KEGG   PATHWAY: praf00230
Entry
praf00230                   Pathway                                
Name
Purine metabolism - Podarcis raffonei (Aeolian wall lizard)
Class
Metabolism; Nucleotide metabolism
Pathway map
praf00230  Purine metabolism
praf00230

Module
praf_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:praf00230]
praf_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:praf00230]
praf_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:praf00230]
praf_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:praf00230]
praf_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:praf00230]
praf_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:praf00230]
praf_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:praf00230]
Other DBs
GO: 0006163 0042278
Organism
Podarcis raffonei (Aeolian wall lizard) [GN:praf]
Gene
128421391  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
128407580  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
128422103  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
128415661  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
128421362  PGM2; phosphopentomutase [KO:K15779] [EC:5.4.2.2 5.4.2.7]
128406706  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
128413209  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
128406071  ribose-phosphate pyrophosphokinase 1-like isoform X1 [KO:K00948] [EC:2.7.6.1]
128420987  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
128412988  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
128412989  trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
128399613  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
128420983  PAICS; bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
128422125  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
128401421  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
128419377  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
128407466  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
128402209  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X1 [KO:K01081] [EC:3.1.3.5]
128418887  NT5C1A; cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
128414282  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
128419964  cytosolic purine 5'-nucleotidase-like [KO:K01081] [EC:3.1.3.5]
128410132  NT5C1B; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
128416424  cytosolic 5'-nucleotidase 1A-like isoform X1 [KO:K01081] [EC:3.1.3.5]
128410310  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
128401023  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
128416652  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
128400119  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
128406717  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
128408542  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
128422452  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
128412791  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
128401825  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
128407398  nucleoside diphosphate kinase isoform X1 [KO:K00940] [EC:2.7.4.6]
128407403  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
128402144  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
128421762  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
128410424  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
128406827  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
128414376  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
128398280  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
128407338  CANT1; LOW QUALITY PROTEIN: soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
128402411  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
128409333  ENTPD5; nucleoside diphosphate phosphatase ENTPD5 [KO:K01511] [EC:3.6.1.6]
128411321  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
128404757  NUDT16; U8 snoRNA-decapping enzyme isoform X1 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
128415219  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
128411045  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
128423611  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
128414689  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
128417751  GMPR; LOW QUALITY PROTEIN: GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
128400555  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
128423064  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
128424094  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
128412037  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
128410165  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
128417178  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
128410507  HDDC2; 5'-deoxynucleotidase HDDC2 isoform X1 [KO:K07023] [EC:3.1.3.89]
128420062  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
128407943  deoxycytidine kinase 2-like [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
128421505  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
128401565  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
128403737  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
128398543  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
128418090  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
128411458  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
128399744  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
128421318  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
128405141  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
128419465  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
128417072  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
128401275  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
128415300  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
128412606  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
128420949  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
128414581  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
128420947  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
128410102  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
128422603  GUCY2C; guanylyl cyclase C isoform X1 [KO:K12320] [EC:4.6.1.2]
128400131  GUCY2D; retinal guanylyl cyclase 1 isoform X1 [KO:K12321] [EC:4.6.1.2]
128412478  retinal guanylyl cyclase 2-like [KO:K12322] [EC:4.6.1.2]
128413386  guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
128403685  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
128423595  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
128405339  atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
128423881  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
128398534  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
128404359  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
128409839  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like isoform X1 [KO:K13755] [EC:3.1.4.17]
128412431  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
128422698  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1 [KO:K19021] [EC:3.1.4.17]
128415681  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
128421163  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
128405329  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
128414054  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
128414895  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
128409583  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
128422344  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
128413052  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
128410735  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
128424114  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
128398479  ADSS1; adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
128404384  adenylosuccinate synthetase isozyme 2-like [KO:K01939] [EC:6.3.4.4]
128410887  ADSS2; adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
128415265  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
128415947  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
128416209  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
128413707  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
128416405  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
128422328  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
128406537  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
128407369  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
128418905  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
128415588  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
128415647  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
128405189  adenylate kinase isoenzyme 1-like isoform X1 [KO:K00939] [EC:2.7.4.3]
128422454  adenylate kinase 8-like [KO:K00939] [EC:2.7.4.3]
128406340  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
128423732  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
128404991  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
128406522  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
128410818  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
128410540  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
128410541  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
128423519  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
128415643  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
128404728  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
128405772  cAMP-specific 3',5'-cyclic phosphodiesterase 4C-like isoform X1 [KO:K13293] [EC:3.1.4.53]
128410566  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
128417403  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
128423045  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
128401722  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
128408513  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
128416987  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
128413362  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
128421282  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
128415116  uricase-like [KO:K00365] [EC:1.7.3.3]
128414442  allantoinase, mitochondrial-like isoform X1 [KO:K01466] [EC:3.5.2.5]
128411347  ALLC; probable inactive allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
praf00030  Pentose phosphate pathway
praf00220  Arginine biosynthesis
praf00250  Alanine, aspartate and glutamate metabolism
praf00260  Glycine, serine and threonine metabolism
praf00340  Histidine metabolism
praf00630  Glyoxylate and dicarboxylate metabolism
praf00730  Thiamine metabolism
praf00740  Riboflavin metabolism
praf00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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