KEGG   PATHWAY: pspa04910
Entry
pspa04910                   Pathway                                
Name
Insulin signaling pathway - Polyodon spathula (Mississippi paddlefish)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
pspa04910  Insulin signaling pathway
pspa04910

Organism
Polyodon spathula (Mississippi paddlefish) [GN:pspa]
Gene
121295106  insulin-like [KO:K04526]
121330389  insulin-like [KO:K04526]
121305882  insulin-2 [KO:K04526]
121300714  insulin receptor-like isoform X1 [KO:K04527] [EC:2.7.10.1]
121309564  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
121306496  insulin receptor substrate 1-like [KO:K16172]
121327022  insulin receptor substrate 1-B-like isoform X1 [KO:K16172]
121322871  insulin receptor substrate 1-B-like [KO:K16172]
121305699  insulin receptor substrate 1-like [KO:K16172]
121295578  insulin receptor substrate 2-B-like [KO:K07187]
121320808  insulin receptor substrate 2-like isoform X1 [KO:K07187]
121327771  insulin receptor substrate 2-like [KO:K07187]
121318669  insulin receptor substrate 2-B-like isoform X1 [KO:K07187]
121300582  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
121300755  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
121326688  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121301490  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
121317026  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121330558  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
121326758  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
121327018  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121328810  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
121323116  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
121323146  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
121329032  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
121305638  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
121300983  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
121330948  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
121316056  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
121317179  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121303838  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121324176  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121330210  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121304828  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
121320753  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121327778  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
121318005  glycogen [starch] synthase, liver-like isoform X1 [KO:K00693] [EC:2.4.1.11]
121305927  gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
121297200  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A isoform X1 [KO:K06269] [EC:3.1.3.16]
121300004  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
121307312  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
121316199  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
121302127  serine/threonine-protein phosphatase PP1-alpha catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
121317328  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
121310072  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like isoform X1 [KO:K06269] [EC:3.1.3.16]
121296713  protein phosphatase 1 regulatory subunit 3D [KO:K07189]
121297971  protein phosphatase 1 regulatory subunit 3D-like [KO:K07189]
121326097  protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
121302305  protein phosphatase 1 regulatory subunit 3C-B-like isoform X1 [KO:K07189]
121322355  protein phosphatase 1 regulatory subunit 3C-B-like isoform X1 [KO:K07189]
121303090  protein phosphatase 1 regulatory subunit 3C-B-like isoform X1 [KO:K07189]
121317601  ppp1r3b; protein phosphatase 1 regulatory subunit 3B isoform X1 [KO:K07189]
121304157  protein phosphatase 1 regulatory subunit 3B-like [KO:K07189]
121318151  protein phosphatase 1 regulatory subunit 3A-like [KO:K07189]
121319406  protein phosphatase 1 regulatory subunit 3D-like [KO:K07189]
121305307  protein phosphatase 1 regulatory subunit 3E-like [KO:K07189]
121305525  uncharacterized protein LOC121305525 [KO:K07189]
121319956  ppp1r3ab; protein phosphatase 1 regulatory subunit 3A [KO:K07189]
121306827  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
121308581  phkg1b; phosphorylase kinase, gamma 1b (muscle) [KO:K00871] [EC:2.7.11.19]
121295798  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform-like [KO:K07190]
121296549  phosphorylase b kinase regulatory subunit beta-like isoform X1 [KO:K07190]
121325656  phosphorylase b kinase regulatory subunit beta-like isoform X1 [KO:K07190]
121327905  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
121318697  phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform-like isoform X1 [KO:K07190]
