KEGG   PATHWAY: mamb04910
Entry
mamb04910                   Pathway                                
Name
Insulin signaling pathway - Megalobrama amblycephala (Wuchang bream)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
mamb04910  Insulin signaling pathway
mamb04910

Organism
Megalobrama amblycephala (Wuchang bream) [GN:mamb]
Gene
125259323  insb; LOW QUALITY PROTEIN: preproinsulin b [KO:K04526]
125266058  ins; insulin [KO:K04526]
125277562  insulin [KO:K04526]
125263650  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
125251149  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
125248458  irs1; insulin receptor substrate 1-B isoform X1 [KO:K16172]
125269983  irs2b; insulin receptor substrate 2 [KO:K07187]
125252736  irs4a; insulin receptor substrate 2-A [KO:K07187]
125272323  irs2a; insulin receptor substrate 2a [KO:K07187]
125265406  insulin receptor substrate 2-B isoform X1 [KO:K07187]
125273996  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
125267879  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125250735  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125250270  pik3r3a; phosphoinositide-3-kinase, regulatory subunit 3a (gamma) [KO:K02649]
125248809  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125256148  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125259868  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125259888  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125270192  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a [KO:K06276] [EC:2.7.11.1]
125257763  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
125262568  akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
125278141  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125271808  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125253756  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125269260  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125276757  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125269959  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125271949  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
125244600  gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
125279463  gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
125278904  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
125265892  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
125266218  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
125254963  ppp1cab; LOW QUALITY PROTEIN: protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
125268817  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
125276563  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
125252186  ppp1r3b; protein phosphatase 1 regulatory subunit 3B isoform X1 [KO:K07189]
125279857  si:ch211-167b20.8; protein phosphatase 1 regulatory subunit 3A isoform X1 [KO:K07189]
125280444  ppp1r3c2b; protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
125247575  ppp1r3ab; uncharacterized protein ppp1r3ab [KO:K07189]
125268739  ppp1r3ca; protein phosphatase 1, regulatory subunit 3Ca [KO:K07189]
125257001  ppp1r3db; protein phosphatase 1, regulatory subunit 3Db [KO:K07189]
125260517  ppp1r3da; protein phosphatase 1, regulatory subunit 3Da [KO:K07189]
125260949  ppp1r3cb; protein phosphatase 1 regulatory subunit 3C-B [KO:K07189]
125254792  protein phosphatase 1 regulatory subunit 3E isoform X1 [KO:K07189]
125252630  phkg1b; phosphorylase kinase, gamma 1b (muscle) [KO:K00871] [EC:2.7.11.19]
125248481  phkg1a; phosphorylase kinase, gamma 1a (muscle) [KO:K00871] [EC:2.7.11.19]
125255993  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
125264910  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
125265073  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
125256461  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
125279053  calm1b; calmodulin-1b [KO:K02183]
125264806  calml4a; calmodulin-like protein 4a [KO:K02183]
125253545  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
125247787  calml4b; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
125248338  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
125255503  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
125268828  calm1a; calmodulin-1a [KO:K02183]
125277263  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
125264482  pygmb; phosphorylase, glycogen, muscle b [KO:K00688] [EC:2.4.1.1]
125252697  pygma; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
125268797  pygb; glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
125277313  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
125264639  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
125278182  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
125255428  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
125256470  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
125251891  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
125263136  prkar2ab; protein kinase, cAMP-dependent, regulatory, type II, alpha, B [KO:K04739]
125271590  prkar1aa; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a [KO:K04739]
125279881  prkar2aa; protein kinase, cAMP-dependent, regulatory, type II, alpha A [KO:K04739]
125246800  cAMP-dependent protein kinase type II-beta regulatory subunit [KO:K04739]
125266897  prkar1b; cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
125255201  prkar1ab; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b [KO:K04739]
125242790  lipeb; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
125275320  lipea; lipase, hormone-sensitive a isoform X1 [KO:K07188] [EC:3.1.1.79]
125279269  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
125250191  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
125265600  solute carrier family 2, facilitated glucose transporter member 4-like [KO:K07191]
125242906  flot1b; flotillin-1b [KO:K07192]
125248405  flot2b; flotillin-2b [KO:K07192]
125267054  flot2a; flotillin-2a [KO:K07192]
125275677  flot1a; flotillin-1a isoform X1 [KO:K07192]
125249001  SH2B adapter protein 2 [KO:K07193]
125276857  sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
125248189  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
125248821  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K04707] [EC:2.3.2.27]
125261588  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
125252400  crkl; crk-like protein [KO:K04438]
125248369  crk; adapter molecule crk [KO:K04438]
125252103  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
125279383  rapgef1a; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
125254949  rhoq; LOW QUALITY PROTEIN: rho-related GTP-binding protein RhoQ [KO:K07194]
125255042  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
125269129  trip10a; cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
125266481  srebf1; sterol regulatory element-binding protein 1 [KO:K07197]
125267910  acaca; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
125267209  acacb; acetyl-CoA carboxylase isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
125255972  fasn; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
125267357  hk2; hexokinase-2 [KO:K00844] [EC:2.7.1.1]
125276845  hkdc1; hexokinase HKDC1 [KO:K00844] [EC:2.7.1.1]
125276846  hk1; hexokinase-1 isoform X1 [KO:K00844] [EC:2.7.1.1]
125280380  gck; hexokinase-4 [KO:K12407] [EC:2.7.1.2]
125279103  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
125267131  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
125280055  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b isoform X1 [KO:K07199]
125250094  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
