KEGG   PATHWAY: schu04530
Entry
schu04530                   Pathway                                
Name
Tight junction - Siniperca chuatsi (mandarin fish)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
schu04530  Tight junction
schu04530

Other DBs
GO: 0005923
Organism
Siniperca chuatsi (mandarin fish) [GN:schu]
Gene
122868672  crb3a; protein crumbs homolog 3a [KO:K06090]
122882219  cldn12; claudin-12 [KO:K06087]
122875685  cldn5a; claudin 5a [KO:K06087]
122862002  cldn11a; claudin-11a [KO:K06087]
122868777  cldni; claudin i [KO:K06087]
122887998  claudin-4-like [KO:K06087]
122887999  claudin-4-like [KO:K06087]
122888000  claudin-4-like isoform X1 [KO:K06087]
122888001  claudin-4-like [KO:K06087]
122888002  claudin-like protein ZF-A89 [KO:K06087]
122888003  claudin-4-like [KO:K06087]
122888005  claudin-4-like [KO:K06087]
122862471  claudin-20 [KO:K06087]
122862667  claudin-like protein ZF-A89 isoform X1 [KO:K06087]
122869337  cldnk; claudin k [KO:K06087]
122888714  cldn2; claudin-2 [KO:K06087]
122888854  cldn15b; claudin-15b [KO:K06087]
122869863  cldn7a; claudin-7-A [KO:K06087]
122876468  cldn26; putative claudin-24 [KO:K06087]
122888567  claudin-7-A-like isoform X1 [KO:K06087]
122888601  claudin-3-like [KO:K06087]
122870574  cldn15a; claudin-15a [KO:K06087]
122877281  claudin-19 [KO:K06087]
122877314  cldn34a; claudin-34 [KO:K06087]
122877315  putative claudin-24 [KO:K06087]
122877555  claudin-18-like isoform X1 [KO:K06087]
122864392  cldn19; claudin-19 isoform X1 [KO:K06087]
122865051  cldn35; claudin-4 [KO:K06087]
122871984  putative claudin-24 [KO:K06087]
122872266  cldn10e; claudin-10 [KO:K06087]
122872267  cldn10d; claudin-10 [KO:K06087]
122872268  claudin-10-like [KO:K06087]
122865397  cldn23.1; claudin 23a [KO:K06087]
122865966  cldn5b; claudin-5b [KO:K06087]
122873202  claudin-9-like [KO:K06087]
122879215  claudin-3-like [KO:K06087]
122879256  claudin-1-like [KO:K06087]
122885514  cldn10b; claudin-10 isoform X1 [KO:K06087]
122879404  claudin-8-like [KO:K06087]
122879405  cldn8.1; claudin-8 [KO:K06087]
122879407  claudin-4-like [KO:K06087]
122879420  claudin-4 [KO:K06087]
122879618  cldnj; claudin j [KO:K06087]
122879619  claudin-9-like [KO:K06087]
122879620  claudin-4-like isoform X1 [KO:K06087]
122879621  claudin-4-like [KO:K06087]
122879622  claudin-3-like [KO:K06087]
122885566  claudin-10 [KO:K06087]
122885651  claudin-14-like [KO:K06087]
122866428  claudin-11-like [KO:K06087]
122886025  claudin-10-like [KO:K06087]
122886980  cldn15la; claudin 15-like a [KO:K06087]
122887286  cldn18; claudin-18 [KO:K06087]
122887304  cldn1; claudin-1 [KO:K06087]
122861902  cldn23l; claudin-23 [KO:K06087]
122871835  claudin-34-like [KO:K06087]
122877484  si:ch73-61d6.3; occludin [KO:K06088]
122888858  f11r.1; F11 receptor, tandem duplicate 1 [KO:K06089]
122871795  jam2a; junctional adhesion molecule 2A isoform X1 [KO:K06735]
122886003  jam2b; junctional adhesion molecule 2b [KO:K06735]
122888089  junctional adhesion molecule 3B-like isoform X1 [KO:K06785]
122879316  jam3a; junctional adhesion molecule 3B [KO:K06785]
122881545  bves; blood vessel epicardial substance isoform X1 [KO:K21108]
122882097  cdc42l; cell division cycle 42, like [KO:K04393]
122883122  cell division control protein 42 homolog isoform X1 [KO:K04393]
122864134  cell division control protein 42 homolog [KO:K04393]
122886115  cell division control protein 42 homolog isoform X1 [KO:K04393]
122883256  pard6b; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
122863865  pard6gb; par-6 family cell polarity regulator gamma b [KO:K06093]
122874879  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
122863302  pals1b; MAGUK p55 subfamily member 5b isoform X1 [KO:K06091]
122861672  pals1a; protein PALS1 [KO:K06091]
122872453  mpp4b; MAGUK p55 subfamily member 4 [KO:K21109]
122885134  MAGUK p55 subfamily member 4-like isoform X1 [KO:K21109]
122878227  tjp3; tight junction protein ZO-3 isoform X1 [KO:K06097]
122877411  patj; inaD-like protein isoform X1 [KO:K06092]
122870060  multiple PDZ domain protein-like isoform X1 [KO:K06095]
122872935  si:dkey-92j12.5; multiple PDZ domain protein isoform X1 [KO:K06095]
122882939  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
122887609  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
122888244  amot; angiomotin isoform X1 [KO:K16819]
122877790  amotl2a; angiomotin-like 2a isoform X1 [KO:K06104]
122887026  angiomotin-like 2a isoform X1 [KO:K06104]
122868717  arhgap17b; rho GTPase-activating protein 17b isoform X1 [KO:K20638]
122867610  arhgap17a; rho GTPase-activating protein 17a isoform X1 [KO:K20638]
122869368  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122867758  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
122888196  nf2b; neurofibromin 2b (merlin) [KO:K16684]
122876348  nf2a; neurofibromin 2a (merlin) isoform X1 [KO:K16684]
122867533  llgl2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
122878315  disks large homolog 1-like isoform X1 [KO:K12076]
122886951  dlg1b; discs large homolog 1-like protein isoform X1 [KO:K12076]
122866354  scrib; protein scribble homolog isoform X1 [KO:K16175]
122876785  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
