KEGG   PATHWAY: ncc04530
Entry
ncc04530                    Pathway                                
Name
Tight junction - Notothenia coriiceps (black rockcod)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ncc04530  Tight junction
ncc04530

Other DBs
GO: 0005923
Organism
Notothenia coriiceps (black rockcod) [GN:ncc]
Gene
104960313  crb3; protein crumbs homolog 3 [KO:K06090]
104960963  claudin-1-like [KO:K06087]
104945655  claudin-6-like [KO:K06087]
104960321  claudin-4-like [KO:K06087]
104967001  claudin-18-like [KO:K06087]
104967965  claudin-18-like isoform X1 [KO:K06087]
104956035  claudin-14-like [KO:K06087]
104961217  claudin-4-like [KO:K06087]
104954195  claudin-9-like [KO:K06087]
104951216  claudin-4-like [KO:K06087]
104951217  claudin-like protein ZF-A89 [KO:K06087]
104951218  claudin-4-like [KO:K06087]
104951219  claudin-4-like [KO:K06087]
104951220  claudin-like protein ZF-A89 [KO:K06087]
104951486  claudin-3-like [KO:K06087]
104955637  claudin-11-like [KO:K06087]
104951614  cldn5; claudin-5 [KO:K06087]
104957832  claudin-4-like [KO:K06087]
104963021  claudin-3-like [KO:K06087]
104963022  claudin-3-like [KO:K06087]
104963023  claudin-4-like [KO:K06087]
104964981  cldn15; claudin-15 [KO:K06087]
104951772  claudin-4-like [KO:K06087]
104951773  claudin-4-like [KO:K06087]
104951774  claudin-4-like [KO:K06087]
104946218  claudin-22-like [KO:K06087]
104946793  claudin-23-like [KO:K06087]
104953056  claudin-9-like [KO:K06087]
104957625  cldn19; claudin-19 isoform X1 [KO:K06087]
104952531  claudin-4-like [KO:K06087]
104952532  claudin-4-like [KO:K06087]
104952533  claudin-4-like [KO:K06087]
104952534  claudin-4-like [KO:K06087]
104952535  claudin-4-like [KO:K06087]
104952536  claudin-4-like [KO:K06087]
104952538  claudin-4-like [KO:K06087]
104940783  claudin-11-like [KO:K06087]
104963589  cldn8; claudin-8 [KO:K06087]
104963590  claudin-8-like [KO:K06087]
104963591  claudin-4-like [KO:K06087]
104965956  claudin-1-like [KO:K06087]
104949956  claudin-10-like [KO:K06087]
104942886  claudin-7-A [KO:K06087]
104947832  putative claudin-24 [KO:K06087]
104947506  claudin-10-like isoform X1 [KO:K06087]
104947507  claudin-10-like [KO:K06087]
104947508  claudin-10-like isoform X1 [KO:K06087]
104940866  claudin-20-like [KO:K06087]
104948916  putative claudin-24 [KO:K06087]
104941271  cldn7; claudin-7 [KO:K06087]
104950247  cldn20; claudin-20 [KO:K06087]
104950749  claudin-23-like [KO:K06087]
104943986  claudin-4-like [KO:K06087]
104944269  claudin-15-like [KO:K06087]
104942176  claudin-10-like [KO:K06087]
104942187  claudin-10-like [KO:K06087]
104942197  claudin-10-like [KO:K06087]
104959146  cldn12; claudin-12 [KO:K06087]
104966541  occludin-like [KO:K06088]
104957385  occludin-like [KO:K06088]
104957781  occludin-like [KO:K06088]
104948062  ocln; occludin [KO:K06088]
104941020  f11r; LOW QUALITY PROTEIN: junctional adhesion molecule A [KO:K06089]
104951935  junctional adhesion molecule B-like [KO:K06735]
104961238  jam2; junctional adhesion molecule B isoform X1 [KO:K06735]
104947295  junctional adhesion molecule C-like [KO:K06785]
104945308  jam3; junctional adhesion molecule C [KO:K06785]
104952457  bves; blood vessel epicardial substance [KO:K21108]
104961355  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104948836  cell division control protein 42 homolog [KO:K04393]
104949687  cell division control protein 42 homolog [KO:K04393]
104957088  partitioning defective 6 homolog gamma-like [KO:K06093]
104950060  mpp5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
104966607  mpp4; MAGUK p55 subfamily member 4 [KO:K21109]
104948077  tjp3; tight junction protein ZO-3 isoform X1 [KO:K06097]
104963497  multiple PDZ domain protein-like [KO:K06095]
104963498  multiple PDZ domain protein-like [KO:K06095]
104962067  multiple PDZ domain protein-like [KO:K06095]
104967216  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
104959458  angiomotin-like 2a [KO:K06104]
104957875  LOW QUALITY PROTEIN: angiomotin-like 2a [KO:K06104]
104943295  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
104951214  merlin-like [KO:K16684]
104949823  merlin-like [KO:K16684]
104966221  llgl2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
104946575  dlg1; disks large homolog 1 isoform X1 [KO:K12076]
104955471  scrib; protein scribble homolog [KO:K16175]
104957031  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
104947755  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
104965971  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
104961741  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform-like [KO:K04354]
104956644  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
104957013  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
104946885  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
104961156  ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
104966303  pard3; partitioning defective 3 homolog [KO:K04237]
104963587  tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
104960119  tjp1; LOW QUALITY PROTEIN: tight junction protein ZO-1 [KO:K05701]
104952246  tight junction protein ZO-1-like [KO:K05701]
104947095  disks large homolog 2-like isoform X1 [KO:K12075]
104947100  disks large homolog 2-like [KO:K12075]
104958394  dlg3; disks large homolog 3 isoform X1 [KO:K21098]
104966441  nedd4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
104948013  nedd4l; E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
104959173  cgn; cingulin [KO:K06102]
104945185  cingulin-like [KO:K06102]
104960101  cingulin-like protein 1 [KO:K21110]
104965846  cgnl1; cingulin-like protein 1 [KO:K21110]
104955117  transforming protein RhoA-like [KO:K04513]
104956202  transforming protein RhoA-like isoform X1 [KO:K04513]
104949002  transforming protein RhoA [KO:K04513]
104941569  rho-related GTP-binding protein RhoC-like [KO:K04513]
104942029  transforming protein RhoA-like [KO:K04513]
104947345  gata4; transcription factor GATA-4 [KO:K09183]
104966872  MARVEL domain-containing protein 3-like [KO:K21099]
104942122  marveld3; MARVEL domain-containing protein 3 [KO:K21099]
104962527  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104954536  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104965693  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
