KEGG   PATHWAY: smeo04912
Entry
smeo04912                   Pathway                                
Name
GnRH signaling pathway - Silurus meridionalis (southern catfish)
Description
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
Class
Organismal Systems; Endocrine system
Pathway map
smeo04912  GnRH signaling pathway
smeo04912

Organism
Silurus meridionalis (southern catfish) [GN:smeo]
Gene
124398050  gnrh2; progonadoliberin-2 [KO:K05252]
124400249  progonadoliberin-1-like [KO:K05252]
124376061  gnrhr1; gonadotropin releasing hormone receptor 1 isoform X1 [KO:K04280]
124383876  gonadotropin-releasing hormone II receptor-like isoform X1 [KO:K04280]
124403716  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
124399393  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
124377387  adcy1a; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
124387690  adcy1b; adenylate cyclase type 1b isoform X1 [KO:K08041] [EC:4.6.1.1]
124381992  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
124384555  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
124385054  adcy3a; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
124381696  adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
124380150  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
124379641  adcy7; LOW QUALITY PROTEIN: adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
124403016  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
124376502  si:dkey-206f10.1; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
124379699  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
124376156  prkacaa; LOW QUALITY PROTEIN: protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
124378405  prkacab; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
124391230  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
124387817  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
124392712  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
124378884  gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
124403004  gna11b; guanine nucleotide-binding protein subunit alpha-11b [KO:K04635]
124390834  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04635]
124389665  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
124390133  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
124390267  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
124376730  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
124376731  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
124386961  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
124402041  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
124382911  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
124396223  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
124399884  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
124398039  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
124402267  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
124389620  calm1a; calmodulin-1a isoform X1 [KO:K02183]
124394271  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
124376646  calm1b; calmodulin-1b isoform X1 [KO:K02183]
124391067  calglandulin-like [KO:K02183]
124379955  calml4a; calmodulin-like protein 4a [KO:K02183]
124388943  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
124397767  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
124375665  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
124386868  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
124380465  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
124388818  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
124393628  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
124381399  camk2d2; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II delta 2 chain [KO:K04515] [EC:2.7.11.17]
124397127  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
124392586  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
124396752  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
124378066  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
124402367  prkcdb; protein kinase C, delta b [KO:K06068] [EC:2.7.11.13]
124390632  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
124401221  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
124400064  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
124402332  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
124399485  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
124399904  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
124400141  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
124402415  cacna1sa; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
124393433  map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
124390226  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
124397000  map3k3; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
124375590  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
124381434  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
124388598  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
124399179  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
124399896  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
124399991  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
124400837  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
124400838  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
124402156  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
124396074  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
124388748  mapk7; LOW QUALITY PROTEIN: mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
124389590  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
124394415  pla2g4aa; LOW QUALITY PROTEIN: cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
124390484  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
124376945  pla2g4ab; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
124394407  pld1a; LOW QUALITY PROTEIN: phospholipase D1a [KO:K01115] [EC:3.1.4.4]
124375317  pld1b; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
124382414  si:ch211-168k14.2; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
124379042  pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
124398760  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
124402185  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
124398941  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
124402572  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
124382029  cell division control protein 42 homolog [KO:K04393]
124382022  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
124388990  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
124378210  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
124397718  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
124397814  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
124396097  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124388678  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
124377376  jun; transcription factor AP-1 [KO:K04448]
124387939  transcription factor AP-1-like [KO:K04448]
124378958  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
124378159  lhb; lutropin subunit beta [KO:K08521]
124390138  cga; glycoprotein hormones alpha chain isoform X1 [KO:K08522]
124380116  fshb; follitropin subunit beta [KO:K05250]
124389721  ptk2ba; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
124376976  ptk2bb; protein tyrosine kinase 2 beta, b [KO:K05871] [EC:2.7.10.2]
124379903  mmp2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
124386873  mmp14b; matrix metalloproteinase-14b [KO:K07763] [EC:3.4.24.80]
124387269  mmp14a; matrix metalloproteinase-14a [KO:K07763] [EC:3.4.24.80]
124398009  hbegfb; heparin-binding EGF-like growth factor b [KO:K08523]
124385631  hbegfa; heparin-binding EGF-like growth factor a [KO:K08523]
124403152  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
124397030  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
124394385  growth factor receptor-bound protein 2-like [KO:K04364]
124386585  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
124396548  sos2; son of sevenless homolog 2 [KO:K03099]
124391513  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
124379989  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
124392405  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
124396747  zgc:55558; GTPase KRas [KO:K07827]
124392449  kras; GTPase KRas isoform X1 [KO:K07827]
124399950  nras; GTPase NRas [KO:K07828]
124399172  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
124402387  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
124396002  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
124403350  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
124391383  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
124396687  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124380646  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
124400169  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
124386344  egr1; early growth response protein 1 [KO:K09203]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:15350605
  Authors
Ruf F, Sealfon SC.
