462]
127179140  si:dkey-246i14.3; ephrin-A4 isoform X1 [KO:K05462]
127152350  efna5a; ephrin-A5b [KO:K05462]
127181304  efna3a; LOW QUALITY PROTEIN: ephrin-A3 [KO:K05462]
127165141  gdnfb; glial cell line-derived neurotrophic factor [KO:K05452]
127171696  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
127172717  nrtn; neurturin [KO:K25414]
127175538  glial cell line-derived neurotrophic factor [KO:K25414]
127153358  LOW QUALITY PROTEIN: uncharacterized protein LOC127153358 [KO:K25415]
127166258  neurturin [KO:K25415]
127154004  persephin [KO:K25416]
127176285  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
127156110  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
127173720  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
127154870  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
127166958  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
127170185  erbb4a; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
127170958  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
127161874  si:ch73-383l1.1; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
127172252  fgfr1b; LOW QUALITY PROTEIN: fibroblast growth factor receptor 1b [KO:K04362] [EC:2.7.10.1]
127169481  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
127175355  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
127175122  fgfr3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
127152664  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
127177942  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
127174343  ngfrb; nerve growth factor receptor b isoform X1 [KO:K02583]
127163096  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
127178297  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
127165292  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
127169494  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
127153917  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
127175297  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
127167905  igf1rb; LOW QUALITY PROTEIN: insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
127180463  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
127183147  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
127176102  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
127176172  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
127152522  csf1rb; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
127171630  kitb; KIT proto-oncogene, receptor tyrosine kinase b isoform X1 [KO:K05091] [EC:2.7.10.1]
127183278  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
127155859  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
127175981  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
127155418  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
127161708  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
127183136  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
127157122  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
127165311  tek; tyrosine-protein kinase receptor Tie-2 [KO:K05121] [EC:2.7.10.1]
127154848  epha2b; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
127166859  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
127175499  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
127167204  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
127160635  grb2b; growth factor receptor-bound protein 2b isoform X1 [KO:K04364]
127172877  sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
127174997  sos2; son of sevenless homolog 2 [KO:K03099]
127156808  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
127168650  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
127156990  kras; GTPase KRas isoform X1 [KO:K07827]
127160738  zgc:55558; GTPase KRas [KO:K07827]
127169998  nras; GTPase NRas [KO:K07828]
127163541  rras; ras-related protein R-Ras [KO:K07830]
127168689  rras2; ras-related protein R-Ras2 [KO:K07830]
127153332  mrasb; ras-related protein M-Ras [KO:K07831]
127170844  mrasa; ras-related protein M-Ras [KO:K07831]
127165632  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
127163979  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
127154571  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
127172884  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
127180735  map2k1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127153291  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
127153476  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
127175637  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
127164820  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
127162808  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
127172850  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
127180681  mknk2a; MAP kinase-interacting serine/threonine-protein kinase 2a [KO:K04372] [EC:2.7.11.1]
127169174  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
127176405  rps6kal; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
127165362  rps6ka3a; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
127155738  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
127179558  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
127175311  rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
127166992  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
127163197  atf4b; activating transcription factor 4b [KO:K04374]
127169677  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
127173420  elk4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
127154385  mycb; transcriptional regulator Myc-B [KO:K04377]
127156107  myca; transcriptional regulator Myc-A [KO:K04377]
127162499  srfa; serum response factor a isoform X1 [KO:K04378]
127175316  srfb; serum response factor b isoform X1 [KO:K04378]
127179306  fosaa; protein c-Fos [KO:K04379]
127183261  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
127183262  si:ch211-153j24.3; LOW QUALITY PROTEIN: protein c-Fos [KO:K04379]
127173839  mapta; microtubule-associated protein tau isoform X1 [KO:K04380]
127182157  stmn1a; stathmin 1a [KO:K04381]
127178426  stmn1b; stathmin 1b isoform X1 [KO:K04381]
127165244  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
127165245  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127165246  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127157537  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
127158235  cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
127158265  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127158631  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
127158929  cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
127158936  cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
127158970  cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
127158974  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
127179630  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
127179819  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
127160695  cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
127161098  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
127182996  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
127181878  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
127172414  il1b; interleukin-1 beta isoform X1 [KO:K04519]
127177456  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
127152294  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
127176018  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
127178652  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
127179824  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
127178952  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
127171275  zmp:0000000936; interleukin-1 receptor type 1 [KO:K04386]
127171365  interleukin-1 receptor type 1 isoform X1 [KO:K04386]
127176949  interleukin-1 receptor accessory protein [KO:K04723]
127155753  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
127178174  tgfbr1a; TGF-beta receptor type-1a [KO:K04674] [EC:2.7.11.30]
127170683  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
127178642  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
127183201  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
127179636  LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 26-like [KO:K04390]
127179732  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
127164254  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
127178200  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
127158366  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
127174083  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
127168243  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
127162984  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
127163181  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
127174070  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
127163279  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
127154286  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
127178154  cdc42l; cell division cycle 42, like [KO:K04393]
127173196  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
127168169  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
127164613  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
127176487  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
127176488  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
127165041  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
127165370  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
127166047  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
127182273  daxx; death domain-associated protein 6 isoform X1 [KO:K02308]
127156015  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