122888512  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
122879960  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
122879564  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
122876653  ppp2r2aa; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
122884131  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
122865184  ppp2r2ab; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
122873638  ppp2r2ca; protein phosphatase 2, regulatory subunit B, gamma a [KO:K04354]
122880563  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
122880846  ppp2r2ba; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
122866596  partitioning defective 3 homolog isoform X1 [KO:K04237]
122886361  partitioning defective 3 homolog isoform X1 [KO:K04237]
122887808  rho guanine nucleotide exchange factor TIAM1-like isoform X1 [KO:K05731]
122879398  rho guanine nucleotide exchange factor TIAM1-like isoform X1 [KO:K05731]
122878499  tjp1a; tight junction protein ZO-1 isoform X1 [KO:K05701]
122874741  tjp1b; tight junction protein ZO-1 isoform X1 [KO:K05701]
122884118  tjap1; LOW QUALITY PROTEIN: tight junction-associated protein 1 [KO:K06105]
122888235  dlg2; disks large homolog 2 isoform X1 [KO:K12075]
122880424  dlg3; disks large homolog 3 isoform X1 [KO:K21098]
122873557  nedd4a; E3 ubiquitin-protein ligase NEDD4a isoform X1 [KO:K10591] [EC:2.3.2.26]
122865294  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
122882192  cingulin isoform X1 [KO:K06102]
122864881  cgnb; cingulin isoform X1 [KO:K06102]
122874960  cgnl1; cingulin-like protein 1 isoform X1 [KO:K21110]
122875215  cingulin-like protein 1 isoform X1 [KO:K21110]
122881584  arhgef2; rho guanine nucleotide exchange factor 2 [KO:K12791]
122863790  arhgef1a; rho guanine nucleotide exchange factor 1a isoform X1 [KO:K12791]
122882438  rho-related GTP-binding protein RhoA-D [KO:K04513]
122882439  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
122883454  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
122883743  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
122884474  transforming protein RhoA [KO:K04513]
122884762  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
122863336  gata4; transcription factor GATA-4 [KO:K09183]
122878072  si:ch211-191a24.4; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
122881232  marveld3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
122883942  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122865666  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122880393  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122867451  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122887568  transcription factor AP-1-like isoform X1 [KO:K04448]
122878280  jun; transcription factor AP-1 [KO:K04448]
122865896  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
122874653  cftr; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
122888471  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
122885450  sympk; symplekin [KO:K06100]
122876532  pcna; proliferating cell nuclear antigen [KO:K04802]
122876462  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
122875207  G1/S-specific cyclin-D1-like [KO:K04503]
122867228  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
122872043  runx1; runt-related transcription factor 1 isoform X1 [KO:K08367]
122888436  hspa4a; heat shock 70 kDa protein 4a isoform X1 [KO:K09489]
122879966  hspa4b; heat shock 70 kDa protein 4b [KO:K09489]
122867327  Na(+)/H(+) exchange regulatory cofactor NHE-RF1-like [KO:K13365]
122863481  ezrb; ezrin b [KO:K08007]
122861778  ezra; ezrin a [KO:K08007]
122871845  radixin-like isoform X1 [KO:K05762]
122885990  radixin [KO:K05762]
122888749  msna; moesin a isoform X1 [KO:K05763]
122879781  moesin-like isoform X1 [KO:K05763]
122884321  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
122867302  prkcea; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
122874135  actb1; actin, cytoplasmic 1 isoform X1 [KO:K05692]
122863128  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
122882704  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
122881813  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
122862735  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
122870668  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122882523  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
122884863  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
122871312  hcls1; src substrate protein p85-like isoform X1 [KO:K06106]
122875238  src substrate protein p85-like isoform X1 [KO:K06106]
122870457  zgc:101810; actin-related protein 2-B [KO:K17260]
122884155  actin-related protein 2-B isoform X1 [KO:K17260]
122873108  actr2a; actin-related protein 2-A [KO:K17260]
122872416  actin-related protein 3 [KO:K18584]
122885503  actin-related protein 3-like [KO:K18584]
122866483  actr3b; actin-related protein 3B [KO:K18584]
122869565  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
122874039  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
122874043  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
122872402  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
122866092  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
