KEGG   PATHWAY: snh04115
Entry
snh04115                    Pathway                                
Name
p53 signaling pathway - Salvelinus namaycush (lake trout)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
snh04115  p53 signaling pathway
snh04115

Organism
Salvelinus namaycush (lake trout) [GN:snh]
Gene
120028560  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
120063063  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
120053972  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
120035287  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
120041456  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
120042744  gorab; RAB6-interacting golgin isoform X1 [KO:K19748]
120050142  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
120065143  mdm4; protein Mdm4 [KO:K10127]
120030359  cellular tumor antigen p53-like [KO:K04451]
120049611  cellular tumor antigen p53-like isoform X1 [KO:K04451]
120057360  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
120028672  ppp1r13l; relA-associated inhibitor isoform X1 [KO:K27356]
120025201  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
120031937  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
120049881  cyclin-dependent kinase inhibitor 1C-like isoform X1 [KO:K06625]
120025309  G1/S-specific cyclin-D1-like [KO:K04503]
120045999  G1/S-specific cyclin-D1 [KO:K04503]
120054165  G1/S-specific cyclin-D1-like [KO:K04503]
120066776  G1/S-specific cyclin-D1-like [KO:K04503]
120042003  G1/S-specific cyclin-D2-like [KO:K10151]
120032172  G1/S-specific cyclin-D2-like [KO:K10151]
120044064  G1/S-specific cyclin-D2-like [KO:K10151]
120034023  G1/S-specific cyclin-D2-like [KO:K10151]
120049937  G1/S-specific cyclin-D2-like [KO:K10151]
120053511  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
120065733  G1/S-specific cyclin-D2-like [KO:K10152]
120062000  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
120065264  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
120022790  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
120044522  cyclin-dependent kinase 4-like [KO:K02091] [EC:2.7.11.22]
120027087  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
120031327  G1/S-specific cyclin-E2-like [KO:K06626]
120024716  G1/S-specific cyclin-E1-like [KO:K06626]
120047633  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
120055905  G1/S-specific cyclin-E1-like isoform X1 [KO:K06626]
120025645  cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
120065256  cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
120063896  rprma; protein reprimo A [KO:K10128]
120060823  rprm3; reprimo, TP53 dependent G2 arrest mediator homolog 3 [KO:K10128]
120021267  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
120025032  G2/mitotic-specific cyclin-B1-like isoform X1 [KO:K05868]
120026371  G2/mitotic-specific cyclin-B1-like isoform X1 [KO:K05868]
120018972  cyclin N-terminal domain-containing protein 2 [KO:K21770]
120047174  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
120017692  cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
120045645  cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
120020508  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
120021704  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
120021736  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
120042825  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
120025527  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
120026357  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
120062802  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
120051883  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
120053376  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
120054420  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
120054544  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
120055494  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
120051751  gtse1; G2 and S phase-expressed protein 1 [KO:K10129]
120061016  znf385a; zinc finger protein 385A [KO:K26543]
120065742  zinc finger protein 385A-like [KO:K26543]
120058806  zinc finger protein 385A-like isoform X1 [KO:K26543]
120017657  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
120045631  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
120052316  pidd1; LOW QUALITY PROTEIN: p53-induced death domain-containing protein 1 [KO:K10130]
120020971  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
120026441  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
120063362  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
120051484  hdr; hematopoietic death receptor [KO:K04722]
120020199  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
120063683  caspase-8-like [KO:K04398] [EC:3.4.22.61]
120058267  caspase-8-like [KO:K04398] [EC:3.4.22.61]
120056102  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
120041999  bida; BH3 interacting domain death agonist [KO:K04726]
120025191  zgc:153993; apoptosis regulator BAX isoform X1 [KO:K02159]
120034478  apoptosis regulator BAX-like [KO:K02159]
120034479  apoptosis regulator BAX-like [KO:K02159]
120045962  apoptosis regulator BAX-like [KO:K02159]
120036277  apoptosis regulator BAX-like isoform X1 [KO:K02159]
120032808  baxb; BCL2 associated X, apoptosis regulator b isoform X1 [KO:K02159]
120052702  apoptosis regulator BAX-like isoform X1 [KO:K02159]
