KEGG   PATHWAY: ncc04514
Entry
ncc04514                    Pathway                                
Name
Cell adhesion molecules - Notothenia coriiceps (black rockcod)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ncc04514  Cell adhesion molecules
ncc04514

Other DBs
GO: 0050839
Organism
Notothenia coriiceps (black rockcod) [GN:ncc]
Gene
104950345  T-lymphocyte surface antigen Ly-9-like [KO:K06449]
104956000  platelet receptor Gi24 [KO:K23268]
104946439  igsf11; immunoglobulin superfamily member 11 [KO:K06791]
104948812  programmed cell death 1 ligand 1-like [KO:K06745]
104945512  uncharacterized protein LOC104945512 isoform X1 [KO:K06470]
104952662  butyrophilin subfamily 3 member A3-like [KO:K05413]
104966627  T-lymphocyte activation antigen CD80-like [KO:K06710]
104959137  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
104959138  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
104968013  H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751]
104959111  H-2 class I histocompatibility antigen, D-P alpha chain-like [KO:K06751]
104964855  cd8a; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
104964854  uncharacterized protein LOC104964854 [KO:K06459]
104948664  butyrophilin-like protein 10 isoform X1 [KO:K06746]
104953673  CD276 antigen-like [KO:K06746]
104944029  V-set domain-containing T-cell activation inhibitor 1-like [KO:K06747]
104958049  tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K03160]
104947926  tumor necrosis factor receptor superfamily member 5-like [KO:K03160]
104953944  CD166 antigen homolog [KO:K06547]
104941017  CD166 antigen homolog A-like isoform X1 [KO:K06547]
104952929  T-cell differentiation antigen CD6-like [KO:K06456]
104957609  CD226 antigen-like isoform X1 [KO:K06567]
104962292  pvrl2; nectin-2 [KO:K06531]
104956319  integrin alpha-M-like [KO:K05718]
104946113  integrin beta-2-like [KO:K06464]
104962003  B-cell receptor CD22-like [KO:K06467]
104953304  B-cell receptor CD22-like [KO:K06467]
104950783  B-cell receptor CD22-like isoform X1 [KO:K06467]
104966428  ptprc; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
104945496  pvrl3; nectin-3 isoform X1 [KO:K06592]
104960963  claudin-1-like [KO:K06087]
104945655  claudin-6-like [KO:K06087]
104960321  claudin-4-like [KO:K06087]
104967001  claudin-18-like [KO:K06087]
104967965  claudin-18-like isoform X1 [KO:K06087]
104956035  claudin-14-like [KO:K06087]
104961217  claudin-4-like [KO:K06087]
104954195  claudin-9-like [KO:K06087]
104951216  claudin-4-like [KO:K06087]
104951217  claudin-like protein ZF-A89 [KO:K06087]
104951218  claudin-4-like [KO:K06087]
104951219  claudin-4-like [KO:K06087]
104951220  claudin-like protein ZF-A89 [KO:K06087]
104951486  claudin-3-like [KO:K06087]
104955637  claudin-11-like [KO:K06087]
104951614  cldn5; claudin-5 [KO:K06087]
104957832  claudin-4-like [KO:K06087]
104963021  claudin-3-like [KO:K06087]
104963022  claudin-3-like [KO:K06087]
104963023  claudin-4-like [KO:K06087]
104964981  cldn15; claudin-15 [KO:K06087]
104951772  claudin-4-like [KO:K06087]
104951773  claudin-4-like [KO:K06087]
104951774  claudin-4-like [KO:K06087]
104946218  claudin-22-like [KO:K06087]
104946793  claudin-23-like [KO:K06087]
104953056  claudin-9-like [KO:K06087]
104957625  cldn19; claudin-19 isoform X1 [KO:K06087]
104952531  claudin-4-like [KO:K06087]
104952532  claudin-4-like [KO:K06087]
104952533  claudin-4-like [KO:K06087]
104952534  claudin-4-like [KO:K06087]
104952535  claudin-4-like [KO:K06087]
104952536  claudin-4-like [KO:K06087]
104952538  claudin-4-like [KO:K06087]
104940783  claudin-11-like [KO:K06087]
104963589  cldn8; claudin-8 [KO:K06087]
104963590  claudin-8-like [KO:K06087]
104963591  claudin-4-like [KO:K06087]
104965956  claudin-1-like [KO:K06087]
104949956  claudin-10-like [KO:K06087]
104942886  claudin-7-A [KO:K06087]
104947832  putative claudin-24 [KO:K06087]
104947506  claudin-10-like isoform X1 [KO:K06087]
104947507  claudin-10-like [KO:K06087]
104947508  claudin-10-like isoform X1 [KO:K06087]
104940866  claudin-20-like [KO:K06087]
104948916  putative claudin-24 [KO:K06087]
104941271  cldn7; claudin-7 [KO:K06087]
104950247  cldn20; claudin-20 [KO:K06087]
104950749  claudin-23-like [KO:K06087]
104943986  claudin-4-like [KO:K06087]
104944269  claudin-15-like [KO:K06087]
104942176  claudin-10-like [KO:K06087]
104942187  claudin-10-like [KO:K06087]
104942197  claudin-10-like [KO:K06087]
104959146  cldn12; claudin-12 [KO:K06087]
104966541  occludin-like [KO:K06088]
104957385  occludin-like [KO:K06088]
104957781  occludin-like [KO:K06088]
104948062  ocln; occludin [KO:K06088]
104941020  f11r; LOW QUALITY PROTEIN: junctional adhesion molecule A [KO:K06089]
