KEGG   PATHWAY: mcoc04726
Entry
mcoc04726                   Pathway                                
Name
Serotonergic synapse - Mastomys coucha (southern multimammate mouse)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
mcoc04726  Serotonergic synapse
mcoc04726

Other DBs
GO: 0007210
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116102248  Tph1; tryptophan 5-hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
116076348  Tph2; tryptophan 5-hydroxylase 2 isoform X1 [KO:K00502] [EC:1.14.16.4]
116068895  Ddc; aromatic-L-amino-acid decarboxylase isoform X1 [KO:K01593] [EC:4.1.1.28 4.1.1.105]
116104058  Slc18a2; synaptic vesicular amine transporter isoform X1 [KO:K08155]
116071446  Slc18a1; chromaffin granule amine transporter [KO:K08155]
116099482  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
116084337  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
116102419  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
116069682  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116084961  Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
116088689  Htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
116089405  Htr2c; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
116103624  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
116103465  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
116090695  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
116090998  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
116090999  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
116099362  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
116099798  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
116075536  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
116076783  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116102917  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116101512  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
116102969  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116073648  Mapk6; mitogen-activated protein kinase 6 [KO:K04371] [EC:2.7.11.24]
116085641  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116100272  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
116100719  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
116090743  Pla2g4b; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
116090754  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
116090758  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
116090760  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
116103883  cytochrome P450 2C23 [KO:K07413] [EC:1.14.14.1]
116101173  cytochrome P450 2C70 isoform X1 [KO:K07413] [EC:1.14.14.1]
116072985  cytochrome P450 2C40-like isoform X1 [KO:K07413] [EC:1.14.14.1]
116072994  cytochrome P450 2C13, male-specific-like isoform X1 [KO:K07413] [EC:1.14.14.1]
116076713  cytochrome P450 2D1-like isoform X1 [KO:K07414] [EC:1.14.14.1]
116081639  cytochrome P450 2D26 isoform X1 [KO:K07414] [EC:1.14.14.1]
116104676  cytochrome P450 2D10-like [KO:K07414] [EC:1.14.14.1]
116095445  cytochrome P450 2J5-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
116095729  cytochrome P450 2J6-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
116095730  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
116096253  cytochrome P450 2J3-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
116096254  cytochrome P450 2J3-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
116096255  cytochrome P450 2J6 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
116096256  cytochrome P450 2J3 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
116096432  cytochrome P450 4X1 isoform X1 [KO:K07428] [EC:1.14.14.1]
116099451  Alox5; arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
116077965  arachidonate 12-lipoxygenase, 12S-type isoform X1 [KO:K00458] [EC:1.13.11.31]
116078134  Alox12b; arachidonate 12-lipoxygenase, 12R-type isoform X1 [KO:K08021] [EC:1.13.11.-]
116077201  Alox15b; arachidonate 15-lipoxygenase B isoform X1 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
116090081  Ptgs1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
116070506  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
116072324  Htr3a; 5-hydroxytryptamine receptor 3A isoform X1 [KO:K04819]
116072384  Htr3b; 5-hydroxytryptamine receptor 3B [KO:K04819]
116087250  Htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
116095628  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
116103776  Htr7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
116091495  guanine nucleotide-binding protein G(s) subunit alpha isoforms short isoform X1 [KO:K04632]
116091496  neuroendocrine secretory protein 55 [KO:K04632]
116085856  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
116093928  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116069698  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116087124  Kcnn2; small conductance calcium-activated potassium channel protein 2 isoform X1 [KO:K04943]
116098615  Kcnd2; potassium voltage-gated channel subfamily D member 2 [KO:K04892]
116102310  Gabrb3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
116076803  Gabrb2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181]
116071171  Gabrb1; gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181]
116078746  Rapgef3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
116086086  App; amyloid-beta precursor protein isoform X1 [KO:K04520]
116096865  Htr1d; 5-hydroxytryptamine receptor 1D [KO:K04153]
116083307  Htr1a; 5-hydroxytryptamine receptor 1A [KO:K04153]
116086048  Htr1f; 5-hydroxytryptamine receptor 1F [KO:K04153]
116073103  Htr1b; 5-hydroxytryptamine receptor 1B [KO:K04153]
116097430  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
116070006  5-hydroxytryptamine receptor 5B [KO:K04161]
116097497  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
116093617  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
116072321  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
116069889  Gnao1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
116097142  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
116068597  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
116099581  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
116095064  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
116073026  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
116085348  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
116103521  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
116082206  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
116093923  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
116076327  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
116101712  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
116096080  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
116098540  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
116099017  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
116069754  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
116078416  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
116097985  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
116078231  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
116069240  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
116078286  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
116099791  Kras; GTPase KRas isoform X1 [KO:K07827]
116093530  Nras; GTPase NRas [KO:K07828]
116073820  Araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
116098774  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116099433  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116073764  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116067850  voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
116089786  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
116090184  Kcnj3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
116086174  Kcnj6; G protein-activated inward rectifier potassium channel 2 isoform X1 [KO:K05000]
116103700  Kcnj9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
116073438  Kcnj5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
116072568  Trpc1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
116078330  Slc6a4; sodium-dependent serotonin transporter isoform X1 [KO:K05037]
116071698  Maoa; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
116091802  Maob; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
mcoc00380  Tryptophan metabolism
mcoc00590  Arachidonic acid metabolism
mcoc04020  Calcium signaling pathway
mcoc04721  Synaptic vesicle cycle
mcoc04976  Bile secretion
KO pathway
ko04726   
LinkDB

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