KEGG   PATHWAY: otw04260
Entry
otw04260                    Pathway                                
Name
Cardiac muscle contraction - Oncorhynchus tshawytscha (Chinook salmon)
Description
Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
Class
Organismal Systems; Circulatory system
Pathway map
otw04260  Cardiac muscle contraction
otw04260

Other DBs
GO: 0060048
Organism
Oncorhynchus tshawytscha (Chinook salmon) [GN:otw]
Gene
112240960  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
112255325  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
112244799  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
112215828  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
112222121  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
112221526  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
112221688  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
112225960  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04862]
112258605  voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
112215649  voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
112227979  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
112215796  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
112238503  voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
112225596  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
112253618  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
112245181  voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858]
112219241  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
121843114  voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858]
112263077  voltage-dependent calcium channel subunit alpha-2/delta-2-like isoform X1 [KO:K04859]
112214695  cacna2d2b; voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X2 [KO:K04859]
112254289  voltage-dependent calcium channel subunit alpha-2/delta-2-like isoform X1 [KO:K04859]
112255324  LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
112244800  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
112221471  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
112260024  voltage-dependent calcium channel subunit alpha-2/delta-4-like isoform X1 [KO:K04861]
112218193  voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
121845906  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
112240155  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
112230348  voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
112265080  voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
112258896  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
112259245  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
121845286  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
121843776  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
112222917  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
112230152  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
112225774  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
112265074  voltage-dependent calcium channel gamma-5 subunit-like isoform X3 [KO:K04870]
112230151  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
112240321  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
112229852  voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
112264836  voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
112247683  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
112237259  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
112233258  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
112244801  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
112264837  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
112248138  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
112229853  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
112266029  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
112247695  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
112253542  ryanodine receptor 2 [KO:K04962]
112232689  aspartyl/asparaginyl beta-hydroxylase-like isoform X1 [KO:K00476] [EC:1.14.11.16]
112227023  aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
112260387  triadin isoform X1 [KO:K00476] [EC:1.14.11.16]
112227765  aspartyl/asparaginyl beta-hydroxylase isoform X12 [KO:K00476] [EC:1.14.11.16]
112240932  calsequestrin-2 [KO:K23445]
112266427  calsequestrin-2 [KO:K23445]
112225447  calsequestrin-2 [KO:K23445]
112253694  calsequestrin-2-like [KO:K23445]
112250130  nucleolar protein dao-5 isoform X20 [KO:K23449]
112217576  trdn; triadin isoform X1 [KO:K23449]
112220368  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
112230928  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
112248355  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
112261377  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
112263049  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
112231823  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
112258329  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
112223858  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
112251644  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
112251457  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
112216777  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like isoform X1 [KO:K05853] [EC:7.2.2.10]
112215769  tnnc1a; troponin C type 1a (slow) isoform X1 [KO:K05865]
112222048  troponin C, slow skeletal and cardiac muscles [KO:K05865]
112222209  troponin C, slow skeletal and cardiac muscles [KO:K05865]
112218896  troponin T, cardiac muscle isoforms [KO:K12045]
112258556  tnnt2a; troponin T type 2a (cardiac) [KO:K12045]
112254193  tnnt2b; troponin T, cardiac muscle isoforms isoform X1 [KO:K12045]