  Title
Genomics view of gonadotrope signaling circuits.
  Journal
Trends Endocrinol Metab 15:331-8 (2004)
DOI:10.1016/j.tem.2004.07.008
Reference
PMID:15613448
  Authors
Harrison GS, Wierman ME, Nett TM, Glode LM.
  Title
Gonadotropin-releasing hormone and its receptor in normal and malignant cells.
  Journal
Endocr Relat Cancer 11:725-48 (2004)
DOI:10.1677/erc.1.00777
Reference
PMID:15982836
  Authors
Pawson AJ, McNeilly AS.
  Title
The pituitary effects of GnRH.
  Journal
Anim Reprod Sci 88:75-94 (2005)
DOI:10.1016/j.anireprosci.2005.05.010
Reference
  Authors
DeGroot LJ, Jameson JL (ed).
  Title
Endocrinology (Fifth edition)
  Journal
Elsevier Saunders (2006)
Reference
PMID:10707049
  Authors
Naor Z, Benard O, Seger R.
  Title
Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor.
  Journal
Trends Endocrinol Metab 11:91-9 (2000)
DOI:10.1016/S1043-2760(99)00232-5
Reference
PMID:14596811
  Authors
Ruf F, Fink MY, Sealfon SC.
  Title
Structure of the GnRH receptor-stimulated signaling network: insights from genomics.
  Journal
Front Neuroendocrinol 24:181-99 (2003)
DOI:10.1016/S0091-3022(03)00027-X
Reference
PMID:12943720
  Authors
Farshori PQ, Shah BH, Arora KK, Martinez-Fuentes A, Catt KJ.
  Title
Activation and nuclear translocation of PKCdelta, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells.
  Journal
J Steroid Biochem Mol Biol 85:337-47 (2003)
DOI:10.1016/S0960-0760(03)00226-7
Reference
PMID:15080147
  Authors
Shah BH, Catt KJ.
  Title
Matrix metalloproteinases in reproductive endocrinology.
  Journal
Trends Endocrinol Metab 15:47-9 (2004)
DOI:10.1016/j.tem.2004.01.004
Reference
PMID:12963732
  Authors
Roelle S, Grosse R, Aigner A, Krell HW, Czubayko F, Gudermann T.
  Title
Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone.
  Journal
J Biol Chem 278:47307-18 (2003)
DOI:10.1074/jbc.M304377200
Reference
PMID:18708085
  Authors
Naor Z
  Title
Signaling by G-protein-coupled receptor (GPCR): studies on the GnRH receptor.
  Journal
Front Neuroendocrinol 30:10-29 (2009)
DOI:10.1016/j.yfrne.2008.07.001
Related
pathway
smeo04010  MAPK signaling pathway
smeo04020  Calcium signaling pathway
smeo04060  Cytokine-cytokine receptor interaction
smeo04080  Neuroactive ligand-receptor interaction
KO pathway
ko04912   
LinkDB

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