125256984  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
125252003  prkag2b; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
125270101  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
125272845  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
125274087  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
125257519  prkag2a; 5'-AMP-activated protein kinase subunit gamma-2a isoform X1 [KO:K07200]
125262191  foxo1b; forkhead box protein O1-B [KO:K07201]
125248756  foxo1a; forkhead box protein O1-A [KO:K07201]
125265670  ppargc1a; LOW QUALITY PROTEIN: peroxisome proliferator-activated receptor gamma coactivator 1-alpha [KO:K07202]
125277750  g6pc1b; glucose-6-phosphatase b isoform X1 [KO:K01084] [EC:3.1.3.9]
125255383  g6pc1a.2; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
125255653  g6pc1a.1; LOW QUALITY PROTEIN: glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 [KO:K01084] [EC:3.1.3.9]
125255953  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
125266424  fbp1b; fructose-1,6-bisphosphatase 1b [KO:K03841] [EC:3.1.3.11]
125267435  fbp2; fructose-1,6-bisphosphatase isozyme 2 isoform X1 [KO:K03841] [EC:3.1.3.11]
125267436  fbp1a; fructose-1,6-bisphosphatase 1a [KO:K03841] [EC:3.1.3.11]
125257792  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
125273405  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
125280262  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
125261534  rptor; regulatory-associated protein of mTOR [KO:K07204]
125262736  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
125248497  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
125272030  rps6; 40S ribosomal protein S6 [KO:K02991]
125252124  eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
125258921  eif4ea; eukaryotic translation initiation factor 4E-1A isoform X1 [KO:K03259]
125267781  eif4e1b; eukaryotic translation initiation factor 4E-1B isoform X1 [KO:K03259]
125250709  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
125276545  eif4eb; eukaryotic translation initiation factor 4eb isoform X1 [KO:K03259]
125276626  eif4e1c; eukaryotic translation initiation factor 4E family member 1c [KO:K03259]
125260565  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
125252238  tsc1b; TSC complex subunit 1b isoform X1 [KO:K07206]
125266734  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
125271746  tsc2; tuberin isoform X1 [KO:K07207]
125258173  rheb; GTP-binding protein Rheb [KO:K07208]
125278119  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
125252459  bada; uncharacterized protein bada [KO:K02158]
125264027  LOW QUALITY PROTEIN: bcl2-associated agonist of cell death-like [KO:K02158]
125264575  bcl2-associated agonist of cell death-like [KO:K02158]
125244114  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
125263808  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
125252380  shc3; SHC-transforming protein 3 isoform X1 [KO:K17448]
125273837  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
125250125  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
125274479  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
125277302  sos2; son of sevenless homolog 2 [KO:K03099]
125265127  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
125247376  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
125279450  zgc:55558; GTPase KRas [KO:K07827]
125246538  kras; GTPase KRas isoform X1 [KO:K07827]
125279259  nras; GTPase NRas [KO:K07828]
125266490  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
125246121  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125259699  raf1a; LOW QUALITY PROTEIN: raf-1 proto-oncogene, serine/threonine kinase a [KO:K04366] [EC:2.7.11.1]
125256524  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125253954  map2k1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125263787  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
125250873  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
125267337  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
125275450  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125279338  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b isoform X1 [KO:K04372] [EC:2.7.11.1]
125250586  mknk2a; MAP kinase-interacting serine/threonine-protein kinase 2a [KO:K04372] [EC:2.7.11.1]
125256350  mknk1; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
125279522  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
125272715  socs1b; suppressor of cytokine signaling 1b [KO:K04694]
125275571  socs1a; suppressor of cytokine signaling 1a [KO:K04694]
125245380  socs2; suppressor of cytokine signaling 2 [KO:K04695]
125263117  socs3a; suppressor of cytokine signaling 3a [KO:K04696]
125255451  socs3b; suppressor of cytokine signaling 3b [KO:K04696]
125268470  socs4; suppressor of cytokine signaling 4 [KO:K04697]
125279725  ptpn1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
125274092  ptprfa; protein tyrosine phosphatase receptor type Fa isoform X1 [KO:K05695] [EC:3.1.3.48]
125250103  ptprfb; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
125252240  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125252441  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
125255077  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125277047  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125279685  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
125258696  inppl1b; inositol polyphosphate phosphatase-like 1b [KO:K15909] [EC:3.1.3.86]
125248110  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A [KO:K15909] [EC:3.1.3.86]
125276508  inositol polyphosphate-5-phosphatase A isoform X1 [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14635525
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
PMID:11282018
  Authors
Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
PMID:12867054
  Authors
Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
PMID:10196204
  Authors
Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
PMID:15733744
  Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
  Journal
Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
  Authors
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.
  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
  Journal
Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
PMID:11742412
  Authors
Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
  Journal
Nature 414:799-806 (2001)
DOI:10.1038/414799a
Reference
PMID:15624019
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
PMID:16288289
  Authors
Ruggero D, Sonenberg N.
  Title
The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
PMID:10567225
  Authors
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
  Journal
Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
  Authors
Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
  Journal
Mol Cell Biochem 182:23-9 (1998)
Reference
PMID:15229476
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
  Authors
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
PMID:17344645
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
PMID:18291668
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
PMID:11343120
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
PMID:12791379
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
mamb00010  Glycolysis / Gluconeogenesis
mamb00061  Fatty acid biosynthesis
mamb00500  Starch and sucrose metabolism
mamb04010  MAPK signaling pathway
mamb04070  Phosphatidylinositol signaling system
mamb04210  Apoptosis
KO pathway
ko04910   
LinkDB

DBGET integrated database retrieval system