KEGG   PATHWAY: pgut00230
Entry
pgut00230                   Pathway                                
Name
Purine metabolism - Pantherophis guttatus (corn snake)
Class
Metabolism; Nucleotide metabolism
Pathway map
pgut00230  Purine metabolism
pgut00230

Module
pgut_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:pgut00230]
pgut_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:pgut00230]
pgut_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:pgut00230]
pgut_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:pgut00230]
pgut_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:pgut00230]
pgut_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:pgut00230]
pgut_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:pgut00230]
Other DBs
GO: 0006163 0042278
Organism
Pantherophis guttatus (corn snake) [GN:pgut]
Gene
117678935  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
117660436  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
117664320  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
117680042  PGM2; phosphopentomutase [KO:K15779] [EC:5.4.2.2 5.4.2.7]
117676124  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
117679663  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
117662103  PPAT; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
117657118  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
117676320  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
132710508  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
132710509  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
117658727  phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
117657156  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
117662104  multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
117655728  ADSL; adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
117675124  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
117671021  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
117665218  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
117660523  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
117663260  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
117678660  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
117679534  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
117674259  NT5C1B; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
117673379  cytosolic purine 5'-nucleotidase-like isoform X2 [KO:K01081] [EC:3.1.3.5]
132711646  5'(3')-deoxyribonucleotidase, cytosolic type-like [KO:K01081] [EC:3.1.3.5]
117660736  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
117662191  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
117664930  LACC1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
117679590  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
117672972  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
117673959  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
117662575  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
117663066  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
117672957  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
117673106  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
132711444  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
117660844  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
117656100  ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
117678569  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
132710191  ectonucleoside triphosphate diphosphohydrolase 3-like [KO:K01510] [EC:3.6.1.5]
117663014  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
117676977  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
132708980  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
117665813  ENTPD5; nucleoside diphosphate phosphatase ENTPD5 [KO:K01511] [EC:3.6.1.6]
117671543  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
117675511  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
117661215  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
117671370  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
117659798  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
117678255  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X3 [KO:K01951] [EC:6.3.5.2]
117657283  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
117672506  GMPR; LOW QUALITY PROTEIN: GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
117661444  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
117680081  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
117676449  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
117668446  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
117674223  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
117666243  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
117673324  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
117673708  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
117676237  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
117670129  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
117664957  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
117662380  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
117667701  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
117662171  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
117668834  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
117662735  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
117670935  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
117668453  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
117679454  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
117661240  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
117660990  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
117674723  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
117674506  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
117674720  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
117678821  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
117655724  GUCY2C; guanylyl cyclase C [KO:K12320] [EC:4.6.1.2]
117671248  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
117678787  guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
117661929  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
117679722  NPR2; atrial natriuretic peptide receptor 2 isoform X2 [KO:K12324] [EC:4.6.1.2]
117666553  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
117674312  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
117671115  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
117665287  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
117680237  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
117662028  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
117673147  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
117658604  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
117655644  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
117669458  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
117671378  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
117671988  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
117666053  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
117660000  adenylosuccinate synthetase isozyme 2-like [KO:K01939] [EC:6.3.4.4]
117671936  ADSS2; adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
117663789  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
117664050  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
117665328  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
117676143  ADK; adenosine kinase isoform X2 [KO:K00856] [EC:2.7.1.20]
117663606  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
117655874  ADA2; adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
117658271  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
117665963  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
117663251  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
117674992  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
117675605  adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
117677114  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
117672974  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
117679336  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
117661490  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
117676616  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
117671990  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
117666268  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
117666270  ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like [KO:K01513] [EC:3.1.4.1 3.6.1.9]
117674987  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
117675571  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X2 [KO:K13293] [EC:3.1.4.53]
117677435  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
117679209  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
117666289  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
117672846  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X2 [KO:K18436] [EC:3.1.4.53]
117675721  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
117679282  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
117671110  bis(5'-adenosyl)-triphosphatase ENPP4-like [KO:K18424] [EC:3.6.1.29]
117670639  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
117679918  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
117677350  uricase-like [KO:K00365] [EC:1.7.3.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
pgut00030  Pentose phosphate pathway
pgut00220  Arginine biosynthesis
pgut00250  Alanine, aspartate and glutamate metabolism
pgut00260  Glycine, serine and threonine metabolism
pgut00340  Histidine metabolism
pgut00630  Glyoxylate and dicarboxylate metabolism
pgut00730  Thiamine metabolism
pgut00740  Riboflavin metabolism
pgut00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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