KEGG   PATHWAY: pgig00230
Entry
pgig00230                   Pathway                                
Name
Purine metabolism - Pteropus giganteus (Indian flying fox)
Class
Metabolism; Nucleotide metabolism
Pathway map
pgig00230  Purine metabolism
pgig00230

Module
pgig_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:pgig00230]
pgig_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:pgig00230]
pgig_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:pgig00230]
pgig_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:pgig00230]
pgig_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:pgig00230]
pgig_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:pgig00230]
pgig_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:pgig00230]
Other DBs
GO: 0006163 0042278
Organism
Pteropus giganteus (Indian flying fox) [GN:pgig]
Gene
120609322  ADP-ribose pyrophosphatase, mitochondrial-like [KO:K13988] [EC:3.6.1.13]
120588296  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
120589741  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
120614600  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
120618822  phosphoglucomutase-1-like [KO:K01835] [EC:5.4.2.2]
120591102  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
120616375  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
120611542  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
120601901  PRPS1L1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
120588102  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
120598631  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
120589708  PFAS; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
120588101  trihelix transcription factor GT-2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
120588103  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
120602988  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
120587618  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
120622887  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
120614040  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
120609137  NT5C2; LOW QUALITY PROTEIN: cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
120621550  NT5C1B; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
120600358  NT5C; LOW QUALITY PROTEIN: 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
120589878  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X1 [KO:K01081] [EC:3.1.3.5]
120594998  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
120590754  LOW QUALITY PROTEIN: purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
120608060  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
120614380  LACC1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
120612662  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
120582336  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
120601070  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
120582300  nucleoside diphosphate kinase 6-like isoform X1 [KO:K00940] [EC:2.7.4.6]
120582301  nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
120617680  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
120620172  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
120620237  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
120588974  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
120588975  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
120608276  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
120582192  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
120609269  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
120599738  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
120600315  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
120606651  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
120586969  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
120582074  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
120603461  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
120621538  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120612906  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1 [KO:K01518] [EC:3.6.1.17]
120598906  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
120605589  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
120608510  GMPR2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
120584529  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
120616649  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
120590280  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
120595448  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
120621968  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
120596007  HDDC2; 5'-deoxynucleotidase HDDC2 isoform X1 [KO:K07023] [EC:3.1.3.89]
120594397  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
120588176  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
120599254  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
120585221  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
120589581  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
120586284  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
120621545  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
120608523  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
120586714  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
120618216  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
120617254  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
120588721  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
120620331  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120617695  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
120596168  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
120613432  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
120599652  GUCY1A2; guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
120613434  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
120583871  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
120613746  GUCY2C; LOW QUALITY PROTEIN: heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
120590531  guanylate cyclase D-like [KO:K12321] [EC:4.6.1.2]
120589911  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
120616380  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
120608930  LOW QUALITY PROTEIN: guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
120592268  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
120612856  NPR2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
120602119  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
120602419  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
120596832  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
120590307  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
120618383  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
120603240  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
120616205  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
120581541  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
120582936  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
120609288  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
120597181  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
120613755  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
120598547  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
120617616  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
120596813  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
120613953  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
120619084  ADSS2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
120603191  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
120584958  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
120584993  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
120609556  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
120603697  ADA; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
120607355  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
120602739  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
120582024  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
120615471  LOW QUALITY PROTEIN: adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
120583180  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
120583252  AK5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
120619673  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
120601706  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
120608258  AK6; adenylate kinase isoenzyme 6 isoform X1 [KO:K18532] [EC:2.7.4.3]
120620199  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
120599806  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
120592595  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
120587398  cancer-related nucleoside-triphosphatase-like [KO:K06928] [EC:3.6.1.15]
120592326  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
120592332  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
120583186  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
120606554  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
120608285  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
120610867  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
120615786  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
120585447  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
120599267  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
120612453  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
120599477  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
120596312  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
120591255  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
120609357  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
120583274  uricase [KO:K00365] [EC:1.7.3.3]
120614422  5-hydroxyisourate hydrolase-like isoform X1 [KO:K07127] [EC:3.5.2.17]
120589162  5-hydroxyisourate hydrolase-like [KO:K07127] [EC:3.5.2.17]
120602475  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase isoform X1 [KO:K13485] [EC:4.1.1.97]
120596539  ALLC; probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
pgig00030  Pentose phosphate pathway
pgig00220  Arginine biosynthesis
pgig00250  Alanine, aspartate and glutamate metabolism
pgig00260  Glycine, serine and threonine metabolism
pgig00340  Histidine metabolism
pgig00630  Glyoxylate and dicarboxylate metabolism
pgig00730  Thiamine metabolism
pgig00740  Riboflavin metabolism
pgig00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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