104951935  junctional adhesion molecule B-like [KO:K06735]
104961238  jam2; junctional adhesion molecule B isoform X1 [KO:K06735]
104947295  junctional adhesion molecule C-like [KO:K06785]
104945308  jam3; junctional adhesion molecule C [KO:K06785]
104951165  endothelial cell-selective adhesion molecule-like [KO:K06787]
104945318  LOW QUALITY PROTEIN: endothelial cell-selective adhesion molecule-like [KO:K06787]
104956393  platelet endothelial cell adhesion molecule-like [KO:K06471]
104948540  platelet endothelial cell adhesion molecule-like [KO:K06471]
104951985  CD99 antigen-like isoform X1 [KO:K06520]
104952280  P-selectin-like isoform X1 [KO:K06496]
104962655  itga4; integrin alpha-4 [KO:K06483]
104965598  itgb1; integrin beta-1 [KO:K05719]
104967819  itga9; integrin alpha-9 [KO:K06585]
104950785  B-cell receptor CD22-like [KO:K06527]
104943594  B-cell receptor CD22-like [KO:K06527]
104967165  B-cell receptor CD22-like [KO:K06527]
104944739  cd34; hematopoietic progenitor cell antigen CD34 [KO:K06474]
104944416  glg1; Golgi apparatus protein 1 isoform X1 [KO:K06816]
104944659  pvrl1; nectin-1 [KO:K06081]
104959304  cdh2; cadherin-2 [KO:K06736]
104959954  ncam1; neural cell adhesion molecule 1 [KO:K06491]
104956932  neural cell adhesion molecule L1-like [KO:K06550]
104943019  cell adhesion molecule 1-like [KO:K06781]
104953000  netrin-G1-like [KO:K07522]
104954183  ntng1; netrin-G1 isoform X1 [KO:K07522]
104966679  lrrc4c; leucine-rich repeat-containing protein 4C [KO:K07523]
104946080  leucine-rich repeat-containing protein 4C-like [KO:K07523]
104943762  filaggrin-2-like isoform X1 [KO:K16359]
104964231  leucine-rich repeat-containing protein 4-like [KO:K16351]
104947187  leucine-rich repeat-containing protein 4-like [KO:K16351]
104967281  usherin-like [KO:K05695] [EC:3.1.3.48]
104957902  receptor-type tyrosine-protein phosphatase F-like [KO:K05695] [EC:3.1.3.48]
104964196  leucine-rich repeat-containing protein 4B-like [KO:K16360]
104967554  sdc2; syndecan-2 [KO:K16336]
104943377  syndecan-2-A-like [KO:K16336]
104943524  syndecan-3-like [KO:K16337]
104946981  integrin beta-8-like [KO:K06591]
104968270  itga8; integrin alpha-8 [KO:K06584]
104951047  neurexin-1a-like [KO:K07377]
104952680  neurexin-1-like [KO:K07377]
104963306  neuroligin-4, X-linked-like [KO:K07378]
104967117  nlgn2; neuroligin-2 [KO:K07378]
104954573  neuroligin-3-like isoform X1 [KO:K07378]
104952214  neuroligin-3-like [KO:K07378]
104951991  nlgn4x; neuroligin-4, X-linked [KO:K07378]
104962319  receptor-type tyrosine-protein phosphatase S-like [KO:K06778] [EC:3.1.3.48]
104958261  receptor-type tyrosine-protein phosphatase delta-like [KO:K06778] [EC:3.1.3.48]
104955087  slitrk1; SLIT and NTRK-like protein 1 [KO:K25832]
104950641  slitrk2; SLIT and NTRK-like protein 2 [KO:K25833]
104965671  slitrk4; SLIT and NTRK-like protein 4 [KO:K25835]
104945265  SLIT and NTRK-like protein 5 [KO:K25836]
104947500  slitrk5; SLIT and NTRK-like protein 5 [KO:K25836]
104955300  slitrk6; SLIT and NTRK-like protein 6 [KO:K25837]
104968047  receptor-type tyrosine-protein phosphatase delta-like [KO:K06777] [EC:3.1.3.48]
104962705  ptprd; receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
104948154  slitrk3; SLIT and NTRK-like protein 3 [KO:K25834]
104965947  SLIT and NTRK-like protein 3 [KO:K25834]
104957426  cell adhesion molecule 3-like [KO:K06780]
104959307  neuronal cell adhesion molecule-like [KO:K06756]
104957432  neuronal cell adhesion molecule-like [KO:K06756]
104946836  nrcam; neuronal cell adhesion molecule [KO:K06756]
104962545  cntn1; contactin-1 [KO:K06759]
104966351  receptor-type tyrosine-protein phosphatase mu-like [KO:K05693] [EC:3.1.3.48]
104958236  contactin-2-like [KO:K06760]
104951829  neurofascin-like [KO:K06757]
104955231  neurofascin-like isoform X1 [KO:K06757]
104944058  cntnap1; contactin-associated protein 1 [KO:K07379]
104963386  contactin-associated protein-like 2 [KO:K07380]
104944814  mpz; myelin protein P0 isoform X1 [KO:K06770]
104962004  mag; myelin-associated glycoprotein isoform X1 [KO:K06771]
104961373  sialoadhesin-like isoform X1 [KO:K06771]
104965112  B-cadherin-like [KO:K05689]
104944126  versican core protein-like isoform X1 [KO:K06793]
104944359  integrin alpha-6-like [KO:K06485]
104948258  itga6; integrin alpha-6 [KO:K06485]
104955428  cadherin-4-like [KO:K06797]
104949831  cadherin-4-like [KO:K06797]
104954991  LOW QUALITY PROTEIN: cadherin-15-like [KO:K06809]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
ncc04520  Adherens junction
ncc04530  Tight junction
KO pathway
ko04514   
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