KEGG   PATHWAY: pcw04115
Entry
pcw04115                    Pathway                                
Name
p53 signaling pathway - Phascolarctos cinereus (koala)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
pcw04115  p53 signaling pathway
pcw04115

Organism
Phascolarctos cinereus (koala) [GN:pcw]
Gene
110214947  ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
110215254  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
110197214  ATR; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
110218134  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
110196966  GORAB; LOW QUALITY PROTEIN: RAB6-interacting golgin [KO:K19748]
110201193  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
110211045  MDM2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
110219529  MDM4; protein Mdm4 isoform X1 [KO:K10127]
110194271  TP53; cellular tumor antigen p53 [KO:K04451]
110203626  PPP1R13L; relA-associated inhibitor isoform X1 [KO:K27356]
110217257  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
110197171  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
110218698  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
110203289  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
110210989  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110209152  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
110207433  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
110195790  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
110210908  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
110205971  SFN; 14-3-3 protein sigma [KO:K06644]
110204348  protein reprimo [KO:K10128]
110196901  RPRM; protein reprimo [KO:K10128]
110216613  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
110205363  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
110216425  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
110212964  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
110223449  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
110195907  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
110201627  GTSE1; G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
110194039  ZNF385A; zinc finger protein 385A isoform X1 [KO:K26543]
110198951  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
110202958  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
110197185  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04722]
110200403  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
110197193  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
110218747  BID; BH3-interacting domain death agonist [KO:K04726]
110219776  BAX; apoptosis regulator BAX [KO:K02159]
110202397  BBC3; bcl-2-binding component 3 isoform X1 [KO:K10132]
110203051  SIVA1; apoptosis regulatory protein Siva isoform X1 [KO:K22744]
110211412  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
110214751  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
110202043  quinone oxidoreductase PIG3-like isoform X1 [KO:K10133] [EC:1.-.-.-]
110218138  EI24; etoposide-induced protein 2.4 homolog isoform X1 [KO:K10134]
110217071  SHISA5; protein shisa-5 isoform X1 [KO:K10135]
110199070  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
110204417  ZMAT3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
110207457  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
110218411  cytochrome c-like [KO:K08738]
110218003  cytochrome c-like [KO:K08738]
110203137  cytochrome c-like [KO:K08738]
110213139  cytochrome c [KO:K08738]
110221734  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
110198824  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
110222594  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
110200088  AIFM2; apoptosis-inducing factor 2 [KO:K22745]
110197536  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
110205653  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
110194266  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
110214425  ADGRB1; brain-specific angiogenesis inhibitor 1 isoform X1 [KO:K04596]
110223948  CD82; CD82 antigen [KO:K06509]
110202873  THBS1; thrombospondin-1 [KO:K16857]
110214763  SERPINB5; serpin B5 [KO:K10139]
110223919  DDB2; LOW QUALITY PROTEIN: DNA damage-binding protein 2 [KO:K10140]
110196375  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
110212710  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
110222931  SESN1; sestrin-1 isoform X1 [KO:K10141]
110218048  SESN3; sestrin-3 isoform X1 [KO:K10141]
110206170  SESN2; sestrin-2 [KO:K20394]
110199935  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110221953  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
110192093  STEAP3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
110206752  RFWD2; E3 ubiquitin-protein ligase RFWD2 [KO:K10143] [EC:2.3.2.27]
110209784  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
110212363  CCNG1; cyclin-G1 [KO:K10145]
110209738  CCNG2; cyclin-G2 [KO:K10146]
110212033  PPM1D; LOW QUALITY PROTEIN: protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
110200220  TP73; LOW QUALITY PROTEIN: tumor protein p73 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
pcw04110  Cell cycle
pcw04210  Apoptosis
pcw04218  Cellular senescence
KO pathway
ko04115   
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