121294605  calmodulin-like protein 4 [KO:K02183]
121298942  calml4a; calmodulin-like protein 4a [KO:K02183]
121316330  calmodulin-1 [KO:K02183]
121316692  calmodulin-1 [KO:K02183]
121303849  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
121329906  calmodulin-1 [KO:K02183]
121323988  calmodulin-1 [KO:K02183]
121304911  calmodulin-1 [KO:K02183]
121315773  glycogen phosphorylase, brain form-like isoform X1 [KO:K00688] [EC:2.4.1.1]
121316875  glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
121310085  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
121330016  glycogen phosphorylase, liver form-like [KO:K00688] [EC:2.4.1.1]
121324956  glycogen phosphorylase, liver form-like [KO:K00688] [EC:2.4.1.1]
121294654  cGMP-inhibited 3',5'-cyclic phosphodiesterase B-like isoform X1 [KO:K13296] [EC:3.1.4.17]
121329848  cGMP-inhibited 3',5'-cyclic phosphodiesterase B-like [KO:K13296] [EC:3.1.4.17]
121326749  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121310175  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
121331016  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
121300936  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
121295532  cAMP-dependent protein kinase type I-alpha regulatory subunit-like [KO:K04739]
121296008  cAMP-dependent protein kinase type I-alpha regulatory subunit [KO:K04739]
121298225  cAMP-dependent protein kinase type II-alpha regulatory subunit-like [KO:K04739]
121328613  LOW QUALITY PROTEIN: cAMP-dependent protein kinase type II-alpha regulatory subunit-like [KO:K04739]
121318309  cAMP-dependent protein kinase type II-beta regulatory subunit-like isoform X1 [KO:K04739]
121330810  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
121319795  cAMP-dependent protein kinase type II-beta regulatory subunit-like [KO:K04739]
121299176  lipeb; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
121304208  hormone-sensitive lipase-like isoform X1 [KO:K07188] [EC:3.1.1.79]
121328449  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
121328637  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
121326834  protein kinase C iota type-like isoform X1 [KO:K06069] [EC:2.7.11.13]
121323120  protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
121306488  solute carrier family 2, facilitated glucose transporter member 4-like isoform X1 [KO:K07191]
121305717  solute carrier family 2, facilitated glucose transporter member 4-like [KO:K07191]
121308444  flotillin-2a isoform X1 [KO:K07192]
121304173  flotillin-1-like [KO:K07192]
121304441  flotillin-1-like [KO:K07192]
121308492  SH2B adapter protein 2 [KO:K07193]
121321895  sorbin and SH3 domain-containing protein 1-like isoform X1 [KO:K06086]
121325201  sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
121302617  E3 ubiquitin-protein ligase CBL-B-A-like [KO:K04707] [EC:2.3.2.27]
121309453  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
121298777  E3 ubiquitin-protein ligase CBL-B-like isoform X1 [KO:K22517] [EC:2.3.2.27]
121302581  E3 ubiquitin-protein ligase CBL-B-like [KO:K22517] [EC:2.3.2.27]
121297140  crk-like protein [KO:K04438]
121299985  crk-like protein [KO:K04438]
121308658  crk; adapter molecule crk isoform X1 [KO:K04438]
121309747  rapgef1a; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
121316339  rho-related GTP-binding protein RhoQ [KO:K07194]
121316684  rho-related GTP-binding protein RhoQ-like [KO:K07194]
121296507  exocyst complex component 7-like isoform X1 [KO:K07195]
121295663  exocyst complex component 7-like isoform X1 [KO:K07195]
121309124  trip10a; cdc42-interacting protein 4 homolog [KO:K07196]
121300763  sterol regulatory element-binding protein 1-like isoform X1 [KO:K07197]
121294130  sterol regulatory element-binding protein 1-like isoform X1 [KO:K07197]
121308805  acetyl-CoA carboxylase 1-like [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
121305083  acetyl-CoA carboxylase-like [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
121307729  LOW QUALITY PROTEIN: acetyl-CoA carboxylase 2-like [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
121295320  fatty acid synthase-like [KO:K00665] [EC:2.3.1.85]
121296635  fatty acid synthase-like [KO:K00665] [EC:2.3.1.85]
121296923  hexokinase-2-like [KO:K00844] [EC:2.7.1.1]
121297019  hexokinase-2-like isoform X1 [KO:K00844] [EC:2.7.1.1]
121326118  hexokinase-1-like [KO:K00844] [EC:2.7.1.1]
121326119  hkdc1; hexokinase HKDC1 [KO:K00844] [EC:2.7.1.1]
121321907  hexokinase-1 [KO:K00844] [EC:2.7.1.1]
121321908  hexokinase HKDC1-like isoform X1 [KO:K00844] [EC:2.7.1.1]
121302348  hexokinase-2-like isoform X1 [KO:K00844] [EC:2.7.1.1]
121303094  hexokinase-2-like [KO:K00844] [EC:2.7.1.1]
121302068  hexokinase-4-like isoform X1 [KO:K12407] [EC:2.7.1.2]
121303104  hexokinase-4-like isoform X1 [KO:K12407] [EC:2.7.1.2]
