KEGG   PATHWAY: ray05146
Entry
ray05146                    Pathway                                
Name
Amoebiasis - Rousettus aegyptiacus (Egyptian rousette)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
ray05146  Amoebiasis
ray05146

Organism
Rousettus aegyptiacus (Egyptian rousette) [GN:ray]
Gene
107514900  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
107498102  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
107498113  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
107517900  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
107497522  RELA; transcription factor p65 [KO:K04735]
107511798  HSPB1; heat shock protein beta-1 [KO:K04455]
107504064  LOW QUALITY PROTEIN: mucin-2-like [KO:K10955]
107517613  COL1A1; collagen alpha-1(I) chain [KO:K06236]
107518820  COL1A2; collagen alpha-2(I) chain [KO:K06236]
107504788  collagen alpha-5(IV) chain-like [KO:K06237]
107506968  collagen alpha-5(IV) chain isoform X1 [KO:K06237]
107511115  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
107511116  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
107501441  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
107497217  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
107497225  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
107513401  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
107497012  LAMA2; laminin subunit alpha-2 [KO:K05637]
107498184  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
107503661  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
107521547  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
107506303  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
107501076  LAMB1; laminin subunit beta-1 [KO:K05636]
107513328  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
107517630  LAMB3; laminin subunit beta-3 [KO:K06244]
107501119  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
107511293  LAMC1; laminin subunit gamma-1 [KO:K05635]
107511295  LAMC2; laminin subunit gamma-2 [KO:K06246]
107504553  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
107510456  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
107507577  Ig heavy chain Mem5-like [KO:K06856]
107517194  GNAQ; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
107520124  GNA11; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
107517193  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
107520107  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
107506114  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
107519930  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
107497081  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
107514464  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
107510307  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
107516091  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107503061  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
107500068  neuroendocrine secretory protein 55-like [KO:K04632]
107500067  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
107497716  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
107512406  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
107519437  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107511590  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107497819  RAB5A; ras-related protein Rab-5A [KO:K07887]
107521267  RAB5B; ras-related protein Rab-5B [KO:K07888]
107513817  RAB5C; ras-related protein Rab-5C [KO:K07889]
107497029  RAB7A; ras-related protein Rab-7a [KO:K07897]
107508859  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
107510758  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
107514466  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
107521575  CD14; monocyte differentiation antigen CD14 [KO:K04391]
107518120  IL6; interleukin-6 isoform X1 [KO:K05405]
107515315  growth-regulated protein homolog [KO:K05505]
107515316  growth-regulated protein homolog gamma-like [KO:K05505]
107497048  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
107515317  C-X-C motif chemokine 15-like [KO:K10030]
107515319  CXCL8; interleukin-8 [KO:K10030]
107498497  TNF; tumor necrosis factor [KO:K03156]
107512954  IL12A; interleukin-12 subunit alpha [KO:K05406]
107521891  IL12B; interleukin-12 subunit beta [KO:K05425]
107499730  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
107499732  T-cell surface glycoprotein CD1e, membrane-associated-like isoform X1 [KO:K06448]
107499736  T-cell surface glycoprotein CD1a-like [KO:K06448]
107512682  IFNG; interferon gamma [KO:K04687]
107512998  COL3A1; collagen alpha-1(III) chain [KO:K19720]
107504408  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
107503016  VCL; vinculin isoform X1 [KO:K05700]
107503261  ACTN1; LOW QUALITY PROTEIN: alpha-actinin-1 [KO:K05699]
107520952  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
107502315  ARG1; arginase-1 isoform X1 [KO:K01476] [EC:3.5.3.1]
107503266  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
107497410  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
107510212  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
107506837  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
107521668  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
107517899  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
107498704  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107520152  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107517828  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107513958  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107506892  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
107501300  LOW QUALITY PROTEIN: peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
107521729  SERPINB6; serpin B6 [KO:K13963]
107521732  SERPINB9; serpin B9 [KO:K13963]
107497267  SERPINB10; serpin B10 [KO:K13963]
107503911  serpin B13-like [KO:K13963]
107513514  cathepsin G-like isoform X1 [KO:K01319] [EC:3.4.21.20]
107513515  CTSG; cathepsin G isoform X1 [KO:K01319] [EC:3.4.21.20]
107502233  IL10; interleukin-10 [KO:K05443]
107505490  TGFB1; transforming growth factor beta-1 [KO:K13375]
107520844  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
107498899  TGFB3; transforming growth factor beta-3 [KO:K13377]
107518357  C8A; complement component C8 alpha chain [KO:K03997]
107518331  C8B; complement component C8 beta chain [KO:K03998]
107503117  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
107512432  C9; complement component C9 [KO:K04000]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
ray00330  Arginine and proline metabolism
ray00590  Arachidonic acid metabolism
ray04144  Endocytosis
ray04210  Apoptosis
ray04510  Focal adhesion
ray04610  Complement and coagulation cascades
ray04612  Antigen processing and presentation
ray04620  Toll-like receptor signaling pathway
ray04672  Intestinal immune network for IgA production
ray04810  Regulation of actin cytoskeleton
KO pathway
ko05146   
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