KEGG   PATHWAY: mcoc04020
Entry
mcoc04020                   Pathway                                
Name
Calcium signaling pathway - Mastomys coucha (southern multimammate mouse)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
mcoc04020  Calcium signaling pathway
mcoc04020

Other DBs
GO: 0019722
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116067850  [KO:K04344]
116068035  [KO:K05863]
116068123  P2rx2; P2X purinoceptor 2 isoform X1 [KO:K05216]
116068158  [KO:K04282]
116068288  Nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
116068318  Tpcn1; two pore calcium channel protein 1 [KO:K16896]
116068368  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
116068374  P2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
116068382  Orai1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
116068481  Phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
116068561  Orai2; protein orai-2 isoform X1 [KO:K16057]
116068639  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116068749  [KO:K05863]
116068780  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116068831  Mcoln1; mucolipin-1 [KO:K04992]
116069012  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
116069056  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116069116  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
116069176  Camk1g; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
116069211  Cckar; cholecystokinin receptor type A [KO:K04194]
116069234  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
116069264  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
116069284  Vegfc; vascular endothelial growth factor C [KO:K05449]
116069603  Ednra; endothelin-1 receptor isoform X1 [KO:K04197]
116069682  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116069690  Ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
116069693  Drd5; D(1B) dopamine receptor [KO:K05840]
116069698  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116069762  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
116069775  Phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
116069817  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
116069961  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116069997  [KO:K02183]
116070006  [KO:K04161]
116070090  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
116070140  Avpr1b; vasopressin V1b receptor [KO:K04227]
116070251  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
116070680  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
116070881  Stim2; stromal interaction molecule 2 isoform X1 [KO:K18196]
116071260  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
116071273  Adrb3; beta-3 adrenergic receptor [KO:K04143]
116071284  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
116071359  Fgf20; fibroblast growth factor 20 [KO:K04358]
116071362  Ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
116071392  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116072446  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
116072648  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
116072666  Sln; sarcolipin [KO:K22642]
116072936  Mst1r; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
116073523  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
116073705  Mst1; hepatocyte growth factor-like protein [KO:K23441]
116074538  Tfeb; transcription factor EB isoform X1 [KO:K15590]
116074720  [KO:K05448]
116074834  Tacr2; substance-K receptor [KO:K04223]
116075043  Adora2a; adenosine receptor A2a [KO:K04266]
116075109  Pln; cardiac phospholamban [KO:K05852]
116075282  Mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
116075521  Mrln; myoregulin [KO:K22643]
116075536  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
116075890  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
116075891  Gna15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
116075957  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
116076053  Avpr1a; vasopressin V1a receptor [KO:K04226]
116076064  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
116076069  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
116076076  Tbxa2r; thromboxane A2 receptor [KO:K04264]
116076095  Grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
116076137  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
116076169  Erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
116076700  Smim6; small integral membrane protein 6 [KO:K26468]
116076727  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
116076770  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
116076778  Adora2b; adenosine receptor A2b [KO:K04267]
116076783  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116076938  Nos2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
116077296  P2rx5; P2X purinoceptor 5 isoform X1 [KO:K05219]
116077605  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116077667  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
116078169  Grin2c; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
116078345  Sphk1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
116078367  Adra1b; alpha-1B adrenergic receptor isoform X1 [KO:K04136]
116078435  Fgf18; fibroblast growth factor 18 [KO:K04358]
116078513  P2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
116078655  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
116078943  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116079029  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
116079663  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
116079808  Calm1; calmodulin-1 [KO:K02183]
116079827  Bdkrb2; B2 bradykinin receptor [KO:K03916]
116079867  Slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
116079993  Calm2; calmodulin-2 [KO:K02183]
116080109  Lhcgr; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
116080412  Bdkrb1; B1 bradykinin receptor [KO:K03915]
116080681  Slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
116080898  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
116081429  Ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
116081489  Mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
116081777  [KO:K02183]
116081906  Camk1d; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
116081961  Trhr; thyrotropin-releasing hormone receptor isoform X1 [KO:K04282]
116082049  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
116082061  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
116082168  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
116082246  Hrh2; histamine H2 receptor [KO:K04150]
116082258  [KO:K04166]
116082298  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
116082411  [KO:K02183]
116082435  Drd1; D(1A) dopamine receptor [KO:K04144]
116083356  Fgf10; fibroblast growth factor 10 [KO:K04358]
116083372  F2r; proteinase-activated receptor 1 [KO:K03914]
116083531  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
116083593  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
116084111  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
116084113  Ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
116084123  Tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
116084124  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116084142  [KO:K10784]
116084172  Cysltr2; cysteinyl leukotriene receptor 2 [KO:K04323]
116084214  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
116084337  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
116084380  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
116084437  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116084481  Adra1a; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
116084570  Ednrb; endothelin receptor type B [KO:K04198]
116084618  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
116084704  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
116084719  Fgf9; fibroblast growth factor 9 [KO:K04358]
116084777  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116084801  [KO:K10784]
116084832  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116084961  Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