121299544  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
121326929  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
121318564  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
121331275  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
121297106  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
121299815  5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
121327017  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
121330680  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
121321492  5'-AMP-activated protein kinase subunit gamma-3-like [KO:K07200]
121308970  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
121310040  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
121314051  5'-AMP-activated protein kinase subunit gamma-2-like isoform X1 [KO:K07200]
121321361  foxo1a; forkhead box protein O1-A [KO:K07201]
121329761  peroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X1 [KO:K07202]
121324292  peroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X1 [KO:K07202]
121301875  g6pc3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
121301985  glucose-6-phosphatase catalytic subunit 1-like isoform X1 [KO:K01084] [EC:3.1.3.9]
121302035  glucose-6-phosphatase catalytic subunit 1-like [KO:K01084] [EC:3.1.3.9]
121322292  glucose-6-phosphatase 2-like [KO:K01084] [EC:3.1.3.9]
121324720  glucose-6-phosphatase catalytic subunit 1-like [KO:K01084] [EC:3.1.3.9]
121300302  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
121300312  fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
121317224  fructose-1,6-bisphosphatase isozyme 2-like [KO:K03841] [EC:3.1.3.11]
121317239  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
121298464  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
121305155  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
121319441  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
121328756  serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
121328834  serine/threonine-protein kinase mTOR-like isoform X1 [KO:K07203] [EC:2.7.11.1]
121295471  regulatory-associated protein of mTOR [KO:K07204]
121296270  regulatory-associated protein of mTOR-like [KO:K07204]
121308414  rps6kb1a; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
121302105  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
121296526  40S ribosomal protein S6 [KO:K02991]
121321685  40S ribosomal protein S6 [KO:K02991]
121302217  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
121303227  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
121295721  eukaryotic translation initiation factor 4E-1A [KO:K03259]
121297490  eukaryotic translation initiation factor 4E-like [KO:K03259]
121306576  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
121326019  eif4e1c; eukaryotic translation initiation factor 4E family member 1c isoform X1 [KO:K03259]
121321986  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
121324880  eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
121309703  hamartin-like [KO:K07206]
121300741  tsc2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
121330994  tuberin-like isoform X1 [KO:K07207]
121308973  rhebl1; ras homolog, mTORC1 binding like 1 isoform X1 [KO:K07208]
121310026  GTP-binding protein Rheb isoform X1 [KO:K07208]
121314049  GTP-binding protein Rheb isoform X1 [KO:K07208]
121310102  badb; BCL2 associated agonist of cell death b isoform X1 [KO:K02158]
121307017  shc1; SHC-transforming protein 1 [KO:K06279]
121301327  shc2; SHC-transforming protein 2 [KO:K17447]
121315808  SHC-transforming protein 3-like isoform X1 [KO:K17448]
121302023  SHC-transforming protein 3-like isoform X1 [KO:K17448]
121294465  SHC-transforming protein 4-like isoform X1 [KO:K17449]
121298902  SHC-transforming protein 3-like isoform X1 [KO:K17449]
121295867  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
121296442  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
121316389  son of sevenless homolog 1-like [KO:K03099]
121316886  son of sevenless homolog 1 isoform X1 [KO:K03099]
121323793  sos2; son of sevenless homolog 2 [KO:K03099]
121294911  GTPase HRas [KO:K02833]
121330312  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
121318385  GTPase KRas isoform X1 [KO:K07827]
121319713  GTPase KRas isoform X1 [KO:K07827]
121300074  GTPase NRas [KO:K07828]
121300091  GTPase NRas [KO:K07828]
121329240  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
121305491  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
121318501  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
121319596  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
121297980  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
121328554  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
121294557  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
