KEGG   PATHWAY: stru03320
Entry
stru03320                   Pathway                                
Name
PPAR signaling pathway - Salmo trutta (river trout)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
stru03320  PPAR signaling pathway
stru03320

Organism
Salmo trutta (river trout) [GN:stru]
Gene
115179993  platelet glycoprotein 4-like [KO:K06259]
115199008  platelet glycoprotein 4-like [KO:K06259]
115159134  long-chain fatty acid transport protein 4-like [KO:K08745] [EC:6.2.1.-]
115171582  long-chain fatty acid transport protein 1-like [KO:K08745] [EC:6.2.1.-]
115149422  long-chain fatty acid transport protein 4-like [KO:K08745] [EC:6.2.1.-]
115204491  long-chain fatty acid transport protein 1-like [KO:K08745] [EC:6.2.1.-]
115182355  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
115182366  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
115192876  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
115166758  very long-chain acyl-CoA synthetase-like isoform X1 [KO:K08746] [EC:6.2.1.- 6.2.1.3]
115166760  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
115160130  long-chain fatty acid transport protein 6-like isoform X1 [KO:K08749]
115160131  long-chain fatty acid transport protein 6-like isoform X1 [KO:K08749]
115165165  fatty acid binding protein 1-B.1-like [KO:K08750]
115165166  fatty acid binding protein 1-B.1-like [KO:K08750]
115164200  fatty acid binding protein 1-B.1-like [KO:K08750]
115204112  fabp1; fatty acid-binding protein, liver [KO:K08750]
115192055  fatty acid-binding protein, intestinal-like [KO:K08751]
115202060  fatty acid-binding protein, intestinal-like [KO:K08751]
115198071  fatty acid-binding protein, intestinal-like [KO:K08751]
115173858  fabp3; fatty acid-binding protein, heart [KO:K08752]
115173912  fatty acid-binding protein, heart-like [KO:K08752]
115175347  fatty acid-binding protein, heart-like [KO:K08752]
115175371  myelin P2 protein-like [KO:K08752]
115187684  fatty acid-binding protein, adipocyte-like [KO:K08753]
115187715  fatty acid-binding protein, adipocyte-like [KO:K08753]
115153929  gastrotropin-like [KO:K08755]
115148467  gastrotropin-like [KO:K08755]
115205433  gastrotropin-like [KO:K08755]
115193536  fabp7; fatty acid-binding protein, brain [KO:K08756]
115174855  fatty acid-binding protein, brain-like [KO:K08756]
115192671  peroxisome proliferator-activated receptor alpha-like [KO:K07294]
115196970  peroxisome proliferator-activated receptor alpha-like [KO:K07294]
115164896  retinoic acid receptor RXR-alpha-B-like [KO:K08524]
115159498  retinoic acid receptor RXR-alpha-A-like isoform X1 [KO:K08524]
115156791  retinoic acid receptor RXR-gamma-A-like isoform X1 [KO:K08524]
115204142  retinoic acid receptor RXR-alpha-A isoform X1 [KO:K08524]
115177095  retinoic acid receptor RXR-beta-A-like isoform X1 [KO:K08524]
115186134  retinoic acid receptor RXR-beta-A-like isoform X1 [KO:K08524]
115173554  retinoic acid receptor RXR-beta-A isoform X1 [KO:K08525]
115175909  retinoic acid receptor RXR-beta-A-like isoform X1 [KO:K08525]
115169906  retinoic acid receptor RXR-gamma-A-like isoform X1 [KO:K08526]
115158852  retinoic acid receptor RXR-gamma-A [KO:K08526]
115169027  peroxisome proliferator-activated receptor delta-like [KO:K04504]
115165438  ppard; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
115208152  peroxisome proliferator-activated receptor delta-like isoform X1 [KO:K04504]
115168395  peroxisome proliferator-activated receptor gamma-like [KO:K08530]
115166142  peroxisome proliferator-activated receptor gamma-like isoform X1 [KO:K08530]
115149901  peroxisome proliferator-activated receptor gamma-like isoform X1 [KO:K08530]