120053464  pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
120023469  apoptosis regulatory protein Siva-like [KO:K22744]
120060245  apoptosis regulatory protein Siva-like [KO:K22744]
120024933  bcl-2-like protein 1 [KO:K04570]
120059356  bcl-2-like protein 1 [KO:K04570]
120065691  bcl-2-like protein 1 [KO:K04570]
120061477  bcl-2-like protein 1 [KO:K04570]
120019795  apoptosis regulator Bcl-2-like [KO:K02161]
120027961  apoptosis regulator Bcl-2-like [KO:K02161]
120055940  apoptosis regulator Bcl-2-like [KO:K02161]
120051010  apoptosis regulator Bcl-2-like [KO:K02161]
120023195  tp53i3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
120045181  etoposide-induced protein 2.4 homolog [KO:K10134]
120057083  etoposide-induced protein 2.4 homolog [KO:K10134]
120024169  protein shisa-4-like [KO:K10135]
120037979  protein shisa-5-like isoform X1 [KO:K10135]
120045748  p53 apoptosis effector related to PMP-22-like [KO:K10136]
120029714  p53 apoptosis effector related to PMP-22-like [KO:K10136]
120052074  zinc finger matrin-type protein 3-like [KO:K10137]
120054261  zinc finger matrin-type protein 3-like [KO:K10137]
120053887  E3 ubiquitin-protein ligase Siah1-like [KO:K04506] [EC:2.3.2.27]
120066227  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
120022728  cytochrome c iso-1/iso-2-like [KO:K08738]
120033413  cytochrome c [KO:K08738]
120064125  cytochrome c [KO:K08738]
120058265  cytochrome c-like [KO:K08738]
120032288  apoptotic protease-activating factor 1-like [KO:K02084]
120050085  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
120059174  caspase-9-like [KO:K04399] [EC:3.4.22.62]
120060666  caspase-9-like isoform X1 [KO:K04399] [EC:3.4.22.62]
120040359  caspase-3-like [KO:K02187] [EC:3.4.22.56]
120035095  caspase-3-like [KO:K02187] [EC:3.4.22.56]
120062476  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
120052764  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
120017596  aifm2; apoptosis-inducing factor 2 isoform X1 [KO:K22745]
120020194  insulin-like growth factor-binding protein 3 [KO:K10138]
120051896  insulin-like growth factor-binding protein 3 [KO:K10138]
120054303  insulin-like growth factor-binding protein 3 [KO:K10138]
120055572  insulin-like growth factor-binding protein 3 [KO:K10138]
120031740  insulin-like growth factor I isoform X1 [KO:K05459]
120049944  insulin-like growth factor I isoform X1 [KO:K05459]
120030394  plasminogen activator inhibitor 1-like [KO:K03982]
120049289  plasminogen activator inhibitor 1-like [KO:K03982]
120030901  adhesion G protein-coupled receptor B1-like [KO:K04596]
120047204  adhesion G protein-coupled receptor B1-like [KO:K04596]
120042931  CD82 antigen-like [KO:K06509]
120043499  CD82 antigen-like [KO:K06509]
120036719  CD82 antigen-like [KO:K06509]
120053555  CD82 antigen-like [KO:K06509]
120065995  CD82 antigen-like [KO:K06509]
120060585  cd37; leukocyte antigen CD37 isoform X1 [KO:K06509]
120023096  thrombospondin-1-like [KO:K16857]
120019198  thrombospondin-1-like [KO:K16857]
120024499  thrombospondin-1-like [KO:K16857]
120060229  thrombospondin-1-like [KO:K16857]
120035709  DNA damage-binding protein 2-like isoform X1 [KO:K10140]
120035710  DNA damage-binding protein 2-like isoform X1 [KO:K10140]
120019463  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
120024157  ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
120027139  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
120019085  sestrin-1-like isoform X1 [KO:K10141]
120048118  sestrin-3-like isoform X1 [KO:K10141]
120024154  sestrin-1-like isoform X1 [KO:K10141]
120045120  sestrin-3-like [KO:K10141]
120062348  sestrin-3-like [KO:K10141]
120057146  sestrin-3-like isoform X1 [KO:K10141]
120022853  sesn2; sestrin-2 [KO:K20394]
120017655  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120030036  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120046138  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120046560  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120018258  tsc2; tuberin isoform X1 [KO:K07207]
120033205  LOW QUALITY PROTEIN: metalloreductase STEAP3-like [KO:K10142] [EC:1.16.1.-]
120051303  metalloreductase STEAP3-like isoform X1 [KO:K10142] [EC:1.16.1.-]
120057950  steap3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
120020366  cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
120055869  E3 ubiquitin-protein ligase COP1-like [KO:K10143] [EC:2.3.2.27]
120062691  RING finger and CHY zinc finger domain-containing protein 1-like isoform X1 [KO:K10144] [EC:2.3.2.27]
120054153  RING finger and CHY zinc finger domain-containing protein 1-like [KO:K10144] [EC:2.3.2.27]
120047886  cyclin-G1-like isoform X1 [KO:K10145]
120062528  cyclin-G1-like [KO:K10145]
120026511  cyclin-G2-like [KO:K10146]
120044863  ccng2; cyclin-G2 [KO:K10146]
120063105  cyclin-G2-like isoform X1 [KO:K10146]
120055323  cyclin-G2-like [KO:K10146]
120018044  protein phosphatase 1D-like [KO:K10147] [EC:3.1.3.16]
120028583  protein phosphatase 1D-like isoform X1 [KO:K10147] [EC:3.1.3.16]
120057204  protein phosphatase 1D-like isoform X1 [KO:K10147] [EC:3.1.3.16]
120059406  tp73; tumor protein p73 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
snh04110  Cell cycle
snh04210  Apoptosis
snh04218  Cellular senescence
KO pathway
ko04115   
LinkDB

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