KEGG   PATHWAY: tru04217
Entry
tru04217                    Pathway                                
Name
Necroptosis - Takifugu rubripes (torafugu)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
tru04217  Necroptosis
tru04217

Organism
Takifugu rubripes (torafugu) [GN:tru]
Gene
654303  tnfa; tumor necrosis factor alpha [KO:K03156]
101071351  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
115248670  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
101075607  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101076265  traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101064444  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
101075779  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
101073092  ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
101075537  inhibitor of apoptosis protein [KO:K16060]
101067395  E3 ubiquitin-protein ligase XIAP-like [KO:K04725] [EC:2.3.2.27]
101070545  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
101064989  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
115247907  E3 ubiquitin-protein ligase RNF31-like isoform X1 [KO:K11974] [EC:2.3.2.31]
101064102  rnf31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
101065618  E3 ubiquitin-protein ligase RNF31-like isoform X1 [KO:K11974] [EC:2.3.2.31]
101068646  E3 ubiquitin-protein ligase RNF31-like isoform X6 [KO:K11974] [EC:2.3.2.31]
101070617  sharpin; sharpin isoform X2 [KO:K20894]
101064168  spata2; spermatogenesis-associated protein 2 [KO:K17595]
101071808  spata2l; spermatogenesis-associated protein 2-like protein [KO:K17595]
101066719  cyld; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
101078865  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
101066916  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
115250596  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
115247195  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
101067067  FAS-associated death domain protein [KO:K02373]
115246498  FAS-associated death domain protein-like [KO:K02373]
101075191  caspase-8-like [KO:K04398] [EC:3.4.22.61]
101075631  caspase-8 [KO:K04398] [EC:3.4.22.61]
101061322  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
101063858  cflar; CASP8 and FADD-like apoptosis regulator [KO:K04724]
445888  gp91phox; gp91phox protein [KO:K21421] [EC:1.-.-.-]
101068297  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5 [KO:K04515] [EC:2.7.11.17]
101064236  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
101073370  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X7 [KO:K04515] [EC:2.7.11.17]
101062260  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101071995  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
101061448  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
751095  slc25a4; ADP/ATP translocase 1 [KO:K05863]
743354  ants6; adenine nucleotide translocator s6 [KO:K05863]
751094  slc25a5; ADP/ATP translocase 2 [KO:K05863]
101066949  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
101068401  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101065268  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
101069732  voltage-dependent anion-selective channel protein 2 [KO:K15040]
101069276  voltage-dependent anion-selective channel protein 2-like isoform X2 [KO:K15041]
101072881  glud1; glutamate dehydrogenase 1, mitochondrial [KO:K00261] [EC:1.4.1.3]
101073641  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
101071091  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
115247848  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
101073278  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
101075522  pygm; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
101074510  glycogen phosphorylase, muscle form-like [KO:K00688] [EC:2.4.1.1]
101065164  pygb; glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
101073575  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101070190  mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
101067839  mapk10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
101078548  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101073513  LOW QUALITY PROTEIN: ferritin, middle subunit [KO:K00522] [EC:1.16.3.1]
101064331  ferritin, heavy subunit [KO:K00522] [EC:1.16.3.1]
101072305  ferritin, lower subunit isoform X2 [KO:K00522] [EC:1.16.3.1]
101065347  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
101065943  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101069259  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
101073653  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
115249799  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
101070784  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
101070832  calpain-1 catalytic subunit-like isoform X2 [KO:K01367] [EC:3.4.22.52]
101075956  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
101063922  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
101072522  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
101080097  LOW QUALITY PROTEIN: calpain-8-like [KO:K01367] [EC:3.4.22.52]
115247065  calpain-8-like isoform X1 [KO:K01367] [EC:3.4.22.52]
101064754  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
101076184  calpain-2 catalytic subunit-like isoform X2 [KO:K03853] [EC:3.4.22.53]
101076595  calpain-2 catalytic subunit-like isoform X2 [KO:K03853] [EC:3.4.22.53]
101061586  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
101069634  pgam5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
101075619  dynamin-1-like protein isoform X2 [KO:K17065] [EC:3.6.5.5]
101073902  dynamin-1-like protein isoform X4 [KO:K17065] [EC:3.6.5.5]
101076232  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
101064415  caspase-1-like [KO:K01370] [EC:3.4.22.36]
101062626  caspase-1-like [KO:K01370] [EC:3.4.22.36]
101080001  il1b; interleukin-1 beta [KO:K04519]
101078962  chmp2a; charged multivesicular body protein 2a [KO:K12191]
101069954  chmp2b; charged multivesicular body protein 2b [KO:K12192]
101069426  chmp3; charged multivesicular body protein 3 [KO:K12193]