115160091  hydroxymethylglutaryl-CoA synthase, cytoplasmic-like isoform X1 [KO:K01641] [EC:2.3.3.10]
115163137  apolipoprotein A-I-1 [KO:K08757]
115206084  apolipoprotein A-I [KO:K08757]
115175773  type-4 ice-structuring protein-like [KO:K08758]
115176891  type-4 ice-structuring protein LS-12-like [KO:K08758]
115178427  type-4 ice-structuring protein LS-12-like [KO:K08758]
115150089  phospholipid transfer protein-like [KO:K08761]
115208376  phospholipid transfer protein-like isoform X1 [KO:K08761]
115175839  NADP-dependent malic enzyme-like [KO:K00029] [EC:1.1.1.40]
115177385  NADP-dependent malic enzyme-like [KO:K00029] [EC:1.1.1.40]
115155899  NADP-dependent malic enzyme-like [KO:K00029] [EC:1.1.1.40]
115161290  NADP-dependent malic enzyme-like [KO:K00029] [EC:1.1.1.40]
115192896  fatty acid desaturase 2-like isoform X1 [KO:K10226] [EC:1.14.19.3]
115192933  fatty acid desaturase 2-like [KO:K10226] [EC:1.14.19.3]
115192934  fatty acid desaturase 2-like [KO:K10226] [EC:1.14.19.3]
115192935  fatty acid desaturase 2-like isoform X1 [KO:K10226] [EC:1.14.19.3]
115193597  acyl-CoA desaturase-like [KO:K00507] [EC:1.14.19.1]
115152744  acyl-CoA desaturase-like [KO:K00507] [EC:1.14.19.1]
115153349  acyl-CoA desaturase-like [KO:K00507] [EC:1.14.19.1]
115159238  stearoyl-CoA desaturase 5-like [KO:K00507] [EC:1.14.19.1]
115148259  stearoyl-CoA desaturase 5-like [KO:K00507] [EC:1.14.19.1]
115169870  cholesterol 7-alpha-monooxygenase-like [KO:K00489] [EC:1.14.14.23]
115156828  cholesterol 7-alpha-monooxygenase-like [KO:K00489] [EC:1.14.14.23]
115169574  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
115169575  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
115157201  5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase-like [KO:K07431] [EC:1.14.14.139]
115167550  oxysterols receptor LXR-alpha-like isoform X1 [KO:K08536]
115202857  oxysterols receptor LXR-alpha-like isoform X1 [KO:K08536]
115156161  sterol 26-hydroxylase, mitochondrial isoform X1 [KO:K00488] [EC:1.14.15.15]
115160652  sterol 26-hydroxylase, mitochondrial-like [KO:K00488] [EC:1.14.15.15]
115160949  sterol 26-hydroxylase, mitochondrial-like isoform X1 [KO:K00488] [EC:1.14.15.15]
115160950  sterol 26-hydroxylase, mitochondrial-like [KO:K00488] [EC:1.14.15.15]
115179454  cytochrome P450 27C1-like [KO:K00488] [EC:1.14.15.15]
115196033  cytochrome P450 27C1-like [KO:K00488] [EC:1.14.15.15]
115155748  acyl-CoA-binding protein-like [KO:K08762]
115161079  acyl-CoA-binding protein-like [KO:K08762]
115179630  acyl-CoA-binding protein-like [KO:K08762]
115196074  acyl-CoA-binding protein-like [KO:K08762]
115157543  lipoprotein lipase-like [KO:K01059] [EC:3.1.1.34]
115158162  lipoprotein lipase-like [KO:K01059] [EC:3.1.1.34]
115158163  lipoprotein lipase-like [KO:K01059] [EC:3.1.1.34]
115151752  lipoprotein lipase-like [KO:K01059] [EC:3.1.1.34]
115151753  lipoprotein lipase-like [KO:K01059] [EC:3.1.1.34]
115161673  acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
115168052  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
115192069  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
115169833  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
115154012  long-chain-fatty-acid--CoA ligase 6-like isoform X1 [KO:K01897] [EC:6.2.1.3]
115154458  long-chain-fatty-acid--CoA ligase 4-like isoform X1 [KO:K01897] [EC:6.2.1.3]
115163632  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
115156865  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
115164541  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
115148550  long-chain-fatty-acid--CoA ligase 6-like isoform X1 [KO:K01897] [EC:6.2.1.3]
