KEGG   PATHWAY: puc04728
Entry
puc04728                    Pathway                                
Name
Dopaminergic synapse - Panthera uncia (snow leopard)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
puc04728  Dopaminergic synapse
puc04728

Other DBs
GO: 0001963
Organism
Panthera uncia (snow leopard) [GN:puc]
Gene
125911546  tyrosine 3-monooxygenase [KO:K00501] [EC:1.14.16.2]
125929774  aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
125923846  chromaffin granule amine transporter isoform X1 [KO:K08155]
125933454  synaptic vesicular amine transporter [KO:K08155]
125934396  D(1A) dopamine receptor [KO:K04144]
125922623  D(1B) dopamine receptor [KO:K05840]
125933083  neuron-specific vesicular protein calcyon [KO:K15493]
125925154  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
125931611  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
125909840  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
125935985  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
125936809  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125929585  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
125920161  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
125938355  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
125915330  calmodulin-3 isoform X1 [KO:K02183]
125923752  calmodulin-like [KO:K02183]
125931555  calmodulin-alpha-like [KO:K02183]
125908913  calmodulin-like protein 4 isoform X1 [KO:K02183]
125909257  calmodulin-1 [KO:K02183]
125918569  calmodulin-like [KO:K02183]
125918572  calmodulin-like protein 3 [KO:K02183]
125936234  calmodulin-2 isoform X1 [KO:K02183]
125913213  calmodulin-like protein 6 [KO:K02183]
125929736  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
125923042  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
125933297  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
125934558  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
125922973  protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
125923333  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125932723  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125927372  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125927972  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125915497  protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
125909334  protein c-Fos [KO:K04379]
125917302  neuroendocrine secretory protein 55 [KO:K04632]
125918189  neuroendocrine secretory protein 55 [KO:K04632]
125936451  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
125914842  guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
125921018  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
125912461  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
125929088  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
125911260  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
125911819  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
125919632  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125930188  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
125925743  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
125934155  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
125919439  cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
125928859  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
125930855  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
125938414  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
125937867  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
125937868  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
125919741  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
125919935  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
125916877  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
125917114  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
125933328  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125935352  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125926479  protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
125937304  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
125914177  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
125930634  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
125911566  sodium channel protein type 1 subunit alpha [KO:K04833]
125920056  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
125928736  LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
125911615  G protein-activated inward rectifier potassium channel 1 [KO:K04997]
125920733  G protein-activated inward rectifier potassium channel 2 [KO:K05000]
125925612  G protein-activated inward rectifier potassium channel 3 [KO:K05002]
125938976  G protein-activated inward rectifier potassium channel 4 [KO:K04999]
125921764  D(3) dopamine receptor isoform X1 [KO:K04146]
125937386  LOW QUALITY PROTEIN: D(4) dopamine receptor [KO:K04147]
125929389  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
125929845  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
125912291  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
125915952  uncharacterized protein LOC125915952 isoform X1 [KO:K04534]
125913218  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
125928229  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
125917979  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
125917990  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
125921860  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
125910003  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
125909505  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
125932224  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
125909421  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3-like [KO:K04540]
125932581  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
125912456  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
125930530  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
125915333  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
125927025  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
125929909  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
125912522  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
125929030  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
125928420  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
125929908  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
125926444  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
125909681  D(2) dopamine receptor [KO:K04145]
125937611  beta-arrestin-1 isoform X1 [KO:K04439]
125927085  beta-arrestin-2 isoform X1 [KO:K04439]
125923391  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
125935491  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
125915504  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
125909965  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
125923363  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
125923928  protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
125933053  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
125935610  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
125931441  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
125909573  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
125921315  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
125931158  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
125925295  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
125909154  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
125917447  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
125910302  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
125918432  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
125915806  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125909102  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125925091  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125916028  glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
125921776  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125934518  glutamate receptor 1 isoform X1 [KO:K05197]
125923148  glutamate receptor 2 isoform X1 [KO:K05198]
125931944  glutamate receptor 3 [KO:K05199]
125910453  glutamate receptor 4 isoform X1 [KO:K05200]
125918677  kinesin-1 heavy chain [KO:K10396]
125919250  kinesin heavy chain [KO:K10396]
125911885  kinesin heavy chain [KO:K10396]
125922736  circadian locomoter output cycles protein kaput isoform X1 [KO:K02223] [EC:2.3.1.48]
125935710  aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1 [KO:K02296]
125934743  sodium-dependent dopamine transporter [KO:K05036]
125931631  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
125931632  amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
125937267  transmembrane O-methyltransferase [KO:K00545] [EC:2.1.1.6]
125914912  catechol O-methyltransferase [KO:K00545] [EC:2.1.1.6]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
puc00350  Tyrosine metabolism
puc04020  Calcium signaling pathway
puc04721  Synaptic vesicle cycle
puc04724  Glutamatergic synapse
puc05012  Parkinson disease
KO pathway
ko04728   
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