121298929  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121304127  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
121300828  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
121301294  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121297147  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121306857  mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
121307738  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121305215  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121301392  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
121301595  MAP kinase-interacting serine/threonine-protein kinase 2-like [KO:K04372] [EC:2.7.11.1]
121330967  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
121305541  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
121301600  suppressor of cytokine signaling 1-like [KO:K04694]
121331018  suppressor of cytokine signaling 1-like [KO:K04694]
121300287  suppressor of cytokine signaling 2-like [KO:K04695]
121318297  socs2; suppressor of cytokine signaling 2 [KO:K04695]
121319817  suppressor of cytokine signaling 2-like isoform X1 [KO:K04695]
121300299  suppressor of cytokine signaling 2-like [KO:K04695]
121295672  suppressor of cytokine signaling 3-like [KO:K04696]
121296491  suppressor of cytokine signaling 3-like [KO:K04696]
121330241  suppressor of cytokine signaling 4-like [KO:K04697]
121324308  suppressor of cytokine signaling 4-like [KO:K04697]
121297909  ptpn1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
121319189  tyrosine-protein phosphatase non-receptor type 1-like isoform X1 [KO:K05696] [EC:3.1.3.48]
121326999  ptprfa; protein tyrosine phosphatase receptor type Fa isoform X1 [KO:K05695] [EC:3.1.3.48]
121331105  receptor-type tyrosine-protein phosphatase F-like isoform X1 [KO:K05695] [EC:3.1.3.48]
121296957  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121325682  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121301569  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121316125  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
121321798  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
121324174  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
121302294  inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X1 [KO:K07209] [EC:2.7.11.10]
121303214  inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X1 [KO:K07209] [EC:2.7.11.10]
121295600  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like [KO:K15909] [EC:3.1.3.86]
121302713  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A isoform X1 [KO:K15909] [EC:3.1.3.86]
121317878  LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like [KO:K15909] [EC:3.1.3.86]
121321733  inositol polyphosphate-5-phosphatase A isoform X1 [KO:K01106] [EC:3.1.3.56]
121325611  inositol polyphosphate-5-phosphatase A-like isoform X1 [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14635525
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
PMID:11282018
  Authors
Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
PMID:12867054
  Authors
Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
PMID:10196204
  Authors
Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
PMID:15733744
  Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
  Journal
Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
  Authors
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.
  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
  Journal
Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
PMID:11742412
  Authors
Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
  Journal
Nature 414:799-806 (2001)
DOI:10.1038/414799a
Reference
PMID:15624019
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
PMID:16288289
  Authors
Ruggero D, Sonenberg N.
  Title
The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
PMID:10567225
  Authors
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
  Journal
Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
  Authors
Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
  Journal
Mol Cell Biochem 182:23-9 (1998)
Reference
PMID:15229476
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
  Authors
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
PMID:17344645
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
PMID:18291668
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
PMID:11343120
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
PMID:12791379
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
pspa00010  Glycolysis / Gluconeogenesis
pspa00061  Fatty acid biosynthesis
pspa00500  Starch and sucrose metabolism
pspa04010  MAPK signaling pathway
pspa04070  Phosphatidylinositol signaling system
pspa04210  Apoptosis
KO pathway
ko04910   
LinkDB

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