112214355  troponin T, cardiac muscle-like isoform X1 [KO:K12045]
112216852  troponin T, cardiac muscle-like isoform X1 [KO:K12045]
112217045  tnnt2c; troponin T2c, cardiac [KO:K12045]
112249372  tropomyosin alpha-1 chain isoform X1 [KO:K10373]
112252396  tropomyosin alpha-1 chain isoform X1 [KO:K10373]
112218576  tropomyosin alpha-1 chain isoform X1 [KO:K10373]
112219998  tpm2; tropomyosin beta chain isoform X1 [KO:K10374]
112264669  tropomyosin alpha-3 chain isoform X3 [KO:K09290]
112229688  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
112228813  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
112250800  tropomyosin alpha-1 chain isoform X1 [KO:K10375]
112260901  tropomyosin alpha-1 chain isoform X1 [KO:K10375]
112252201  tropomyosin alpha-1 chain isoform X1 [KO:K10375]
112235643  actin, alpha cardiac muscle [KO:K12314]
112218885  actin, alpha cardiac muscle 1-like [KO:K12314]
112256654  actin, alpha cardiac muscle [KO:K12314]
112217913  actin, alpha cardiac muscle 1 [KO:K12314]
112217949  actc1a; actin, alpha cardiac muscle [KO:K12314]
112252672  acte1; beta-actin-like protein 2 [KO:K12314]
112261625  actin, alpha cardiac muscle 1 [KO:K12314]
112261825  actin, alpha cardiac muscle [KO:K12314]
112227823  myosin-7-like [KO:K17751]
112227824  myosin-7 isoform X1 [KO:K17751]
112227826  myosin-7-like [KO:K17751]
112260537  myosin-7-like [KO:K17751]
112226875  myosin-6 [KO:K17751]
112215298  myosin-7 [KO:K17751]
112224716  myosin-7 [KO:K17751]
112215297  myosin-7-like [KO:K17751]
112227825  myosin-7-like [KO:K17751]
112249906  myh6; myosin-6 [KO:K17751]
112215535  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
112255301  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
112260649  myosin light chain 1, cardiac muscle-like isoform X1 [KO:K12749]
112226781  myosin light chain 1, cardiac muscle-like [KO:K12749]
112259399  myl4; myosin light chain 4 isoform X2 [KO:K12750]
112225812  myosin light chain 4-like [KO:K12750]
112233494  myosin light chain 4-like [KO:K12750]
112248900  cmlc1; cardiac myosin light chain-1 [KO:K12750]
112249074  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
112263551  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
112218748  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
KEF73_p01  CYTB; cytochrome b [KO:K00412]
112266919  cytochrome c1, heme protein, mitochondrial [KO:K00413]
112254115  cytochrome c1, heme protein, mitochondrial [KO:K00413]
112254399  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
112219492  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
112259530  cytochrome b-c1 complex subunit 2, mitochondrial isoform X1 [KO:K00415]
112224473  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
112239959  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
112250661  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
112226492  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
112246700  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
112264370  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
112229470  cytochrome b-c1 complex subunit 7 [KO:K00417]
112241491  cytochrome b-c1 complex subunit 8 [KO:K00418]
112221245  cytochrome b-c1 complex subunit 8 [KO:K00418]
112257556  cytochrome b-c1 complex subunit 9 [KO:K00419]
112237790  cytochrome b-c1 complex subunit 10 [KO:K00420]
KEF73_p07  COX3; cytochrome c oxidase subunit III [KO:K02262]
KEF73_p11  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
KEF73_p10  COX2; cytochrome c oxidase subunit II [KO:K02261]
112215998  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
112263771  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
112232699  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
112237512  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
112222375  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
121839623  cytochrome c oxidase subunit 4 isoform 2, mitochondrial-like [KO:K02263]
112249137  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
112266675  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
112236257  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
112263663  cytochrome c oxidase subunit 5A, mitochondrial isoform X1 [KO:K02264]
112220254  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
112252791  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
112230829  zgc:86599; cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
112259030  cytochrome c oxidase subunit 6A, mitochondrial [KO:K02266]
112248396  cytochrome c oxidase subunit 6A, mitochondrial [KO:K02266]
112258979  cytochrome c oxidase subunit 6A, mitochondrial [KO:K02266]
112263028  cytochrome c oxidase subunit 6A, mitochondrial [KO:K02266]
112229851  cytochrome c oxidase subunit 6B1 isoform X1 [KO:K02267]
112237109  cytochrome c oxidase subunit 6B1 [KO:K02267]
112247815  cytochrome c oxidase subunit 6B1 [KO:K02267]
112223663  cytochrome c oxidase subunit 6B1 [KO:K02267]
112266676  cytochrome c oxidase subunit 6C-1 [KO:K02268]
112254135  cytochrome c oxidase subunit 6C-1 [KO:K02268]
112256558  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
112252875  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
112223282  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
112266797  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
112217485  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
112261992  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
112257912  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
112247261  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
112263377  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
112250442  si:dkey-85n7.8; COX8 domain-containing protein [KO:K02273]
