KEGG   PATHWAY: pki04625
Entry
pki04625                    Pathway                                
Name
C-type lectin receptor signaling pathway - Paramormyrops kingsleyae
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
Pathway map
pki04625  C-type lectin receptor signaling pathway
pki04625

Organism
Paramormyrops kingsleyae [GN:pki]
Gene
111840699  GTPase HRas-like [KO:K02833]
111859528  hras; GTPase HRas [KO:K02833]
111842404  GTPase KRas-like [KO:K07827]
111845660  kras; GTPase KRas isoform X1 [KO:K07827]
111853914  nras; GTPase NRas [KO:K07828]
111851762  mras; ras-related protein M-Ras [KO:K07831]
111849456  ras-related protein M-Ras-like [KO:K07831]
111841178  ras-related protein R-Ras2 isoform X1 [KO:K07830]
111836888  rras; ras-related protein R-Ras isoform X1 [KO:K07830]
111837477  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111840300  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
111851986  putative transcription factor p65 homolog [KO:K04735]
111855422  putative transcription factor p65 homolog [KO:K04735]
111844863  relb; transcription factor RelB isoform X1 [KO:K09253]
111841504  il12a; interleukin-12 subunit alpha isoform X1 [KO:K05406]
111847694  interleukin-12 subunit alpha-like isoform X1 [KO:K05406]
111839189  interleukin-12 subunit beta-like [KO:K05425]
111850579  interleukin-12 subunit beta-like isoform X1 [KO:K05425]
111860726  il12b; interleukin-12 subunit beta isoform X1 [KO:K05425]
111851454  interleukin-1 beta-like [KO:K04519]
111848567  interleukin-1 beta-like [KO:K04519]
111841163  syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
111842068  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
111853334  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
111850568  tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
111832882  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
111855960  mitogen-activated protein kinase kinase kinase 14-like isoform X1 [KO:K04466] [EC:2.7.11.25]
111836749  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
111839432  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
111848470  nuclear factor NF-kappa-B p100 subunit-like [KO:K04469]
111851875  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
111839848  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
111840603  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111845672  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111844730  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
111836038  calml4; calmodulin-like protein 4 [KO:K02183]
111839522  calmodulin [KO:K02183]
111852631  calm1; calmodulin-1 [KO:K02183]
111844882  calm3; calmodulin-3 [KO:K02183]
111839995  calmodulin [KO:K02183]
111848450  calmodulin-A isoform X1 [KO:K02183]
111841764  calmodulin [KO:K02183]
111858903  calml6; calmodulin-like protein 6 [KO:K02183]
111848699  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111849849  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111853026  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111836737  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
111857559  ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
111850760  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
111859769  calcineurin subunit B type 1 isoform X1 [KO:K06268]
111852343  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111845775  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
111835865  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
111855820  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
111832689  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111843522  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
111854528  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
111854443  il10; interleukin-10 [KO:K05443]
111853677  egr2; E3 SUMO-protein ligase EGR2 [KO:K12496]
111838993  egr3; early growth response protein 3 isoform X1 [KO:K12497]
111857332  early growth response protein 3-like [KO:K12497]
111840107  prostaglandin G/H synthase 2-like isoform X1 [KO:K11987] [EC:1.14.99.1]
111841020  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
111839856  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
111840581  protein kinase C delta type-like isoform X1 [KO:K06068] [EC:2.7.11.13]
111835825  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111857802  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111859606  NACHT, LRR and PYD domains-containing protein 3-like [KO:K12799]
111846294  NACHT, LRR and PYD domains-containing protein 6-like [KO:K12799]
111844200  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
111846447  pyrin domain-containing protein 1-like [KO:K12799]
111840044  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
111856855  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
111841516  caspase-1-like [KO:K01370] [EC:3.4.22.36]
111848592  card9; caspase recruitment domain-containing protein 9 [KO:K12794]
111847637  bcl10; B-cell lymphoma/leukemia 10 [KO:K07368]
111843550  mucosa-associated lymphoid tissue lymphoma translocation protein 1-like [KO:K07369] [EC:3.4.22.-]
111847568  mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog [KO:K07369] [EC:3.4.22.-]
111838728  malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369] [EC:3.4.22.-]
111860391  mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog [KO:K07369] [EC:3.4.22.-]
111859385  mucosa-associated lymphoid tissue lymphoma translocation protein 1-like [KO:K07369] [EC:3.4.22.-]
111852220  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
111852221  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
111859672  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
111859671  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
111837508  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
111855295  NF-kappa-B essential modulator-like [KO:K07210]
111854363  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
111852632  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
111841750  NF-kappa-B inhibitor alpha-like [KO:K04734]
111833172  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111853948  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
111838992  tumor necrosis factor-like [KO:K03156]
111846921  il6; interleukin-6 [KO:K05405]
111835993  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111845666  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
111845679  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111840348  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
111853904  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
111856186  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
111850762  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
111839372  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111850356  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111848368  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111852585  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111855469  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111842196  transcription factor AP-1-like [KO:K04448]
111834818  transcription factor AP-1-like [KO:K04448]
111847550  transcription factor AP-1-like [KO:K04448]