116084963  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
116085323  Ptk2b; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
116085663  P2rx6; P2X purinoceptor 6 isoform X1 [KO:K05221]
116085852  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
116085949  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
116086957  Camk4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
116087087  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116087223  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
116087226  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
116087250  Htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
116087292  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
116087327  Phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
116087416  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
116087679  Adrb2; beta-2 adrenergic receptor [KO:K04142]
116088031  Cysltr1; cysteinyl leukotriene receptor 1 isoform X1 [KO:K04322]
116088089  Asph; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
116088530  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
116088574  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
116088689  Htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
116089405  Htr2c; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
116089786  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
116089804  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
116090205  Phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
116090361  Grpr; gastrin-releasing peptide receptor [KO:K04169]
116090374  Pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
116090409  P2rx3; P2X purinoceptor 3 isoform X1 [KO:K05217]
116090438  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
116090647  Ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
116090648  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
116090695  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
116090730  Itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
116090856  Fgf7; fibroblast growth factor 7 [KO:K04358]
116090966  Adra1d; alpha-1D adrenergic receptor isoform X1 [KO:K04137]
116090998  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
116090999  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
116091182  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
116091233  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
116091317  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
116091445  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
116091495  [KO:K04632]
116091496  [KO:K04632]
116092531  Tnnc2; troponin C, skeletal muscle [KO:K12042]
116092587  Ntsr1; neurotensin receptor type 1 [KO:K04211]
116093026  Pdgfc; platelet-derived growth factor C [KO:K05450]
116093096  [KO:K03176] [EC:2.7.10.1]
116093516  Casq2; calsequestrin-2 [KO:K23445]
116093520  Ngf; beta-nerve growth factor isoform X1 [KO:K02582]
116093731  CUNH4orf3; uncharacterized protein C4orf3 homolog isoform X1 [KO:K26467]
116093748  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
116093773  Egf; pro-epidermal growth factor [KO:K04357]
116093810  Tacr3; neuromedin-K receptor isoform X1 [KO:K04224]
116093830  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116093914  Mcoln3; mucolipin-3 [KO:K04994]
116093915  Mcoln2; mucolipin-2 isoform X1 [KO:K04993]
116093928  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116093940  Fgf16; fibroblast growth factor 16 [KO:K04358]
116093942  Ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
116093986  Ptger3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
116094433  [KO:K03176] [EC:2.7.10.1]
116094815  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
116094994  Agtr1; type-1 angiotensin II receptor [KO:K04166]
116095116  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
116095628  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
116096011  Grin3a; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
116096012  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
116096767  Ptafr; platelet-activating factor receptor [KO:K04279]
116097430  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
116097489  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
116097543  Nos3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
116097763  Grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
116097895  Trdn; triadin [KO:K23449]
116098343  Fgf6; fibroblast growth factor 6 [KO:K04358]
116098344  Fgf23; fibroblast growth factor 23 [KO:K22428]
116098601  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
116098629  Cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
116098726  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
116098968  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
116099029  [KO:K05862]
116099115  Tacr1; substance-P receptor [KO:K04222]
116099176  Tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
116099362  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
116099377  Oxtr; oxytocin receptor [KO:K04229]
116099379  Atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
116099389  Camk1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
116099413  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
116099419  Hrh1; histamine H1 receptor isoform X1 [KO:K04149]
116099474  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
116099482  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
116099710  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
116099747  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
116099798  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
116100498  Fgf21; fibroblast growth factor 21 [KO:K22429]
116100789  Cckbr; gastrin/cholecystokinin type B receptor [KO:K04195]
116100989  Fgf3; fibroblast growth factor 3 [KO:K04358]
116100990  Fgf4; fibroblast growth factor 4 [KO:K04358]
116100991  Fgf19; fibroblast growth factor 19 [KO:K22603]
116101280  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116101512  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
116101525  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
116101674  Slc8a2; sodium/calcium exchanger 2 [KO:K05849]
116101711  Calm3; calmodulin-3 [KO:K02183]
116101874  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
116101936  Ryr1; ryanodine receptor 1 isoform X1 [KO:K04961]
116102192  Hrc; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
116102223  Grin2d; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
116102330  Chrna7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
116102418  Ntrk3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
116102419  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
116102534  Grm5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
116102663  [KO:K02183]
116102693  Stim1; stromal interaction molecule 1 isoform X1 [KO:K16059]
116102917  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116102951  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
116103020  Phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
116103033  Orai3; protein orai-3 [KO:K16058]
116103077  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116103286  Tpcn2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
116103465  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
116103472  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
116103504  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
116103624  [KO:K04634]
116103627  Gna14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
116103688  Casq1; calsequestrin-1 [KO:K23468]
116103776  Htr7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
116103808  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
116104027  Adrb1; beta-1 adrenergic receptor [KO:K04141]
116104656  Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
mcoc04010  MAPK signaling pathway
mcoc04070  Phosphatidylinositol signaling system
mcoc04210  Apoptosis
mcoc04720  Long-term potentiation
mcoc04730  Long-term depression
KO pathway
ko04020   

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