Entry Name AMPK signaling pathway - Panthera uncia (snow leopard)
Description AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Panthera uncia (snow leopard) [GN:
puc ]
Gene 125926677 STE20-related kinase adapter protein alpha isoform X1 [KO:K08271 ]
125913268 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199 ]
125919017 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200 ]
125911173 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200 ]
125911260 cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
125930188 cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
125925743 cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048 ]
125934155 cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048 ]
125919439 cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048 ]
125928859 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048 ]
125930855 cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047 ]
125922677 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202 ]
125926175 solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191 ]
125927545 sterol regulatory element-binding protein 1 isoform X1 [KO:K07197 ]
125935491 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382 ] [EC:3.1.3.16 ]
125915504 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
125909965 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456 ]
125923363 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354 ]
125933053 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354 ]
125935610 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354 ]
125931441 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583 ]
125909573 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583 ]
125921315 serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583 ]
125931158 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584 ]
125925295 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584 ]
125909154 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584 ]
125917447 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584 ]
125910302 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584 ]
125918432 serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584 ]
125913143 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
125921289 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
125913493 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
125935698 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
125929237 phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
125923271 eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
125930730 peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530 ]
Compound C00354 D-Fructose 1,6-bisphosphate
C00665 beta-D-Fructose 2,6-bisphosphate
C00668 alpha-D-Glucose 6-phosphate
C01172 beta-D-Glucose 6-phosphate
C04677 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C09731 Epigallocatechin gallate
Reference Authors Steinberg GR, Kemp BE
Title AMPK in Health and Disease.
Journal Reference Authors Hardie DG.
Title The AMP-activated protein kinase pathway--new players upstream and downstream.
Journal Reference Authors Russo GL, Russo M, Ungaro P
Title AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
Journal Reference Authors Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
Title AMPK in the brain: its roles in energy balance and neuroprotection.
Journal Reference Authors Li J, McCullough LD
Title Effects of AMP-activated protein kinase in cerebral ischemia.
Journal Reference Authors Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
Title The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
Journal Reference Authors Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
Title Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
Journal Reference Authors Shackelford DB, Shaw RJ
Title The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
Journal Reference Authors Chung JH, Manganiello V, Dyck JR
Title Resveratrol as a calorie restriction mimetic: therapeutic implications.
Journal Reference Authors Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
Title Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
Journal Reference Authors Towler MC, Hardie DG
Title AMP-activated protein kinase in metabolic control and insulin signaling.
Journal Reference Authors Richter EA, Hargreaves M
Title Exercise, GLUT4, and skeletal muscle glucose uptake.
Journal Reference Authors Kahn BB, Alquier T, Carling D, Hardie DG
Title AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
Journal Reference Authors Minokoshi Y, Toda C, Okamoto S
Title Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
Journal Reference Authors Guggino WB, Stanton BA
Title New insights into cystic fibrosis: molecular switches that regulate CFTR.
Journal Reference Authors Cheng A, Saltiel AR
Title More TORC for the gluconeogenic engine.
Journal Reference Authors Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
Title TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
Journal Reference Authors Morris DL, Rui L
Title Recent advances in understanding leptin signaling and leptin resistance.
Journal Reference Authors Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
Title Role of hypothalamic AMP-kinase in food intake regulation.
Journal Reference Authors Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
Title Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
Journal Related puc01040 Biosynthesis of unsaturated fatty acids
puc04920 Adipocytokine signaling pathway
KO pathway LinkDB All DBs