111855703  cblb; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
111845338  high affinity immunoglobulin epsilon receptor subunit gamma-like isoform X1 [KO:K07983]
111833140  high affinity immunoglobulin epsilon receptor subunit gamma-like [KO:K07983]
111846252  arhgef12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
111842305  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
111839832  rho-related GTP-binding protein RhoA-D [KO:K04513]
111851074  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
111855859  rhoa; transforming protein RhoA [KO:K04513]
111857025  rho-related GTP-binding protein RhoA-C-like isoform X1 [KO:K04513]
111860004  transforming protein RhoA-like [KO:K04513]
111833901  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
111842626  serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
111849919  kinase suppressor of Ras 1-like isoform X1 [KO:K14958]
111860829  kinase suppressor of Ras 1-like isoform X1 [KO:K14958]
111836956  serine/threonine-protein kinase PLK3-like isoform X1 [KO:K08862] [EC:2.7.11.21]
111835923  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
111855741  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111854439  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
111842948  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
111845415  stat1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
111850884  interferon regulatory factor 9-like isoform X1 [KO:K04693]
111854344  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11221]
111837180  il17d; interleukin-17D [KO:K05492]
111832717  cyld; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
111835868  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
111856452  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
111860747  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
111854830  bcl3; B-cell lymphoma 3 protein isoform X1 [KO:K09258]
111834362  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
111854424  mapkapk2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
111834621  C-type lectin domain family 4 member E-like [KO:K10059]
111836364  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
111860453  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111853566  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111860909  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111853393  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111835615  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111834821  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111847640  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
111860386  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111856594  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
111838854  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111852355  akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111850633  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111860965  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111861008  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111851197  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
111833417  interferon regulatory factor 1-like [KO:K09444]
111839571  interferon regulatory factor 1-like [KO:K09444]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00159  D-Mannose
C00165  Diacylglycerol
C00584  Prostaglandin E2
C00965  1,3-beta-D-Glucan
C01019  L-Fucose
C01245  D-myo-Inositol 1,4,5-trisphosphate
C16844  Hydroxyl radical
C21790  Mycobacterial trehalose dimycolate
C21791  Rhodocytin
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:27291962
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
C-type lectin receptors in the control of T helper cell differentiation.
  Journal
Nat Rev Immunol 16:433-48 (2016)
DOI:10.1038/nri.2016.55
Reference
PMID:21350579
  Authors
Hajishengallis G, Lambris JD
  Title
Microbial manipulation of receptor crosstalk in innate immunity.
  Journal
Nat Rev Immunol 11:187-200 (2011)
DOI:10.1038/nri2918
Reference
PMID:28604735
  Authors
Iliev ID, Leonardi I
  Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
  Journal
Nat Rev Immunol 17:635-646 (2017)
DOI:10.1038/nri.2017.55
Reference
PMID:25002863
  Authors
Richardson MB, Williams SJ
  Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
  Journal
Front Immunol 5:288 (2014)
DOI:10.3389/fimmu.2014.00288
Reference
PMID:21924922
  Authors
Vautier S, MacCallum DM, Brown GD
  Title
C-type lectin receptors and cytokines in fungal immunity.
  Journal
Cytokine 58:89-99 (2012)
DOI:10.1016/j.cyto.2011.08.031
Reference
PMID:22170181
  Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
  Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
  Journal
Acta Derm Venereol 92:291-8 (2012)
DOI:10.2340/00015555-1250
Reference
PMID:22973279
  Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
  Title
DAMP signaling in fungal infections and diseases.
  Journal
Front Immunol 3:286 (2012)
DOI:10.3389/fimmu.2012.00286
Reference
PMID:29449845
  Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
  Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
  Journal
Front Immunol 9:123 (2018)
DOI:10.3389/fimmu.2018.00123
Reference
PMID:27999992
  Authors
Mayer S, Raulf MK, Lepenies B
  Title
C-type lectins: their network and roles in pathogen recognition and immunity.
  Journal
Histochem Cell Biol 147:223-237 (2017)
DOI:10.1007/s00418-016-1523-7
Reference
PMID:23570314
  Authors
Plato A, Willment JA, Brown GD
  Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
  Journal
Int Rev Immunol 32:134-56 (2013)
DOI:10.3109/08830185.2013.777065
Reference
PMID:22344277
  Authors
Dupaul-Chicoine J, Saleh M
  Title
A new path to IL-1beta production controlled by caspase-8.
  Journal
Nat Immunol 13:211-2 (2012)
DOI:10.1038/ni.2241
Reference
PMID:24009832
  Authors
Batbayar S, Lee DH, Kim HW
  Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
  Journal
Biomol Ther (Seoul) 20:433-45 (2012)
DOI:10.4062/biomolther.2012.20.5.433
Reference
PMID:28606994
  Authors
Bendickova K, Tidu F, Fric J
  Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
  Journal
EMBO Mol Med 9:990-999 (2017)
DOI:10.15252/emmm.201707698
Reference
PMID:18998127
  Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
  Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
  Journal
Cancer Immunol Immunother 58:1149-57 (2009)
DOI:10.1007/s00262-008-0615-1
Reference
PMID:28640912
  Authors
Marakalala MJ, Ndlovu H
  Title
Signaling C-type lectin receptors in antimycobacterial immunity.
  Journal
PLoS Pathog 13:e1006333 (2017)
DOI:10.1371/journal.ppat.1006333
Reference
PMID:24867235
  Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
  Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
  Journal
Nat Commun 5:3898 (2014)
DOI:10.1038/ncomms4898
Reference
PMID:19521399
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
Signalling through C-type lectin receptors: shaping immune responses.
  Journal
Nat Rev Immunol 9:465-79 (2009)
DOI:10.1038/nri2569
Reference
PMID:19122653
  Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
  Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
  Journal
Nat Immunol 10:203-13 (2009)
DOI:10.1038/ni.1692
KO pathway
ko04625   
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