127169561  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
127156541  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
127168474  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
127169699  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
127154806  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
127173084  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
127167386  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
127173994  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
127152353  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
127167459  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
127162147  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
127167653  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
127173442  map4k3a; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
127179603  map4k3b; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
127176444  si:zfos-2326c3.2; misshapen-like kinase 1 isoform X1 [KO:K04407] [EC:2.7.11.1]
127162852  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
127180889  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
127153773  pak2b; serine/threonine-protein kinase PAK 2b isoform X1 [KO:K04410] [EC:2.7.11.1]
127178121  pak2a; serine/threonine-protein kinase PAK 2a [KO:K04410] [EC:2.7.11.1]
127182233  stk3; serine/threonine-protein kinase 3 [KO:K04412]
127152205  map4k6; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 6 [KO:K04414] [EC:2.7.11.1]
127168522  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
127174075  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
127171924  map3k1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
127168741  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
127166627  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
127155446  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
127156602  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
127175690  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
127181196  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
127175161  map3k21; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
127171209  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
127170973  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
127171135  map3k20a; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
127167429  protein kinase Npk [KO:K04424] [EC:2.7.11.25]
127178933  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
127182713  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
127182744  map3k7; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
127174736  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
127176905  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
127165228  taok3a; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
127165606  taok3b; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
127173818  taok2b; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
127162509  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
127152932  taok1b; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO1-B [KO:K04429] [EC:2.7.11.1]
127173925  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
127162692  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
127164041  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
127174013  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
127156877  mapk8ip1a; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 1a [KO:K04434]
127168419  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
127180867  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
127162610  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
127154838  flna; LOW QUALITY PROTEIN: filamin-B [KO:K04437]
127177264  crk; adapter molecule crk [KO:K04438]
127152559  crkl; crk-like protein [KO:K04438]
127177447  arrb1; beta-arrestin-1 [KO:K04439]
127172054  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
127167890  arrb2b; arrestin, beta 2b isoform X1 [KO:K04439]
127173973  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127152220  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
127174909  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127152675  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127154860  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
127173065  mapk14b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
127160702  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
127160703  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
127180572  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
127169462  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
127169667  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
127165094  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
127169970  mapkapk2b; MAP kinase-activated protein kinase 2b [KO:K04443] [EC:2.7.11.1]
127173203  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
127172743  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
127180092  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
127165663  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
127175099  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
127182089  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
127156555  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
127168966  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
127165315  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
127183046  jun; transcription factor AP-1 [KO:K04448]
127181005  jund; transcription factor jun-D [KO:K04449]
127171249  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
127165300  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
127160767  cellular tumor antigen p53 [KO:K04451]
127166974  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
127182965  max; protein max isoform X1 [KO:K04453]
127164779  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
127172156  mef2ca; myocyte enhancer factor 2ca [KO:K04454]
127165438  hspb1; heat shock protein beta-1 [KO:K04455]
127171830  akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
127168081  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127179883  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127151836  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
127180526  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127174741  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
127176820  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
127174809  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
127152814  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
127183121  ppm1ab; protein phosphatase, Mg2+/Mn2+ dependent, 1Ab [KO:K04457] [EC:3.1.3.16]
127164025  ptprr; tyrosine-protein phosphatase non-receptor type 5 [KO:K04458] [EC:3.1.3.48]
127168439  ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
127161711  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
127153933  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127164146  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127170295  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127156373  dusp8a; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127173115  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127152260  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
127156712  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
127183379  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
127158252  dusp3b; dual specificity protein phosphatase 3b isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
127174064  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
127177455  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
127173972  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
127175073  ppm1ba; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
127177124  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
127177156  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
127171678  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
127158896  heat shock 70 kDa protein [KO:K03283]
127158906  heat shock 70 kDa protein 1 [KO:K03283]
127163081  heat shock 70 kDa protein-like [KO:K03283]
127169183  hspa1b; LOW QUALITY PROTEIN: heat shock 70 kDa protein-like [KO:K03283]
127163131  LOW QUALITY PROTEIN: heat shock 70 kDa protein-like [KO:K03283]
127177158  mecom; MDS1 and EVI1 complex locus protein EVI1-A isoform X1 [KO:K04462] [EC:2.1.1.367]
127168263  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
127173906  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
127154818  nr4a1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
127155908  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
127162681  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
127175327  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
127169911  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
127155107  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
127176734  nlk2; LOW QUALITY PROTEIN: serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
127162656  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
127175896  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
127175279  nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
127167944  rela; transcription factor p65 [KO:K04735]
127177091  relb; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
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Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
lroh04070  Phosphatidylinositol signaling system
lroh04110  Cell cycle
lroh04115  p53 signaling pathway
lroh04210  Apoptosis
lroh04310  Wnt signaling pathway
KO pathway
ko04010   
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