KEGG   PATHWAY: puc04150
Entry
puc04150                    Pathway                                
Name
mTOR signaling pathway - Panthera uncia (snow leopard)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
puc04150  mTOR signaling pathway
puc04150

Organism
Panthera uncia (snow leopard) [GN:puc]
Gene
125916438  large neutral amino acids transporter small subunit 1 [KO:K13780]
125931967  4F2 cell-surface antigen heavy chain [KO:K06519]
125935622  sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
125931695  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
125920967  V-type proton ATPase catalytic subunit A isoform X1 [KO:K02145] [EC:7.1.2.2]
125937089  V-type proton ATPase subunit B, kidney isoform [KO:K02147]
125923843  V-type proton ATPase subunit B, brain isoform [KO:K02147]
125937682  V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
125924776  V-type proton ATPase subunit C 1 [KO:K02148]
125909431  V-type proton ATPase subunit D [KO:K02149]
125918701  V-type proton ATPase subunit E 1 [KO:K02150]
125936229  V-type proton ATPase subunit E 2 [KO:K02150]
125930131  V-type proton ATPase subunit F [KO:K02151]
125938468  V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
125925371  V-type proton ATPase subunit G 3 [KO:K02152]
125927205  V-type proton ATPase subunit G 1 [KO:K02152]
125924691  V-type proton ATPase subunit H isoform X1 [KO:K02144]
125937226  ragulator complex protein LAMTOR1 [KO:K20397]
125925692  ragulator complex protein LAMTOR2 [KO:K20398]
125922091  ragulator complex protein LAMTOR3-like [KO:K04370]
125922966  ragulator complex protein LAMTOR3 [KO:K04370]
125928257  ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
125912274  ragulator complex protein LAMTOR5 [KO:K16344]
125927547  folliculin isoform X1 [KO:K09594]
125934868  folliculin-interacting protein 1 isoform X1 [KO:K20400]
125923158  folliculin-interacting protein 2 isoform X1 [KO:K20401]
125914238  ras-related GTP-binding protein A [KO:K16185]
125932168  ras-related GTP-binding protein B isoform X1 [KO:K16185]
125937948  ras-related GTP-binding protein D [KO:K16186]
125912740  ras-related GTP-binding protein C [KO:K16186]
125913579  sestrin-2 [KO:K20394]
125914511  cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
125928655  cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
125929936  GATOR complex protein MIOS [KO:K20407]
125914857  nucleoporin SEH1 isoform X1 [KO:K14299]
125928404  GATOR complex protein WDR24 [KO:K20408]
125916424  GATOR complex protein WDR59 isoform X1 [KO:K20409]
125929631  protein SEC13 homolog isoform X1 [KO:K14004]
125913988  GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
125929393  GATOR complex protein NPRL2 [KO:K20405]
125928373  GATOR complex protein NPRL3 isoform X1 [KO:K20406]
125934645  S-phase kinase-associated protein 2 [KO:K03875]
125914487  E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
125926268  regulatory-associated protein of mTOR [KO:K07204]
125915937  proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
125913121  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
125924446  DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
125927183  target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
125927143  telomere length regulation protein TEL2 homolog [KO:K11137]
125936623  TELO2-interacting protein 1 homolog [KO:K20403]
125914221  CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
125929769  growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
125937671  phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
125914795  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
125936597  phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
125915056  serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
125927563  serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
125923271  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
125922952  eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
125911066  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
125935265  eukaryotic translation initiation factor 4E type 1B [KO:K03259]
125930574  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
125926762  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
125919104  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
125921655  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
125914541  40S ribosomal protein S6 [KO:K02991]
125925545  40S ribosomal protein S6-like [KO:K02991]
125934023  40S ribosomal protein S6-like [KO:K02991]
125911359  40S ribosomal protein S6-like [KO:K02991]
125926677  STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
125911315  STE20-related kinase adapter protein beta [KO:K17532]
125928796  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
125933760  calcium-binding protein 39-like [KO:K08272]
125911089  calcium-binding protein 39 isoform X1 [KO:K08272]
125935020  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