122888977  actin-related protein 2/3 complex subunit 4 [KO:K05755]
122866812  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
122877694  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
122886441  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
122879581  WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
122883149  wiskott-Aldrich syndrome protein-like isoform X1 [KO:K05747]
122888700  vasodilator-stimulated phosphoprotein-like isoform X1 [KO:K06274]
122878628  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
122868669  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
122877466  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
122873333  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122887397  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
122882164  rab13; ras-related protein Rab-13 isoform X1 [KO:K06109]
122887605  arhgef18a; rho guanine nucleotide exchange factor 18a isoform X1 [KO:K21066]
122878003  arhgef18b; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
122886396  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
122863432  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
122861382  rock2a; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
122868939  myl2a; myosin regulatory light chain 2a [KO:K10351]
122877065  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
122881264  epb41l4b; band 4.1-like protein 4B isoform X1 [KO:K21111]
122886527  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
122877156  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
122866157  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
122876033  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
122865732  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
122886406  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
122872181  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
122885372  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b [KO:K07200]
122867091  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
122887133  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
122869075  myosin-11-like isoform X1 [KO:K10352]
122869405  myosin-10-like isoform X1 [KO:K10352]
122869441  myosin-9-like isoform X1 [KO:K10352]
122870658  myosin-9-like isoform X1 [KO:K10352]
122872346  myh11a; myosin-11a isoform X1 [KO:K10352]
122873803  myosin-10 isoform X1 [KO:K10352]
122882928  zgc:153867; myosin light polypeptide 6 isoform X1 [KO:K12751]
122867202  myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
122868634  myl9b; myosin regulatory light polypeptide 9b isoform X1 [KO:K12755]
122887654  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
122866922  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
122888470  igsf5a; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
122878643  igsf5b; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
122863705  magi1b; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1b isoform X1 [KO:K05631]
122883351  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1-like isoform X1 [KO:K05631]
122880825  synaptopodin 2-like protein [KO:K21112]
122862148  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
122879385  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
122868382  micall2a; MICAL-like protein 2a isoform X1 [KO:K21068]
122872091  MICAL-like protein 2 isoform X1 [KO:K21068]
122878036  ras-related protein Rab-8A [KO:K07901]
122887447  ras-related protein Rab-8A-like [KO:K07901]
122876379  ras-related protein Rab-8B isoform X1 [KO:K07902]
122874329  ras-related protein Rab-8B-like [KO:K07902]
122888738  rap guanine nucleotide exchange factor 6-like isoform X1 [KO:K08020]
122882912  ras-related protein Rap-1A [KO:K04353]
122866755  ras-related protein Rap-1A-like [KO:K04353]
122866790  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
122887601  integrin beta-1-like isoform X1 [KO:K05719]
122862991  afdna; afadin isoform X1 [KO:K05702]
122861812  afadin isoform X1 [KO:K05702]
122876891  tight junction protein ZO-2-like isoform X1 [KO:K06098]
122865255  tjp2a; tight junction protein ZO-2a isoform X1 [KO:K06098]
122880728  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
122880090  rap2c; ras-related protein Rap-2c [KO:K07839]
122876218  uncharacterized protein LOC122876218 [KO:K17291]
122865991  marveld2a; uncharacterized protein marveld2a [KO:K17291]
122882529  tuba1c; tubulin alpha-1C chain [KO:K07374]
122882530  tuba1a; LOW QUALITY PROTEIN: tubulin alpha-1A chain [KO:K07374]
122882531  tubulin alpha chain-like [KO:K07374]
122862820  tubulin alpha-1B chain-like [KO:K07374]
122883627  tuba5; tubulin alpha 5 isoform X1 [KO:K07374]
122883693  tubulin alpha chain [KO:K07374]
122871760  tubulin alpha-4A chain-like [KO:K07374]
122871820  tubulin alpha-1A chain-like [KO:K07374]
122871822  tubulin alpha-1D chain-like [KO:K07374]
122886126  LOW QUALITY PROTEIN: tubulin alpha chain-like [KO:K07374]
122886127  tubulin alpha chain-like [KO:K07374]
122886128  tubulin alpha chain-like [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
schu04520  Adherens junction
schu04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
LinkDB

DBGET integrated database retrieval system