KEGG   PATHWAY: nmel00230
Entry
nmel00230                   Pathway                                
Name
Purine metabolism - Numida meleagris (helmeted guineafowl)
Class
Metabolism; Nucleotide metabolism
Pathway map
nmel00230  Purine metabolism
nmel00230

Module
nmel_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:nmel00230]
nmel_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:nmel00230]
nmel_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:nmel00230]
nmel_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:nmel00230]
nmel_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:nmel00230]
nmel_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:nmel00230]
Other DBs
GO: 0006163 0042278
Organism
Numida meleagris (helmeted guineafowl) [GN:nmel]
Gene
110398552  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
110407346  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
110392265  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
110402844  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
110397320  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
110405312  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
110403246  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
110398447  PPAT; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
110402500  trifunctional purine biosynthetic protein adenosine-3-like isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
110402542  trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
110398445  uncharacterized protein LOC110398445 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
110392409  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
110399888  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
110404194  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
110407511  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
110400520  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
110396191  cytosolic 5'-nucleotidase 1B-like [KO:K01081] [EC:3.1.3.5]
110387519  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
110405816  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
110401769  cytosolic 5'-nucleotidase 1A-like isoform X1 [KO:K01081] [EC:3.1.3.5]
110397051  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
110404402  PNP; purine nucleoside phosphorylase isoform X1 [KO:K03783] [EC:2.4.2.1]
110387290  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
110403219  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
110404466  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
110405073  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
110407150  NME2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
110407151  nucleoside diphosphate kinase-like isoform X1 [KO:K00940] [EC:2.7.4.6]
110399934  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
110392176  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
110405774  nucleoside diphosphate kinase, mitochondrial-like [KO:K00940] [EC:2.7.4.6]
110405775  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
110395424  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
110406879  ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
110406881  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
110406882  ectonucleoside triphosphate diphosphohydrolase 8-like isoform X1 [KO:K01510] [EC:3.6.1.5]
110393876  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
110399890  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
110407357  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
110387090  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
110395638  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
110400927  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
110391435  uncharacterized protein LOC110391435 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
110402695  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
110395607  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110389297  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
110398071  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
110394163  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
110389826  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
110394465  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
110392111  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
110396768  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
110393093  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
110395329  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
110387203  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
110405511  deoxycytidine kinase-like [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
110398815  DCK; deoxycytidine kinase isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
110403485  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
110387873  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
110390836  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110394300  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
110395965  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
110399200  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
110404374  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
110394336  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110405807  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
110390200  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
110403886  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
110398017  GUCY1A3; guanylate cyclase soluble subunit alpha-3 isoform X1 [KO:K12318] [EC:4.6.1.2]
110397302  GUCY1B3; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
110398465  guanylate cyclase soluble subunit beta-2-like isoform X1 [KO:K12319] [EC:4.6.1.2]
110392293  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
110391669  retinal guanylyl cyclase 1-like [KO:K12321] [EC:4.6.1.2]
110391472  GUCY2F; retinal guanylyl cyclase 2 isoform X1 [KO:K12322] [EC:4.6.1.2]
110390071  atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
110389689  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
110390423  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
110399623  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
110393085  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
110405126  cGMP-dependent 3',5'-cyclic phosphodiesterase-like [KO:K18283] [EC:3.1.4.17]
110395999  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
110401246  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
110398607  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
110389804  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
110399337  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
110397605  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
110407143  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
110407478  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
110403376  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
110395968  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
110400111  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
110396845  ADSS; adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
110400746  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
110388060  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
110401594  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
110388138  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
110399476  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
110408102  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
110395547  ADA2; adenosine deaminase CECR1 [KO:K19572] [EC:3.5.4.4]
110387262  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
110402220  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
110406979  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
110402892  AK5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
110406748  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
110402173  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
110390205  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
110390348  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
110407102  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
110396114  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
110395304  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
110396372  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
110402281  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
110402282  cAMP-specific 3',5'-cyclic phosphodiesterase 4B-like isoform X1 [KO:K13293] [EC:3.1.4.53]
110388933  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
110389449  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
110395451  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
110393547  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
110403905  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
110389284  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
110404621  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
110395834  bis(5'-adenosyl)-triphosphatase ENPP4-like isoform X1 [KO:K18424] [EC:3.6.1.29]
110390503  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
110397840  PAPSS1; LOW QUALITY PROTEIN: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
110402305  uricase-like [KO:K00365] [EC:1.7.3.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
nmel00030  Pentose phosphate pathway
nmel00220  Arginine biosynthesis
nmel00250  Alanine, aspartate and glutamate metabolism
nmel00260  Glycine, serine and threonine metabolism
nmel00340  Histidine metabolism
nmel00630  Glyoxylate and dicarboxylate metabolism
nmel00730  Thiamine metabolism
nmel00740  Riboflavin metabolism
nmel00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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