KEGG   PATHWAY: pbi00230
Entry
pbi00230                    Pathway                                
Name
Purine metabolism - Python bivittatus (Burmese python)
Class
Metabolism; Nucleotide metabolism
Pathway map
pbi00230  Purine metabolism
pbi00230

Module
pbi_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:pbi00230]
pbi_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:pbi00230]
pbi_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:pbi00230]
pbi_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:pbi00230]
pbi_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:pbi00230]
pbi_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:pbi00230]
pbi_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:pbi00230]
Other DBs
GO: 0006163 0042278
Organism
Python bivittatus (Burmese python) [GN:pbi]
Gene
103048069  ADSS; adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
103048266  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
103048410  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
103048469  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
103048720  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
103048850  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
103048917  [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
103049018  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103049155  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
103049322  ATIC; bifunctional purine biosynthesis protein PURH isoform X1 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
103049689  [KO:K01939] [EC:6.3.4.4]
103049984  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
103050074  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
103050139  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
103050190  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
103050340  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103051020  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
103051113  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
103051430  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
103051661  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103051745  [KO:K00364] [EC:1.7.1.7]
103051862  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
103051878  CANT1; soluble calcium-activated nucleotidase 1 isoform X3 [KO:K12304] [EC:3.6.1.6]
103051922  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
103052438  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
103052551  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
103052637  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
103052703  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
103052911  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
103052921  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
103053308  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
103053315  [KO:K00948] [EC:2.7.6.1]
103053545  [KO:K01466] [EC:3.5.2.5]
103053833  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X2 [KO:K01510] [EC:3.6.1.5]
103053973  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X2 [KO:K18436] [EC:3.1.4.53]
103054355  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
103054566  [KO:K12324] [EC:4.6.1.2]
103054576  AMPD3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
103054669  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
103054690  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
103054757  [KO:K13296] [EC:3.1.4.17]
103054800  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
103055237  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
103055318  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
103055695  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
103055787  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X3 [KO:K01518] [EC:3.6.1.17]
103056105  PRUNE1; exopolyphosphatase PRUNE1 isoform X3 [KO:K01514] [EC:3.6.1.11]
103056440  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
103056546  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
103056571  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
103056945  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
103057116  AK9; LOW QUALITY PROTEIN: adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
103057117  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X2 [KO:K13755] [EC:3.1.4.17]
103057336  [KO:K13293] [EC:3.1.4.53]
103057351  [KO:K13293] [EC:3.1.4.53]
103057412  [KO:K12319] [EC:4.6.1.2]
103057564  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
103057609  [KO:K13293] [EC:3.1.4.53]
103057790  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
103057873  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
103057964  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
103058911  [KO:K00365] [EC:1.7.3.3]
103059065  [KO:K00940] [EC:2.7.4.6]
103059230  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
103059501  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
103059568  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
103059826  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
103060035  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103060301  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
103060465  [KO:K22600] [EC:4.6.1.2]
103060584  ADCY5; adenylate cyclase type 5 isoform X2 [KO:K08045] [EC:4.6.1.1]
103060629  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
103060841  PAICS; multifunctional protein ADE2 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
103060907  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
103060958  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
103061057  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
103061069  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
103061345  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
103061767  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
103062157  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
103062293  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
103062350  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
103062355  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
103062420  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
103062440  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
103062663  GMPR2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
103062671  [KO:K10808] [EC:1.17.4.1]
103062751  [KO:K12322] [EC:4.6.1.2]
103063135  [KO:K00088] [EC:1.1.1.205]
103063168  ALLC; LOW QUALITY PROTEIN: probable allantoicase [KO:K01477] [EC:3.5.3.4]
103063300  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
103063318  [KO:K13811] [EC:2.7.7.4 2.7.1.25]
103063344  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
103063377  [KO:K00939] [EC:2.7.4.3]
103063664  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X2 [KO:K01081] [EC:3.1.3.5]
103063696  [KO:K12319] [EC:4.6.1.2]
103063739  [KO:K00948] [EC:2.7.6.1]
103063891  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
103064012  NT5C2; cytosolic purine 5'-nucleotidase isoform X3 [KO:K01081] [EC:3.1.3.5]
103064294  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
103064447  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
103064571  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
103064680  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
103064683  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
103064925  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
103065373  [KO:K01081] [EC:3.1.3.5]
103065460  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2 [KO:K13755] [EC:3.1.4.17]
103066047  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
103066159  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X3 [KO:K00760] [EC:2.4.2.8]
103066259  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
103066411  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
103066426  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
103066456  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
103066530  [KO:K18438] [EC:3.1.4.17 3.1.4.35]
103066589  [KO:K00939] [EC:2.7.4.3]
103066668  [KO:K13755] [EC:3.1.4.17]
103066886  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
103066932  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
103066987  ADK; adenosine kinase isoform X2 [KO:K00856] [EC:2.7.1.20]
103067155  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X2 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
103067156  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
103067250  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
103067331  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
103067655  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
103067773  GUCY2C; heat-stable enterotoxin receptor isoform X1 [KO:K12320] [EC:4.6.1.2]
103068192  [KO:K08041] [EC:4.6.1.1]
103068240  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
112542373  [KO:K01466] [EC:3.5.2.5]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
pbi00030  Pentose phosphate pathway
pbi00220  Arginine biosynthesis
pbi00250  Alanine, aspartate and glutamate metabolism
pbi00260  Glycine, serine and threonine metabolism
pbi00340  Histidine metabolism
pbi00630  Glyoxylate and dicarboxylate metabolism
pbi00730  Thiamine metabolism
pbi00740  Riboflavin metabolism
pbi00790  Folate biosynthesis
KO pathway
ko00230   

DBGET integrated database retrieval system