112218889  cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
112252679  cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
112228971  cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
112230645  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
112230454  sodium/calcium exchanger 1 isoform X1 [KO:K05849]
112265287  sodium/calcium exchanger 2 [KO:K05849]
112239129  slc8a3; sodium/calcium exchanger 3 [KO:K05849]
112228418  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
112255898  sodium/calcium exchanger 1 isoform X1 [KO:K05849]
112253157  slc8a1b; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
112228808  sodium/calcium exchanger 1-like [KO:K05849]
112239860  sodium/calcium exchanger 3 [KO:K05849]
112265943  slc8a1a; sodium/calcium exchanger 1a isoform X1 [KO:K05849]
112266873  slc8a2b; sodium/calcium exchanger 2b [KO:K05849]
112231337  sodium/calcium exchanger 1 [KO:K05849]
112241344  sodium/calcium exchanger 3-like isoform X1 [KO:K05849]
112252007  slc9a7; sodium/hydrogen exchanger 7 [KO:K12041]
112231167  sodium/hydrogen exchanger 6 isoform X1 [KO:K12041]
112256169  sodium/hydrogen exchanger 6 [KO:K12041]
112220863  slc9a6a; sodium/hydrogen exchanger 6 isoform X1 [KO:K12041]
112255118  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
112226568  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
112253654  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
112237535  atp1a2a; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
112264803  sodium/potassium-transporting ATPase subunit alpha-3 isoform X3 [KO:K01539] [EC:7.2.2.13]
112266352  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
112266353  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
112223108  sodium/potassium-transporting ATPase subunit alpha-3-like isoform X1 [KO:K01539] [EC:7.2.2.13]
112233288  sodium/potassium-transporting ATPase subunit alpha-3-like isoform X1 [KO:K01539] [EC:7.2.2.13]
112240137  sodium/potassium-transporting ATPase subunit alpha-1-like [KO:K01539] [EC:7.2.2.13]
112246559  sodium/potassium-transporting ATPase subunit alpha-3-like isoform X1 [KO:K01539] [EC:7.2.2.13]
112260242  sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
112257770  atp1b2b; sodium/potassium-transporting ATPase subunit beta-2b isoform X1 [KO:K01540]
112216692  sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
112251468  sodium/potassium-transporting ATPase subunit beta-233-like [KO:K01540]
112228636  sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
112235047  sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
112240226  sodium/potassium-transporting ATPase subunit beta-233 isoform X1 [KO:K01540]
112227219  sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
112264988  sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
112221088  protein ATP1B4 [KO:K01540]
112256375  protein ATP1B4 [KO:K01540]
121846643  atp1b1a; sodium/potassium-transporting ATPase subunit beta-1a [KO:K01540]
112246138  sodium/hydrogen exchanger 1 [KO:K05742]
112229545  slc9a1b; Na(+)/H(+) exchanger beta isoform X1 [KO:K05742]
112223053  sodium/hydrogen exchanger 1 [KO:K05742]
Compound
C00076  Calcium cation
C00080  H+
C00238  Potassium cation
C01330  Sodium cation
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:16799263
  Authors
Endoh M
  Title
Signal transduction and Ca2+ signaling in intact myocardium.
  Journal
J Pharmacol Sci 100:525-37 (2006)
DOI:10.1254/jphs.CPJ06009X
Reference
PMID:18981594
  Authors
Endoh M
  Title
Cardiac Ca2+ signaling and Ca2+ sensitizers.
  Journal
Circ J 72:1915-25 (2008)
DOI:10.1253/circj.CJ-08-0838
Reference
PMID:16552170
  Authors
Bers DM, Despa S
  Title
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.
  Journal
J Pharmacol Sci 100:315-22 (2006)
DOI:10.1254/jphs.CPJ06001X
Reference
PMID:10747208
  Authors
Gordon AM, Homsher E, Regnier M
  Title
Regulation of contraction in striated muscle.
  Journal
Physiol Rev 80:853-924 (2000)
DOI:10.1152/physrev.2000.80.2.853
Reference
PMID:16701909
  Authors
Phrommintikul A, Chattipakorn N
  Title
Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.
  Journal
Int J Cardiol 112:142-52 (2006)
DOI:10.1016/j.ijcard.2005.11.106
Reference
PMID:16096350
  Authors
Lacinova L
  Title
Voltage-dependent calcium channels.
  Journal
Gen Physiol Biophys 24 Suppl 1:1-78 (2005)
Reference
PMID:12763850
  Authors
Lingrel J, Moseley A, Dostanic I, Cougnon M, He S, James P, Woo A, O'Connor K, Neumann J
  Title
Functional roles of the alpha isoforms of the Na,K-ATPase.
  Journal
Ann N Y Acad Sci 986:354-9 (2003)
DOI:10.1111/j.1749-6632.2003.tb07214.x
Reference
PMID:11294886
  Authors
Berg JS, Powell BC, Cheney RE
  Title
A millennial myosin census.
  Journal
Mol Biol Cell 12:780-94 (2001)
DOI:10.1091/mbc.12.4.780
Reference
PMID:15736582
  Authors
Parmacek MS, Solaro RJ
  Title
Biology of the troponin complex in cardiac myocytes.
  Journal
Prog Cardiovasc Dis 47:159-76 (2004)
DOI:10.1016/j.pcad.2004.07.003
Reference
PMID:14659803
  Authors
Yamashita H, Sugiura S, Fujita H, Yasuda S, Nagai R, Saeki Y, Sunagawa K, Sugi H
  Title
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
  Journal
Cardiovasc Res 60:580-8 (2003)
DOI:10.1016/j.cardiores.2003.09.011
Reference
PMID:19403607
  Authors
Pritchard TJ, Kranias EG
  Title
Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis.
  Journal
J Physiol 587:3125-33 (2009)
DOI:10.1113/jphysiol.2009.172171
Reference
PMID:28596175
  Authors
Landstrom AP, Dobrev D, Wehrens XHT
  Title
Calcium Signaling and Cardiac Arrhythmias.
  Journal
Circ Res 120:1969-1993 (2017)
DOI:10.1161/CIRCRESAHA.117.310083
Related
pathway
otw04020  Calcium signaling pathway
KO pathway
ko04260   
LinkDB

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