104964063  jun; transcription factor AP-1 [KO:K04448]
104967900  transcription factor AP-1-like [KO:K04448]
104962417  transcription factor AP-1-like [KO:K04448]
104955917  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
104962469  symplekin-like [KO:K06100]
104958877  pcna; proliferating cell nuclear antigen [KO:K04802]
104967413  G1/S-specific cyclin-D1-like [KO:K04503]
104950786  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
104946774  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
104961881  runt-related transcription factor 1-like [KO:K08367]
104962644  heat shock 70 kDa protein 4-like [KO:K09489]
104954924  hspa4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
104942880  slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
104951563  ezrin-like [KO:K08007]
104967153  radixin-like [KO:K05762]
104953806  moesin-like [KO:K05763]
104941446  msn; moesin isoform X1 [KO:K05763]
104951027  prkce; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
104949865  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
104951171  actb; actin, cytoplasmic 1 [KO:K05692]
104946163  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
104942817  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
104941909  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
104951572  map2k7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
104966359  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
104942589  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
104950087  src substrate protein p85-like isoform X1 [KO:K06106]
104958382  actr2; actin-related protein 2 [KO:K17260]
104951274  actin-related protein 2-B [KO:K17260]
104962092  actin-related protein 3 [KO:K18584]
104946044  actin-related protein 3-like [KO:K18584]
104949745  actin-related protein 3-like [KO:K18584]
104962380  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
104947298  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
104959677  arpc2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
104960023  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
104960029  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
104967102  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
104949942  actin-related protein 2/3 complex subunit 4 [KO:K05755]
104955372  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
104949882  whamm; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
104951558  was; wiskott-Aldrich syndrome protein [KO:K05747]
104960311  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
104956568  cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
104956098  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
104941347  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104958851  rab13; ras-related protein Rab-13 [KO:K06109]
104961396  arhgef18; rho guanine nucleotide exchange factor 18 [KO:K21066]
104959841  rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
104956174  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
104965458  myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104959133  epb41l4b; band 4.1-like protein 4B [KO:K21111]
104959130  band 4.1-like protein 4B isoform X1 [KO:K21111]
104948984  stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
104959371  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
104959556  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
104952377  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
104955653  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
104965153  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
104957657  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
104942933  prkag3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
104941417  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
104945505  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
104941201  myh11; myosin-11 isoform X1 [KO:K10352]
104951567  LOW QUALITY PROTEIN: myosin-9-like [KO:K10352]
104951635  myosin-10-like [KO:K10352]
104966834  myosin light polypeptide 6-like [KO:K12751]
104956861  myosin light polypeptide 6 isoform X1 [KO:K12751]
104959430  myosin regulatory light polypeptide 9 [KO:K12755]
104962921  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
104949658  myosin regulatory light polypeptide 9 [KO:K12757]
104958883  butyrophilin subfamily 1 member A1-like [KO:K06786]
104956771  immunoglobulin superfamily member 5-like isoform X1 [KO:K06786]
104953754  magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
104949857  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1-like [KO:K05631]
104959829  synaptopodin 2-like protein [KO:K21112]
104961894  LOW QUALITY PROTEIN: alpha-actinin-1-like [KO:K05699]
104948803  alpha-actinin-4-like [KO:K05699]
104962429  MICAL-like protein 2 isoform X1 [KO:K21068]
104944875  ras-related protein Rab-3A-like [KO:K07901]
104955514  ras-related protein Rab-8A-like [KO:K07901]
104950312  ras-related protein Rab-8A [KO:K07901]
104953436  rab8b; ras-related protein Rab-8B [KO:K07902]
104943230  rapgef6; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 6 [KO:K08020]
104961557  ras-related protein Rap-1A [KO:K04353]
104965598  itgb1; integrin beta-1 [KO:K05719]
104966282  tight junction protein ZO-2-like [KO:K06098]
104956084  tight junction protein ZO-2-like [KO:K06098]
104941952  rapgef2; rap guanine nucleotide exchange factor 2 [KO:K08018]
104960673  rap2c; ras-related protein Rap-2c [KO:K07839]
104957384  MARVEL domain-containing protein 2-like [KO:K17291]
104948039  marveld2; MARVEL domain-containing protein 2 [KO:K17291]
104942740  MARVEL domain-containing protein 2-like [KO:K17291]
104964154  tubulin alpha-4A chain-like [KO:K07374]
104966925  tubulin alpha chain-like [KO:K07374]
104945935  tubulin alpha chain-like [KO:K07374]
104948347  tubulin alpha chain [KO:K07374]
104942540  tubulin alpha chain-like isoform X1 [KO:K07374]
104949664  tubulin alpha-1A chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
ncc04520  Adherens junction
ncc04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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