KEGG   PATHWAY: puc04151
Entry
puc04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Panthera uncia (snow leopard)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
puc04151  PI3K-Akt signaling pathway
puc04151

Other DBs
GO: 0043491
Organism
Panthera uncia (snow leopard) [GN:puc]
Gene
125923024  pro-epidermal growth factor isoform X1 [KO:K04357]
125937079  protransforming growth factor alpha [KO:K08774]
125922819  proepiregulin [KO:K09784]
125922818  amphiregulin isoform X1 [KO:K09782]
125934898  fibroblast growth factor 1 isoform X1 [KO:K18496]
125923095  fibroblast growth factor 2 [KO:K18497]
125922856  fibroblast growth factor 5 [KO:K04358]
125923316  fibroblast growth factor 17 [KO:K04358]
125923425  fibroblast growth factor 20 [KO:K04358]
125915576  fibroblast growth factor 4 [KO:K04358]
125931780  fibroblast growth factor 16 [KO:K04358]
125908857  fibroblast growth factor 7 [KO:K04358]
125932896  fibroblast growth factor 8 [KO:K04358]
125911102  fibroblast growth factor 3 [KO:K04358]
125918741  fibroblast growth factor 6 [KO:K04358]
125934060  fibroblast growth factor 9 isoform X1 [KO:K04358]
125934607  fibroblast growth factor 10 [KO:K04358]
125928773  fibroblast growth factor 22 [KO:K04358]
125911104  fibroblast growth factor 19 [KO:K22603]
125915130  fibroblast growth factor 21 [KO:K22429]
125918740  fibroblast growth factor 23 [KO:K22428]
125912209  beta-nerve growth factor [KO:K02582]
125935341  brain-derived neurotrophic factor [KO:K04355]
125918754  neurotrophin-3 [KO:K04356]
125915407  neurotrophin-4 [KO:K12457]
125911602  insulin [KO:K04526]
125919488  insulin-like growth factor I isoform X1 [KO:K05459]
125911611  insulin-like growth factor II [KO:K13769]
125928362  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
125919624  platelet-derived growth factor subunit B isoform X1 [KO:K17386]
125923778  platelet-derived growth factor C isoform X1 [KO:K05450]
125910662  platelet-derived growth factor D isoform X1 [KO:K05450]
125912284  macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
125919390  kit ligand isoform X1 [KO:K05461]
125915189  fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
125938202  vascular endothelial growth factor A [KO:K05448]
125931731  vascular endothelial growth factor B isoform X1 [KO:K16858]
125909344  placenta growth factor isoform X1 [KO:K16859]
125923470  vascular endothelial growth factor C [KO:K05449]
125931496  vascular endothelial growth factor D [KO:K05449]
125929849  hepatocyte growth factor isoform X1 [KO:K05460]
125924751  angiopoietin-1 isoform X1 [KO:K05465]
125923491  angiopoietin-2 [KO:K05466]
125936734  angiopoietin-4 [KO:K05467]
125925721  ephrin-A1 [KO:K05462]
125925728  ephrin-A4 [KO:K05462]
125917495  LOW QUALITY PROTEIN: ephrin-A2-like [KO:K05462]
125917498  ephrin-A2-like [KO:K05462]
125925844  ephrin-A3 [KO:K05462]
125934955  ephrin-A5 [KO:K05462]
125934633  glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
125928902  neurturin [KO:K25414]
125913682  LOW QUALITY PROTEIN: artemin [KO:K25415]
125928919  persephin [KO:K25416]
125929783  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
125926482  receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
125919219  receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
125911361  receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
125923281  fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
125933011  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
125934963  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
125926436  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
125925658  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
125938004  BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
125928720  insulin receptor [KO:K04527] [EC:2.7.10.1]
125910252  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
125923629  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
125934559  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
125934562  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
125922732  mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
125934067  receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
125934080  vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
125934762  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
125922733  vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
125930874  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
125916653  angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
125913061  ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
125933341  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
125926370  growth factor receptor-bound protein 2 [KO:K04364]
125909520  son of sevenless homolog 2 isoform X1 [KO:K03099]
125917913  son of sevenless homolog 1 [KO:K03099]
125917917  son of sevenless homolog 1 [KO:K03099]
125937753  GTPase HRas isoform X1 [KO:K02833]
125918906  GTPase KRas isoform X1 [KO:K07827]
125912218  GTPase NRas [KO:K07828]
125930728  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125910082  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125918032  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125918034  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125914884  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
125928028  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
