KEGG   PATHWAY: morg04371
Entry
morg04371                   Pathway                                
Name
Apelin signaling pathway - Microtus oregoni (creeping vole)
Description
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.
Class
Environmental Information Processing; Signal transduction
Pathway map
morg04371  Apelin signaling pathway
morg04371

Other DBs
GO: 0060183
Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121459308  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
121433645  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
121439713  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121439725  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121434995  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
121461694  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
121441427  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
121446853  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
121461516  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
121463621  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
121455092  Adcy10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
121455756  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121451033  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121450098  Lipe; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
121444823  apelin-like [KO:K05225]
121444891  apelin [KO:K05225]
121462524  Apela; apelin receptor early endogenous ligand [KO:K25355]
121458474  apelin receptor early endogenous ligand-like [KO:K25355]
121452735  apelin receptor early endogenous ligand-like [KO:K25355]
121439121  apelin receptor [KO:K04174]
121439309  apelin receptor-like [KO:K04174]
121464390  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
121458947  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
121437910  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121446778  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121434752  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
121448045  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
121441334  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like [KO:K04536]
121443529  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
121445292  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
121437224  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
121452935  Gnb4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
121466217  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
121438645  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
121454312  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
121432656  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4-like [KO:K04541]
121432753  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
121452966  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
121447724  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
121459792  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
121450195  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
121451544  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
121463435  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
121447476  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
121447130  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
121434081  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
121462469  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
121463952  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
121463507  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
121456481  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
121454687  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
121460541  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
121454560  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
121465646  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
121460033  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
121440758  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121433763  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
121435401  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
121449089  Ryr1; ryanodine receptor 1 isoform X1 [KO:K04961]
121432610  Ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
121465671  Ryr3; ryanodine receptor 3 [KO:K04963]
121462368  calmodulin-1 [KO:K02183]
121465992  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
121432548  Calml5; calmodulin-like protein 5 isoform X1 [KO:K02183]
121432747  calmodulin-like protein 3 [KO:K02183]
121432887  Calm2; calmodulin-2 [KO:K02183]
121434435  Calm1; calmodulin-1 [KO:K02183]
121449209  Calm3; calmodulin-3 [KO:K02183]
121445990  Nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
121456433  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
121439958  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
121432846  Prkce; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
121448105  Slc9a1; sodium/hydrogen exchanger 1 [KO:K05742]
121452329  Slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
121432854  Slc8a1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
121449173  Slc8a2; sodium/calcium exchanger 2 [KO:K05849]
121461750  Mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
121460317  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
121447126  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
121433988  Mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
121446255  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
121464393  Myl3; myosin light chain 3 [KO:K12749]
121436246  Myl4; myosin light chain 4 [KO:K12750]
121458090  Hras; GTPase HRas [KO:K02833]
121466497  Kras; GTPase KRas isoform X1 [KO:K07827]
121437938  Nras; GTPase NRas [KO:K07828]
121456962  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
121457996  Rras2; ras-related protein R-Ras2 [KO:K07830]
121464286  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
121443425  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121466018  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121459389  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121458143  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121464725  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121454174  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
121457121  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
121454447  40S ribosomal protein S6-like [KO:K02991]
121455927  40S ribosomal protein S6-like [KO:K02991]
121455946  40S ribosomal protein S6-like [KO:K02991]
121452391  40S ribosomal protein S6-like [KO:K02991]
121440057  40S ribosomal protein S6-like [KO:K02991]
121441148  40S ribosomal protein S6-like [KO:K02991]
121448763  Rps6; 40S ribosomal protein S6 [KO:K02991]