125912556  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
125927652  hamartin isoform X1 [KO:K07206]
125926191  tuberin [KO:K07207]
125939553  TBC1 domain family member 7 isoform X1 [KO:K20396]
125930322  GTP-binding protein Rheb [KO:K07208]
125932711  DNA damage-inducible transcript 4 protein [KO:K08270]
125920405  proto-oncogene Wnt-1 [KO:K03209]
125930076  protein Wnt-2 [KO:K00182]
125912240  protein Wnt-2b [KO:K00182]
125934822  protein Wnt-3a [KO:K00312]
125927692  proto-oncogene Wnt-3 [KO:K00312]
125913720  protein Wnt-4 [KO:K00408]
125929490  protein Wnt-5a [KO:K00444]
125920070  protein Wnt-5b [KO:K00444]
125911162  LOW QUALITY PROTEIN: protein Wnt-6 [KO:K00445]
125929663  protein Wnt-7a isoform X1 [KO:K00572]
125919709  protein Wnt-7b [KO:K00572]
125933437  protein Wnt-8b [KO:K00714]
125935540  protein Wnt-8a [KO:K00714]
125911171  protein Wnt-10a [KO:K01357]
125920404  protein Wnt-10b [KO:K01357]
125914412  protein Wnt-11 [KO:K01384]
125931011  protein Wnt-16 [KO:K01558]
125929896  frizzled-1 [KO:K02432]
125911307  frizzled-7 [KO:K02432]
125926635  frizzled-2 [KO:K02235]
125923798  frizzled-3 isoform X1 [KO:K02329]
125938072  frizzled-4 [KO:K02354]
125911259  frizzled-5 [KO:K02375]
125919776  frizzled-8 [KO:K02375]
125924487  frizzled-6 [KO:K02376]
125915041  frizzled-10 [KO:K02842]
125928505  frizzled-9 [KO:K02842]
125911115  low-density lipoprotein receptor-related protein 5 [KO:K03068]
125920089  low-density lipoprotein receptor-related protein 6 [KO:K03068]
125927067  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
125913233  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
125921126  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
125921776  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125938466  tumor necrosis factor [KO:K03156]
125918761  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
125923306  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
125911602  insulin [KO:K04526]
125919488  insulin-like growth factor I isoform X1 [KO:K05459]
125928720  insulin receptor [KO:K04527] [EC:2.7.10.1]
125910252  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
125926370  growth factor receptor-bound protein 2 [KO:K04364]
125909520  son of sevenless homolog 2 isoform X1 [KO:K03099]
125917913  son of sevenless homolog 1 [KO:K03099]
125917917  son of sevenless homolog 1 [KO:K03099]
125937753  GTPase HRas isoform X1 [KO:K02833]
125918906  GTPase KRas isoform X1 [KO:K07827]
125912218  GTPase NRas [KO:K07828]
125930477  serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
125930728  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125910082  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125918032  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125918034  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125914884  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
125928028  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
125931535  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
125939048  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
125931793  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
125912889  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
125911117  insulin receptor substrate 1 [KO:K16172]
125913493  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
125935698  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125929237  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
125921850  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125913143  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125921289  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125933550  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125927192  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
125915806  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125909102  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125925091  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125932873  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
125921380  target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
125935026  rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
125934547  proline-rich protein 5-like isoform X1 [KO:K20411]
125919693  proline-rich protein 5 [KO:K20411]
125929348  transforming protein RhoA [KO:K04513]
125927372  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125927972  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125915497  protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
125937990  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
puc00561  Glycerolipid metabolism
puc04010  MAPK signaling pathway
puc04140  Autophagy - animal
puc04151  PI3K-Akt signaling pathway
puc04152  AMPK signaling pathway
puc04810  Regulation of actin cytoskeleton
puc04910  Insulin signaling pathway
KO pathway
ko04150   
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