125911117  insulin receptor substrate 1 [KO:K16172]
125923764  toll-like receptor 2 [KO:K10159]
125920696  toll-like receptor 4 isoform X1 [KO:K10160]
125928294  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
125924291  tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
125928006  B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
125933410  phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
125927640  somatotropin [KO:K05438]
125914512  oncostatin-M isoform X1 [KO:K05418]
125923086  interleukin-2 [KO:K05429]
125935200  interleukin-3 [KO:K04736]
125930836  interleukin-6 [KO:K05405]
125935484  interleukin-4 [KO:K05430]
125924837  interleukin-7 isoform X1 [KO:K05431]
125925935  interferon beta-like [KO:K05414]
125925953  interferon alpha-2-like [KO:K05414]
125925944  interferon beta [KO:K05415]
125928226  LOW QUALITY PROTEIN: erythropoietin [KO:K05437]
125926494  granulocyte colony-stimulating factor [KO:K05423]
125935006  growth hormone receptor isoform X1 [KO:K05080]
125934655  prolactin receptor [KO:K05081]
125935027  oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
125918586  interleukin-2 receptor subunit alpha [KO:K05068]
125919566  interleukin-2 receptor subunit beta [KO:K05069]
125931753  cytokine receptor common subunit gamma [KO:K05070]
125932326  interleukin-3 receptor subunit alpha [KO:K04737]
125925736  interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
125927986  interleukin-4 receptor subunit alpha [KO:K05071]
125934650  interleukin-7 receptor subunit alpha [KO:K05072]
125921711  interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
125921705  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
125929007  erythropoietin receptor isoform X1 [KO:K05079]
125912766  granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
125913423  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
125931060  tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
125929213  tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
125929912  collagen alpha-2(I) chain [KO:K06236]
125926420  collagen alpha-1(I) chain isoform X1 [KO:K06236]
125920221  collagen alpha-1(II) chain [KO:K19719]
125931891  collagen alpha-6(IV) chain [KO:K06237]
125931892  collagen alpha-5(IV) chain [KO:K06237]
125933953  collagen alpha-2(IV) chain [KO:K06237]
125934049  collagen alpha-1(IV) chain [KO:K06237]
125911119  collagen alpha-4(IV) chain [KO:K06237]
125911120  collagen alpha-3(IV) chain [KO:K06237]
125922008  collagen alpha-6(VI) chain [KO:K06238]
125911027  collagen alpha-3(VI) chain isoform X1 [KO:K06238]
125920650  collagen alpha-2(VI) chain isoform X1 [KO:K06238]
125920651  collagen alpha-1(VI) chain [KO:K06238]
125921326  collagen alpha-5(VI) chain isoform X1 [KO:K06238]
125921328  collagen alpha-4(VI) chain-like [KO:K06238]
125913521  collagen alpha-2(IX) chain [KO:K08131]
125938616  collagen alpha-1(IX) chain [KO:K08131]
125936349  collagen alpha-3(IX) chain [KO:K08131]
125914808  LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
125937984  laminin subunit alpha-2 [KO:K05637]
125914386  laminin subunit alpha-3 isoform X1 [KO:K06240]
125936426  laminin subunit alpha-5 [KO:K06240]
125937961  laminin subunit alpha-4 isoform X1 [KO:K06241]
125929828  laminin subunit beta-1 [KO:K05636]
125929332  laminin subunit beta-2 [KO:K06243]
125925325  laminin subunit beta-3 [KO:K06244]
125929830  laminin subunit beta-4 [KO:K06245]
125925244  laminin subunit gamma-1 [KO:K05635]
125925243  laminin subunit gamma-2 [KO:K06246]
125922657  laminin subunit gamma-3 [KO:K06247]
125926414  chondroadherin [KO:K06248]
125929839  reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
125909843  thrombospondin-1 [KO:K16857]
125939067  thrombospondin-2 [KO:K04659]
125925699  LOW QUALITY PROTEIN: thrombospondin-3 [KO:K04659]
125935778  thrombospondin-4 [KO:K04659]
125929262  cartilage oligomeric matrix protein [KO:K04659]
125911221  fibronectin isoform X1 [KO:K05717]
125922915  osteopontin isoform X1 [KO:K06250]
125927483  vitronectin [KO:K06251]
125938413  tenascin-X [KO:K06252]
125925177  tenascin-R [KO:K06252]
125926032  tenascin-N [KO:K06252]
125927211  tenascin [KO:K06252]
125918758  von Willebrand factor [KO:K03900]
125922914  bone sialoprotein 2 [KO:K06253]
125934599  integrin alpha-1 isoform X1 [KO:K06480]
125918095  integrin alpha-2 [KO:K06481]
125918098  integrin alpha-2 [KO:K06481]
125926633  integrin alpha-IIb [KO:K06476]
125926426  integrin alpha-3 [KO:K06482]
125911511  integrin alpha-4 isoform X1 [KO:K06483]
125919148  integrin alpha-5 [KO:K06484]
125911548  integrin alpha-6 isoform X1 [KO:K06485]
125919183  integrin alpha-7 isoform X1 [KO:K06583]
125918614  integrin alpha-8 isoform X1 [KO:K06584]
125921436  integrin alpha-9 [KO:K06585]
125912176  integrin alpha-10 [KO:K06586]
125910096  integrin alpha-11 [KO:K06587]
125911491  integrin alpha-V [KO:K06487]
125918681  integrin beta-1 isoform X1 [KO:K05719]
125927330  integrin beta-3 [KO:K06493]
125926357  integrin beta-4 isoform X1 [KO:K06525]
125921789  integrin beta-5 [KO:K06588]
125911873  integrin beta-6 isoform X1 [KO:K06589]
125919112  integrin beta-7 isoform X1 [KO:K06590]
125929987  integrin beta-8 [KO:K06591]
125924709  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