121452362  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
121456538  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
121456743  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
121434429  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121449224  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121435875  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121448014  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
121441746  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
121453637  early growth response protein 1 [KO:K09203]
121443037  early growth response protein 1-like [KO:K09203]
121440975  Spp1; osteopontin [KO:K06250]
121460325  Jag1; protein jagged-1 [KO:K06052]
121432424  Notch3; neurogenic locus notch homolog protein 3 [KO:K20995]
121454505  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
121457865  G1/S-specific cyclin-D1 [KO:K04503]
121457850  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
121453313  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
121441902  phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
121464448  Pik3r4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
121442443  Becn1; beclin-1 isoform X1 [KO:K08334]
121460108  Map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
121447271  Map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
121432949  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
121447974  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
121438000  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
121446539  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
121439948  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
121447397  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
121441426  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
121453362  Plin1; perilipin-1 [KO:K08768]
121442270  Ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
121455936  Ucp1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
121463346  Nrf1; nuclear respiratory factor 1 isoform X1 [KO:K11831]
121450901  Tfam; transcription factor A, mitochondrial [KO:K11830]
121462787  Klf2; Krueppel-like factor 2 isoform X1 [KO:K17845]
121457079  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
121436240  Sphk1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
121436098  Gna13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
121453240  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
121445161  Camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
121446843  Hdac4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
121433402  histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
121435990  Hdac5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
121451443  Mef2a; myocyte-specific enhancer factor 2A isoform X1 [KO:K09260]
121463032  myocyte-specific enhancer factor 2B isoform X1 [KO:K09261]
121455823  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
121450642  Mef2d; myocyte-specific enhancer factor 2D isoform X1 [KO:K09262]
121458328  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
121438761  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
121466030  Smad3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121438756  Smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
121453934  Acta2; actin, aortic smooth muscle [KO:K12313]
121447012  Cdh1; cadherin-1 [KO:K05689]
121450066  Ccn2; CCN family member 2 [KO:K06827]
121452947  Agtr1; type-1 angiotensin II receptor [KO:K04166]
121433907  type-1A angiotensin II receptor [KO:K04166]
121446504  Serpine1; plasminogen activator inhibitor 1 [KO:K03982]
121462448  Plat; tissue-type plasminogen activator isoform X1 [KO:K01343] [EC:3.4.21.68]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
Reference
PMID:26143239
  Authors
Yang P, Maguire JJ, Davenport AP
  Title
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
  Journal
Trends Pharmacol Sci 36:560-7 (2015)
DOI:10.1016/j.tips.2015.06.002
Reference
PMID:22140623
  Authors
Andersen CU, Hilberg O, Mellemkjaer S, Nielsen-Kudsk JE, Simonsen U
  Title
Apelin and pulmonary hypertension.
  Journal
Pulm Circ 1:334-46 (2011)
DOI:10.4103/2045-8932.87299
Reference
PMID:25275559
  Authors
Chapman NA, Dupre DJ, Rainey JK
  Title
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.
  Journal
Biochem Cell Biol 92:431-40 (2014)
DOI:10.1139/bcb-2014-0072
Reference
PMID:18272138
  Authors
Japp AG, Newby DE
  Title
The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential.
  Journal
Biochem Pharmacol 75:1882-92 (2008)
DOI:10.1016/j.bcp.2007.12.015
Reference
PMID:25652330
  Authors
Folino A, Montarolo PG, Samaja M, Rastaldo R
  Title
Effects of apelin on the cardiovascular system.
  Journal
Heart Fail Rev 20:505-18 (2015)
DOI:10.1007/s10741-015-9475-x
Reference
PMID:23943882
  Authors
O'Carroll AM, Lolait SJ, Harris LE, Pope GR
  Title
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
  Journal
J Endocrinol 219:R13-35 (2013)
DOI:10.1530/JOE-13-0227
Reference
PMID:23973488
  Authors
Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ
  Title
Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
  Journal
Biochem Biophys Res Commun 439:235-40 (2013)
DOI:10.1016/j.bbrc.2013.08.051
Reference
PMID:26254105
  Authors
Novakova V, Sandhu GS, Dragomir-Daescu D, Klabusay M
  Title
Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia.
  Journal
Vascul Pharmacol 76:1-10 (2016)
DOI:10.1016/j.vph.2015.08.005
Reference
PMID:21725702
  Authors
Castan-Laurell I, Dray C, Attane C, Duparc T, Knauf C, Valet P
  Title
Apelin, diabetes, and obesity.
  Journal
Endocrine 40:1-9 (2011)
DOI:10.1007/s12020-011-9507-9
Reference
PMID:23924696
  Authors
Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D, Lu Q, Chen L, Li J
  Title
Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:875-81 (2013)
DOI:10.1093/abbs/gmt085
Reference
PMID:24990699
  Authors
Wu D, He L, Chen L
  Title
Apelin/APJ system: a promising therapy target for hypertension.
  Journal
Mol Biol Rep 41:6691-703 (2014)
DOI:10.1007/s11033-014-3552-4
Reference
PMID:20539939
  Authors
Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F, Chen F, Liao D, Chen L
  Title
PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13.
  Journal
Acta Biochim Biophys Sin (Shanghai) 42:396-402 (2010)
DOI:10.1093/abbs/gmq035
Reference
PMID:26607438
  Authors
Xie F, Liu W, Feng F, Li X, He L, Lv D, Qin X, Li L, Li L, Chen L
  Title
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
  Journal
Acta Biochim Biophys Sin (Shanghai) 47:969-80 (2015)
DOI:10.1093/abbs/gmv111
Reference
PMID:27979574
  Authors
Lu L, Wu D, Li L, Chen L
  Title
Apelin/APJ system: A bifunctional target for cardiac hypertrophy.
