KEGG   PATHWAY: pspa04260
Entry
pspa04260                   Pathway                                
Name
Cardiac muscle contraction - Polyodon spathula (Mississippi paddlefish)
Description
Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
Class
Organismal Systems; Circulatory system
Pathway map
pspa04260  Cardiac muscle contraction
pspa04260

Other DBs
GO: 0060048
Organism
Polyodon spathula (Mississippi paddlefish) [GN:pspa]
Gene
121318589  voltage-dependent L-type calcium channel subunit alpha-1C-like isoform X1 [KO:K04850]
121319532  voltage-dependent L-type calcium channel subunit alpha-1C-like [KO:K04850]
121298208  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
121328825  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
121305498  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04853]
121299863  voltage-dependent L-type calcium channel subunit alpha-1S-like isoform X1 [KO:K04857]
121299885  voltage-dependent L-type calcium channel subunit alpha-1S-like isoform X1 [KO:K04857]
121302005  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04862]
121302007  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04862]
121324486  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04862]
121312688  voltage-dependent L-type calcium channel subunit beta-2-like isoform X1 [KO:K04863]
121314145  voltage-dependent L-type calcium channel subunit beta-2-like isoform X1 [KO:K04863]
121309021  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
121322389  voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
121323228  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
121318192  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
121319909  voltage-dependent calcium channel subunit alpha-2/delta-1-like isoform X1 [KO:K04858]
121298155  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
121328816  voltage-dependent calcium channel subunit alpha-2/delta-2-like isoform X1 [KO:K04859]
121298277  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
121329136  voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
121317842  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
121319534  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
121295556  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
121296365  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
121306111  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
121300659  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
121330686  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
121295554  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
121296363  voltage-dependent calcium channel gamma-4 subunit-like isoform X1 [KO:K04869]
121295555  cacng5b; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
121296364  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
121307210  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
121302388  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
121307195  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
121302250  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
121307228  voltage-dependent calcium channel gamma-8 subunit-like [KO:K04873]
121302147  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
121315498  ryanodine receptor 2-like [KO:K04962]
121316738  ryanodine receptor 2 isoform X1 [KO:K04962]
121313375  aspartyl/asparaginyl beta-hydroxylase-like isoform X1 [KO:K00476] [EC:1.14.11.16]
121314303  probable serine/threonine-protein kinase kinX isoform X1 [KO:K00476] [EC:1.14.11.16]
121320723  calsequestrin-2-like [KO:K23445]
121327857  calsequestrin-2-like [KO:K23445]
121315796  triadin-like isoform X1 [KO:K23449]
121316903  trdn; triadin isoform X1 [KO:K23449]
121297424  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
121300218  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
121307343  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like isoform X1 [KO:K05853] [EC:7.2.2.10]
121302124  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
121308548  sarcoplasmic/endoplasmic reticulum calcium ATPase 3-like [KO:K05853] [EC:7.2.2.10]
121305032  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
121305230  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
121297753  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
121328441  troponin C, slow skeletal and cardiac muscles [KO:K05865]
121329295  troponin C, slow skeletal and cardiac muscles [KO:K05865]
121305479  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
121299821  troponin T, cardiac muscle-like isoform X1 [KO:K12045]
121318554  troponin T, cardiac muscle-like isoform X1 [KO:K12045]
121304773  troponin T, cardiac muscle-like isoform X1 [KO:K12045]
121319696  troponin T, cardiac muscle isoforms-like [KO:K12045]
121294514  tropomyosin alpha-1 chain isoform X1 [KO:K10373]