125921850  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125913143  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125921289  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125913493  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
125935698  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125929237  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
125935758  proteinase-activated receptor 1 isoform X1 [KO:K03914]
125931960  muscarinic acetylcholine receptor M1 [KO:K04129]
125930180  muscarinic acetylcholine receptor M2 [KO:K04130]
125926724  lysophosphatidic acid receptor 1 [KO:K04289]
125930629  lysophosphatidic acid receptor 2 [KO:K04291]
125913384  lysophosphatidic acid receptor 3 [KO:K04294]
125931787  lysophosphatidic acid receptor 4 [KO:K04275]
125918779  lysophosphatidic acid receptor 5 [KO:K08390]
125933775  lysophosphatidic acid receptor 6 [KO:K04273]
125913218  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
125928229  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
125917979  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
125917990  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
125921860  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
125910003  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
125909505  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
125932224  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
125909421  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3-like [KO:K04540]
125932581  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
125912456  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
125930530  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
125915333  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
125927025  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
125929909  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
125912522  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
125929030  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
125928420  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
125929908  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
125926444  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
125929832  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
125926990  phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
125926991  phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
125927192  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
125928796  serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
125935020  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
125912556  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
125932711  DNA damage-inducible transcript 4 protein [KO:K08270]
125927652  hamartin isoform X1 [KO:K07206]
125926191  tuberin [KO:K07207]
125930322  GTP-binding protein Rheb [KO:K07208]
125927183  target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
125913121  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
125926268  regulatory-associated protein of mTOR [KO:K07204]
125923271  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
125922952  eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
125911066  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
125935265  eukaryotic translation initiation factor 4E type 1B [KO:K03259]
125930574  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
125926762  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
125919104  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
125921655  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
125914541  40S ribosomal protein S6 [KO:K02991]
125925545  40S ribosomal protein S6-like [KO:K02991]
125934023  40S ribosomal protein S6-like [KO:K02991]
125911359  40S ribosomal protein S6-like [KO:K02991]
125927372  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125929090  serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
125912431  serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
125922030  serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
125937990  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
125936586  serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
125924846  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
125915806  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125909102  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125925091  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125930693  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
125930408  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
125933550  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125912075  acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
125923391  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
125935491  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
125915504  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
125909965  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
125923363  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
125923928  protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
125933053  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
125935610  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
125931441  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
125909573  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