  Journal
Int J Cardiol 230:164-170 (2017)
DOI:10.1016/j.ijcard.2016.11.215
Reference
PMID:16182514
  Authors
Carmen GY, Victor SM
  Title
Signalling mechanisms regulating lipolysis.
  Journal
Cell Signal 18:401-8 (2006)
DOI:10.1016/j.cellsig.2005.08.009
Reference
PMID:27650065
  Authors
Hu H, He L, Li L, Chen L
  Title
Apelin/APJ system as a therapeutic target in diabetes and its complications.
  Journal
Mol Genet Metab 119:20-7 (2016)
DOI:10.1016/j.ymgme.2016.07.012
Reference
PMID:25914650
  Authors
Bertrand C, Valet P, Castan-Laurell I
  Title
Apelin and energy metabolism.
  Journal
Front Physiol 6:115 (2015)
DOI:10.3389/fphys.2015.00115
Reference
PMID:26385179
  Authors
Yao F, Lv YC, Zhang M, Xie W, Tan YL, Gong D, Cheng HP, Liu D, Li L, Liu XY, Zheng XL, Tang CK
  Title
Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway.
  Journal
Biochem Biophys Res Commun 466:637-43 (2015)
DOI:10.1016/j.bbrc.2015.09.045
Reference
PMID:22842084
  Authors
Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P
  Title
Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
  Journal
Mol Cell Endocrinol 362:227-41 (2012)
DOI:10.1016/j.mce.2012.07.002
Reference
PMID:24055369
  Authors
Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK
  Title
Apelin and its receptor APJ in cardiovascular diseases.
  Journal
Clin Chim Acta 428:1-8 (2014)
DOI:10.1016/j.cca.2013.09.001
Reference
PMID:25931124
  Authors
Than A, He HL, Chua SH, Xu D, Sun L, Leow MK, Chen P
  Title
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes.
  Journal
J Biol Chem 290:14679-91 (2015)
DOI:10.1074/jbc.M115.643817
Reference
PMID:25139773
  Authors
Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X
  Title
Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.
  Journal
Diabetes Metab Res Rev 31:433-52 (2015)
DOI:10.1002/dmrr.2600
Reference
PMID:21464822
  Authors
Aharoni-Simon M, Hann-Obercyger M, Pen S, Madar Z, Tirosh O
  Title
Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice.
  Journal
Lab Invest 91:1018-28 (2011)
DOI:10.1038/labinvest.2011.55
Reference
PMID:22995518
  Authors
McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ
  Title
Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.
  Journal
Arterioscler Thromb Vasc Biol 32:2640-3 (2012)
DOI:10.1161/ATVBAHA.112.300317
Reference
PMID:22028387
  Authors
Pchejetski D, Foussal C, Alfarano C, Lairez O, Calise D, Guilbeau-Frugier C, Schaak S, Seguelas MH, Wanecq E, Valet P, Parini A, Kunduzova O
  Title
Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.
  Journal
Eur Heart J 33:2360-9 (2012)
DOI:10.1093/eurheartj/ehr389
Reference
PMID:26944568
  Authors
Huang S, Chen L, Lu L, Li L
  Title
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis.
  Journal
Clin Chim Acta 456:81-8 (2016)
DOI:10.1016/j.cca.2016.02.025
Reference
PMID:19093215
  Authors
Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA
  Title
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
  Journal
Angiogenesis 12:1-15 (2009)
DOI:10.1007/s10456-008-9123-3
Reference
PMID:23603510
  Authors
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ
  Title
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
  Journal
Circ Res 113:22-31 (2013)
DOI:10.1161/CIRCRESAHA.113.301324
Reference
PMID:25164121
  Authors
Wang LY, Diao ZL, Zhang DL, Zheng JF, Zhang QD, Ding JX, Liu WH
  Title
The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis.
  Journal
Amino Acids 46:2693-704 (2014)
DOI:10.1007/s00726-014-1826-8
Reference
PMID:26756969
  Authors
Zhou Y, Deng L, Zhao D, Chen L, Yao Z, Guo X, Liu X, Lv L, Leng B, Xu W, Qiao G, Shan H
  Title
MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13.
  Journal
J Cell Mol Med 20:495-505 (2016)
DOI:10.1111/jcmm.12754
Reference
PMID:27825851
  Authors
Zhong JC, Zhang ZZ, Wang W, McKinnie SM, Vederas JC, Oudit GY
  Title
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.
  Journal
Biochim Biophys Acta 1863:1942-1950 (2017)
DOI:10.1016/j.bbadis.2016.11.007
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