121298887  tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
121301633  tropomyosin alpha-1 chain-like [KO:K10373]
121301712  tropomyosin alpha-1 chain-like isoform X1 [KO:K10374]
121316022  tropomyosin alpha-1 chain-like isoform X1 [KO:K10374]
121306981  tropomyosin alpha-3 chain-like isoform X1 [KO:K09290]
121309832  tropomyosin alpha-3 chain-like [KO:K09290]
121301189  tropomyosin alpha-1 chain-like [KO:K10375]
121300559  tropomyosin alpha-1 chain isoform X1 [KO:K10375]
121295041  actin, aortic smooth muscle-like [KO:K12314]
121316038  actin, alpha skeletal muscle 2 [KO:K12314]
121317153  actin, alpha skeletal muscle 2 [KO:K12314]
121329870  actin, alpha cardiac muscle 1 [KO:K12314]
121329947  actin, aortic smooth muscle-like [KO:K12314]
121324248  actin, alpha cardiac muscle 1 [KO:K12314]
121324506  actc1a; actin, alpha cardiac muscle 1a [KO:K12314]
121329983  actin, alpha cardiac muscle-like [KO:K12314]
121306743  myosin-7-like [KO:K17751]
121306744  myosin-6 [KO:K17751]
121306846  myosin-6-like [KO:K17751]
121305136  myosin-7-like [KO:K17751]
121305137  myosin-7-like [KO:K17751]
121305150  myosin-7 [KO:K17751]
121305152  myosin-7-like [KO:K17751]
121305153  myosin-7-like [KO:K17751]
121296803  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
121300097  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
121303501  myosin light chain 4-like [KO:K12750]
121303508  myosin light chain 4-like [KO:K12750]
121303606  myosin light chain 4-like [KO:K12750]
121303608  myosin light chain 4-like [KO:K12750]
121313371  myosin light chain 1, cardiac muscle-like [KO:K12750]
121325036  myl4; myosin light chain 4 [KO:K12750]
121296589  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
121326162  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
805406  CYTB; cytochrome b [KO:K00412]
121297789  cytochrome c1, heme protein, mitochondrial-like [KO:K00413]
121319455  cytochrome c1, heme protein, mitochondrial-like [KO:K00413]
121298108  cytochrome b-c1 complex subunit 1, mitochondrial-like [KO:K00414]
121328742  cytochrome b-c1 complex subunit 1, mitochondrial-like [KO:K00414]
121308025  cytochrome b-c1 complex subunit 2, mitochondrial isoform X1 [KO:K00415]
121331075  cytochrome b-c1 complex subunit 2, mitochondrial-like isoform X1 [KO:K00415]
121326939  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
121330611  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
121314961  cytochrome b-c1 complex subunit 7-like [KO:K00417]
121313223  cytochrome b-c1 complex subunit 7 [KO:K00417]
121296822  cytochrome b-c1 complex subunit 8-like [KO:K00418]
121324725  cytochrome b-c1 complex subunit 8-like [KO:K00418]
121296897  cytochrome b-c1 complex subunit 9-like [KO:K00419]
121299438  cytochrome b-c1 complex subunit 9-like [KO:K00419]
121301311  cytochrome b-c1 complex subunit 10-like [KO:K00420]
121301325  cytochrome b-c1 complex subunit 10-like [KO:K00420]
805408  COX3; cytochrome c oxidase subunit III [KO:K02262]
805409  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
805412  COX2; cytochrome c oxidase subunit II [KO:K02261]
121296400  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
121297974  cytochrome c oxidase subunit 4 isoform 2, mitochondrial-like [KO:K02263]
121325777  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
121314577  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
121307793  cytochrome c oxidase subunit 4 isoform 2, mitochondrial-like [KO:K02263]
121295078  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
121299298  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
121321466  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
121302203  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
121303150  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
121325120  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
121296777  cytochrome c oxidase subunit 6A, mitochondrial-like [KO:K02266]
121296886  cytochrome c oxidase subunit 6A, mitochondrial-like [KO:K02266]
121300139  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
121307287  cytochrome c oxidase subunit 6B1-like [KO:K02267]
121301367  cytochrome c oxidase subunit 6B1-like [KO:K02267]
121302493  cytochrome c oxidase subunit 6B1 [KO:K02267]
121330790  cytochrome c oxidase subunit 6B1-like [KO:K02267]
121298187  cytochrome c oxidase subunit 6C-1-like [KO:K02268]
121319477  cytochrome c oxidase subunit 6C-1-like [KO:K02268]
121315422  cytochrome c oxidase subunit 7A2, mitochondrial-like isoform X1 [KO:K02270]
121316359  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
121316669  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
121317621  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
121303870  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
121305020  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