125921315  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
125931158  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
125925295  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
125909154  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
125917447  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
125910302  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
125918432  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
125937878  heat shock protein HSP 90-beta [KO:K04079]
125909153  heat shock protein HSP 90-alpha [KO:K04079]
125919493  endoplasmin isoform X1 [KO:K09487]
125930562  hsp90 co-chaperone Cdc37 [KO:K09554]
125920867  LOW QUALITY PROTEIN: hsp90 co-chaperone Cdc37-like [KO:K09554]
125914710  PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
125916363  PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
125908968  T-cell leukemia/lymphoma protein 1A [KO:K10167]
125908970  T-cell leukemia/lymphoma protein 1B [KO:K16836]
125932113  protein p13 MTCP-1 [KO:K16837]
125930302  LOW QUALITY PROTEIN: nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
125926591  breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
125921776  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125915136  glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
125918889  glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
125909664  phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
125936463  phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
125926590  glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
125926619  glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
125911859  glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
125924410  myc proto-oncogene protein [KO:K04377]
125930010  G1/S-specific cyclin-D1 [KO:K04503]
125938307  cyclin-dependent kinase inhibitor 1 [KO:K06625]
125918841  cyclin-dependent kinase inhibitor 1B [KO:K06624]
125919210  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
125919257  cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
125930419  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
125917183  G1/S-specific cyclin-D2 [KO:K10151]
125918030  G1/S-specific cyclin-D2 [KO:K10151]
125938244  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125924535  G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
125917277  G1/S-specific cyclin-E1 [KO:K06626]
125917289  G1/S-specific cyclin-E1 [KO:K06626]
125938770  forkhead box protein O3 [KO:K09408]
125915346  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
125925158  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125937460  bcl-2-like protein 11 isoform X1 [KO:K16341]
125937699  14-3-3 protein theta [KO:K16197]
125914587  14-3-3 protein zeta/delta-like [KO:K16197]
125924489  14-3-3 protein zeta/delta [KO:K16197]
125916266  LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like [KO:K16197]
125936561  14-3-3 protein beta/alpha [KO:K16197]
125926855  14-3-3 protein epsilon isoform X1 [KO:K06630]
125921013  LOW QUALITY PROTEIN: 14-3-3 protein epsilon-like [KO:K06630]
125913991  14-3-3 protein eta isoform X1 [KO:K16198]
125928518  14-3-3 protein gamma [KO:K16198]
125931741  bcl2-associated agonist of cell death [KO:K02158]
125936704  bcl-2-like protein 1 isoform X1 [KO:K04570]
125914709  apoptosis regulator Bcl-2 [KO:K02161]
125913078  caspase-9 [KO:K04399] [EC:3.4.22.62]
125911260  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
125911819  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
125919632  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125930188  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
125925743  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
125934155  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
125919439  cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
125928859  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
125930855  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
125938414  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
125912129  induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
125922972  retinoic acid receptor RXR-alpha [KO:K08524]
125919068  nuclear receptor subfamily 4 group A member 1 [KO:K04465]
125932096  NF-kappa-B essential modulator isoform X1 [KO:K07210]
125932873  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
125923306  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
125912163  transcription factor p65 [KO:K04735]
125923687  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125938928  transcriptional activator Myb isoform X1 [KO:K09420]
125919324  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
125927023  LOW QUALITY PROTEIN: cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
puc00010  Glycolysis / Gluconeogenesis
puc04010  MAPK signaling pathway
puc04012  ErbB signaling pathway
puc04062  Chemokine signaling pathway
puc04064  NF-kappa B signaling pathway
puc04068  FoxO signaling pathway
puc04110  Cell cycle
puc04115  p53 signaling pathway
puc04150  mTOR signaling pathway
puc04210  Apoptosis
puc04370  VEGF signaling pathway
puc04510  Focal adhesion
puc04620  Toll-like receptor signaling pathway
puc04630  JAK-STAT signaling pathway
puc04662  B cell receptor signaling pathway
puc04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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