101072878  charged multivesicular body protein 4b [KO:K12194]
101063168  chmp4b; charged multivesicular body protein 4b [KO:K12194]
101075600  charged multivesicular body protein 4c-like [KO:K24782]
101074991  chmp6; charged multivesicular body protein 6 [KO:K12195]
101067383  charged multivesicular body protein 6-like [KO:K12195]
101066795  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
101077130  vacuolar protein sorting-associated protein 4B-like isoform X1 [KO:K12196]
101069250  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
101067023  chmp1a; charged multivesicular body protein 1a [KO:K12197]
101061059  chmp1b; charged multivesicular body protein 1b [KO:K12197]
101079293  charged multivesicular body protein 5-like [KO:K12198]
101070321  charged multivesicular body protein 5 [KO:K12198]
101077971  chmp7; charged multivesicular body protein 7 [KO:K15053]
101077272  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X2 [KO:K04982] [EC:2.7.11.1]
101067170  high mobility group protein B1 [KO:K10802]
115252562  high mobility group-T protein-like [KO:K10802]
101061420  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
100653422  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
101068795  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
101073992  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04722]
101068020  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
101074300  tumor necrosis factor ligand superfamily member 6-like isoform X1 [KO:K04389]
101067230  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
101064747  interferon a3-like [KO:K05414]
115251511  interferon a3-like [KO:K05414]
105416329  ifngr1l; interferon gamma receptor 1-like precursor [KO:K05132]
105418770  ifngr1; interferon gamma receptor 1 precursor [KO:K05132]
101072065  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101065198  tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
101068778  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
101073316  tyrosine-protein kinase JAK2-like [KO:K11218] [EC:2.7.10.2]
101080190  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
101079646  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
101068828  stat1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
101071462  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11221]
101070968  stat3; signal transducer and activator of transcription 3 isoform X2 [KO:K04692]
101068057  signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
101071345  signal transducer and activator of transcription 5B [KO:K11224]
101065277  signal transducer and activator of transcription 5B-like isoform X1 [KO:K11225]
101063878  irf9; interferon regulatory factor 9 [KO:K04693]
100144316  eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
100134852  ticam; toll-like receptor adaptor molecule [KO:K05842]
101061662  tlr3; toll-like receptor 3 [KO:K05401]
101076868  ubiquitin carboxyl-terminal hydrolase 21-like [KO:K21634] [EC:3.4.19.12]
101074386  sequestosome-1 isoform X2 [KO:K14381]
115248426  sequestosome-1-like isoform X1 [KO:K14381]
101076976  heat shock protein HSP 90-beta [KO:K04079]
101069079  heat shock protein HSP 90-alpha 1 [KO:K04079]
101068853  heat shock protein HSP 90-alpha [KO:K04079]
101062530  tnfaip3; tumor necrosis factor alpha-induced protein 3 isoform X2 [KO:K11859] [EC:3.4.19.12]
101080146  parp1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
101068139  bax; apoptosis regulator BAX [KO:K02159]
101069964  apoptosis regulator BAX-like [KO:K02159]
101067511  apoptosis regulator BAX-like [KO:K02159]
101063298  aifm1; apoptosis-inducing factor 1, mitochondrial isoform X3 [KO:K04727] [EC:1.-.-.-]
101065890  histone H2A.Z [KO:K11251]
101072117  late histone H2A.2.2-like [KO:K11251]
101067696  histone H2A [KO:K11251]
101079598  histone H2A [KO:K11251]
101077111  histone H2A [KO:K11251]
101075392  histone H2A type 1-H [KO:K11251]
101078553  core histone macro-H2A.1 isoform X1 [KO:K11251]
101068629  histone H2AX [KO:K11251]
101071831  histone H2A-like [KO:K11251]
101071610  histone H2A-like [KO:K11251]
101071383  histone H2A-like [KO:K11251]
101080230  histone H2A.V [KO:K11251]
101078211  histone H2A [KO:K11251]
101074545  histone H2A-like [KO:K11251]
101075283  core histone macro-H2A.2-like [KO:K11251]
101061396  histone H2A [KO:K11251]
101063100  histone H2A-like [KO:K11251]
101079120  histone H2A [KO:K11251]
101069475  histone H2A-like [KO:K11251]
115253393  histone H2A-like [KO:K11251]
115248313  histone H2A [KO:K11251]
115248350  core histone macro-H2A.2-like [KO:K11251]
101071268  peptidyl-prolyl cis-trans isomerase-like isoform X1 [KO:K03767] [EC:5.2.1.8]
101069204  peptidyl-prolyl cis-trans isomerase-like [KO:K03767] [EC:5.2.1.8]
101071036  peptidyl-prolyl cis-trans isomerase-like [KO:K03767] [EC:5.2.1.8]
101066520  peptidyl-prolyl cis-trans isomerase A-like [KO:K03767] [EC:5.2.1.8]
101071405  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
DOI:10.1038/cdd.2009.118
Reference
PMID:23898178
  Authors
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
  Title
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
  Journal
Proc Natl Acad Sci U S A 110:E3109-18 (2013)
DOI:10.1073/pnas.1301218110
Reference
PMID:21576359
  Authors
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
  Title
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
  Journal
Mol Cell Biol 31:2934-46 (2011)
DOI:10.1128/MCB.05445-11
Reference
PMID:24565922
  Authors
Sridharan H, Upton JW
  Title
Programmed necrosis in microbial pathogenesis.
  Journal
Trends Microbiol 22:199-207 (2014)
DOI:10.1016/j.tim.2014.01.005
Reference
PMID:21738214
  Authors
Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA
  Title
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
  Journal
Cell Death Differ 19:245-56 (2012)
DOI:10.1038/cdd.2011.91
Reference
PMID:20697198
  Authors
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pathway
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tru04210  Apoptosis
KO pathway
ko04217   
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