115149000  long-chain-fatty-acid--CoA ligase 4-like isoform X1 [KO:K01897] [EC:6.2.1.3]
115206524  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
115202052  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
115205514  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
115200105  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
115164760  long-chain-fatty-acid--CoA ligase ACSBG2-like isoform X1 [KO:K15013] [EC:6.2.1.3]
115192554  long-chain-fatty-acid--CoA ligase ACSBG2-like isoform X1 [KO:K15013] [EC:6.2.1.3]
115158325  long-chain-fatty-acid--CoA ligase ACSBG2-like isoform X1 [KO:K15013] [EC:6.2.1.3]
115199882  long-chain-fatty-acid--CoA ligase ACSBG2-like [KO:K15013] [EC:6.2.1.3]
115155396  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
115183174  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
115157509  scp2; non-specific lipid-transfer protein [KO:K08764] [EC:2.3.1.176]
115178807  peroxisomal acyl-coenzyme A oxidase 1-like isoform X1 [KO:K00232] [EC:1.3.3.6]
115208632  peroxisomal acyl-coenzyme A oxidase 1-like isoform X1 [KO:K00232] [EC:1.3.3.6]
115198552  acox3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
115170852  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
115160513  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
115166773  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
115152077  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
115203631  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
115197187  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
115197256  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
115158680  cpt2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
115179855  acadl; long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00255] [EC:1.3.8.8]
115157647  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
115169964  angiopoietin-related protein 4-like [KO:K08767]
115156733  angiopoietin-related protein 4-like [KO:K08767]
115193998  sorbin and SH3 domain-containing protein 1-like isoform X1 [KO:K06086]
115153011  sorbs1; sorbin and SH3 domain-containing protein 1 [KO:K06086]
115151991  perilipin-1-like isoform X1 [KO:K08768]
115191521  perilipin-2-like isoform X1 [KO:K17284]
115194203  perilipin-2-like [KO:K17284]
115198209  perilipin-2-like isoform X1 [KO:K17284]
115156597  adiponectin-like [KO:K07296]
115148164  adiponectin-like [KO:K07296]
115163685  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
115206565  integrin-linked protein kinase-like [KO:K06272] [EC:2.7.11.1]
115171189  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
115159572  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
115200924  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
115198728  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
115154315  polyubiquitin-C isoform X1 [KO:K08770]
115148848  ubc; polyubiquitin-C isoform X1 [KO:K08770]
115149607  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like isoform X1 [KO:K01596] [EC:4.1.1.32]
115195610  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [KO:K01596] [EC:4.1.1.32]
115208392  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
115161411  glycerol kinase-like [KO:K00864] [EC:2.7.1.30]
115179457  glycerol kinase-like isoform X1 [KO:K00864] [EC:2.7.1.30]
115196406  glycerol kinase-like isoform X1 [KO:K00864] [EC:2.7.1.30]
115208243  aquaporin-7-like isoform X1 [KO:K08771]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
stru00071  Fatty acid degradation
stru00120  Primary bile acid biosynthesis
stru00564  Glycerophospholipid metabolism
stru04920  Adipocytokine signaling pathway
KO pathway
ko03320   
LinkDB

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