121295271  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
121318685  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
121312922  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
121306227  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
121294775  cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
121329491  si:dkey-85n7.8; COX8 domain-containing protein [KO:K02273]
121315787  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
121316889  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
121310101  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
121303720  sodium/calcium exchanger 2-like [KO:K05849]
121324512  slc8a3; sodium/calcium exchanger 3 [KO:K05849]
121295871  sodium/hydrogen exchanger 6-like [KO:K12041]
121321006  sodium/hydrogen exchanger 7-like [KO:K12041]
121307629  sodium/hydrogen exchanger 6-like [KO:K12041]
121328062  sodium/hydrogen exchanger 7-like isoform X1 [KO:K12041]
121298585  sodium/potassium-transporting ATPase subunit alpha-3-like [KO:K01539] [EC:7.2.2.13]
121320726  sodium/potassium-transporting ATPase subunit alpha-1-like [KO:K01539] [EC:7.2.2.13]
121320727  sodium/potassium-transporting ATPase subunit alpha-1-like isoform X1 [KO:K01539] [EC:7.2.2.13]
121307362  sodium/potassium-transporting ATPase subunit alpha-2 isoform X1 [KO:K01539] [EC:7.2.2.13]
121321082  sodium/potassium-transporting ATPase subunit alpha-1-like [KO:K01539] [EC:7.2.2.13]
121327697  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
121327885  sodium/potassium-transporting ATPase subunit alpha-1-like [KO:K01539] [EC:7.2.2.13]
121304271  sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
121295635  protein ATP1B4-like [KO:K01540]
121306623  sodium/potassium-transporting ATPase subunit beta-2-like isoform X1 [KO:K01540]
121320578  sodium/potassium-transporting ATPase subunit beta-1-like [KO:K01540]
121327353  sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
121327758  sodium/potassium-transporting ATPase subunit beta-1-like [KO:K01540]
121323714  sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
121318830  protein ATP1B4-like [KO:K01540]
121308281  sodium/hydrogen exchanger 1-like [KO:K05742]
Compound
C00076  Calcium cation
C00080  H+
C00238  Potassium cation
C01330  Sodium cation
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:16799263
  Authors
Endoh M
  Title
Signal transduction and Ca2+ signaling in intact myocardium.
  Journal
J Pharmacol Sci 100:525-37 (2006)
DOI:10.1254/jphs.CPJ06009X
Reference
PMID:18981594
  Authors
Endoh M
  Title
Cardiac Ca2+ signaling and Ca2+ sensitizers.
  Journal
Circ J 72:1915-25 (2008)
DOI:10.1253/circj.CJ-08-0838
Reference
PMID:16552170
  Authors
Bers DM, Despa S
  Title
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.
  Journal
J Pharmacol Sci 100:315-22 (2006)
DOI:10.1254/jphs.CPJ06001X
Reference
PMID:10747208
  Authors
Gordon AM, Homsher E, Regnier M
  Title
Regulation of contraction in striated muscle.
  Journal
Physiol Rev 80:853-924 (2000)
DOI:10.1152/physrev.2000.80.2.853
Reference
PMID:16701909
  Authors
Phrommintikul A, Chattipakorn N
  Title
Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.
  Journal
Int J Cardiol 112:142-52 (2006)
DOI:10.1016/j.ijcard.2005.11.106
Reference
PMID:16096350
  Authors
Lacinova L
  Title
Voltage-dependent calcium channels.
  Journal
Gen Physiol Biophys 24 Suppl 1:1-78 (2005)
Reference
PMID:12763850
  Authors
Lingrel J, Moseley A, Dostanic I, Cougnon M, He S, James P, Woo A, O'Connor K, Neumann J
  Title
Functional roles of the alpha isoforms of the Na,K-ATPase.
  Journal
Ann N Y Acad Sci 986:354-9 (2003)
DOI:10.1111/j.1749-6632.2003.tb07214.x
Reference
PMID:11294886
  Authors
Berg JS, Powell BC, Cheney RE
  Title
A millennial myosin census.
  Journal
Mol Biol Cell 12:780-94 (2001)
DOI:10.1091/mbc.12.4.780
Reference
PMID:15736582
  Authors
Parmacek MS, Solaro RJ
  Title
Biology of the troponin complex in cardiac myocytes.
  Journal
Prog Cardiovasc Dis 47:159-76 (2004)
DOI:10.1016/j.pcad.2004.07.003
Reference
PMID:14659803
  Authors
Yamashita H, Sugiura S, Fujita H, Yasuda S, Nagai R, Saeki Y, Sunagawa K, Sugi H
  Title
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
  Journal
Cardiovasc Res 60:580-8 (2003)
DOI:10.1016/j.cardiores.2003.09.011
Reference
PMID:19403607
  Authors
Pritchard TJ, Kranias EG
  Title
Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis.
  Journal
J Physiol 587:3125-33 (2009)
DOI:10.1113/jphysiol.2009.172171
Reference
PMID:28596175
  Authors
Landstrom AP, Dobrev D, Wehrens XHT
  Title
Calcium Signaling and Cardiac Arrhythmias.
  Journal
Circ Res 120:1969-1993 (2017)
DOI:10.1161/CIRCRESAHA.117.310083
Related
pathway
pspa04020  Calcium signaling pathway
KO pathway
ko04260   
LinkDB

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